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| 1 | Expression and clinical significance of TAp73α, p53, PCNA and apoptosis in hepatocellular carcinoma显示文摘AIM: To study the prognostic role of TAp73α, p53, proliferating cell nuclear antigen (PCNA) and apoptosis inpatients with hepatocellular carcinoma (HCC) atter surgical tumor ablation.METHODS: Forty-seven human resected HCC tissues and 42 adjacent non-cancerous tissues were studied with 10 normal liver tissues as control group. TAp73α, p53, and PCNA were detected with Elivision immunohistochemistry.Terminal deoxynucleotidyl transferase (TdT)-mediatedd-UTP-biotin nick-end labeling (TUNEL) method wasused to detect the apoptosis cells. All clinical and pathological materials were analyzed by SPSS10.0statistical package.RESULTS: TAp73α overexpressed in HCC tissues (36.2%) when compared with adjacent non-cancerous tissues (2.38%, P<0.005) and normal liver tissues (0, P<0.01).Mutant type p53 (mt-p53) overexpressed in HCC tissues (38.3%) when contracted with adjacent non-cancerous tissues (16.7%, P<0.05) and normal liver tissues (0, P<0.01). Proliferation index (PI) level in HCC tissues was significantly higher than that in adjacent non-cancerous tissues (30.34%±4.46% vs 27.88%±5.89%, t, P= 0.028). Apoptosis index (AI) level in HCC tissues was higher than that in adjacent non-cancerous tissues (8.62%±2.28% vs 7.38%±2.61%, t, P = 0.019). Expression of TAp73α was associated with lymph node metastasis and mt-p53, with r = 0.407 and 0.265, respectively. Expression of mtp53 was associated with Edmondson's stage and AFP, with r = 0.295 and -0.357, respectively. In Kaplan-Meier univariant analysis, TAp73α, AFP, TNM stage, portal vein invasion, liver membrane invasion and HBsAg correlated with prognosis (log rank, P = 0.039, 0.012, 0.002, 0.000,0.014, 0.007, respectively). Multivariant Cox regression analysis showed that TAp73α, AFP, TNM stage, portal vein invasion, liver membrane invasion and age were independent factors of prognosis. CONCLUSION: These results suggest that TAp73α can be used as a prognostic indicator of patients with HCC undergoing surgical tumor ablation. AFP, TNM, portal vein invasion, liver membrane invasion and age also have a potency of predicting the prognosis of HCC. | Hai-XiaQin Ke-JunNan GuangYang ZhaoJing Zhi-PingRuan Chun-LiLi RuiXu HuiGuo Chen-GuangSui Yong-ChangWei | 2005 | World Journal of Gastroenterology2005，11，18： | 12 |
| 2 | Elevated G6PD expression contributes to migration and invasion of hepatocellular carcinoma cells by inducing epithelial-mesenchymal transition显示文摘改变的新陈代谢是癌症房间的特点之一。戊糖磷酸盐小径(PPP ) 是细胞的新陈代谢的一个基本部件。Glucose-6-phosphate 脱氢酶(G6PD ) , PPP 的限制率的酶,在许多癌症被提高并且由通过 PPP 生产 ribose-5-phosphate 和 NADPH 贡献肿瘤生长。然而,在 hepatocellular 的 G6PD 的角色癌(HCC ) 转移和在 HCC 前进和预后的 G6PD 的临床的意义一直不是很好坚定的。在这研究,由从 HCC 病人和 HCC 房间线调查织物样品,我们发现那提高的 G6PD 表情显著地与 HCC 转移和差的预后被联系 HCC,和那 G6PD 击倒在 vitro 禁止 HCC 房间线的增长,移植和侵略。进一步的研究表明 G6PD 由通过信号变换器的激活和抄写 3 的使活跃之物(STAT3 ) 导致上皮间充质的转变贡献 HCC 移植和 hepatocellular 癌房间的侵略小径。我们的调查结果建议那指向的 G6PD 能为转移干预开创可能性并且为 HCC 改进病人结果。 | Ming Lu Lu Lu Qiongzhu Dong Guangyang Yu Jinhong Chen Lunxiu Qin Lianxin Wang Wenwei Zhu Huliang Jia | 2018 | Acta Biochimica et Biophysica Sinica2018，50，4： | 10 |
| 3 | Prognostic factors in 165 elderly colorectal cancer patients显示文摘AIM: To analyse the prognostic factors in 165 colorectal patients aged ≥70.METHODS: One hundred and sixty-five elderly patients with colorectal cancer diagnosed by histology were entered into the retrospective study between 1994 and 2001. Patients were given optimal operation alone, chemotherapy after operation, or chemotherapy alone according to tumor stage,histology, physical strength, and co-morbid problems.Survival rate was calculated by Kaplan-Meier method, and compared with meaningful variances by Log-rank method.Prognostic factors were analyzed by Cox regression.RESULTS: The 1,2,3,4,5 year survival rate (all-cause rnortality)was 87.76%, 65.96%, 52.05%, 42.77%, 40.51%,respectively. The mean survival time was 41.89±2.33 months (95% CI: 37.33-46.45 months), and the median survival time was 37 months. Univariate analysis showed that factors such as age, nodal metastasis, treatment method, Duke's stage, gross findings, kind of histology, and degree of differentiation had influences on the survival rate. Multivariate analysis showed that factors such as treatment method,Duke's stage, kind of histology and degree of differentiation were independent prognostic factors.CONCLUSION: This study suggests that the prognosis of elderly colorectal cancer patients is influenced by several factors. Most of elderly patients can endure surgery and/or chemotherapy, and have a long-time survival and good quality of life. | Ke-JunNan Hai-XiaQin GuangYang | 2003 | World Journal of Gastroenterology2003，9，10： | 8 |
| 4 | Umbilical cord-derived mesenchymal stem cells regulate thymic epithelial cell development and function in Foxn 1^-/- mice显示文摘 | Guangyang Liu Lihua Wang Tianxiang Pang Delin Zhu Yi Xu Hanyu Wang Xiuli Cong Yongjun Liu | 2014 | Cellular & Molecular Immunology2014，11，3： | 6 |
| 5 | Clinical evaluation of radiotherapy for advanced esophageal cancer after metallic stent placement显示文摘AIM: To evaluate the therapeutic effect of radiotherapy for esophageal cancer after expandable metallic stent placement. METHODS: Ten cases of advanced esophageal cancer were evaluated, 7 having complete obstruction and 3 with digestive-respiratory fistula. Ten nitinol stents were placed at the site of stenosis. Patients were treated with a total dose of i 200 cGy divided into 3 fractions of 400 cGy 4-7 d after stents placement.RESULTS: All the 10 stents were placed successfully at one time. After radiotherapy for advanced esophageal cancer, the survival period of the cases ranged from 14 to 22 too, with a mean survival of 17 mo. No re-stenosis occurred among all the 10 cases.CONCLUSION: Stent placement combined with radiotherapy for esophageal cancer is helpful to prolong patients' survival and reduce occurrence of re-stenosis. | You-TaoYu GuangYang YanLiu Bao-ZhongShen | 2004 | World Journal of Gastroenterology2004，10，14： | 4 |
| 6 | Simultaneous gene editing of three homoeoalleles in self-incompatible allohexaploid grasses显示文摘Clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system has been widely used for precise gene editing in plants.However,simultaneous gene editing of multiple homoeoalleles remains challenging,especially in self-incompatible polyploid plants.Here,we simultaneously introduced targeted mutations in all three homoeoalleles of two genes in the self-incompatible allohexaploid tall fescue,using both CRISPR/Cas9 and LbCas12a(LbCpf1)systems.Loss-of-function mutants of FaPDS exhibited albino leaves,while knockout of FaHSP17.9 resulted in impaired heat resistance in T0 generation of tall fescue.Moreover,these mutations were inheritable.Our findings demonstrate the feasibility of generating loss-of-function mutants in T0 generation polyploid perennial grasses using CRISPR/Cas systems. | Liang Zhang Tao Wang Guangyang Wang Aoyue Bi Misganaw Wassie Yan Xie Liwen Cao Huawei Xu Jinmin Fu Liang Chen Yang Zhao Tao Hu | 2021 | Journal of Integrative Plant Biology2021，63，8： | 3 |
| 7 | Glycerolipid Profiling of Yellow Sarson Seeds Using Ultra High Performance Liquid Chromatography Coupled to Triple Time-of-Flight Mass Spectrometry显示文摘Yellow sarson(Brassica rapa ssp. trillocularis) is an important rapeseed-mustard species of Brassica rapa due to its high seed oil content. Glycerolipids and fatty acid composition affect seed germination and determine the quality of seed oil. To date, no information is available on the composition of individual glycerolipids in this species. Therefore, in this study the glycerolipid profiling of yellow sarson seeds was performed using ultra high performance liquid chromatography coupled to triple time-of-flight mass spectrometry(UPLC-Triple-TOF-MS).A fast and efficient chromatographic separation of glycerolipids was accomplished based on an UPLCTMBEH C8 column within 22 min.In ESI positive ion mode, TOF-MS scan-information dependent acquisition-product ion scan was carried out to acquire both high resolution MS and MS/MS information from one injection. According to MS/MS spectra, predominant fragmentation patterns of glycerolipids were elucidated in detail. Based on retention time, accurate mass, isotopic distribution, and fragmentation patterns, the composition of 144 glycerolipids and fatty acids were finally identified in yellow sarson seeds, including 77 triacylglycerols, 32 diacylglycerols, 18sulfoquinovosyl-diacylglycerols, 5 monogalactosyl-diaclyglycerols, and 12 digalactosyl-diacylglycerols. Of them, the most abundant glycerolipids in yellow sarson seeds were triacylglycerols, the major storage form of seed oil in plants. In addition, diacylglycerols were found as a minor component of glycerolipids. The lowest amounts of glycerolipids detected in seeds were glycosyl-acylglycerols. The results revealed the composition and relative content of glycerolipids in yellow sarson seeds, which will provide a more comprehensive assessment of the quality of seed oil and also help to select functional cultivars with higher beneficial glycerolipids. This profiling method has the advantages of high throughput, high sensitivity and good accuracy, which will provide a reliable analysis platform for glycerolipids metabolism in plants. | ZHENG Shuning ZHANG Yanguo LIU Guangyang LV Jun LIU Zhongxiao XU Xiaomin LI Lingyun XU Donghui | 2017 | Horticultural Plant Journal2017，3，4： | 2 |
| 8 | Wearable and flexible electrochemical sensors for sweat analysis:a review显示文摘Flexible wearable sweat sensors allow continuous,real-time,noninvasive detection of sweat analytes,provide insight into human physiology at the molecular level,and have received significant attention for their promising applications in personalized health monitoring.Electrochemical sensors are the best choice for wearable sweat sensors due to their high performance,low cost,miniaturization,and wide applicability.Recent developments in soft microfluidics,multiplexed biosensing,energy harvesting devices,and materials have advanced the compatibility of wearable electrochemical sweat-sensing platforms.In this review,we summarize the potential of sweat for medical detection and methods for sweat stimulation and collection.This paper provides an overview of the components of wearable sweat sensors and recent developments in materials and power supply technologies and highlights some typical sensing platforms for different types of analytes.Finally,the paper ends with a discussion of the challenges and a view of the prospective development of this exciting field. | Fupeng Gao Chunxiu Liu Lichao Zhang Tiezhu Liu Zheng Wang Zixuan Song Haoyuan Cai Zhen Fang Jiamin Chen Junbo Wang Mengdi Han Jun Wang Kai Lin Ruoyong Wang Mingxiao Li Qian Mei Xibo Ma Shuli Liang Guangyang Gou Ning Xue | 2023 | Microsystems & Nanoengineering2023，9，1： | 2 |
| 9 | Cytosolic protection against ultraviolet induced DNA damage by blueberry anthocyanins and anthocyanidins in hepatocarcinoma HepG2 cells 显示文摘 | Wei Liu Xiangyi Lu Guangyang He | 2013 | Biotechnol Lett2013，，： | 1 |
| 10 | Inositol 1,4,5-trisphosphate 3-kinases:functions and regulations显示文摘Inositol 1,4,5-trisphosphate 3-kinase (IP3 3-kinase/IP3K) plays an important role in signal transduction in animal cellsby phosphorylating inositol 1,4,5-trisphosphate (IP3) to inositol 1,3,4,5-tetrakisphosphate (IP4). Both IP3 and IP4 arecritical second messengers which regulate calcium (Ca2+) homeostasis. Mammalian IP3Ks are involved in many biologicalprocesses, including brain development, memory, learning and so on. It is widely reported that Ca2+ is a canonicalsecond messenger in higher plants. Therefore, plant IP3K should also play a crucial role in plant development. Recently,we reported the identification of plant IP3K gene (AtIpk2β/AtIP3K) from Arabidopsis thaliana and its characterization.Here, we summarize the molecular cloning, biochemical properties and biological functions of IP3Ks from animal, yeastand plant. This review also discusses potential functions of IP3Ks in signaling crosstalk, inositol phosphate metabolism,gene transcriptional control and so on. | HuiJunXIA GuangYANG | 2005 | Cell Research2005，15，2： | 1 |
| 11 | Anaerobic Oxidation of Ferrous Iron by Microbial Mixture and its potential to remove Mercury and Nitrate from the Groundwater显示文摘 | Guangyang W Daoyong Z Xiangliang P | 2010 | Research Jour- nal of Chemistry and Environmen Vol2010，14，： | 1 |
| 12 | Pig islet xenograft rejection in a mouse model with an established human immune system显示文摘 | NorikoTonomura AkiraShimizu ShumeiWang KazuhikoYamada VajaTchipashvili Gordon C.Weir Yong‐GuangYang | 2008 | Xenotransplantation2008，，2： | 1 |
| 13 | Inhibition of a C‐rich oligodeoxynucleotide on activation of immune cells in vitro and enhancement of antibody response in mice显示文摘 | GuangYang MinWan YongshengZhang LuguoSun RanSun DaliHu XiaojingZhou LiWang XiuliWu LiyingWang YongliYu | 2010 | Immunology2010，，4： | 1 |
| 14 | Background progenitor activation is associated with recurrence after hepatectomy of combined hepatocellular‐cholangiocarcinoma显示文摘 | Xiong Cai Jian Zhai David E. Kaplan Yijun Zhang Lining Zhou Xutao Chen Guangyang Qian Qiudong Zhao Yonghai Li Lu Gao Wenming Cong Minghua Zhu Zhenlin Yan Lehua Shi Dong Wu Lixin Wei Feng Shen Mengchao Wu | 2012 | Hepatology2012，，5： | 1 |
| 15 | Estimation of secondary nucleation kinetics of benzoic acid in batch crystallizer显示文摘The nucleation and growth kinetics of benzoic acid were determined in a population balance model,describing the seeded batch antisolvent crystallization process.The process analytical technologies(PATs)were utilized to record the evolution of chord length distributions(CLDs)in solid phase together with the concentration decay in liquid phase,which provided essential experimental information for parameter estimation.The model was solved using standard method of moments based on the moments calculated from CLDs and solute concentration.A developed model,incorporating the nucleation and crystal growth as functions of both supersaturation and solvent composition,has been constructed by fitting the zeroth moment of particles and concentration trends.The determined kinetic parameters were consequently validated against a new experiment with a different flow rate,indicating that the developed model predicted crystallization process reasonably well.This work illustrates the strategy in construct a population balance model for further simulation,model-based optimization and control studies of benzoic acid in antisolvent crystallization. | Yan Zhao Weiyuan Zhang Jinbo Ouyang Guangyang Hou Vamsi Krishna Kamaraju Brian Glennon | 2024 | Particuology2024，87，4： | 0 |
| 16 | Modeling the Resilience of Power Distribution Systems Subjected to Extreme Winds Considering Tree Failures:An Integrated Framework显示文摘Overhead electrical power distribution systems(PDS)are very susceptible to extreme wind hazards.Power outages can cause catastrophic consequences,including economic losses,loss of critical services,and disruption to daily life.Therefore,it is very important to model the resilience of PDS against extreme winds to support disaster planning.While several frameworks currently exist to assess the resilience of PDS subjected to extreme winds,these frameworks do not systematically consider the tree-failure risk.In other words,there is no integrated framework that can simultaneously consider tree failures,PDS component failures induced by falling trees,resilience assessment,and evaluation of resilience enhancement with vegetation management.Therefore,this study proposed an integrated simulation framework to model the resilience of PDS against extreme winds,which includes tree fragility modeling,PDS fragility modeling,PDS component failure estimation,system performance evaluation,system restoration modeling,and resilience enhancement evaluation.The framework is demonstrated with a power distribution network in Oklahoma.The results show that the estimated system resilience will reduce if tree failures are considered.Crown thinning can effectively enhance the system’s resilience,but the effectiveness is affected by both wind speed and direction. | Guangyang Hou Kanthasamy K.Muraleetharan | 2023 | International Journal of Disaster Risk Science2023，14，2： | 0 |
| 17 | Tuning the electron transport behavior at Li/LATP interface for enhanced cyclability of solid-state Li batteries显示文摘An interlayer is usually employed to tackle the interfacial instability issue between solid electrolytes(SEs)and Li metal caused by the side reaction.However,the failure mechanism of the ionic conductor interlayers,especially the influence from electron penetration,remains largely unknown.Herein,using Li1.3Al0.3Ti1.7(PO4)3(LATP)as the model SE and LiF as the interlayer,we use metal semiconductor contact barrier theory to reveal the failure origin of Li/LiF@LATP interface based on the calculation results of density functional theory(DFT),in which electrons can easily tunnel through the LiF grain boundary with F vacancies due to its narrow barrier width against electron injection,followed by the reduction of LATP.Remarkably,an Al-LiF bilayer between Li/LATP is found to dramatically promote the interfacial stability,due to the highly increased barrier width and homogenized electric field at the interface.Consequently,the Li symmetric cells with Al-LiF bilayer can exhibit excellent cyclability of more than 2,000 h superior to that interlayered by LiF monolayer(~860 h).Moreover,the Li/Al-LiF@LATP/LiFePO4 solid-state batteries deliver a capacity retention of 83.2%after 350 cycles at 0.5 C.Our findings emphasize the importance of tuning the electron transport behavior by optimizing the potential barrier for the interface design in high-performance solid-state batteries. | Linshan Luo Feng Zheng Haowen Gao Chaofei Lan Zhefei Sun Wei Huang Xiang Han Ziqi Zhang Pengfei Su Peng Wang Shengshi Guo Guangyang Lin Jianfang Xu Jianyuan Wang Jun Li Cheng Li Qiaobao Zhang Shunqing Wu Ming-Sheng Wang Songyan Chen | 2023 | Nano Research2023，16，1： | 0 |
| 18 | Single-ended Fault Detection Scheme Using Support Vector Machine for Multi-terminal Direct Current Systems Based on Modular Multilevel Converter显示文摘This paper proposes a single-ended fault detection scheme for long transmission lines using support vector machine(SVM)for multi-terminal direct current systems based on modular multilevel converter(MMC-MTDC).The scheme overcomes existing detection difficulties in the protection of long transmission lines resulting from high grounding resistance and attenuation,and also avoids the sophisticated process of threshold value selection.The high-frequency components in the measured voltage extracted by a wavelet transform and the amplitude of the zero-mode set of the positive-sequence voltage are the inputs to a trained SVM.The output of the SVM determines the fault type.A model of a four-terminal DC power grid with overhead transmission lines is built in PSCAD/EMTDC.Simulation results of EMTDC confirm that the proposed scheme achieves 100%accuracy in detecting short-circuit faults with high resistance on long transmission lines.The proposed scheme eliminates mal-operation of DC circuit breakers when faced with power order changes or AC-side faults.Its robustness and time delay are also assessed and shown to have no perceptible effect on the speed and accuracy of the detection scheme,thus ensuring its reliability and stability. | Guangyang Zhou Xiahui Zhang Minxiao Han Shaahin Filizadeh Zhi Geng | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，3： | 0 |
| 19 | Simulation of the effects of defects in low temperature Ge buffer layer on dark current of Si-based Ge photodiodes显示文摘The influence of defects in low temperature Ge layer on electrical characteristics of p-Ge/i-Ge/n-Si and n-Ge/i-Ge/p-Ge photodiodes(PDs) was studied.Due to a two-step growth method,there are high defect densities in low-temperature buffer Ge layer.It is shown that the defects in low-temperature Ge layer change the band diagrams and the distribution of electric field,leading to the increase of the total dark current for p-Ge/i-Ge/n-Si PDs,whereas these defects have no influence on the dark current for n-Ge/i-Ge/p-Ge PDs.As a complement,a three-dimensional simulation of the total current under illumination was also performed. | Xiaohui Yi Zhiwei Huang Guangyang Lin Cheng Li Songyan Chen Wei Huang Jun Li Jianyuan Wang | 2017 | Journal of Semiconductors2017，38，4： | 0 |
| 20 | High gain,broadband p-WSe_(2)/n-Ge van der Waals heterojunction phototransistor with a Schottky barrier collector显示文摘Mixed-dimensional van der Waals(vdW)heterostructures based on two-dimensional transition metal dichalcogenides and threedimensional semiconductors have led to a new era in next-generation optoelectronics due to the high-quality interfaces and energy band complementation,especially in broadband photodetectors which can be used for all-weather navigation,object identification,etc.However,the reported photodetectors conventionally operated in photodiode mode with low responsivity and a narrow response spectrum.In this study,we report a p-WSe_(2)/n-Ge vdW heterojunction phototransistor with a Schottky barrier collector on n-Ge for broadband photodetection.Large hole/electron injection ratio from p-WSe_(2)/n-Ge heterojunction under forward bias due to their large bandgap offset renders the high photocurrent gain,while the Ge Schottky barrier limits the dark current.The responsivities of the phototransistor at 1.0 V emitter-collector bias are 55,95,and 120 A·W−1 at 405,1,310,and 1,550 nm,respectively,which is superior to that of the corresponding p-WSe_(2)/n-Ge photodiodes.The phototransistor shows a high photocurrent gain of 80,a specific detectivity of 1011 Jones,as well as a fast response time of 290μs at 1,550 nm.The results suggest that the novel phototransistor being implemented with complementary metal-oxide-semiconductor processing is an ideal strategy for high-performance broadband photodetection. | Shuo Li Qiang Wu Haokun Ding Songsong Wu Xinwei Cai Rui Wang Jun Xiong Guangyang Lin Wei Huang Songyan Chen Cheng Li | 2023 | Nano Research2023，16，4： | 0 |
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