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| 1 | Expression of fragile histidine triad in primary hepatocellular carcinoma and its relation with cell proliferation and apoptosis显示文摘AIM: To evaluate the expression of fragile histidine triad (FHIT) gene protein, product of a candidate tumor suppressor,and to investigate the relationship between FHIT, cell apoptosis and proliferation, and pathological features of primary hepatocellular carcinoma (HCC).METHODS: Forty-seven HCC and ten normal liver specimens were collected during surgical operation between 2001and 2003. FHIT and proliferating cell nuclear antigen (PCNA)expression were detected by immunohistochemistry, and apoptotic level was evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay on the tissue sections.RESULTS: All normal liver tissues showed a strong expression of FHIT, whereas 28 of 47 (59.6%) carcinomas showed a significant loss or absence of FHIT expression (P = 0.001).The proportion of reduced FHIT expression in those carcinomas at stages Ⅲ-Ⅳ (70.6%) and in those with extrahepatic metastasis (86.7%) showed an increasing trend compared with those at stages Ⅰ-Ⅱ (30.8%, P= 0.013) and those without metastasis (46.9%, P = 0.010) respectively. Apoptotic incidence in advanced TNM stage carcinoma and those with positive FHIT expression was higher than that in early stage carcinoma (P = 0.030) and in those with negative FHIT expression (P = 0.044) respectively. The proliferating potential of hepatocellular carcinoma was associated with FHIT expression (P = 0.016) and the aggressive feature (P = 0.019). Kaplan-Meier analysis demonstrated that the survival time of these 47 patients correlated with TNM stage,FHIT expression and metastasis.CONCLUSION: There is marked loss or absence of FHIT expression, as well as abnormal apoptosis-proliferation balance in HCC. FHIT may play an important role in carcinogenesis and development of HCC. | Ke-JunNan Zhi-PingRuan ZhaoJing Hai-XiaQin Hong-YanWang HuiGuo RuiXu | 2005 | World Journal of Gastroenterology2005，11，2： | 33 |
| 2 | Expression of p57^(kip2) and its relationship with clinicopathology, PCNA and p53 in primary hepatocellular carcinoma显示文摘AIM: To investigate the expression of p57kip2 and its relationship with dinicopathology, PCNA and p53 in primary hepatocellular carcinoma (HCC).METHODS: Expression of p57kip2, PCNA and p53 in tumor tissues from 32 patients with HCC and 10 liver tissues of normal persons was detected with Elivision immunohistochemical technique.RESULTS: The p57kip2 protein positive-expression rate in HCC was 56.25%, lower than that in normal tissues (100%, P<0.05). The reduced expression of p57kip2 protein correlated significantly with moderate or low differentiation of tumor cells (P = 0.007 <0.05), high clinical stage (P = 0.041 <0.05) and poor prognosis (P = 0.036 <0.05),but did not correlate significantly with metastasis, tumor size, level of AFP and age (P>0.05). The PCNA positiveexpression rate was 56.25%, which was correlated significantly with the expression of p57kip2 (P= 0.025<0.05).The p53 positive-expression rate was 46.88%, which was not correlated significantly with the expression of p57kip2(P>0.05).CONCLUSION: There is a marked loss or absence of p57kip2 expression and high expression of PCNA in HCC,which are involved in carcinogenesis and development of HCC. The p57kip2 and p53 may induce apoptosis via different mechanisms. | Ke-JunNan HuiGuo Zhi-PingRuan ZhaoJing Shaan-XiLiu | 2005 | World Journal of Gastroenterology2005，11，8： | 20 |
| 3 | The research progress on lateral shift of reflected electromagnetic wave at the interface of two conductive media显示文摘In this paper the research status of lateral shift of reflected electromagnetic wave at the interface of conductive media was reviewed, the lateral shift and the lateral delay were analyzed, and the charac-teristic of lateral shift curves varying with the angle of incidence was introduced in detail. For electro-magnetic wave logging, the error correction method of lateral shift was stressed in this paper, the magnitude of measured errors caused by the lateral shift was established. It is noticed that the longer wavelength, the larger error of measured results. With respect to the effect of lateral shift, the problem which still needs to be settled in the measurement of electromagnetic wave, as well as prospects on the further research and applications of lateral shift are described. | LIU FuPing WANG AnLing CHEN Qiang LI RuiZhong CHEN HuiGuo YANG ChangChun | 2008 | Chinese Science Bulletin2008，53，7： | 15 |
| 4 | Expression and clinical significance of TAp73α, p53, PCNA and apoptosis in hepatocellular carcinoma显示文摘AIM: To study the prognostic role of TAp73α, p53, proliferating cell nuclear antigen (PCNA) and apoptosis inpatients with hepatocellular carcinoma (HCC) atter surgical tumor ablation.METHODS: Forty-seven human resected HCC tissues and 42 adjacent non-cancerous tissues were studied with 10 normal liver tissues as control group. TAp73α, p53, and PCNA were detected with Elivision immunohistochemistry.Terminal deoxynucleotidyl transferase (TdT)-mediatedd-UTP-biotin nick-end labeling (TUNEL) method wasused to detect the apoptosis cells. All clinical and pathological materials were analyzed by SPSS10.0statistical package.RESULTS: TAp73α overexpressed in HCC tissues (36.2%) when compared with adjacent non-cancerous tissues (2.38%, P<0.005) and normal liver tissues (0, P<0.01).Mutant type p53 (mt-p53) overexpressed in HCC tissues (38.3%) when contracted with adjacent non-cancerous tissues (16.7%, P<0.05) and normal liver tissues (0, P<0.01). Proliferation index (PI) level in HCC tissues was significantly higher than that in adjacent non-cancerous tissues (30.34%±4.46% vs 27.88%±5.89%, t, P= 0.028). Apoptosis index (AI) level in HCC tissues was higher than that in adjacent non-cancerous tissues (8.62%±2.28% vs 7.38%±2.61%, t, P = 0.019). Expression of TAp73α was associated with lymph node metastasis and mt-p53, with r = 0.407 and 0.265, respectively. Expression of mtp53 was associated with Edmondson's stage and AFP, with r = 0.295 and -0.357, respectively. In Kaplan-Meier univariant analysis, TAp73α, AFP, TNM stage, portal vein invasion, liver membrane invasion and HBsAg correlated with prognosis (log rank, P = 0.039, 0.012, 0.002, 0.000,0.014, 0.007, respectively). Multivariant Cox regression analysis showed that TAp73α, AFP, TNM stage, portal vein invasion, liver membrane invasion and age were independent factors of prognosis. CONCLUSION: These results suggest that TAp73α can be used as a prognostic indicator of patients with HCC undergoing surgical tumor ablation. AFP, TNM, portal vein invasion, liver membrane invasion and age also have a potency of predicting the prognosis of HCC. | Hai-XiaQin Ke-JunNan GuangYang ZhaoJing Zhi-PingRuan Chun-LiLi RuiXu HuiGuo Chen-GuangSui Yong-ChangWei | 2005 | World Journal of Gastroenterology2005，11，18： | 12 |
| 5 | A Qualitative Appraisal of China’s Efforts in Fishing Capacity Management显示文摘This paper provides a critical review of some major efforts made by China to manage the fishing capacity of its marine capture fisheries. It begins by reviewing the key concepts and issues closely related to fishing capacity management. Following on this, a brief introduction to China’s marine capture fisheries is offered, especially the trends of its marine landings and marine fishing fleets and the status of fish stocks in waters under its jurisdiction. Next comes the main concern of the paper, i.e., some major actions recently initiated by China to deal with the overcapacity problem confronting it. The paper ends with conclusions and suggestions. | MU Yongtong*, YU Huiguo, CHEN Jingna, and ZHU Yugui Division of Life Science and Technology, Ocean University of China, Qingdao 266003, P. R. China | 2007 | Journal of Ocean University of China2007，6，1： | 6 |
| 6 | Overview of HBV whole genome data in public repositories and the Chinese HBV reference sequences显示文摘The number of Hepatitis B virus (HBV) whole genomic sequences in public nucleotide databases (GenBank, EMBL, and DDBJ) had reached 866 by January 1, 2007. Coming from 46 countries and regions, these sequences were categorized as eight genotypes (A–H). With the statistical and phylogenetic analysis on all available complete genomic data of HBV, we here present an overview of HBV sequences in public databases. From all registered 229 HBV genomes in Chinese regions as well as 59 sequencing data from our research group, we report the establishment of reference sequences of HBV strains prevailing in China. These analyses provide clues for the effects of HBV genotypes in host clinical progressions, geographic distribution of the infection, and the viral evolutionary history. Moreover, the viral sequence reference would be helpful in the identiffcation of various HBV mutations. Based on the analysis of various public databases, we suggest that the Chinese HBV database with the clinical information should be constructed. | Guanghua Wu Huiguo Ding Changqing Zeng | 2008 | Progress in Natural Science:Materials International2008，18，1： | 5 |
| 7 | Commercial Applications of Paraxylene Adsorbents RAX-2000A and RAX-3000显示文摘The RAX series paraxylene (PX) adsorbents RAX-2000A and RAX-3000, are developed by the Sinopec Research Institute of Petroleum Processing (RIPP) and manufactured by the Sinopec Catalyst Company. Performance test of RAX-2000A showed that the average purity of the PX product reached 99.81%, with an average PX yield of 98.6% per pass. The new generation of PX adsorbents, RAX-3000 not only retains most advantages of the adsorbent RAX-2000A, but also has higher selective adsorption capacity by at least 8%. The actual unit production capability of the adsorbent RAX-3000 was increased by about 18%. The RAX series PX adsorbents exhibited good adaptability to unfavorable feedstock containing high ethyl benzene (EB) fraction besides their better mechanical strength. Preliminary test results indicated that compared to the adsorbent RAX-2000A, the A/F a and D/F relating to the adsorbent RAX-3000 were notably decreased due to the higher selective adsorption capacity of the adsorbent RAX-3000. | Li Ben Wang Huiguo Yu Zhuo Wang Dehua Wu Wei | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，1： | 3 |
| 8 | The impacts of ‘05.6’ extreme flood event on riverine carbon fluxes in Xijiang River显示文摘An extreme flood event with a frequency of nearly 200 year occurred in June of 2005 in the Xijiang River, the main trunk stream of the Zhujiang River. Samples were systematically collected during the flood event, and water quality parameters, including total suspended sediment (TSS), dissolved inorganic carbon (DIC), dissolved organic carbon (DOC), and particulate organic carbon (POC) were analyzed, and riverine carbon concentrations associated with its changing pattern through the flood process were discussed. These parameters reflect the changes in basin surface flow and subsurface flow dur-ing the flood. This flood event influenced annual flux estimations of POC, DOC, and DIC to great extents. Based on carbon flux estimations for the year 2005 and the flood event (June 21-28) in the Xijiang River, it was found that DIC, DOC, and POC fluxes during ‘05.6’ flood event are 1.52×106 g.km?2.a?1, 0.24×106 g.km?2.a?1, and 0.54×106 g.km?2.a?1, and account for 14.87%, 24.75% and 44.89% of the annual fluxes in 2005, respectively. The results suggested that carbon exports during extreme flood events had great contributions to the total carbon fluxes and composition of various carbon components, be-ing important for accurate estimates of annual carbon fluxes in rivers with frequent floods. | SUN HuiGuo HAN JingTai ZHANG ShuRong LU XiXi | 2007 | Chinese Science Bulletin2007，52，6： | 3 |
| 9 | Glypican-3 as a potential differential diagnosis marker for hepatocellular carcinoma: A tissue microarray-based study显示文摘 | Lijie Zhang Hui Liu Lin Sun Ning Li Huiguo Ding Jie Zheng | 2011 | Acta Histochemica2011，，6： | 3 |
| 10 | Progress in the Application of X Zeolite in Adsorption显示文摘The application of X zeolite in the areas for producing para-xylene by adsorptive separation, N_2/O_2 separation,etc., was reviewed, and the framework SiO_2/Al_2 O_3 molar ratio, the cations and the water content of X zeolite significantly affected its selectivity and capacity. As the active component of para-xylene adsorbent, the X zeolite with a framework SiO_2/Al_2 O_3 molar ratio of 2.2—2.4 coupled with cations of Ba^(2+) and K^+, as well as a water content of 4.0%—5.0% exhibited higher para-xylene selectivity. For N_2/O_2 separation, higher N_2 capacity and N_2/O_2 separation factor were achieved when the X zeolite had a framework SiO_2/Al_2 O_3 molar ratio of 2.0 coupled with Li^+ cations. The introduction of another cation in X zeolite could further increase the N_2/O_2 separation factor, while the adsorption of water, however, could lead to a remarkable decrease of N_2 capacity. Besides, the X zeolite could be used in adsorptive separation of highly pure He and selective adsorption of CO_2, CO, CH_4, N_2, Ar,and H_2. | Wang Yubing Wang Huiguo | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，1： | 2 |
| 11 | Spatial and seasonal variability of organic carbon transport in the Yellow River, China显示文摘 | Lishan Ran X.X. Lu Huiguo Sun Jingtai Han Ronghua Li Jianming Zhang | 2013 | Journal of Hydrology2013，，： | 2 |
| 12 | Chronological dating and tectonic implications of late Cenozoic volcanic rocks and lacustrine sequence in Oiyug Basin of southern Tibet显示文摘Reconstruction of uplift history of the Tibetan Plateau is crucial for understanding its environmental impacts. The Oiyug Basin in southern Tibet contains multiple periods of sedimentary sequences and volcanic rocks that span much of the Cenozoic and has great potential for further studying this issue. However, these strata were poorly dated. This paper presents a chronological study of the 145 m thick and horizontally-distributed lacustrine sequence using paleomagnetic method as well as a K-Ar dating of the underlying volcanic rocks. Based on these dating results, a chronostratigraphic framework and the basin-developmental history have been established for the past 15 Ma, during which three tectonic stages are identified. The period of 15-8.1 Ma is characterized by intense volcanic activities involving at least three major eruptions. Subsequently, the basin came into a tectonically quiescent period and a lacustrine sedimentary sequence was developed. Around 2.5 Ma, an N-S fault occurred across the southern margin of the basin, leading to the disappearance of the lake environment and the development of the Oiyug River. The Gyirong basin on northern slope of the Himalayas shows a similar basin developmental history and thus there is a good agreement in tectonic activities between the Himalayan and Gangdise orogenic belts. Therefore, the tectonic evolution stages experienced by the Oiyug Basin during the past 15 Ma could have a regional significance for southern Tibet. The chronological data obtained from this study may provide some constraints for further studies with regard to the tectonic processes and environmental changes in southern Tibetan Plateau. | CHEN HeHai HAN JingTai DING ZhongLi SUN HuiGuo GUO ZhengFu | 2008 | Science China Earth Sciences2008，51，2： | 2 |
| 13 | Standardization of tritiated water by the CIEMAT/NIST and TDCR methods显示文摘The activity of tritiated water has been standardized by two liquid scintillation counting methods:The CIEMAT/NIST method with the54Mn-standard efficiency tracing and the triple-to-double coincidence ratio(TDCR)method.The samples were prepared with Ultima Gold TM AB liquid scintillation cocktail in low-potassium glass vials.In the application of the CIEMAT/NIST method,the computer program EMILIA was used to calculate the efficiency of3H and54Mn according to the KL1L2L3M atomic rearrangement model.And the detection efficiency of the TDCR counter was calculated using TDCR07 code,which makes it possible to allow for the potential asymmetry between the three photomultiplier tubes.The influence of stopping power and k B factor is discussed in the paper.When a power approach is adopted for the stopping power for electrons below 1ke V and k B is chosen to be 0.0075 cm/Me V,the relative deviation will be only 0.3%between the two methods. | WU YongLe LIU HaoRan LIANG JunCheng LIU JiaCheng XIONG WenJun YUE HuiGuo LIU SenLin YANG YuanDi YUAN DaQing | 2015 | Science China(Technological Sciences)2015，58，3： | 1 |
| 14 | A Grid-Based Method to Represent the Covariance Structure for Earthquake Ground Motion显示文摘 | Yingmin Li Zheqian Wu Huiguo Chen Yuri Vladimirovich Mikhlin | 2012 | Mathematical Problems in Engineering2012，，： | 1 |
| 15 | Spatial and seasonal variability of organic carbon transport in the Yellow River, China显示文摘 | Ran L Lu X X Huiguo Sun | 2013 | Jour- nal of Hydrology2013，498，： | 1 |
| 16 | CFTR negatively regulates cyclooxygenase‐2‐PGE2 positive feedback loop in inflammation显示文摘 | JingChen Xiao HuaJiang HuiChen Jing HuiGuo Lai LingTsang Mei KuenYu Wen MingXu Hsiao ChangChan | 2012 | J. Cell. Physiol2012，，： | 1 |
| 17 | Two new secolignan glycosides from the roots of Urtica triangularis Hand-Mazz 显示文摘 | FENG Baomin YAN Xingguo WANG Huiguo | 2010 | Fitoterapia2010，81，： | 1 |
| 18 | Synthesis and Photochromic Properties of Azido Analogues of Spiropyran and Spirooxazine as Nucleic Acid Labeling Reagent显示文摘A series of photo active azido analogues have been synthesized and their photochromic properties have also been investigated by UV-Vis spectrum. It will be used for the rapid and reliable preparation of large amounts of stable, non-radioactive labeled DNA and RNA hybridization probes. And it is supposed to be easily detected for its photochromic properties. | HuiGUO WuXinZOU QiJI JiBenMENG | 2005 | Chinese Chemical Letters2005，16，6： | 1 |
| 19 | The diagnosis value and its implication of impulse oscillometry in obstructive sleep apnea syndrome patients显示文摘 | Liu Huiguo | 2002 | J Clin Intern Med2002，19，7： | 1 |
| 20 | Computer generated cireular-viewing plane rainbow hologram显示文摘 | QIAN Huiguo WANG Hui JIN Hongzhen | 2005 | Journal of Optoelectronics · Laser2005，16，6： | 1 |
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