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| 1 | Angiographic evaluation and management of acute gastrointestinal hemorrhage显示文摘Although most cases of acute nonvariceal gastrointestinal hemorrhage either spontaneously resolve or respond to medical management or endoscopic treatment,there are still a significant number of patients who require emergency angiography and transcatheter treatment.Evaluation with noninvasive imaging such as nuclear scintigraphy or computed tomography may localize the bleeding source and/or confirm active hemorrhage prior to angiography.Any angiographic evaluation should begin with selective catheterization of the artery supplying the most likely site of bleeding,as determined by the available clinical,endoscopic and imaging data.If a hemorrhage source is identified,superselective catheterization followed by transcatheter microcoil embolization is usually the most effective means of successfully controlling hemorrhage while minimizing potential complications.This is now wellrecognized as a viable and safe alternative to emergency surgery.In selected situations transcatheter intra-arterial infusion of vasopressin may also be useful in controlling acute gastrointestinal bleeding.One must be aware of the various side effects and potential complications associated with this treatment,however,and recognize the high re-bleeding rate.In this article we review the current role of angiography,transcatheter arterial embolization and infusion therapy in the evaluation and management of nonvariceal gastrointestinal hemorrhage. | T Gregory Walker Gloria M Salazar Arthur C Waltman | 2012 | World Journal of Gastroenterology2012，18，11： | 24 |
| 2 | Optimizing hepatitis C virus treatment through pharmacist interventions: Identification and management of drug-drug interactions显示文摘AIM To quantify drug-drug-interactions(DDIs) encountered in patients prescribed hepatitis C virus(HCV) treatment, the interventions made, and the time spent in this process.METHODS As standard of care, a clinical pharmacist screened for DDIs in patients prescribed direct acting antiviral(DAA) HCV treatment between November 2013 and July 2015 at the University of Colorado Hepatology Clinic. HCV regimens prescribed included ledipasvir/sofosbuvir(LDV/SOF), paritaprevir/ritonavir/ombitasvir/dasabuvir(OBV/PTV/r + DSV), simeprevir/sofosbuvir (SIM/SOF), and sofosbuvir/ribavirin (SOF/RBV). This retrospective analysis reviewed the work completed by the clinical pharmacist in order to measure the aims identified for the study. The number and type of DDIs identified were summarized with descriptive statistics.RESULTS Six hundred and sixty four patients(83.4% Caucasian, 57% male, average 56.7 years old) were identified; 369 for LDV/SOF, 48 for OBV/PTV/r + DSV, 114 for SIM/SOF, and 133 for SOF/RBV. Fifty-one point five per cent of patients were cirrhotic. Overall, 5217 medications were reviewed (7.86 medications per patient) and 781 interactions identified (1.18 interactions per patient). The number of interactions were fewest for SOF/RBV (0.17 interactions per patient) and highest for OBV/PTV/r + DSV (2.48 interactions per patient). LDV/SOF and SIM/SOF had similar number of interactions (1.28 and 1.48 interactions per patient, respectively). Gastric acid modifiers and vitamin/herbal supplements commonly caused interactions with LDV/SOF. Hypertensive agents, analgesics, and psychiatric medications frequently caused interactions with OBV/PTV/r + DSV and SIM/SOF. To manage these interactions, the pharmacists most often recommended discontinuing the medication (28.9%), increasing monitoring for toxicities (24.1%), or separating administration times (18.2%). The pharmacist chart review for each patient usually took approximately 30 min, with additional time for more complex patients. CONCLUSION DDIs are common with HCV medications and management can require medication adjustments and increased monitoring. An interdisciplinary team including a clinical pharmacist can optimize patient care. | Jacob A Langness Matthew Nguyen Amanda Wieland Gregory T Everson Jennifer J Kiser | 2017 | World Journal of Gastroenterology2017，23，9： | 5 |
| 3 | ENETS Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Neoplasms: Functional Pancreatic Endocrine Tumor Syndromes显示文摘 | Jensen Robert T Cadiot Guillaume Brandi Maria L De Herder Wouter W Kaltsas Gregory Komminoth Paul Scoazec Jean-yves Salazar Ramon Sauvanet Alain Kianmanesh Reza | 2012 | Neuroendocrinology2012，，2： | 3 |
| 4 | Mobile Pb isotopes in Proterozoic sedimentary basins as guides for exploration of uranium deposits显示文摘 | Gregory J Holk T Kurtis K | 2003 | Journal of Geochemical Exploration2003，80，23： | 1 |
| 5 | Oxygen isotope exchange kinetics of mineral pairs in closed and open systems: applications to problems of hydrothermal alteration of igneous rocks and Precambrian iron formations显示文摘 | GREGORY R T CRISS R E TAYLOR H P Jr | 1989 | Chem Geol1989，75，： | 1 |
| 6 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 7 | The Drosophila dead ringer gene is required for early embryonic patterning through regulation of argos and buttonhead expression显示文摘 | Shandala T Kortschak R D Gregory S | 1999 | Development1999，126，19： | 1 |
| 8 | Mediation of transforming growth factor-β1 -stimulated matrix contraction by fibroblasts 显示文摘 | Julie T Gregory S Timothy D | 2003 | Am J Pathol2003，163，： | 1 |
| 9 | Rapid one-step quantitative reverse transcriptase PCR assay with competitive internal positive control for detection of enteroviruses in environmental samples 显示文摘 | GREGORY J B LITAKER R W NOBLE R T | 2006 | Appl Environ Microbiol2006，72，6： | 1 |
| 10 | The effect of diameter ratio and volume ratio on the viscosity of bimodal suspensions of polymer latices 显示文摘 | GREENWOOD R LUCKHAM P F GREGORY T | 1997 | Journal of Colloid and Interface Science1997，191，1： | 1 |
| 11 | Anterior and posterior fusion for children with tuberculosis of the spine显示文摘 | Altman Gregory T Altnab Daniel T Frankovitch Karl F | 1996 | Clin Orthop Relat Res1996，，325： | 1 |
| 12 | A mo- dle of cockpit karst landscape, Jamaica显示文摘 | Cyril Fleurant Gregory E T Heather A | 2008 | Geomor phologie : relief processus environment2008，1514，： | 1 |
| 13 | Human RISC couples microRNA biogenesis and post transcriptional gene silencing显示文摘 | GREGORY R I CHENDRIMADA T P COOCH N | 2005 | Cell2005，123，4： | 1 |
| 14 | The promise of DNA barcoding for taxon- omy显示文摘 | Hebert P D N Gregory T R | 2005 | Systematic Biology2005，54，5： | 1 |
| 15 | Assessing Dependence : Some Experimental Results 显示文摘 | Robert T Clemen Gregory W Fischer Robert L Winkler | 2000 | Management Science2000，46，8： | 1 |
| 16 | Minimising the viscosity of concentrated dispersions by using bimodal particle size distributions 显示文摘 | GREENWOOD R LUCKHAM P F GREGORY T | 1998 | Colloids and Surfaces A : Physicochemical and Engineering Aspects1998，144，13： | 1 |
| 17 | Catalytic inhibition of laminar flames by transition metal compounds 显示文摘 | Gregory T Linteris Marc D Rumminger Valeri I Babushok | 2008 | Progress in Energy and Combustion Science2008，，34： | 1 |
| 18 | Cryptosporidium removal during water treatment using dissolved air flotation显示文摘 | Hall T Pressdee J Gregory R | 1995 | Water Science and Technology1995，31，3： | 1 |
| 19 | Epidemiologic evaluation of reoperation for surgically treated pelvic organ prolapse and urinary incontinence显示文摘 | Clark AL Gregory T Smith V J | 2003 | Am J Obstet Gynecol2003，189，5： | 1 |
| 20 | Update on the Antimicrobial Management of Foot Infections in Patients With Diabetes显示文摘 | Matsuura Gregory T Barg Neil | 2013 | Clinical Diabetes2013，，2： | 1 |
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