|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Metastatic type 1 gastric carcinoid:A real threat or just a myth?显示文摘AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were recorded.Patients’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and histopathologically.Patients were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also recorded.The evaluation of response to treatment was defined using established WHO criteria.RESULTS:We studied twenty consecutive patients with a mean age of 55.1 years.The mean follow-up period was 83 mo.Twelve patients had regional lymph node metastases and 8 patients had liver metastases.The primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean Ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the tumor.The disease was stable in all but 3 patients who had progressive liver disease.All patients remained alive during the follow-up period.CONCLUSION:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated Ki-67 index and high serum gastrin levels. | Simona Grozinsky-Glasberg Dimitrios Thomas Jonathan R Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia Reissman Gregory Kaltsas David J Gross | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 2 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 3 | Developmental and Feedforward Control of the Expression of Folate Biosynthesis Genes in Tomato Fruit显示文摘很少植物怎么调整他们的叶酸的内容被知道,包括叶酸的生合成基因的表达式是否在开发期间被安排或由叶酸的层次调制了。也很不叶酸的层次怎么影响另外的基因的表示被知道。这些点用为高叶酸的内容设计的野类型的西红柿水果和水果被探讨。在野类型的水果,在叶酸的生合成指定早步的基因的表示在开发而是另外的基因的期间衰退了。在设计水果 overexpressing 外国 GTP cyclohydrolase 我和 aminodeoxychorismate synthase 基因,各自的内长的基因的表示没变化,但是三下游的小径 genesaminodeoxychorismate lyase , dihydroneopterin aldolase ,和 mitochondrial folylpolyglutamate 的 synthaserespectively 增加了由直到7.8-,2.8-,和1.7褶层,显然响应特定的叶酸的小径代谢物的逐渐增加。这些结果显示在水果,某些叶酸的小径基因发展地被调整并且某些其它由小径中介服从于前馈控制控制。Microarray 分析显示出那仅仅 14 个另外的抄本(11 ? 000 调查了) 在丰富增加了由双重或更在里面高度叶酸的水果,证明叶酸的小径基因的正式就职是相对特定的。 | Jeffrey C. Wallera Tariq A. Akhtar Aurora Lara-Nunez Jesse F. Gregory lli Ryan R McQuinn James J. Giovannoni Andrew D. Hanson | 2010 | Molecular Plant2010，3，1： | 5 |
| 4 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 5 | Hematopoietic AMPK [Beta]1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity显示文摘 | Galic Sandra Fullerton Morgan D Schertzer Jonathan D Sikkema Sarah Marcinko Katarina Walkley Carl R Izon David Honeyman Jane Chen Zhi-Ping van Denderen Bryce J Kemp Bruce E Steinberg Gregory R | 2011 | Journal of Clinical Investigation2011，，12： | 2 |
| 6 | Protective effect of amifostine during fractionated radiotherapy in patients with pelvic carcinomas: Results of a randomized trial显示文摘 | Helen Athanassiou Dosia Antonadou Nikos Coliarakis Athina Kouveli Maria Synodinou Michalakis Paraskevaidis George Sarris Gregory R Georgakopoulos Katerina Panousaki Pantelis Karageorgis Nicolas Throuvalas | 2003 | International Journal of Radiation Oncology, Biology, Physics2003，，4： | 2 |
| 7 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://gffzz783b6e01a04243c3hkfk65puc5xv66wbo.ffgz.tsg.suse.edu.cn/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 8 | Spontaneous intracranial hypotension显示文摘 | Renowden SA Gregory R Hyman N | 1995 | J Neurol Neurosurg Psychiatry1995，59，5： | 2 |
| 9 | Elastic wave velocities in heterogeneous and porous media 显示文摘 | Wyllie M R J Gregory A R Gardner L W | 1956 | Geophysics1956，21，1： | 1 |
| 10 | MicroRNA biogenesis and cancer显示文摘 | Gregory R I Shiekhattar R | 2005 | Cancer Res2005，65，803： | 1 |
| 11 | Transient synovitis:lack of serologic evidence for acute parvovirus B219 or Human Herpesvirus 26 Infection 显示文摘 | Gregory R L Yen L L Michae E | 1999 | J of Pediatric Orthop1999，19，6： | 1 |
| 12 | Operative treatment of intra-articular fractures of the calcaneus显示文摘 | Gregory P | 1995 | J Orthop Clin North(Am)1995，26，2： | 1 |
| 13 | Formation velocity and density-The diagnostic basis for stratigraphic traps 显示文摘 | Gardner G H F Gardner L W Gregory A R | 1974 | Geophysics1974，39，6： | 1 |
| 14 | Acceptable practices in Ontario's forests: differences between the public and forestry professionals显示文摘 | WAGNER R G FLYNN J GREGORY R | 1998 | New For1998，16，： | 1 |
| 15 | Oxygen isotope exchange kinetics of mineral pairs in closed and open systems: applications to problems of hydrothermal alteration of igneous rocks and Precambrian iron formations显示文摘 | GREGORY R T CRISS R E TAYLOR H P Jr | 1989 | Chem Geol1989，75，： | 1 |
| 16 | Trl cells: from discovery to their clinical application 显示文摘 | Battaglia M Gregori S Bacchetta R | 2006 | Semin Immunol2006，18，： | 1 |
| 17 | Optimal capacity of p-persis- tent CSMA protocols显示文摘 | BRUNO R CONTI M GREGORI E | 2003 | IEEE Communication Letters2003，7，3： | 1 |
| 18 | Geno- type-phenotype con elation in X-linked Alport syndrome显示文摘 | BEKHEIRNIA M R REED B GREGORY M C | 2010 | Jo- urnal of the American Society of Nephrology (JASN)2010，21，5： | 1 |
| 19 | Cyclooxygenase-2 inhi-bition delays the attainment of peak woven bone formationfollowing four-point bending in the rat 显示文摘 | GREGORY L S FORWOOD M R | 2007 | Caleif Tiss2007，80，3： | 1 |
| 20 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员