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1827篇 您的检索式:作者名="Hall T"
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1全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T 2015中国药物依赖性杂志2015,24,6:3
27-iodo-8-hydroxy quinoline-5-sulfonic acid as a reagent for the colorimetric determination of ferric iron显示文摘Yoe J H Hall R T 1937J Am Chem SOC1937,54,:2
3显示文摘Hall H T 1970Science1970,868,:2
4The protean career: A quarter-century journey显示文摘Douglas T Hall 2003Journal of Vocational Behavior2003,,1:2
5The protean career: A quarter-century journey显示文摘Douglas T Hall 2003Journal of Vocational Behavior2003,,1:2
6胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 2017中华高血压杂志2017,25,9:2
7Sevoflurane(12% and 8%)inhalational induction in children显示文摘Chawathe M Zatman T Hall J E 2005Paediatr Anaesth2005,15,6:1
8Pond heat and temperature regulation (PHATR) : Modeling temperature and energy balances in earthen outdoor aquaculture ponds显示文摘Lamoureux J Tiersch T R Hall S G 2006Aquaculural Engineering2006,34,2:1
9The 5 UTR negatively regulates quantitative and spatial expression from the ABI3 promoter显示文摘Ng D W Chandrasekharan M B Hall T C 2004Plant Molecular Biology2004,54,1:1
10Man-made diamonds显示文摘Bundy F P Hall H T Strong H M 1955Nature1955,176,:1
11Design and testing of a double X-frame piezoelectric actuator显示文摘Hall S R Tzianetopolou T Straub F 2000Smart Structures and Integrated Systems2000,3985,:1
12The effects of increasingplasma concentrations of dexmedetomidine in humans显示文摘Ebert T J Hall J E Barney J A 2000Anesthe-siology2000,93,2:1
13Type- and subtype-specific detection of influenza viruses in clinical specimens by rapid culture assay 显示文摘Ziegler T Hall H Sanchez-Fauquier A 1995J Clin Microbiol1995,33,2:1
14The Square Kilometere Array 显示文摘DEWENEY PETER E HALL PETER J SCHILIZZI RICHARD T 2009Proceedings of the IEEE2009,97,8:1
15Purification and a dehydrin involved in chilling tolerance during seedling emergence of cowpea 显示文摘Ismail A M Hall A E Close T partial characterization of Sequence and their Biology J 1999Plant Physiology1999,120,1:1
16The effects of increasing plasma concentrations of dexmedemidine in humans 显示文摘EBERT T J HALL J E BAMEY J A 2000Anesthesiology2000,93,2:1
17The protean career: A quarter - century journey 显示文摘Hall D T 2004Journal of Vocational Behavior2004,65,1:1
18BiOhemical factors underlying the age - related sensitivity of turkeys to aflatoxin B1显示文摘Klein P J Van - Vleet T R Hall J O 0,,:1
19Fingerprints of globalwarming on wild animals and plants显示文摘ROOTT L PRICE J T’HALL K R 2003Nats2003,421,:1
20Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts显示文摘Fukumoto S Kiba T Hall B 2004J Cell Biol2004,167,5:1
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