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| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | The Effects of the Chemical Components of Soil Salinity on Electrical Conductivity in the Region of the Delta Oasis of Weigan and Kuqa Rivers,China显示文摘In order to assess the effects of chemical properties of soil salinity on electrical conductivity of 1:5 soil/water extract (EC1:5), the study focused on revealing the main chemical factors contributing to EC of soil extracts and their relative importance. The relationship between EC1:5 and the chemical properties of soil salinity in the delta oasis of Weigan and Kuqa rivers, China, were studied using path coefficient analysis, a path analysis method. We studied each key element affecting EC1:5 either directly or indirectly. The results obtained show that the salt content, total dissolved solids (TDS), and the sum of the sodium ion concentration and the kalium ion concentration are the most influential factors on 1:5 soil/ water extract (EC1:5) in the 0-10 cm and the 30-50 cm soil layer. The results show that the sequence of direct path coefficients in the 0-10 cm and the 30-50 cm soil layers on soil conductivity is TDS→Na+ + K+→Salt content→Ca2+→Cl-→the sodium dianion ratio (SDR)→pH→SO42-→HCO3-→Mg2+→the soluble sodium percentage (SSP)→sodium absorption ratio (SAR) and TDS→Salt content→Na+ + K+→Ca2+→SDR→Mg2+→HCO3-→SSP→pH→SO42-→SAR→Cl-. The salt content, chlorine ion, and SAR are the main factors affecting 1:5 soil/water extract (EC1:5) in the 10-30 centimeter soil layer. The order of direct path coefficients result is as follows: Salt content→Cl-→SAR→SSP→TDS→Ca2+→Mg2+ = SO42-→HCO3-→pH→SDR→Na+ + K+. Moreover, the effects of HCO3-, pH were very weak. Though the direct path coefficients between EC1:5 and SAR, SO42- and Ca2+ were not high, influence of other chemical factors caused the coefficients to increase, making the summation of their direct and indirect path coefficients relatively high. The models of the different soil layers were structured separately. Evidences showed that multiple regression relations between EC1:5 and most of the primary factors had sound reliability and very good accuracy. The research results can serve as a reference to the scientific management amelioration and utilization of saline in the Delta Oasis of Weigan and Kuqa rivers. | ZHANG Fei Tashpolat Tiyip DING Jian-li Gregory N Taff HE Qi-sheng | 2009 | Agricultural Sciences in China2009，8，8： | 4 |
| 3 | Computed tomography-based diagnostics might be insufficient in the determination of pancreatic cancer unresectability显示文摘AIM: To inquire into a question of an overestimation of arterial involvement in patients with pancreatic cancer (PC). METHODS: Radiology data were compared with the findings from 51 standard, 58 extended and 17 total pancreaticoduodenectomies; 9 distal resections with celiac artery (CA) excision; and 28 palliations for PC. The survival of 11 patients with controversial computed tomography (CT) and endoscopic ultrasound data with regard to arterial invasion, after R0/R1 procedures (false-positive CT results, Group A), was compared to survival after eight R2 resections (false-negative CT results, Group B) and after 12 bypass procedures for locally advanced cancer (true-positive CT results, Group C).RESULTS: In all of the cases in group A, operative exploration revealed no arterial invasion, which was predicted by CT. The one-year survival in Group A was 88.9%, and the two-year survival was 26.7%, with a median follow-up of 22 mo. One-year survival was not attained in groups B and C, with a significant difference in survival (P a-b = 0.0029, P b-c = 0.003).CONCLUSION: Arterial encasement on CT does not necessarily indicate arterial invasion. Whenever PC is considered unresectable, endoUS should be used. In patients with controversial CT an EUS data for peripan-creatic arteries involvement radical resection might be possible, providing survival benefits as compared to R2-resections or palliative surgery. | Vyacheslav I Egorov Roman V Petrov Elena N Solodinina Gregory G Karmazanovsky Natalia S Starostina Natalia A Kuruschkina | 2013 | World Journal of Gastrointestinal Surgery2013，5，4： | 4 |
| 4 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 5 | Validity and Reliability of the Reflux Symptom Index (RSI)显示文摘 | Peter C Belafsky Gregory N Postma James A Koufman | 2002 | Journal of Voice2002，，2： | 3 |
| 6 | DNA polymerase zeta (pol ζ) in higher eukaryotes显示文摘 | Gregory N Gan John P Wittschieben Birgitte ф Wittschieben Richard D Wood | 2008 | Cell Research2008，18，1： | 2 |
| 7 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 8 | A contribution to the empirics of economic growth 显示文摘 | Gregory Mankiw N David Romer David N Weil | 1992 | The Quarterly Journal of Economics1992，5，： | 2 |
| 9 | Spontaneous intracranial hypotension显示文摘 | Renowden SA Gregory R Hyman N | 1995 | J Neurol Neurosurg Psychiatry1995，59，5： | 2 |
| 10 | Metabolic engineering for the microbial production of 1,3-propanediol显示文摘 | Charles E N Gregory M W | 2003 | Current Opinion in Biotechnology2003，14，： | 1 |
| 11 | A 4-point interpolatory subdivision scheme for curve design显示文摘 | Dyn N Gregory J A Levin D | 1987 | Computer Aided Geometric Design1987，4，： | 1 |
| 12 | A Contribution to the Empirics of Economic Growth显示文摘 | Mankiw N Gregory David Romer David Well | 1992 | Quarterly Journal of Economics1992，，107： | 1 |
| 13 | A 4-point interpolatory subdivision scheme for curve design 显示文摘 | DYN N LEVIN D GREGORY J A | 1987 | Computer Aided Geometric Design1987，4，4： | 1 |
| 14 | An asset allocation puzzle显示文摘 | N GREGORY MANKIW etc | 1997 | American Economic Review1997，87，： | 1 |
| 15 | American brachytherapy society recommendations for reporting morbidity after prostate brachytherapy 显示文摘 | Subir N Rodney JE Gregory SM | 2002 | Int J Radiat Oncol Biol Phys2002，54，： | 1 |
| 16 | A 4-point interpolatory subdivision scheme for curve design 显示文摘 | Dyn N Levin D Gregory J A | 1987 | Computer Aided Geometric Design1987，4，4： | 1 |
| 17 | TP53 R249S mutation, genetic variations in HBX and risk of hepatocellular carcinoma in The Gambia显示文摘 | Doriane A. Gouas Stéphanie Villar Sandra Ortiz-Cuaran Pénélope Legros Gilles Ferro Gregory D. Kirk Olufunmilayo A. Lesi Maimuna Mendy Ebrima Bah Marlin D. Friesen John Groopman Isabelle Chemin Pierre Hainaut | 2012 | Carcinogenesis2012，，6： | 1 |
| 18 | Im-mune evasion genes from filarial nematodes显示文摘 | Maizels R M Gomez E N* Gregory W F | 2001 | Int JParasitol2001，31，9： | 1 |
| 19 | Human RISC couples microRNA biogenesis and post transcriptional gene silencing显示文摘 | GREGORY R I CHENDRIMADA T P COOCH N | 2005 | Cell2005，123，4： | 1 |
| 20 | The promise of DNA barcoding for taxon- omy显示文摘 | Hebert P D N Gregory T R | 2005 | Systematic Biology2005，54，5： | 1 |
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