|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Stereotactic body radiation therapy for non-small cell lung cancer:A review显示文摘Stereotactic body radiation therapy(SBRT) is the treatment of choice for medically inoperable patients with early stage non-small cell lung cancer(NSCLC). A literature search primarily based on PubMed electronic databases was completed in July 2018. Inclusion and exclusion criteria were determined prior to the search, and only prospective clinical trials were included. Nineteen trials from 2005 to 2018 met the inclusion criteria, reporting the outcomes of 1434 patients with central and peripheral early stage NSCLC. Patient eligibility,prescription dose and delivery, and follow up duration varied widely. Threeyears overall survival ranged from 43% to 95% with loco-regional control of up to 98% at 3 years. Up to 33% of patients failed distantly after SBRT at 3 years. SBRT was generally well tolerated with 10%-30% grade 3-4 toxicities and a few treatment-related deaths. No differences in outcomes were observed between conventionally fractionated radiation therapy and SBRT, central and peripheral lung tumors, or inoperable and operable patients. SBRT remains a reasonable treatment option for medically inoperable and select operable patients with early stage NSCLC. SBRT has shown excellent local and regional control with toxicity rates equivalent to surgery. Decreasing fractionation schedules have been consistently shown to be both safe and effective. Distant failure is common, and chemotherapy may be considered for select patients. However, the survival benefit of additional interventions, such as chemotherapy, for early stage NSCLC treated with SBRT remains unclear. | Kavitha M Prezzano Sung Jun Ma Gregory M Hermann Charlotte I Rivers Jorge A Gomez-Suescun Anurag K Singh | 2019 | World Journal of Clinical Oncology2019，10，1： | 10 |
| 2 | Arabidopsis PTD Is Required for Type Ⅰ Crossover Formation and Affects Recombination Frequency in Two Different Chromosomal Regions显示文摘In eukaryotes,crossovers together with sister chromatid cohesion maintain physical association between homologous chromosomes,ensuring accurate chromosome segregation during meiosis I and resulting in exchange of genetic information between homologues.The Arabidopsis PTD(Parting Dancers)gene affects the level of meiotic crossover formation,but its functional relationships with other core meiotic genes,such as AtSPO11-1,AtRAD51,and AtMSH4,are unclear;whether PTD has other functions in meiosis is also unknown.To further analyze PTD function and to test for epistatic relationships,we compared the meiotic chromosome behaviors of Atspol 1-1 ptd and AtradSl ptd double mutants with the relevant single mutants.The results suggest that PTD functions downstream of AtSPOll-1 and AtRAD51 in the meiotic recombination pathway.Furthermore,we found that meiotic defects in rck ptd and Atmsh4 ptd double mutants showed similar meiotic phenotypes to those of the relevant single mutants,providing genetic evidences for roles of PTD and RCK in the type I crossovers pathway.Moreover,we employed a pollen tetrad-based fluorescence method and found that the meiotic crossover frequencies in two genetic intervals were significantly reduced from 6.63%and 22.26%in wild-type to 1.14%and 6.36%,respectively,in the ptd-2 mutant.These results revealed new aspects of PTD function in meiotic crossover formation. | Pingli Lu Asela J.Wijeratne Zhengjia Wang Gregory P.Copenhaver Hong Ma | 2014 | Journal of Genetics and Genomics2014，41，3： | 5 |
| 3 | Plant Programmed Cell Death Caused by an Autoactive Form of Prf Is Suppressed by Co-Expression of the Prf LRR Domain显示文摘在西红柿, NBARC-LRR 抵抗(R) 蛋白质 Prf 与 Pto 或分 kinase 在音乐会行动对 Pseudomonas syringae pv 决定免疫。西红柿(Pst ) 。发信号的调停 Prf 的防卫被二顺序无关的藏匿 Pst 的受动器蛋白质, AvrPto 和 AvrPtoB 的识别开始,由西红柿 Pto 或分。Prf 检测这些相互作用并且激活发信号包括与 Pst 生长的拘捕被联系的局部性的规划细胞死亡(PCD ) 导致宿主防卫回答。当短暂地在 Nicotiana benthamiana 的叶子表示了时,我们发现有在在在 NBARC 领域的 IHD 主题(isoleucine-histidine-aspartic 酸) 的 D1416 的单个氨基酸替换的 Prf 变体引起受动器无关的 PCD,建议 D1416 起在 Prf 的激活的一个重要作用。Prf (NPrf ) 和 LRR 领域的 N 终端区域为发信号的这 autoactive Prf 房间死亡被要求但是为 PrfD1416V 蛋白质的累积非必需。显著地, Prf LRR 然而并非 NPrf 的合作表示与 PrfD1416V, AvrPto/Pto, AvrPtoB/Pto, Pto (PtoY207D ) 的一种 autoactive 形式,或分完全压制 PCD。然而, Prf LRR 不防碍 PCD 由 Rpi-blb1D475V 引起了,表明事件的不同 R 调停蛋白质的 PCD,或由 MAPKKK 的 overexpression 引起了, Prf 下游地行动的蛋白质。而且,我们发现当与 Prf LRR 领域共同表示时, PrfD1416V 蛋白质是不能的在植物房间积累,多半向房间死亡解释抑制。为 PrfD1416V 的导致 LRR 的降级的机制是未知的,但是可以在 Prf 或到独立 LRR 的绑定的 intramolecular 相互作用包含干扰到为 Prf 稳定性被需要的另外的主机蛋白质。 | Xinran Du Min Miao Xinrong Ma Yongsheng Liu Joseph C. Kuhl Gregory B. Martin Fangming Xiao | 2012 | Molecular Plant2012，5，5： | 4 |
| 4 | The prognostic value of Ki67 immunostaining in non-Hodgkin’s lymphoma显示文摘 | Hall PA Richards MA Gregory WM | 1988 | J Pathol1988，154，3： | 1 |
| 5 | Acute fatty liver of pregnancy:three cases and discussion of analgesia and anaesthesia显示文摘 | Gregory TL Hughes S Coleman MA | | 0，，02： | 1 |
| 6 | MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions显示文摘 | du Rieu Ma?l Chalret Torrisani Jér?me Selves Janick Al Saati Talal Souque Anny Dufresne Marlène Tsongalis Gregory J Suriawinata Arief A Carrére Nicolas Buscail Louis Cordelier Pierre | 2010 | Clinical Chemistry2010，，： | 1 |
| 7 | Wnt/Ca^2+/NFAT signa- ling maintains survival of Ph + leukemia ceils upon inhibition of Ber - Abl 显示文摘 | Gregory MA Phang TL Neviani P | 2010 | Cancer Cell2010，18，1： | 1 |
| 8 | The haemodynamic effects of propofol and thiopentone for induction of caesarean section 显示文摘 | Gin T Gregory MA Oh Te | 1990 | Anaesthesia and Intensive Care1990，18，2： | 1 |
| 9 | c-Myc proteolysis by the ubiquitin-proteasome pathway: Stabilization of c-Myc in Burkitt's lymphoma cells显示文摘 | Gregory MA Harm SR | 2000 | Mol Cell Biol2000，20，7： | 1 |
| 10 | Antigonadotropins : a novel strategy to halt Alzheimer's disease显示文摘 | Gregory CW Atwood CS Smith MA | 2006 | Curr Pharm Des2006，12，6： | 1 |
| 11 | Acute fatty liver of pregnancy; three cases and discussion of analgesia and anaesthesia显示文摘 | Gregory TL Hughes S Coleman MA | 2007 | Int J Obstet Anesth2007，16，： | 1 |
| 12 | The addition of fentanyl to epidu- ral bupivacaine in first stage labour显示文摘 | Yau G Gregory MA Gin T | 1990 | Anaesth Intensive Care1990，18，： | 1 |
| 13 | Combination chemotherapy versus melphalan and prednisolone in the treatment of multiple myeloma: an overview of published triMs显示文摘 | Gregory WM Richards MA Malpas JS | 1992 | J Clin Onco11992，10，2： | 1 |
| 14 | Type, Rather Than Number, of Mental and Physical Comorbidities Increases the Severity of Symptoms in Patients With Irritable Bowel Syndrome显示文摘 | Jeffrey M. Lackner Chang–Xing Ma Laurie Keefer Darren M. Brenner Gregory D. Gudleski Nikhil Satchidanand Rebecca Firth Michael D. Sitrin Leonard Katz Susan S. Krasner Sarah K. Ballou Bruce D. Naliboff Emeran A. Mayer | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 1 |
| 15 | Investigating the Effects of Para-methoxy Substitution in Sterically Enhanced Unsymmetrical Bis(arylimino)pyridine-cobalt Ethylene Polymerization Catalysts显示文摘A group of five bis(arylimino)pyridine-cobalt(Ⅱ)chloride complexes,[2-{(2,6-(Ph_(2)CH)_(2)-4-MeOC_(6)H_(2))N=CMe}-6-(ArN=CMe)C_5 H_(3)N]CoCl_(2)(Ar=2,6-Me_(2)C_(6)H_(3)Co1,2,6-Et_(2)C_(6)H_(3)Co2,2,6-iPr_(2)C_(6)H_(3)Co3,2,4,6-Me_(3)C_(6)H_(2)Co4,2,6-Et_(2)-4-MeC_(6)H_(2)Co5),each containing one N-4-methoxy-2,6-dibenzhydrylphenyl group and one smaller sterically/electronically variable N-aryl group,have been synthesized in good yield(>71%)from the corresponding neutral terdentate nitrogen-donor precursor,L1-L5.All complexes have been characterized by^(1)H-NMR and FTIR spectroscopy with the former highlighting the paramagnetic nature of these cobaltous species and the unsymmetrical nature of the chelating ligand.The molecular structures of Co3 and Co4 emphasize the steric differences of the two inequivalent N-aryl groups and the distorted square pyramidal geometry about the metal centers.In the presence of MAO or MMAO,Co1-Co5 collectively displayed high activities for ethylene polymerization producing high molecular weight polyethylenes that,in general,exhibited narrow dispersities(M_w/M_n values:2.12-4.07).Notably,the least sterically hindered Co1 when activated with MAO was the most productive(6.92×10^(6)g_(PE)·mol^(-1)_((Co))·h^(-1))at an operating temperature of60℃.Conversely,the most sterically hindered Co3/MMAO produced the highest molecular weight polyethylene(M_w=6.29×10^(5)g·mol^(-1)).All the polymers displayed high linearity as demonstrated by their melting temperatures(>130℃)and their~1 H-and^(13)C-NMR spectra.By comparison of Co1 with its para-methyl,-chloro and-nitro counterparts,the presence of the para-methoxy substituent showed the most noticeable effect of enhancing the thermal stability of the catalyst. | Yi Yan Shi-Fang Yuan Ming Liu Gregory A.Solan Yan-Ping Ma Tong-Ling Liang Wen-Hua Sun | 2022 | Chinese Journal of Polymer Science2022，40，3： | 1 |
| 16 | Developmental pharmacology-drug disposition,action,and therapy in infants and children显示文摘 | Gregory LK Susan MA Sarah WA | 2003 | N Engl J Med2003，349，12： | 1 |
| 17 | Mask dependent etch rates II显示文摘 | Grynkewich Gregory W Ma Tso-Ping | 1987 | J Electrochem Soc:Solid-state Science and Technology1987，134，10： | 1 |
| 18 | Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain显示文摘 | Wilkinson B Gregory MA Moss SJ | | 0，，22： | 1 |
| 19 | Objective sleep in pediatric anxiety disorders and major depressive disorder显示文摘 | Forbes EE Bertocci MA Gregory AM | 2008 | J Am Acad Child Adolesc Psychiatry2008，7，2： | 1 |
| 20 | Acute fatty liver of preg- nancy;three cases and discussion of analgesia and anaesthesia显示文摘 | Gregory TL Hughes S Coleman MA | 2007 | Int J Obstet Anesth2007，16，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员