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| 1 | Multisciplinary management of patients with liver metastasis from colorectal cancer显示文摘Colorectal cancer(CRC) is one of the leading causes of cancer-related death. Surgery, radiotherapy and chemotherapy have been till now the main therapeutic strategies for disease control and improvement of the overall survival. Twenty-five per cent(25%) of CRC patients have clinically detectable liver metastases at the initial diagnosis and approximately 50% develop liver metastases during their disease course. Twentythirty per cent(20%-30%) are CRC patients with metastases confined to the liver. Some years ago various studies showed a curative potential for liver metastases resection. For this reason some authors proposed the conversion of unresectable liver metastases to resectable to achieve cure. Since those results were published, a lot of regimens have been studied for resectability potential. Better results could be obtained by the combination of chemotherapy with targeted drugs, such as anti-VEGF and antiEGFR monoclonal antibodies. However an accurate selection for patients to treat with these regimens and to operate for liver metastases is mandatory to reduce the risk of complications. A multidisciplinary team approach represents the best way for a proper patient management. The team needs to include surgeons, oncologists, diagnostic and interventional radiologists with expertise in hepatobiliary disease, molecular pathologists, and clinical nurse specialists. This review summarizes the most important findings on surgery and systemic treatment of CRC-related liver metastases. | Kathleen De Greef Christian Rolfo Antonio Russo Thiery Chapelle Giuseppe Bronte Francesco Passiglia Andreia Coelho Konstantinos Papadimitriou Marc Peeters | 2016 | World Journal of Gastroenterology2016，22，32： | 22 |
| 2 | 源于近端股骨间充质干细胞免疫抑制作用的研究显示文摘目的探讨源于成人近端股骨的间充质干细胞(MSC)是否具有免疫抑制功能,为临床移植物抗宿主病的防治寻找理想的细胞储备库。方法从全髋关节置换术患者的近端股骨中分离并培养MSC,将不同数量的细胞直接或以Transwell法加入混合淋巴细胞反应(MLR)中,检测MSC对外周血淋巴细胞(PBL)增殖水平的影响。以ELISA法及抗体中和法探讨细胞因子TGFβ1在MSC免疫调节中的作用。结果3×103、1×104、3×104、1×105个源于近端股骨的MSC对PBL增殖的抑制率分别为62%±18%、38%±4%、31%±16%、28%±12%,与采自髂骨骨髓穿刺物MSC的抑制作用相比差异无统计学意义(均P>0.05),后者对PBL的增殖抑制率为58%±12%、37%±8%、28%±6%、27%±6%;以0.2μm的微孔膜对MSC与MLR进行分隔,3×104及1×104个MSC对PBL的增殖抑制率为36%±8%和53%±12%;在ELISA实验中,MSC单独培养,MSC与MLR直接接触,或经Transwell共培养的这3种上清中转化生长因子(TGF)β1的表达水平差异无统计学意义,加入浓度递增的TGFβ1抗体不能逆转MSC对PBL增殖的抑制作用。结论源于近端股骨的MSC具有一定的免疫抑制功能,除TGFβ1外其他可溶性因子可能介导这一作用。 | 张翼鷟 Loic Fouillard Alain Chapel Morad Bensidhoum Christelle Mazurier Aish Nasef Sandrine Bouchet Manuel Lopez Dominique Thierry Norbert Cclaucle Gorin 达万明 | 2005 | 中华医学杂志2005，85，39： | 11 |
| 3 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 4 | Fifteen years of preclinical and clinical experiences about biotherapy treatment of lesions induced by accidental irradiation and radiotherapy显示文摘High dose radiation exposures involving medical treatments or accidental irradiation may lead to extended damage to the irradiated tissue. Alleviation or even eradication of irradiation induced adverse events is therefore crucial. Because developments in cell therapy have brought some hope for the treatment of tissues damages induced by irradiation, the Institute for Radiation and Nuclear Safety contributed to establish the clinical guidelines for the management of accidentally irradiated victims and to provide the best supportive care to patients all over the world. In the past 15 years, we contributed to develop and test cell therapy for protection against radiation side effects in several animalmodels, and we proposed mechanisms to explain the benefit brought by this new therapeutic approach. We established the proof of concept that mesenchymal stem cells (MSCs) migrate to damaged tissues in the nonobese diabetic/severe combined immunodeficiency immunotolerant mice model and in non-human primate after radiation exposure. We showed that the intravenous injection of MSCs sustains hematopoiesis after total body irradiation, improves wound healing after radiodermatitis and protects gut function from irradiation damages. Thanks to a tight collaboration with clinicians from several French hospitals, we report successful treatments of therapeutic/accidental radiation damages in several victims with MSC infusions for hematopoiesis correction, radio-induced burns, gastrointestinal disorders and protection homeostatic functions of gut management after radio-therapy. | Alain Chapel Sabine Francois Luc Douay Marc Benderitter Jan Voswinkel | 2013 | World Journal of Stem Cells2013，5，3： | 5 |
| 5 | Prediction of delayed graft function using different scoring algorithms: A single-center experience显示文摘AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each patient.METHODS This single-center,retrospective study included 247 consecutive kidney transplants from a deceased donor.These kidney transplantations were performed at our institution between January 2003 and December 2012.We compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under study.The c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P < 0.0001). However,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without DGF.The sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations. | Magda Michalak Kristien Wouters Erik Fransen Rachel Hellemans Amaryllis H Van Craenenbroeck Marie M Couttenye Bart Bracke Dirk K Ysebaert Vera Hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen Marie-Paule Emonds Daniel Abramowicz Jean-Louis Bosmans | 2017 | World Journal of Transplantation2017，7，5： | 3 |
| 6 | Choosing Multiple Parameters for Support Vector Machines显示文摘 | Olivier Chapelle Vladimir Vapnik Olivier Bousquet Sayan Mukherjee | 2002 | Machine Learning (-)2002，，1： | 3 |
| 7 | 纳米碳管模板法制取的GaP纳米棒拉曼光谱研究显示文摘报道了用纳米碳管模板法制备的GaP纳米棒的拉曼光谱特征 .观测到声子限制效应引起的GaP纳米棒TO和LO模的红移 .红移量一般在 2~ 10cm-1之间 ,与所测到的纳米棒的尺寸有关 .在偏振特性研究中 ,发现GaP纳米棒的偏振特性不能用单根纳米棒的选择定则来解释 ,而与测量光斑内多根纳米棒的无序取向有关 .无序程度越高 ,偏振特性的方向性越弱 .当激发光功率增加时 ,GaP纳米棒的TO和LO模的频率显著减少 ,表明纳米棒中的激光加热效应比体材料中强很多 .而且GaP纳米棒的拉曼散射强度随激发光功率的增加先饱和 ,然后减小 ,表明在强激发功率下GaP纳米棒中的缺陷会迅速增加 . | 马宝珊 方再利 苏付海 丁琨 韩和相 李国华 arklamy de la Chapelle 范守善 | 2003 | 红外与毫米波学报2003，22，1： | 3 |
| 8 | Gaining effciency via weighted estimators for multivariate failure time data显示文摘Multivariate failure time data arise frequently in survival analysis.A commonly used tech-nique is the working independence estimator for marginal hazard models.Two natural questions are how to improve the effciency of the working independence estimator and how to identify the situations under which such an estimator has high statistical effciency.In this paper,three weighted estimators are proposed based on three different optimal criteria in terms of the asymptotic covariance of weighted estimators.Simplifiedclose-form solutions are found,which always outperform the working indepen-dence estimator.We also prove that the working independence estimator has high statistical effciency,when asymptotic covariance of derivatives of partial log-likelihood functions is nearly exchangeable or diagonal.Simulations are conducted to compare the performance of the weighted estimator and work-ing independence estimator.A data set from Busselton population health surveys is analyzed using the proposed estimators. | FAN JianQing1,2,ZHOU Yong2,3,CAI JianWen4 & CHEN Min3 1 Department of Operations Research and Financial Engineering,Princeton University,Princeton,NJ08544,USA 2 Department of Statistics,Shanghai University of Finance and Economics,Shanghai 200433,China 3 Institute of Applied Mathematics,Academy of Mathematics and Systems Science,Chinese Academy of Sci-ences,Beijing 100190,China 4 Department of Biostatistics,University of North Carolina at Chapel Hill,Chapel Hill,NC 27599-7420,USA | 2009 | Science China Mathematics2009，52，6： | 2 |
| 9 | New insights for pelvic radiation disease treatment:Multipotent stromal cell is a promise mainstay treatment for the restoration of abdominopelvic severe chronic damages induced by radiotherapy显示文摘Radiotherapy may induce irreversible damage on healthy tissues surrounding the tumor. It has been reported that the majority of patients receiving pelvic radiation therapy show early or late tissue reactions of graded severity as radiotherapy affects not only the targeted tumor cells but also the surrounding healthy tissues. The late adverse effects of pelvic radiotherapy concern 5% to 10% of them, which could be life threatening. However, a clear medical consensus concerning the clinical management of such healthy tissue sequelae does not exist. Although no pharmacologic interventions have yet been proven to efficiently mitigate radiotherapy severe side effects, few preclinical researches show the potential of combined and sequential pharmacological treatments to prevent the onset of tissue damage. Our group has demonstrated in preclinical animal models that systemic mesenchymal stromal cell(MSC) injection is a promising approach for the medical management of gastrointestinal disorder after irradiation. We have shown that MSCs migrate to damaged tissues and restore gut functions after irradiation.We carefully studied side effects of stem cell injection for further application in patients. We have shown that clinical status of four patients suffering from severe pelvic side effects resulting from an over-dosage was improved following MSC injection in a compationnal situation. | Alain Chapel Sabine Francois Marc Benderitter Luc Douay Jan Voswinkel | 2013 | World Journal of Stem Cells2013，5，4： | 2 |
| 10 | Closed form solutions for inverse kinematics approximation of general 6R manipulators显示文摘 | CHAPELLE F BIAUDP B | 2004 | Mechanism and Machine Theory2004，39，3： | 2 |
| 11 | NEW EMERGING CONCEPTS IN THE MEDICAL MANAGEMENT OF LOCAL RADIATION INJURY显示文摘 | Marc Benderitter Patrick Gourmelon Eric Bey Alain Chapel Isabelle Clairand Marie Prat Jean Jacques Lataillade | 2010 | Health Physics2010，，6： | 2 |
| 12 | Role of the complement cascade in cerebral aneurysm formation,growth,and rupture显示文摘Rupture of intracranial aneurysms is the most common cause of nontraumatic subarachnoid hemorrhage,but the intricate neuroinflammatory processes which contribute to aneurysm pathophysiology are not well‑understood.Mounting evidence has implicated the complement cascade in the progression of aneurysms from their formation to rupture.In this article,we identify and review studies that have sought to determine the role of the complement system in the aneurysm pathogenesis.The studies were generally conducted by immunhistological analyses on aneurysm tissue collected intraoperatively,and multiple components of the complement cascade and its modulators were identified in specific regions of the aneurysm wall.The results of the studies suggest that the complement cascade is locally upregulated and disinhibited in the perianeurysmal environment,and that it contributes to chronic as well as acute immunological damage to the aneurysm wall.In the future,understanding the mechanisms at work in complement‑mediated damage is necessary to leading the development of novel therapies. | Blake E.S.Taylor Geoff Appelboom Robert Zilinyi Ariana Goodman David Chapel Melissa LoPresti Edward Sander Connolly Jr. | 2015 | Neuroimmunology and Neuroinflammation2015，2，1： | 2 |
| 13 | Support vector machines for histogram-based image classification显示文摘 | Olivier Chapelle Patrick Haffner Vladimir N Vapnik | 1999 | IEEE Transaction 0n Neural Networks1999，10，5： | 2 |
| 14 | Biomarker discovery for inflammatory bowel disease, using proteomic serum profiling显示文摘 | Marie-Alice Meuwis Marianne Fillet Pierre Geurts Dominique de Seny Laurence Lutteri Jean-Paul Chapelle Vincent Bours Louis Wehenkel Jacques Belaiche Michel Malaise Edouard Louis Marie-Paule Merville | 2007 | Biochemical Pharmacology2007，，9： | 2 |
| 15 | 小型非直喷式自然吸气柴油机发展趋势显示文摘对车用非直喷式和直喷式非增压柴油机的性能、燃油耗、噪声、排放和价格各方面进行了比较,开对今后的发展提出了一些新思路。与直喷式发动机相比,非直喷自然吸气柴油机具有较高的性能、较低的噪声、排放和成本。 | Chapelle M C 吴新潮 | 1998 | 国外内燃机1998，30，1： | 2 |
| 16 | 汽车乘客位置的光学三角测量法显示文摘本文着重介绍一种测量汽车内人体位置的测量传感方法-光学测量法的原理及应用 | Walt Chapelle Ed Gillis | 1997 | 传感器世界1997，3，2： | 1 |
| 17 | Support vector machines for histogram-bas ed image classification 显示文摘 | Haffner P Vapnik V | 1999 | IEEE Trans on neural networks1999，10，5： | 1 |
| 18 | Primary immunodeficiencies : 2009 update 显示文摘 | Chapel H Conley ME Cunningham -Rundles C | 2009 | Allergy Clin lmmunol2009，124，6： | 1 |
| 19 | Lipid composition of tissues of marine crusta- ceas 显示文摘 | Chapelle S | 1977 | Biochem Syst Ecol1977，5，： | 1 |
| 20 | Choosing multiple parameters for Support Vector Machines显示文摘 | Chapelle O Vapnik V | 2002 | Machine Learning2002，46，： | 1 |
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