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| 1 | Role of MMP-2 and MMP-9 and their natural inhibitors in liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases显示文摘BACKGROUND: There is a growing evidence that matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinases) play an important role in the pathogenesis of numerous disorders especially with inflammatory etiology and extracellular matrix (ECM) remodeling. Despite the fact that gelatinases involve in liver cirrhosis is provided in the literature, their role in the pathogenesis of chronic pancreatitis and non-specific inflammatory bowel diseases is still under investigation.DATA SOURCES: We carried out a PubM ed search of English language articles relevant to the involvement of gelatinases in the pathogenesis of liver fibrosis, pancreatitis, and non-specific inflammatory bowel diseases.RESULTS: The decreased activity of gelatinases, especially MMP-2, is related to the development of liver fibrosis, probably due to the decrease of capability for ECM remodeling. Similar situation can be found in chronic pancreatitis; however reports on this matter are rare. The presence of non-specific inflammatory bowel diseases results in MMP-9 activity elevation.CONCLUSION: The fluctuation of gelatinases activity during liver fibrosis, chronic pancreatitis and non-specific inflammatorybowel diseases is observed, but the exact role of these enzymes demands further studies. | Jacek Kurzepa Agnieszka M?dro Gra?yna Czechowska Joanna Kurzepa Krzysztof Celiński Weronika Kazmierak Maria S?omka | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 15 |
| 2 | ICE3列车直线涡流制动装置显示文摘目前 ,德国铁路公司的第三代高速列车 ICE3已采用直线涡流制动装置。因为物理作用原理的缘故 ,该制动装置的使用要求从技术角度出发 ,对线路基础结构的一些特性 ,特别是信号技术方面的敏感元件和轨道 (几何 )位置的热稳定性 ,要进行重新审查。文章阐述了涡流制动装置 ( WB)在制动技术和运行方面的一些优点 ,讲述了从 2 0 0 2年 8月起 ,在科隆—莱茵 /美因这一新的高速行车区段的使用情况。叙述的重点是运转方案和对 ICE3调控区段基础设施事先所进行的强化检查。最后 ,介绍了自2 0 0 1年以来 ,在汉堡—慕尼黑区段上涡流制动装置 ( WB)在运转试验方面的一些经验。 | Johannes GRA■BER 张彦儒 | 2003 | 国外机车车辆工艺2003，，5： | 10 |
| 3 | Virulence factors of Enterococcus strains isolated from patients with inflammatory bowel disease显示文摘AIM: To determine the features of Enterococcus that contribute to the development and maintenance of the inflammatory process in patients with inflammatory bowel disease (IBD). METHODS: Multiplex polymerase chain reaction (PCR) was applied to assess the presence of genes that encode virulence factors [surface aggregating protein (asa1), gelatinase (gelE), cytolysin (cylA), extracellular surface protein (esp) and hyaluronidase (hyl)] in the genomic DNA of 28 strains of Enterococcus isolated from the intestinal tissues of children with IBD (n =16) and of children without IBD (controls; n = 12). Additionally, strains with confirmed presence of the gelE gene were tested by PCR for the presence of quorum sensing genes (fsrA, fsrB, fsrC) that control the gelatinase production. Gelatinase activity was tested on agar plates containing 1.6% gelatin. We also analysed the ability of Enterococcus strains to release and decompose hydrogen peroxide (using Analytical Merckoquant peroxide test strips) and tested their ability to adhere to Caco-2 human gut epithelium cells and form biofilms in vitro. RESULTS: A comparison of the genomes of Enterococcus strains isolated from the inflamed mucosa of patients with IBD with those of the control group showed statistically significant differences in the frequency of theasa1 gene and thegelE gene. Furthermore, the cumulative occurrence of different virulence genes in the genome of a single strain ofEnterococcus isolated from the IBD patient group is greater than in a strain from the control group, although no significant difference was found. Statistically significant differences in the decomposition of hydrogen peroxide and adherence to the Caco-2 epithelial cell line between the strains from the patient group and control group were demonstrated. The results also showed that profuse biofilm production was more frequent amongEnterococcus strains isolated from children with IBD than in control strains. CONCLUSION: Enterococcus strains that adhere strongly to the intestinal epithelium, form biofilms and possess antioxidant defence mechanisms seem to have the greatest influence on the inflammatory process. | Edyta Golińska Anna Tomusiak Tomasz Gosiewski Gra yna Wiecek Agnieszka Machul Diana Mikoajczyk Magorzata Bulanda Piotr B Heczko Magdalena Strus | 2013 | World Journal of Gastroenterology2013，19，23： | 8 |
| 4 | Application of a biochemical and clinical model to predict individual survival in patients with end-stage liver disease显示文摘AIM:To investigate the capability of a biochemical and clinical model,BioCliM,in predicting the survival of cirrhotic patients.METHODS:We prospectively evaluated the survival of 172 cirrhotic patients.The model was constructed using clinical(ascites,encephalopathy and variceal bleeding) and biochemical(serum creatinine and serum total bilirubin) variables that were selected from a Cox proportional hazards model.It was applied to estimate 12-,52-and 104-wk survival.The model's calibration using the Hosmer-Lemeshow statistic was computed at 104 wk in a validation dataset.Finally,the model's validity was tested among an independent set of 85 patients who were stratified into 2 risk groups(low risk≤8 and high risk>8).RESULTS:In the validation cohort,all measures of fi t,discrimination and calibration were improved when the biochemical and clinical model was used.The proposed model had better predictive values(c-statistic:0.90,0.91,0.91) than the Model for End-stage Liver Disease(MELD) and Child-Pugh(CP) scores for 12-,52-and 104-wk mortality,respectively.In addition,the Hosmer-Lemeshow(H-L) statistic revealed that the biochemical and clinical model(H-L,4.69) is better calibrated than MELD(H-L,17.06) and CP(H-L,14.23).There were no significant differences between the observed and expected survival curves in the stratified risk groups(low risk,P=0.61;high risk,P=0.77).CONCLUSION:Our data suggest that the proposed model is able to accurately predict survival in cirrhotic patients. | Eduardo Vilar Gomez Luis Calzadilla Bertot Bienvenido Gra Oramas Enrique Arus Soler Raimundo Llanio Navarro Javier Diaz Elias Oscar Villa Jiménez Maria del Rosario Abreu Vazquez | 2009 | World Journal of Gastroenterology2009，15，22： | 6 |
| 5 | Multi-element determination of Cu, Fe, Ni and Zn content in vegetable oils samples by high-resolution continuum source atomic absorption spectrometry and microemulsion sample preparation显示文摘 | Luana S. Nunes José T.P. Barbosa Andréa P. Fernandes Valfredo A. Lemos Walter N.L. dos Santos Maria Gra?as A. Korn Leonardo S.G. Teixeira | 2011 | Food Chemistry2011，，2： | 4 |
| 6 | Lamivudine therapy for children with chronic hepatitis B显示文摘瞄准:为了估计,为失败到的有长期的肝炎 B (CHB ) 的孩子的 lamivudine 治疗的有效性和副作用对作出回应或有禁止徵候到 interferon-alpha (IFN-alpha ) 治疗。方法:有 CHB 的 59 个孩子被对待, 100 片 mg lamivudine 药片每天为 12 瞬间口头上地给一次。丙氨酸 aminotransferase (中高音) 活动在它的中止以后在治疗和每 3 瞬间期间每月被评估。HBe 抗原, anti-HBe 抗体,在浆液的 HBV DNA 水平在基线和每六个月被评估在期间并且在 lamivudine 治疗以后。对 lamivudine 治疗的持续病毒的反应(SVR ) 被定义为永久(比在治疗的结束以后的 6 瞬间不短) ,也就是中高音活动正规化,到 anti-HBe 抗体的 HBeAg 的 seroconversion,和在浆液的无法发现的病毒的 HBV-DNA (比 200 个拷贝低每 mL ) 。lamivudine 治疗的副作用的分析有关测试在治疗以后在治疗,和每 3 瞬间期间每月在临床的访问期间执行了的主观、客观的症状,临床的考试,和实验室用一张问询表在病人和他们的父母的会见之上被基于。结果:中高音 normalisation 发生在 47 (79.7%) 病人在之间第一和 11 (th ) 治疗的瞬间(吝啬的 4.4+/-2.95 瞬间,中部 4.0 瞬间) ,并且在 18 (30.5%) 他们在治疗的 2 瞬间以后。在中高音正规化和孩子们的年龄的时间之间没有关联, HBV 感染的年龄, HBV 感染的持续时间,发炎活动分数(分级) ,阶段,在治疗前的中高音活动,浆液 HBV DNA 水平,和 lamivudine 每体重的 kg 开。HBeAg/anti HBe seroconversion 在 27.1% 盒子中被完成。seroconversion 的更高的率与更低的浆液 HBV DNA 水平和 HBV 感染的更长的持续时间被连接。在 HBeAg/anti HBeAb seroconversion 和孩子们之间没有连接,分级是年龄, HBV 感染的年龄,阶段,在治疗前的中高音活动,和 lamivudnie 每体重的 kg 开。没有抱怨或临床的症状在 lamivudine 治疗期间被观察。肾的功能或骨髓中毒的效果的缺陷病人在没有被注意。结论:为有长期的肝炎 B 的孩子的一年 lamivudine 治疗有效、很好容忍。HBeAg/HBeAb 和 SVR 的 Seroconversion 与更低的预告的处理浆液 HBV DNA 水平被连接。 | Anna Liberek Anna Szaflarska-Poplawska Maria Korzon Gra(?)yna (?)uczak Magdalena Góra-Gebka Ewa (?)o(s|')-Rycharska Wanda Bako Mieczyslawa Czerwionka-Szaflarska | 2006 | World Journal of Gastroenterology2006，12，15： | 4 |
| 7 | Transformation of wheat with high molecular weight subunit genes results in improved functional properties显示文摘 | Barro F Rooke L Bekes F Gras P Tatham A S Fido R Lazzeri P A Shewry P R Barcelo P | 1997 | Nat Biotechnol1997，15，12： | 2 |
| 8 | MicroRNA-124 Regulates STAT3 Expression and Is Down-regulated in Colon Tissues of Pediatric Patients With Ulcerative Colitis显示文摘 | Georgios Koukos Christos Polytarchou Jess L. Kaplan Alessio Morley–Fletcher Beatriz Gras–Miralles Efi Kokkotou Mariah Baril–Dore Charalabos Pothoulakis Harland S. Winter Dimitrios Iliopoulos | 2013 | Gastroenterology2013，，： | 2 |
| 9 | Impact of thermal power plants on aquatic ecosystems: the French experience 显示文摘 | Gras R A | 1983 | WSAT1983，15，10： | 2 |
| 10 | UVA-induced decerease ill nuclear factor-kappaB activity in human keratinocytes显示文摘 | Djavaheri-Mergny M Gras MP Mergny JL | 1999 | Biochem J1999，338，3： | 1 |
| 11 | Arthroscopic con- trolled reduction of femoral condyle fractures using a retro- grade navigated approach 显示文摘 | Gras F Marintsehev I Koenig V | 2011 | Arch Orthop Trauma Surg2011，131，3： | 1 |
| 12 | Supplementing defect in Club Cell Secretory Protein attenuates airway inflammation in COPD显示文摘 | Gamez AS Gras D Petit A | 2015 | Chest2015，147，6： | 1 |
| 13 | Life Prediction for HLW Containers-issues Re- lated to Long-teml Extrapolation of Corrosion Resestance 显示文摘 | Gras J M | 2002 | Comptes Rendus Physique2002，3，： | 1 |
| 14 | Localization ofVGLUT3 ,the vesicular glutamate transporter type 3 , inthe rat brain显示文摘 | Herzog E Gilchrist J Gras C | 2004 | Neuroscience2004，123，4： | 1 |
| 15 | Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8 T-cell re- sponses显示文摘 | Day E B Guillonneau C Gras S | 2011 | Proc Natl Acad Sci USA2011，108，23： | 1 |
| 16 | Clinical trial:a nutritional supplement Viusid,in combination with diet and exercise,in patients with nonalcoholic fatty liver disease显示文摘 | Vilar gomez E Rodriguez de miranda A Gra oramas B | | 0，，10： | 1 |
| 17 | The response of some vegetables to vacuum impregnation 显示文摘 | Gras M Vidal-Brotonl D Betoret N | 2002 | Innovative Food Science & Emerging Technology2002，3，3： | 1 |
| 18 | Premature rupture of membranes before 32 weeks of gestation: Prenatal prognosis factors 显示文摘 | PaumierA Gras - Leguen C Branger B | 2008 | Gynecol Obstet Ferti12008，36，7： | 1 |
| 19 | T cell aUorecognition via molecular mimicry显示文摘 | Macdonald WA Chen Z Gras S | 2009 | Immunity2009，31，6： | 1 |
| 20 | A nalysis of genetic predisiposition to pulmonary tuberculosis in native Russians显示文摘 | Gra OA Kozhekbaeva ZHM Litvinov VI | 2010 | Russian Journal of Genetic2010，46，2： | 1 |
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