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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Diminished over - load - induced hypertrophy in aged fast -twitch skeletal muscle is associated with AMPK hyperphosphorylation 显示文摘 | Thomson DM Gordon SE | 2005 | J Appl Physiol2005，98，2： | 1 |
| 3 | AMPK activation attenuates S6KI, 4E-BP1, and eEF2 signaling responses to high -frequency electrically stimulated skeletal muscle contractions 显示文摘 | Thomson DM Fick CA Gordon SE | 2008 | J Appl Physiol2008，104，3： | 1 |
| 4 | Diminished overload- induced hypertrophy in aged fast- twitch skeletal muscle is associated with AMPK hyperphosphorylation 显示文摘 | Thomson D M Gordon S E | 2005 | J Appl Physiol2005，98，2： | 1 |
| 5 | Can intervention modi- fyadverse lifestyle variables in a rheumatoid population Results of a pilotstudy显示文摘 | Gordon MM Thomson EA Madhok R | 2002 | Ann RheumDis2002，61，： | 1 |
| 6 | Diminished overload-induced hypertrophy in aged fast-twitch skeletal muscle is associated with AMPK hyperphosphorylation显示文摘 | THOMSON D GORDON S | 2005 | J Appl Physiol2005，98，： | 1 |
| 7 | Parathyroidhormone - related peptide modulates signal pathways in skinand hair follicle cells 显示文摘 | Thomson M Mc Carroll J Gordon TC | 2003 | Exp Dermatol2003，12，4： | 1 |
| 8 | AMPK activation attenuates $6K1, 4E-BP1, and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle contrac- tions显示文摘 | THOMSON D M FICK C A GORDON S E | 2008 | J Appl Physlol(1985)2008，104，3： | 1 |
| 9 | Impaired overload-induced muscle growth is associated with diminished translational signaling in aged rat fast-twitch skeletal muscle 显示文摘 | Thomson D M Gordon S E | 2006 | J Physiol ( Lond)2006，574，1： | 1 |
| 10 | Differential cataractogenic potency of TGF-beta 1,beta 2,beta 3 and their expression in the postnatal rat eye显示文摘 | Gordon Thomson C De Jorgh RU Hales AM | 1998 | Invest Ophthalmol Vis Sci1998，39，8： | 1 |
| 11 | AMPK activation attenuates S6K1,4E-BP1,and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle contractions显示文摘 | Thomson Fick and Gordon | 2008 | J Appl Physiol(1985)2008，104，3： | 1 |
| 12 | Diminished overload-induced hypertrophy in aged fast-twitch skeletal muscle is associated with AMPK hyperphosphorylation 显示文摘 | Thomson D M Gordon S E | 2005 | J Appl Physiol2005，98，2： | 1 |
| 13 | AMPK activation attenuates S6K1, 4E-BPI, and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle contractions显示文摘 | Thomson D M Fick C A Gordon S E | 2008 | J Appl Physiol2008，104，3： | 1 |
| 14 | Diminished over-load-induced hypertrophy in aged fast-twitch skeletal muscle is associated with AMPK hyperphosphoryla- tion显示文摘 | Thomson D M Gordon S E | 2005 | J Appl Physiol2005，98，2： | 1 |
| 15 | Diminished overload-induced hypertrophy in aged fast-twitch skeletal muscle is associated with AMPK hyperphosphoryla- tion显示文摘 | Thomson D M Gordon S E | 2005 | J ApplPhysiol2005，98，2： | 1 |
| 16 | AMPK activation at- tenuates S6K1,4E-BP1, and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle con- tractions 显示文摘 | Thomson DM Fick CA Gordon SE | 2008 | J Appl Physiol2008，104，3： | 1 |
| 17 | Diminished overload-induced hypertrophy in aged fast-twitch skeletal muscle is associated with AMPK hyperphosphorylation显示文摘 | Thomson D Gordon S | 2005 | J Appl Physiol2005，98，： | 1 |
| 18 | A single tube, quantitative real-time RT-PCR assay that detects four potato viruses simultaneously显示文摘 | Sheila M. Mortimer-Jones Michael G.K. Jones Roger A.C. Jones Gordon Thomson Geoffrey I. Dwyer | 2009 | Journal of Virological Methods2009，，2： | 1 |
| 19 | Gangliosides Protect Bowel in an Infant Model of Necrotizing Enterocolitis by Suppressing Proinflammatory Signals显示文摘 | Kareena L Schnabl Bodil Larsen John E Van Aerde Gordon Lees Mark Evans Miodrag Belosevic Catherine Field ABR Thomson Michael T Clandinin | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，4： | 1 |
| 20 | Differential cataractogenic potency of TGF-beta 1,beta 2,beta 3 and their expression in the postnatal rat eye显示文摘 | Gordon Thomson C De Jorgh RU Hales AM | 1998 | Invest Ophthalmol Vis Sci1998，39，8： | 1 |
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