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| 1 | Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells显示文摘AIM:To determine the effect of ellagic acid on apop-tosis and proliferation in pancreatic cancer cells and to determine the mechanism of the pro-survival effects of ellagic acid. METHODS:The effect of ellagic acid on apoptosis was assessed by measuring Phosphatidylserine externalization,caspase activity,mitochondrial membrane potential and DNA fragmentation;and proliferation by measuring DNA thymidine incorporation. Mitochondrial membrane potential was measured in permeabilized cells,and in isolated mitochondria. Nuclear factor kB(NF-kB) activity was measured by electromobility shift assay(EMSA) . RESULTS:We show that ellagic acid,a polyphenolic compound in fruits and berries,at concentrations 10 to 50 mmol/L stimulates apoptosis in human pancreatic adenocarcinoma cells. Further,ellagic acid decreases proliferation by up to 20-fold at 50 mmol/L. Ellagic acid stimulates the mitochondrial pathway of apoptosis associated with mitochondrial depolarization,cytochrome C release,and the downstream caspaseactivation. Ellagic acid does not directly affect mitochondria. Ellagic acid dose-dependently decreased NF-kB binding activity. Furthermore,inhibition of NF-kB activity using IkB wild type plasmid prevented the effect of ellagic acid on apoptosis. CONCLUSION:Our data indicate that ellagic acid stimulates apoptosis through inhibition of the prosu-rvival transcription factor NF-kB. | Mouad Edderkaoui Irina Odinokova Izumi Ohno Ilya Gukovsky Vay Liang W Go Stephen J Pandol Anna S Gukovskaya | 2008 | World Journal of Gastroenterology2008，14，23： | 30 |
| 2 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 12 |
| 3 | 活性氧介导的肿瘤微环境在胰腺癌发生与发展中作用的研究进展显示文摘胰腺癌是一种在全世界范围内发病率和死亡率都很高的恶性肿瘤,当前缺少有效的手术方法和治疗药物。近年来,活性氧(reactive oxygen species,ROSs)已成为胰腺癌研究领域的热点。ROSs可调节肿瘤微环境(tumor microenvironment,TME)、肿瘤干细胞(cancer stem cells,CSCs)更新和上皮-间质转化(epithelial-mesenchymal transition,EMT)等过程,从而导致胰腺癌的耐药和复发。当前,包括免疫浸润、成纤维细胞、血管和细胞外基质在内的TME已成为肿瘤研究的热点。同时,已有大量文献报道ROSs介导的TME在胰腺癌的发生与发展中具有重要的作用,靶向调节ROSs可能是治疗胰腺癌的一种方法。因此,本文综述了ROSs在胰腺癌肿瘤发生和耐药中的调控作用、ROSs在胰腺癌信号转导中的作用以及ROSs在胰腺癌基质细胞中的作用,并总结了靶向调节ROSs的抗胰腺癌的潜在药物。 | 陶旭锋 Vay Liang W(Bill)Go 肖桂山 | 2021 | 生理学报2021，73，2： | 5 |
| 4 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013，，12： | 2 |
| 5 | Applying importance-performance analysis to Beijing as an international meeting destination 显示文摘 | Go F Zhang W | 1997 | Journal of Travel Research1997，35，1： | 1 |
| 6 | The natural andartificial aging response of semi-solid metal processed alloy A356显示文摘 | MOLLER H GO VENDER G STUMPF W E | 2008 | Solid State Phenomena2008，，： | 1 |
| 7 | Phylogentic analysis of Erwinia species based on 16S rDNA gene sequences显示文摘 | KWON S W GO S J KANG H W | 1997 | International Union of Microbiological Societies1997，47，4： | 1 |
| 8 | Scasonal patterns of nitriogen and denitrification in a natural and a restored salt marsh 显示文摘 | Paerl H W Go M C | 1995 | Estuaries1995，18，： | 1 |
| 9 | Evaluation of the flavor-- noid oroxylin A as an inhibitor of P--glycoprotein--mediated cellular efflux-- 显示文摘 | Go W J Ryu J H Qiang F | 2009 | JNatProd2009，72，9： | 1 |
| 10 | Differentiation of liver epithelial (stem-like) cells into hepatoeytes induced by eoeuhure with hepatic stellate ceils 显示文摘 | Hirokazu N Kunihiko T Go W | 2002 | Biochem Biophys Res Commun2002，293，5： | 1 |
| 11 | Synthesis and characterization of heparin conjugated Tetronic-PCL copolymer for protein drug delivery显示文摘 | Lee J S Go D H Bae J W | 2007 | Current Applied Physlcs2007，71，： | 1 |
| 12 | Synthesis and characterization of Pluronic grafted chitosan copolymer as a novel injectable biomaterial显示文摘 | Chung H J Go D H Bae J W | 2005 | Curr Applied Physics2005，5，： | 1 |
| 13 | Seasonal patterns of nitrification and denitrification in a natural and a restored salt marsh显示文摘 | Thompson S P Paeri H W Go M C | 1995 | Estuaries1995，18，2： | 1 |
| 14 | Minimally invasive surgery f~r gas- tric cancer : the future standard of care 显示文摘 | Keisuke K Satoshi N Go W | 2011 | World J Surg2011，35，7： | 1 |
| 15 | Statin therapy and risks for death and hospitalization in chronic heart failure 显示文摘 | Go A S Lee W Y Yang J | 2006 | JAMA2006，296，17： | 1 |
| 16 | Cyelooxygenase-2 ex- pression in Helieobaeter pylori-associated premalignant and malignant gastric lesions显示文摘 | Sung J J Leung W K Go M Y | 2000 | Am J Pathol2000，157，3： | 1 |
| 17 | Phylogenetic analysis of erwinia species based on 16s rRNA gene sequences显示文摘 | Kwon S W Go S J Kang H W | | 0，，04： | 1 |
| 18 | Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma显示文摘 | Djojosubroto M W Chin A C Go N | 2005 | Hepatol2005，42，5： | 1 |
| 19 | Tumor-associated lymphangiogenesisin the development of coryunctival squamous cell carcinoma显示文摘 | Heindl LM Hofmann-Rummelt C Adler W Holbach LM Nau-mann GO Kruse FE et at | 2010 | Ophthalmology2010，117，4： | 1 |
| 20 | Minimally invasive surgery for gastriccancer:the future standard of care 显示文摘 | Keisuke K Satoshi N Go W | 2011 | World J Surg2011，35，7： | 1 |
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