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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Therapeutic efficiency of everolimus and lapatinib in xenograft model of human colorectal carcinoma with KRAS mutation显示文摘 | Céline Chu Marie‐Sophie No?l‐Hudson Valérie Boige Diane Goéré Sylvie Marion Mélanie Polrot Ludovic Bigot Patrick Gonin Robert Farinotti Laurence Bonhomme‐Faivre | 2013 | Fundamental & Clinical Pharmacology2013，，4： | 2 |
| 3 | Nutri?ent-gene interaction: metabolic genotype-phenotype re?lationship显示文摘 | GO V L NGUYEN C T HARRIS D M | 2005 | TheJournal of Nutrition2005，135，12： | 1 |
| 4 | Structure and thermal properties of blends of nylon 6 and a liquid crystal copolyester显示文摘 | Campoy I Go'mez M A Marco C | | 0，，25： | 1 |
| 5 | Thirty-day mortality after ischemic stroke and intracranial hemorrhage in patients with atrial fibrillation on and off anticoagulants显示文摘 | Fang M C Go A S Chang Y | 2012 | Stroke2012，43，7： | 1 |
| 6 | Automatic change detection of build-ings in urban environment from very high spatial resolution images using existing geodatabase and prior knowledge显示文摘 | Bouziani M Go'ta K He D C | 2010 | ISPRS Journal of PhotogTammetry and Remote Sensing2010，65，1： | 1 |
| 7 | Phosphatidylinositol4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes显示文摘 | Go?i G M Epifano C Boskovic J | 2014 | Proc Natl Acad Sci USA2014，111，31： | 1 |
| 8 | Scasonal patterns of nitriogen and denitrification in a natural and a restored salt marsh 显示文摘 | Paerl H W Go M C | 1995 | Estuaries1995，18，： | 1 |
| 9 | Systematic evolution of ligands by exponential enrichment RNA ligands to bacteriophage T4 DNA polymerase显示文摘 | Tuerk C Go M L | 1990 | Science1990，249，4968： | 1 |
| 10 | Neuronal Histamine Regulates Food Intake,Adiposity,and Uncoupling Protein Expression in Agouti Yellow (Ay/a) Obese显示文摘 | Seiichi C GO Y | 2003 | Mice Endocrinology2003，144，6： | 1 |
| 11 | Extraction of gelatin from fish skins by high pressure treatment显示文摘 | M C Go'mez-Guille'n B Gime'nez P Montero | 2005 | Food hydrocolloids2005，19，： | 1 |
| 12 | Seasonal patterns of nitrification and denitrification in a natural and a restored salt marsh显示文摘 | Thompson S P Paeri H W Go M C | 1995 | Estuaries1995，18，2： | 1 |
| 13 | Effects of supercritical carbon dioxide treatment for sterilization purpose on meat quality of porcine longissimus dorsi muscle 显示文摘 | Choi Y M Ryu Y C Lee S H Go H G Kim K H | 2008 | LWT-Food Science and Technology2008，41，2： | 1 |
| 14 | Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma显示文摘 | Djojosubroto M W Chin A C Go N | 2005 | Hepatol2005，42，5： | 1 |
| 15 | Increased prevalence of subclinical and clinical hypothyroidism in persons with chronic kidney disease显示文摘 | Lo d C Chertow G M Go A S | 2005 | Kidney Int2005，67，： | 1 |
| 16 | Chronic kidney disease and the risks of death, cardi ovascular events,and hospitalization显示文摘 | Go A S Chertow G M Fan D McCulloch C E Hsu C Y | 2004 | N Engl J Med2004，351，： | 1 |
| 17 | Changing indications for penetrating keratoplasty: histopathology of 1250 corneal buttons 显示文摘 | Cursiefen C Kuchle M Naumann GO | 1998 | Cornea1998，17，： | 1 |
| 18 | Social and economic interest in the control of phthalic acid esters显示文摘 | A GO'MEX-HENS M AGUILAR C | | Trends in Analytical Chemistry0，，： | 1 |
| 19 | Social and economic interest in the control of phthalic acid esters 显示文摘 | A Go' mez- Hens M Aguilar C | 2003 | Trends in Analytical Chemistry2003，22，11： | 1 |
| 20 | Cadmiumcauses the oxidative modification of proteins in pea plants显示文摘 | ROMERO-PUERTAS M C PALMA J M GO'MEZ M | 2002 | Plant Cell&Environment2002，25，5： | 1 |
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