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| 1 | Fat:A matter of disturbance for the immune system显示文摘Obesity is increasingly being recognized as a risk factor for a number of benign and malignant gastrointestinal conditions. However, literature on the underlying pathophysiological mechanisms is sparse and ambiguous. There is compelling evidence that both overnutrition and undernutrition negatively interfere with the immune system. Overnutrition has been found to increase susceptibility to the development of inflammatory diseases, autoimmune diseases and cancer. In the regulation of immune and in? ammatory processes, white adipose tissue plays a critical role, not only as an energy store but also as an important endocrine organ. The obese state is characterised by a low-grade systemic in? ammation, mainly as a result of increased adipocytes as well as fat resident-and recruited-macrophage activity. In the past few years, various products of adipose tissue including adipokines and cytokines have been characterised and a number of pathways linking adipose tissue metabolism with the immune system have been identified. Activation of the innate immune system plays a major role in hepatic steatosis. Non-alcoholic fatty liver disease includes a wide spectrum of diseases, from pure steatosis to non-alcoholic steato-hepatitis in the absence of signif icant alcohol consumption. Although steatosis is considered a non-progressive disease, non-alcoholic steatohepatitis may deteriorate in advanced chronic liver diseases, cirrhosis, and hepatocellular carcinoma. An important parallel between obesityrelated pathology of adipose tissue and liver pertains to the emerging role of macrophages, and growing evidence suggests that Kupffer cells critically contribute to progression of non-alcoholic fatty liver disease. Moreover, a close link between specif ic immune activation and atherosclerosis has been well established, suggesting that fat can directly trigger immune responses. This review discusses the role of fat as 'a matter of disturbance for the immune system' with a focus on hepatic steatosis. | Alessandro Federico Elena D’Aiuto Francesco Borriello Giusi Barra Antonietta Gerarda Gravina Marco Romano Raffaele De Palma | 2010 | World Journal of Gastroenterology2010，16，38： | 12 |
| 2 | Wilson's disease: Prospective developments towards new therapies显示文摘Wilson's disease(WD) is an autosomal recessive disorder of copper metabolism, caused by mutations in the ATP7 B gene. A clear demand for novel WD treatment strategies has emerged. Although therapies using zinc salts and copper chelators can effectively cure WD, these drugs exhibit limitations in a substantial pool of WD patients who develop intolerance and/or severe side effects. Several lines of research have indicated intriguing potential for novel strategies and targets for development of new therapies. Here, we review these new approaches, which comprise correction of ATP7 B mutants and discovery of new compounds that circumvent ATP7B-deficiency, as well as cell and gene therapies. We also discuss whether and when these new therapeutic strategies will be translated into clinical use, according to the key requirements for clinical trials that remain to be met. Finally, we discuss the hope for the current rapidly developing research on molecular mechanisms underlying WD pathogenesis and for the related potential therapeutic targets to provide a solid foundation for the next generation of WD therapies that may lead to an effective, tolerable and safe cure. | Giusy Ranucci Roman Polishchuck Raffaele Iorio | 2017 | World Journal of Gastroenterology2017，23，30： | 6 |
| 3 | Magnetic resonance imaging:Is there a role in clinical management for acute ischemic colitis?显示文摘AIM:To validate the utility of magnetic resonance imaging(MRI) for the clinical management of acute ischemic colitis(IC).METHODS:This is a magnetic resonance(MR) prospective evaluation of 7 patients who were proved to have acute IC on the basis of clinical,endoscopic and computed tomography(CT) findings and who were imaged in our institution between February 2011 and July 2012.The mean age of the patients was 72.28 years.Abdominal CTs were obtained using a 64-detector row configuration for all patients with un-enhanced and contrast-enhanced scans,in the late arterial phase(start delay 45-50 s) and in the portal venous phase(start delay 70-80 s).The MR examinations were performed using a 1.5T superconducting magnet,using Fast Imaging Employing Steady State Acquisition and T2-weighted fast-recovery fast-spin echo sequences in axial and coronal plane.CT and MRI examinations were analysed for the presence of colonic abnormalities and associated findings.RESULTS:Segmental involvement was seen in 6 patients(85.71%),with a mean length of involvement of 412 mm(range 145.5-1000 mm).Wall thickness varied between 6 mm and 17.5 mm(mean 10.52 mm) upon CT examinations and from 5 to 15 mm(mean 8.8 mm) upon MR examinations.The MRI appearance of the colonic wall varied over the time:TypeⅠappearance with a 3 layer sandwich sign was seen in 5 out of 12 examinations(41.66%),patients underwent MR within a mean of 36 h(ranging from 1 to 54 h) after the CT examination.Type Ⅱ and Ⅲ appearance with a 2 layer sign,was seen in 4 examinations(33.33%),patients underwent MR within a mean of 420.5 h(ranging from 121 to 720 h) after the CT examination.In the remaining three MRI examinations,performed within a mean of 410 h(ranging from 99.5 to 720 h) the colonic wall appeared normal.CONCLUSION:MRI,only using precontrast images,may be used as a substitute for invasive procedures in diagnosis and follow-up of acute IC. | Maria Antonietta Mazzei Susanna Guerrini Nevada Cioffi Squitieri Giusi Imbriaco Raffaele Chieca Serenella Civitelli Vinno Savelli Francesco Giuseppe Mazzei Luca Volterrani | 2013 | World Journal of Gastroenterology2013，19，8： | 5 |
| 4 | Influence of meal frequency on postprandial variations in the production and absorption of volatile fatty acids in the digestive tract of the conscious pigs 显示文摘 | Rerat A Fiszlewicz M Giusi A | 1987 | Journal ofAnimal Science1987，64，： | 1 |
| 5 | Understanding individual mobility patterns from urban sensing data: A mobile phone trace example显示文摘 | Francesco Calabrese Mi Diao Giusy Di Lorenzo Joseph Ferreira Carlo Ratti | 2013 | Transportation Research Part C2013，，： | 1 |
| 6 | A sexually dimorphic distribution pattern of the novel estrogen receptor G-protein-coupled receptor 30 in some brain areas of the hamster显示文摘 | Canonaco M Giusi G Madeo A | 2008 | J Endocrinol2008，196，1： | 1 |
| 7 | Ovarian stripping versus cystectomy: recurrence of endometriosis and pregnancy rate显示文摘 | Massimo Moscarini Giusi Natalia Milazzo Chiara Assorgi Arianna Pacchiarotti Donatella Caserta | 2014 | Archives of Gynecology and Obstetrics2014，，1： | 1 |
| 8 | Inhibitory Effect of Aureobasidin A on Toxoplasma gondii显示文摘 | Sabrina Sonda Giusy $ala Riccardo Ghidoni | 2005 | Antimlcrobial Agents and Chemotherapy2005，49，5： | 1 |
| 9 | Simvastatin maintains function and viability of steatotic rat livers procured for transplantation显示文摘 | Jordi Gracia-Sancho Héctor García-Calderó Diana Hide Giusi Marrone Sergi Guixé-Muntet Carmen Peralta Juan Carlos García-Pagán Juan G. Abraldes Jaime Bosch | 2013 | Journal of Hepatology2013，，6： | 1 |
| 10 | Consumer perceptions of traceability: A cross-national comparison of the associated benefits显示文摘 | Wendy van Rijswijk Lynn J. Frewer Davide Menozzi Giusi Faioli | 2008 | Food Quality and Preference2008，，5： | 1 |
| 11 | Characterization,Fluxes and Toxicity of Leather Tanning Bath Chemicals in a Large Tanning District Area(IT)显示文摘 | Giusy Lofrano Egemen Aydin Francesca Russo | 2008 | Water Air Soil Pollut2008，8，： | 1 |
| 12 | Review on endocrine disrupting-emerging compounds in urban wastewater: occurrence and removal by photocatalysis and ultrasonic irradiation for wastewater reuse显示文摘 | Vincenzo Belgiorno Luigi Rizzo Despo Fatta Claudio Della Rocca Giusy Lofrano Anastasia Nikolaou Vincenzo Naddeo Sureyya Meric | 2007 | Desalination2007，，1： | 1 |
| 13 | Identification of an optimal concentration of platelet gel for promoting angiogenesis in human endothelial cells 显示文摘 | Giusi I Rughetti A D'Ascenzo S | 2009 | Transfusion2009，49，4： | 1 |
| 14 | Consumer perceptions of traceability: A cross-national comparison of the associated benefits显示文摘 | Wendy van Rijswijk Lynn J. Frewer Davide Menozzi Giusi Faioli | 2008 | Food Quality and Preference2008，，5： | 1 |
| 15 | IGF-1R/MDM2 relationship confers enhanced sensitivity to RITA in ewing sarcoma ceils 显示文摘 | Giusy Di Conza Marianna Buttarelli Olimpia Monti | 2012 | Mol Cancer Ther2012，11，6： | 1 |
| 16 | Infinitely many positive solutions for a SchrSdinger-Poisson system 显示文摘 | Pietro d'Avenia Alessio Pomponio Giusi Vaira | 2011 | Nonlinear Analysis2011，74，： | 1 |
| 17 | Light-and dark-dependent orexinergic neuronal signals pro-mote neurodegenerative phenomena accounting fordistinct behavioral responses in the teleost Thalassomapavo显示文摘 | FACCIOLO R M CRUDO M GIUSI G | 2009 | Journal of Neuroscience Research2009，87，3： | 1 |
| 18 | Current role of surgery for tuberous sclerosis complex-associated epilepsy显示文摘Tuberous sclerosis complex(TSC)is a rare multisystem,autosomal dominant neurocutaneous syndrome in which epilepsy is the most common of several neurological and psychiatric manifestations.Around two thirds of patients develop drug-resistant epilepsy for whom surgical resection of epileptogenic foci is indicated when seizures remain inadequately controlled following trial of two antiseizure medications.The challenge with presurgical and surgical approaches with patients with TSC is overcoming the complexity from the number of tubers and the multiplex epileptogenic network forming the epileptogenic zone.Data suggest that seizure freedom is achieved by 55%-60%of patients,but predictive factors for success have remained elusive,which makes for unconfident selection of surgical candidates.This article presents three different cases as illustrations of the potential challenges faced when assessing the suitability of TSC patients for epilepsy surgery. | Nicola Specchio Giusy Carfi Pavia Luca de Palma Alessandro De Benedictis Chiara Pepi Marta Conti Carlo Efisio Marras Federico Vigevano Paolo Curatolo | 2022 | Pediatric Investigation2022，6，1： | 1 |
| 19 | SJWD14080700000148显示文摘 | Emilio Bajetta Laura Catena Nicola Fazio Sara Pusceddu Pamela Biondani Giusi Blanco Sergio Ricci Michele Aieta Francesca Pucci Monica Valente Nadia Bianco Chiara Maria Mauri Francesca Spada | 2014 | Cancer2014，，16： | 1 |
| 20 | Muhiehannel Amplifier Topologies for High-Sensitivity and Reduced Measurement Time in Voltage Noise Measurements 显示文摘 | Scandurra G Giusi G Ciofi C | 2013 | IEEE Transactions on Instrumentationand Measurement2013，62，5： | 1 |
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