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| 1 | A randomized trial of iron depletion in patients with nonalcoholic fatty liver disease and hyperferritinemia显示文摘AIM:To compare iron depletion to lifestyle changes alone in patients with severe nonalcoholic fatty liver disease(NAFLD)and hyperferritinemia,a frequent feature associated with more severe liver damage,despite at least 6 mo of lifestyle changes.METHODS:Eligible subjects had to be 18-75 years old who underwent liver biopsy for ultrasonographically detected liver steatosis and hyperferritinemia,ferritin levels≥250 ng/mL,and NAFLD activity score>1.Iron depletion had to be achieved by removing 350 cc of blood every 10-15 d according to baseline hemoglobin values and venesection tolerance,until ferritin<30 ng/mL and/or transferrin saturation(TS)<25%.Thirty-eight patients were randomized 1:1 to phlebotomy(n=21)or lifestyle changes alone(n=17).The main outcome of the study was improvement in liver damage according to the NAFLD activity score at 2 years,secondary outcomes were improvements in liver enzymes[alanine aminotransferases(ALT),aspartate aminotransferase(AST),and gamma-glutamyl-transferases(GGT)].RESULTS:Phlebotomy was associated with normalization of iron parameters without adverse events.In the21 patients compliant to the study protocol,the rate of histological improvement was higher in iron depleted vs control subjects(8/12,67%vs 2/9,22%,P=0.039).There was a better improvement in steatosis grade in iron depleted vs control patients(P=0.02).In patients followed-up at two years(n=35),ALT,AST,and GGT levels were lower in iron-depleted than in control patients(P<0.05).The prevalence of subjects with improvement in histological damage or,in the absence of liver biopsy,ALT decrease≥20%(associated with histological improvement in biopsied patients)was higher in the phlebotomy than in the control arm(P=0.022).The effect of iron depletion on liver damage improvement as assessed by histology or ALT decrease≥20%was independent of baseline AST/ALT ratio and insulin resistance(P=0.0001).CONCLUSION:Iron depletion by phlebotomy is likely associated with a higher rate of improvement of histological liver damage than lifestyle changes alone in patients with NAFLD and hyperferritinemia,and with amelioration of liver enzymes. | Luca Valenti Anna Ludovica Fracanzani Paola Dongiovanni Serena Rovida Raffaela Rametta Erika Fatta Edoardo Alessandro Pulixi Marco Maggioni Silvia Fargion | 2014 | World Journal of Gastroenterology2014，20，11： | 8 |
| 2 | A genetic algorithm for the design of a fuzzy controller for active queue management 显示文摘 | Fatta D G Hoffmann F Re Lo G | 2003 | IEEE Trans on System Man and Cybernetic2003，33，3： | 2 |
| 3 | Occurrence patterns of pharmaceuticals in water and wastewater environments 显示文摘 | Nikolski A Meric S Fatta D | 2007 | Anal Bioanal Chem2007，387，4： | 1 |
| 4 | Adaptive routing in activenetworks显示文摘 | Di Fatta G Gaglio S Lo Re G | 2000 | IEEE Openarch2000，，3： | 1 |
| 5 | A study on the landfill leachate and its impact on the groundwater quality of greater area 显示文摘 | Fatta D Papadopoulos A Loizidou M | 1999 | Environmental Geochemistry & Health1999，20，： | 1 |
| 6 | Generation and Management of Construction and Demolition Waste in Greece-an Existing Challenge显示文摘 | Fatta D Papadopoulos A Avramikos E | 2003 | Resources Conservation and Recycling2003，40，1： | 1 |
| 7 | Active networks:An Evolution of the Internet显示文摘 | Di Fatta G Lo Re | 2001 | Proc of AICA2001-39th Annual Conference2001，，9： | 1 |
| 8 | Adaptive routing in active networks显示文摘 | Di Fatta G Gaglio S Lo Re G | 2000 | IEEE Openarch2000，，3： | 1 |
| 9 | comparison of closed reduction alone versus primary open repair of acute nasoseptal fractures 显示文摘 | ROBERT J FATTA D DUDE Y | 2008 | J Otolaryngol Head Neck Surg2008，37，： | 1 |
| 10 | Elevated expression of eIF4E in confined early breast cancer lesions :possible role of hypoxia显示文摘 | Fatta RJ Turbat-Herrera EA Li BD | 1999 | Int J Cancer1999，80，4： | 1 |
| 11 | Review on endocrine disrupting-emerging compounds in urban wastewater: occurrence and removal by photocatalysis and ultrasonic irradiation for wastewater reuse显示文摘 | Vincenzo Belgiorno Luigi Rizzo Despo Fatta Claudio Della Rocca Giusy Lofrano Anastasia Nikolaou Vincenzo Naddeo Sureyya Meric | 2007 | Desalination2007，，1： | 1 |
| 12 | Analytical methods for tracing pharmaceutical residues in water and wastewater显示文摘 | D Fatta A Nikolaou A Achilleos | 2007 | Trends in Analytical Chemistry2007，26，6： | 1 |
| 13 | Simulated annealing technique for fast learning of SOM networks 显示文摘 | FIANNACA A DI FATTA G RIZZO R | 2013 | Neural Computing and Applications2013，22，5： | 1 |
| 14 | Demonstration plasma gasification/vitrification system for effective hazardous waste treatment 显示文摘 | MOUSTAKAS K FATTA D MALAMIS S | 2005 | Journal of Hazardous Materials2005，123，13： | 1 |
| 15 | Occurrence patterns of phar-maceuticals in water and wastewater environments显示文摘 | Nikolaou A Meric S Fatta D | 2007 | Anal Bioanal Chem2007，387，4： | 1 |
| 16 | Occurrence patterns of pharmaceuticals in water and wastewater environments显示文摘 | Nikolaou A Meric S Fatta D | 2007 | Analytical and bioanalytical chemistry2007，387，4： | 1 |
| 17 | Production and characterization of new triploid seedless progenies for mandarin improvement显示文摘 | S. Fatta Del Bosco M. Siragusa L. Abbate S. Lucretti N. Tusa | 2007 | Scientia Horticulturae2007，，4： | 1 |
| 18 | Occurrence patterns of pharmaceuticals in water and wastewater environments显示文摘 | Anastasia Nikolaou Sureyya Meric Despo Fatta | 2007 | Analytical and Bioanalytical Chemistry2007，，4： | 1 |
| 19 | Occurrence patterns of pharmaceuticals in water and wastewater environments显示文摘 | Anastasia Nikolaou Sureyya Meric Despo Fatta | 2007 | Analytical and Bioanalytical Chemistry2007，，4： | 1 |
| 20 | Pesticides, volatile and sernivolatile organic compounds in the inland surface waters of Cyprus显示文摘 | Fatta D Michael C Canna-michaehdou S | 2007 | Desalination2007，215，13： | 1 |
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