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| 1 | JAMA子刊:健康生活方式真的可以预防癌症吗?显示文摘根据2016年5月19日发表在国际学术期刊《JAMA Oncology》上的一项最新研究,如果能够遵循良好的生活习惯,包括戒烟,避免酗酒,将BMI维持在正常的18.5到27.5之间,并能够每周适度运动至少150分钟或剧烈运动至少75分钟,美国患癌或死于癌症的白种人中很大一部分人或可避免癌症或癌症死亡的发生。在这项研究中,研究人员对两项针对白种人的研究数据进行了分析, | Song M Giovannucci E | 2016 | 疾病监测2016，31，5： | 12 |
| 2 | Higher Predicted Vitamin D Status Is Associated With Reduced Risk of Crohn’s Disease显示文摘 | Ashwin N. Ananthakrishnan Hamed Khalili Leslie M. Higuchi Ying Bao Joshua R. Korzenik Edward L. Giovannucci James M. Richter Charles S. Fuchs Andrew T. Chan | 2012 | Gastroenterology2012，，3： | 6 |
| 3 | Markers of systemic inflammation and colorectal adenoma risk: Meta-analysis of observational studies显示文摘AIM To perform a meta-analysis of observational studies on inflammatory markers levels and occurrence of colorectal adenoma.METHODS Pub Med and EMBASE databases were searched until March 2016 for the articles reporting on the circulating levels of inflammatory markers, including: C-reactive protein(CRP), interleukin-6(IL-6), and tumor necrosis factor-alpha(TNF-a) and risk of colorectal adenoma. Random-effects models were used to calculate summary odds ratios(ORs) with 95%CIs for the highest vs lowest category of exposure. Heterogeneity was assessed by using the Q test and I2 statistic. Subgroup analyses were also performed to test for potential source of heterogeneity.RESULTS A total of 14 case-control studies were included. Ten studies on CRP including a total of 3350 cases and 4168 controls showed non-significant summary(OR = 1.23, 95%CI: 0.98-1.54; I2 = 54%, P heterogeneity = 0.01) in the general analysis, but significant increased odds when considering only advanced adenoma(OR = 1.59, 95%CI: 1.09-2.32; I2 = 44%, P heterogeneity = 0.15). Subgroup and stratified analyses revealed a potential influence of smoking status and aspirin use on the association between CRP levels and colorectal adenoma. Five studies examined the association between circulating levels of TNF-a and colorectal adenoma risk, including a total of 1,568 cases and 2,832 controls. The summary OR for the highest vs the lowest category of exposure was 1.00(95%CI: 0.77-1.29). The relationship between circulating IL-6 levels and colorectal adenoma risk was investigated in 7 studies including a total of 1936 cases and 3611 controls. The summary OR for the highest vs the lowest category of exposure was 1.19(95%CI: 0.92-1.55).CONCLUSION Summary of current evidence suggests a positive association of CRP levels and advanced colorectal adenoma risk. The role of potential confounding factors should be further evaluated. | Justyna Godos Antonio Biondi Fabio Galvano Francesco Basile Salvatore Sciacca Edward L Giovannucci Giuseppe Grosso | 2017 | World Journal of Gastroenterology2017，23，10： | 5 |
| 4 | A Prospective Cohort Study Shows Unique Epigenetic, Genetic, and Prognostic Features of Synchronous Colorectal Cancers显示文摘 | Katsuhiko Nosho Shoko Kure Natsumi Irahara Kaori Shima Yoshifumi Baba Donna Spiegelman Jeffrey A. Meyerhardt Edward L. Giovannucci Charles S. Fuchs Shuji Ogino | 2009 | Gastroenterology2009，，5： | 4 |
| 5 | Folate Intake, MTHFR Polymorphisms, and Risk of Esophageal, Gastric, and Pancreatic Cancer: A Meta-analysis显示文摘 | Susanna C. Larsson Edward Giovannucci Alicja Wolk | 2006 | Gastroenterology2006，，4： | 3 |
| 6 | Primary Prevention of Colorectal Cancer显示文摘 | Andrew T. Chan Edward L. Giovannucci | 2010 | Gastroenterology2010，，6： | 3 |
| 7 | Use of Aspirin or Nonsteroidal Anti-inflammatory Drugs Increases Risk for Diverticulitis and Diverticular Bleeding显示文摘 | Lisa L. Strate Yan L. Liu Edward S. Huang Edward L. Giovannucci Andrew T. Chan | 2011 | Gastroenterology2011，，5： | 3 |
| 8 | 生活方式和饮食因素:预防致死性前列腺癌显示文摘预防致死性前列腺癌是一个重要的公共卫生难题。解决该难题可以改善人们的健康状况,减少罹患该疾病的痛苦。本综述围绕某些与致命性前列腺癌预防有关的生活方式和饮食因素研究进行讨论。我们还对以下行为风险因素的研究进行总结:肥胖和体重变化、体育活动、吸烟状况、抗氧化剂摄入量、维生素D和钙、以及咖啡摄入量。 | Kathryn M Wilson Edward L Giovannucci Lorelei A Mucci | 2012 | Asian Journal of Andrology2012，14，3： | 3 |
| 9 | Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men显示文摘 | Giovannucci E Rimm EB Ascherio A | 1995 | J Natl Cancer Inst1995，87，： | 2 |
| 10 | Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men显示文摘 | Giovannucci E Rimm EB Ascherio A | 1995 | J Natl Cancer Inst1995，87，： | 2 |
| 11 | The Role of Obesity and Related Metabolic Disturbances in Cancers of the Colon, Prostate, and Pancreas显示文摘 | Edward Giovannucci Dominique Michaud | 2007 | Gastroenterology2007，，6： | 2 |
| 12 | Vitamin B6 and colorectal cancer:Current evidence and future directions显示文摘Colorectal cancer remains the third most common cancer in both women and men worldwide.Identifying modifiable dietary factors is crucial in developing primary prevention strategies.Vitamin B6 is involved in more than 100 coenzyme reactions,and may influence colorectal cancer risk in multiple ways including through its role in one-carbon metabolism related DNA synthesis and methylation and by reducing inflammation,cell proliferation,and oxidative stress.Observational studies of dietary or dietary plus supplementary intake of vitamin B6 and colorectal cancer risk have been inconsistent with most studies reporting nonsignificant positive or inverse associations.However,published studies of plasma pyridoxal 5'-phosphate(the active form of vitamin B6) levels consistently support an approximately 30%-50% reduction in risk of colorectal cancer comparing high with low concentrations.The reasons for the discrepancy in the results between dietary-based and plasma-based studies remain unresolved.Other unresolved questions include the effects of vitamin B6 intake in early life(i.e.,childhood or adolescence) and of suboptimal vitamin B6 status on colorectal cancer risk,whether the associations with vitamin B6 differ across molecular subtypes of colorectal cancer,and whether the vitamin B6-colorectal cancer association is modified by genetic variants of one-carbon metabolism. | Xue-Hong Zhang Jing Ma Stephanie A Smith-Warner Jung Eun Lee Edward Giovannucci | 2013 | World Journal of Gastroenterology2013，19，7： | 2 |
| 13 | Vitamin D and prevention of colorectal cancer显示文摘 | Edward D. Gorham Cedric F. Garland Frank C. Garland William B. Grant Sharif B. Mohr Martin Lipkin Harold L. Newmark Edward Giovannucci Melissa Wei Michael F. Holick | 2005 | Journal of Steroid Biochemistry and Molecular Biology2005，，1： | 2 |
| 14 | Dietary fiber and distal colorectal adenoma in men 显示文摘 | Platz EA Giovannucci E Rimm EB | 1997 | Cancer Epidemiol Biomarkers Prey1997，6，9： | 1 |
| 15 | Folate intake, MTHFR polymorphisms,and risk of esophageal,gastric, and pancreatic cancer:a meta-analysis显示文摘 | Larsson SC Giovannucci E Wolk A | 2006 | Gastroenterology2006，131，4： | 1 |
| 16 | A prospective study of plasma C-peptide and colorectal cancer risk in men显示文摘 | Ma J Giovannucci E Pollak M | 2004 | J Natl Cancer Inst2004，96，7： | 1 |
| 17 | Diabetes and colorectal cancer incidence in the cohort of Swedish men显示文摘 | Larsson SC Giovannucci E Wolk A | 2005 | Diabetes Care2005，28，7： | 1 |
| 18 | The epidemiology of vitaminDand cancer incidence and mortality:A review (United States)显示文摘 | Edward Giovannucci | 2005 | Cancer Causes and Control2005，16，： | 1 |
| 19 | A prospective study of plasma selenium levels and prostate cancer risk显示文摘 | Li H Stampfer MJ Giovannucci EL | 2004 | J Natl Cancer Inst2004，96，： | 1 |
| 20 | Association of type and duration of diabetes with erectile dysfunction in a large cohort of men显示文摘 | ON CG HU FB GIOVANNUCCI E et 01 | 2002 | Diabetes Care2002，25，8： | 1 |
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