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| 1 | Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype显示文摘AIM To identify whether Cp G island methylator phenotype(CIMP) is predictive of response to neoadjuvant chemoradiotherapy(NACRT) and outcomes in rectal cancer.METHODS Patients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status(high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined uponhistological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed.RESULTS There were 160 patients analysed with a median followup time of 46.4 mo. Twenty-one(13%) patients demonstrated high levels of CIMP methylation(CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion(EMVI) compared with CIMP-L [8/21(38%) vs 15/99(15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival(P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation(P = 0.01). There were 14(9%) patients with a pathological complete response(pC R) compared to 116(73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pC R had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant(P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced 'T' stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurrence.CONCLUSION We report a novel association of pre-treatment characterisation of CIMP-H with EMVI status which has prognostic implications and is not readily detectable on pre-treatment histological examination. | Jeremy Stuart Williamson Huw Geraint Jones Namor Williams Anthony Paul Griffiths Gareth Jenkins John Beynon Dean Anthony Harris | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 4 |
| 2 | 高等教育定价:2004年英格兰高等教育法案对大学的政策意义显示文摘2004年英格兰高等教育法案确定了不同学校、不同学科可以收取不同学费的差异收费原则。文章根据这一政策,运用博弈论的方法,提出了一个高等教育定价模型。在对模型解释的基础上,从一般意义上探讨了高等教育法案对于大学的政策意义。 | Geraint Johnes 杜育红 周雪飞 | 2005 | 教育与经济2005，21，2： | 3 |
| 3 | Measuring the Research Performance of UK Economics Departments:An Application of Data Envelopment Analysis显示文摘 | Geraint Johnes and Jill Johnes | 1993 | Oxford Economic Paper1993，45，： | 1 |
| 4 | Stochastic Frontier Estimation of a CES Cost Function:The Case of Higher Education in Britain 显示文摘 | IZADI HOOSHANG JOHNES GERAINT OSKRO CHI REZA | 2002 | Economics of Education Review2002，21，1： | 1 |
| 5 | Apples and oranges: The aggregation problem in publications analysis显示文摘 | Geraint Johnes Jill Johnes | 1992 | Scientometrics1992，，2： | 1 |
| 6 | Measuring the Research Performance of UK Economics Departments: an Application of Data Envelop- ment Analysis 显示文摘 | Geraint Johnes Jill Johnes | 1993 | Oxford Economics Papers1993，45，： | 1 |
| 7 | House prices and regional labor markets显示文摘 | Geraint Johnes Thomas Hyclak | 1999 | The Annals of Regional Science1999，33，1： | 1 |
| 8 | Market forces schools to improve 显示文摘 | Bradley Steve Johnes Geraint Millington Jim | 1999 | The Times Educational Supplement London1999，，6： | 1 |
| 9 | A Randomized Trial of Nicotine Enemas for Active Ulcerative Colitis显示文摘 | John R. Ingram Gareth A.O. Thomas John Rhodes John T. Green Neil D. Hawkes Jill L. Swift Emmanuel D. Srivastava Brian K. Evans Geraint T. Williams Robert G. Newcombe Edward Courtney Suresh Pillai | 2005 | Clinical Gastroenterology and Hepatology2005，，11： | 1 |
| 10 | Research funding and performance in U.K. University Departments of Economics: A frontier analysis显示文摘 | Jill Johnes Geraint Johnes | 1995 | Economics of Education Review1995，，3： | 1 |
| 11 | Stochastic frontier estimation of a CES cost function: the case of higher education in Britain显示文摘 | Hooshang Izadi Geraint Johnes Reza Oskrochi Robert Crouchley | 2001 | Economics of Education Review2001，，1： | 1 |
| 12 | Erosion response to anthropogenic activity and climatic changes during the Holocene: case studies in northwestern China and southern Norway显示文摘Soil erosion assessment and prediction play critical roles in addressing problems associated with erosion control or soil conservation. The past dynamics of soil erosion can provide valuable information for us to understand the relations of soil erosion to environmental change and anthropogenic activity. The present paper has compared Holocene climatic changes in northwestern China with those in southern Norway, and investigated the past dynamics of erosion activity during the Holocene. Modern soil erosion on the Loess Plateau is a combination of the intensive natural erosion and human-induced erosion, the latter being four times greater than the former. Because of global warming and increasing human activities, climate on the Loess Plateau is becoming dryer and more unstable, causing an enhanced erosion problem and water scarcity. In the arctic-alpine region of southern Norway, however, the global warming and regional wetting caused expansion of the largest European ice cap. This has accentuated the erosion in that region, with a higher frequency of avalanches and debris flows. | HE Xiubin1,2, TANG Keli1, John A Matthews3, Geraint Owen3(1. Institute of Soil and Water Conservation, CAS, Yangling 712100, China 2. Northwest SCI-Tech University of Agriculture and Forestry, Yangling 712100, China 3. Department of Geography, Univer | 2002 | Journal of Geographical Sciences2002，12，4： | 0 |
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