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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients显示文摘AIM: To assess pre-orthotopic liver transplantation (OLT) factors that could be evaluated pre-operatively or con- trolled post-operatively associated with hepatocellular carcinoma (HCC) recurrence and disease-free survival after liver transplantation (LT).METHODS: Four hundred and twelve patients trans- planted for HCC between 1988 and 1998 in 14 French centers, who survived the postoperative period were studied. Kaplan Meier estimates were calculated for 24 variables potentially associated with recurrence of HCC. Uni- and multivariate analyses were conducted to iden- tify independent predictors of recurrence. RESULTS: Overall 5-year disease-free survival was 57.1%. By univariate analysis, variables associated with disease-free survival were: presence of cirrhosis (P = 0.001), etiology of liver disease (P = 0.03), α fetoprotein level (< 200, 200 to 2000, or > 2000; P < 0.0001), γ-GT activity (N, N to 2N or > 2N; P = 0.02), the number of nodules (1, 2-3 or ≥ 4; P = 0.02), maximal diameter of the largest nodule (< 3 cm, 3 to 5 cm or > 5 cm; P < 0.0001), the sum of the diameter of the nodules (< 3 cm, 3 to 5 cm, 5 to 10 cm or >10 cm; P < 0.0001), bi- lobar location (P = 0.01), preoperative portal thrombosis (P < 0.0001), peri-operative treatment of the tumor (P = 0.002) and chemoembolization (P = 0.03), tumor differentiation (P = 0.01), initial type of calcineurin inhibitor (P = 0.003), the use of antilymphocyte antibodies (P = 0.02), rejection episodes (P = 0.003) and period of LT (P < 0.0001). By multivariate analysis, 6 variables were independently associated with HCC recurrence: maximal diameter of the largest nodule (P < 0.0001), time of LT (P < 0.0001), tumor differentiation (P < 0.0001), use of anti-lymphocyte antibody (ATG) or anti-CD3 antibody (OKT3) (P = 0.005), preoperative portal thrombosis (P = 0.06) and the number of nodules (P = 0.06). CONCLUSION: This study identif ies immunosuppression, through the use of ATG or OKT3, as a predictive factor of tumor recurrence, and confi rms the prognostic value of tumor differentiation. | Thomas Decaens Franoise Roudot-Thoraval Solange Bresson-Hadni Carole Meyer Jean Gugenheim Francois Durand Pierre-Henri Bernard Olivier Boillot Philippe Compagnon Yvon Calmus Jean Hardwigsen Christian Ducerf Georges Philippe Pageaux Sébastien Dharancy Olivier Chazouillères Daniel Cherqui Christophe Duvoux | 2006 | World Journal of Gastroenterology2006，12，45： | 10 |
| 3 | 垃圾气化分析及其对中国实现碳中和与无废城市建设的贡献显示文摘气化是实现化学利用碳资源(尤其是煤)生产化学品和燃料的关键工艺。目前,全球拥有超过272套气化装置,主要应用于煤化工,尤其在中国。由于在一个化工厂通过技术集成达到工业规模的集中生产可实现减少二氧化碳排放并促进碳密集型行业的循环经济,如废物管理、化学和交通行业,因此,近年来全球对垃圾气化的兴趣日益浓厚,尤其是那些在煤气化技术方面积累了丰富的人力资本和运营经验以及拥有完整Coal-to-X产品价值链的国家,如中国,在挖掘通过垃圾气化实现Waste-to-X的潜力方面处于独特的地位。具体而言,废弃物可用于补充煤气化生产如下产品:(1)具有较低或零碳足迹的化学品,具体取决于废物是来源于化石资源还是生物资源。(2)来自生物废弃物的零碳足迹的绿色“氢”,以补充或替代来自煤气化或蒸汽重整得到的“灰色”氢,以供给氢能汽车,并推动工业脱碳。(3)来自生物废弃物的CO_(2)中性合成液体燃料,用于交通工具,以补充或替代石油燃料和合成煤制液体燃料。然而,迄今为止,利用垃圾作为气化原料的操作经验有限,并且文献中也很少涉及以前和当前的工业垃圾气化经验。为了填补这些空白,本研究介绍了1980年代至2000年代德国的两项开创性技术发展—贝伦拉特(Berrenrath)和SVZ黑水泵(即Sekundärrohstoff-Verwertungszentrum:黑水泵二次原料回收中心),并分享了以下三种垃圾与煤共气化技术(即Waste&Coal-to-X)的相关认识和经验教训:固定床气化:鲁奇干法排渣技术以及BGL熔渣气化技术。流化床气化:高温温克勒(HTW-High Temperature Winkler)气化工艺。气流床气化:GSP(Gaskombinat Schwarze Pumpe),即西门子气化工艺。此外,本研究也总结了目前全球100%垃圾气化技术的发展,即Waste-to-X。在气化技术的三种类型中,研发领域和工业界均对流化床与气流床(作为后期气化)技术的结合产生了浓厚的兴趣,这里介绍三个相关技术的重大发展—Ebara-Ube、Enerkem和ThermoChem Recovery International的技术。除此之外,固定床气化工艺的发展也得到了关注,本文介绍了两个相关技术的重大发展—InEnTec(将固定床与等离子气化相结合)和Sierra Energy(改造传统高炉转炉进行垃圾气化)的技术。借鉴以往和当前的国际发展经验,凭借其庞大的气化规模和丰富的专业知识,逐步将垃圾作为原料融入到煤气化中可以作为中国迈向循环经济和无废城市的第一步。将垃圾与煤共气化技术作为通向垃圾气化的桥梁,不仅可以使中国利用现有的人力资本和基础设施,还可以创造新的就业和商业机会,并支持中国实现可持续的垃圾管理策略,即在进行焚烧和填埋之前先进行减量、再利用和再循环。然而,将煤气化技术直接用于垃圾气化具有挑战性并且充满了较大的风险。本研究分享了贝伦拉特和SVZ黑水泵在垃圾与煤共气化方面遇到的各种运行问题以及从中得到的最新认识。然后介绍了这些积累的经验及认识是如何被考虑并应用到德国弗莱贝格工业大学的能源化工所开发的Flexi技术当中,包括:基于BGL熔渣气化技术开发FlexiSlag固定床气化技术。基于GSP气化技术开发FlexiEntrained气流床气化技术。基于HTW气化技术开发FlexiCOORVED气化技术。目前,Flexi技术在德国弗莱贝格开展中试规模运行,其目标是实现:(1)多元原料气化(例如生物质、煤、石油焦、不同类型的废物);(2)100%垃圾气化;(3)灵活的目标产品(即调整配置得到最大化的合成气产出,其中可含有最大化或最小化的甲烷、焦油和油的含量)以支持全球向碳中和和无废城市转型。鉴于全球(包括中国)实现无废城市和碳中和的目标,垃圾气化技术的长远发展不仅要向100%垃圾气化发展,还必须满足以下可持续性标准才能做出实质性的贡献:(1)多元进料,能够灵活利用多种类型的(废物)原料。(2)碳回收率最大化,以确保垃圾中的碳转移到产品中,而不是在整个过程链中以CO_(2)的形式排放到环境中。(3)通过生产玻璃渣、从渣中回收金属和零废水排放,将环境影响降至最低。本研究最后根据上述三个可持续性标准对三种气化类型进行了定性的整体评价,阐述了它们在垃圾气化应用中的优势和劣势。 | LEE Roh Pin SEIDL Ludwig Georg HUANG Qiu-liang MEYER Bernd | 2021 | 燃料化学学报2021，49，8： | 10 |
| 4 | Diffusion-limited interfacial electron transfer with large apparent driving forces显示文摘 | GEORG M MEYER G J | 1999 | J Phys Chem B1999，103，36： | 1 |
| 5 | Intensified fuzzy clusters for classifying plant, soil, and residue regions of interest from color images 显示文摘 | George E Meyer Joan Camargo Nero David D Jones | 2004 | Computers and electronics in agriculture2004，42，3： | 1 |
| 6 | Intensified fuzzy clusters for classifying plant, soil, and residue regions of interest from color images 显示文摘 | George E Meyer Joao Camargo Neto David D Jones | 2004 | Computers and Electronics in Agriculture2004，42，3： | 1 |
| 7 | New Chlamydia trachomatis L2 Strains Identified in a Recent Out- break of Lymphogranuloma Venereum in Vienna显示文摘 | Georg Stary Thomas Meyer Christine Bangert | 2008 | Sexually Transmitted Diseases2008，35，4： | 1 |
| 8 | Postconditioning with a CpG containing Oligodeoxynucleotide ameliorates myocardial infarction in a murine closed-chest model显示文摘 | Se-Chan Kim Shuijing Wu Xiangming Fang Jens Neumann Lars Eichhorn Grigorij Schleifer Olaf Boehm Rainer Meyer Stilla Frede Andreas Hoeft Georg Baumgarten Pascal Knuefermann | 2014 | Life Sciences2014，，： | 1 |
| 9 | Sustained virologic response rates with telaprevir by response after 4<ce:hsp sp='0.25'/>weeks of lead-in therapy in patients with prior treatment failure显示文摘 | Graham R. Foster Stefan Zeuzem Pietro Andreone Stanislas Pol Eric J. Lawitz Moises Diago Stuart Roberts Paul J. Pockros Zobair Younossi Isabelle Lonjon-Domanec Sandra De Meyer Don Luo Shelley George Maria Beumont Gaston Picchio | 2012 | Journal of Hepatology2012，，： | 1 |
| 10 | Lack of gelsolin promotes perpetuation of atrial fibrillation in the mouse heart显示文摘 | Jan Wilko Schrickel Klaus Fink Rainer Meyer Christian Grohé Florian Stoeckigt Klaus Tiemann Alexander Ghanem Lars Lickfett Georg Nickenig Thorsten Lewalter | 2009 | Journal of Interventional Cardiac Electrophysiology2009，，1： | 1 |
| 11 | Verification of color vegetation in- dices for automated imaging applications显示文摘 | George E Meyer Joao Camargo Neto | 2008 | Computers and Electron- ics in Agricuhure2008，63，1： | 1 |
| 12 | A crop water stress index for tall fescue irrigation decision-making-a fuzzy logic method显示文摘 | Abdulelah Al-Faraj George E Meyer Garald L Horst | 2001 | Computers and Electronics in Agriculture2001，，32： | 1 |
| 13 | Verification of color vegetation indices fo automated crop image applicati0n显示文摘 | Meyer George E Neto Joao Camargo | 2008 | Computers and Electronics in Agriculture2008，，63： | 1 |
| 14 | Combined Heterozygous Deficiency of the Classical Complement Pathway Proteins C2 and C4显示文摘 | Dominique Hartmann Veronique Fremeaux-Bacchi Laurence Weiss Alice Meyer Jacques Blouin Georges Hauptmann Michel Kazatchkine Beatrice Uring-Lambert | 1997 | Journal of Clinical Immunology1997，，： | 1 |
| 15 | Global Transformations of Nonlinear Systems显示文摘 | Hunt L R Renjeng Su George Meyer | 1983 | IEEE Transactions on Automatic Control1983，28，1： | 1 |
| 16 | Laser activation of endodontic irrigants with improved conical laser fiber tips for removing smear layer in the apical third of the root canal显示文摘 | George R Meyers IA Walsh LJ | 2008 | J Endod2008，34，12： | 1 |
| 17 | Iron metabolism in Pseudomonas: salicylic acid, a siderophore of Pseudomonasfluorescens CHAO显示文摘 | Meyer J M Azelvandre P Georges C | 1992 | BioFactors (Oxford England)1992，4，1： | 1 |
| 18 | In vivo antitumor activity of NVP-AEW541—A novel, potent, and selective inhibitor of the IGF-IR kinase显示文摘 | Carlos Garc??a-Echeverr??a Mark A Pearson Andreas Marti Thomas Meyer Juergen Mestan Johann Zimmermann Jiaping Gao Josef Brueggen Hans-Georg Capraro Robert Cozens Dean B Evans Doriano Fabbro Pascal Furet Diana Graus Porta Janis Liebetanz Georg Martiny-Baro | 2004 | Cancer Cell2004，，3： | 1 |
| 19 | Clinical and pharmacokinetic study of TNP-470, an angiogenesis inhibitor, in combination with paclitaxel and carboplatin in patients with solid tumors显示文摘 | Hai T. Tran George R. Blumenschein Charles Lu Christina A. Meyers Vali Papadimitrakopoulou Frank V. Fossella Ralph Zinner Timothy Madden Lori G. Smythe Vinay K. Puduvalli Reggie Munden Mylene Truong Roy S. Herbst | 2004 | Cancer Chemotherapy and Pharmacology2004，，4： | 1 |
| 20 | Lateralization in autononic dysfunction in ischemic stroke involving the insular cortex显示文摘 | S. Meyer M. Strittmatter C. Fischer T. Georg B. Schmitz | 2004 | NeuroReport2004，，2： | 1 |
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