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| 1 | Profound neutralization evasion and augmented host cell entry are hallmarks of the fast-spreading SARS-CoV-2 lineage XBB.1.5显示文摘Since late 2022, the share of infections caused by the SARS-CoV2 lineage XBB.1.5 has gradually increased in the United States,resulting in XBB.1.5 becoming the dominating SARS-CoV-2lineage in the United States and a similar trend is likely to soontake place also in European countries. However, information onthe virological properties of XBB.1.5 is scarce. Here, weconducted an initial virological assessment of the SARS-CoV-2XBB.1.5 lineage. | Markus Hoffmann Prerna Arora Inga Nehlmeier Amy Kempf Anne Cossmann Sebastian R.Schulz Gema Morillas Ramos Luis A.Manthey Hans-Martin Jäck Georg M.N.Behrens Stefan Pöhlmann | 2023 | Cellular & Molecular Immunology2023，20，4： | 2 |
| 2 | Delta variant(B.1.617.2)sublineages do not show increased neutralization resistance显示文摘The emergence of SARS-CoV-2 variants threatens efforts to control the COVID-19 pandemic.At present,the global spread of the Delta(B.1.617.2)variant is responsible for a rapid increase in COVID-19 cases and hospitalizations in many countries.The variant evades neutralizing antibodies and is believed to be more transmissible and pathogenic[1,2,3,4]. | Prerna Arora Amy Kempf Inga Nehlmeier Luise Graichen Anzhalika Sidarovich Martin S.Winkler Sebastian Schulz Hans-Martin Jäck Metodi V.Stankov Georg M.N.Behrens Stefan Pöhlmann Markus Hoffmann | 2021 | Cellular & Molecular Immunology2021，18，11： | 1 |
| 3 | Efficient antibody evasion but reduced ACE2 binding by the emerging SARS-CoV-2 variant B.1.640.2显示文摘The SARS-CoV-2 spike(S)protein engages ACE2 for cell entry,and the S protein/ACE2 interface is an important target for neutralizing antibodies.In the course of the COVID-19 pandemic,SARS-CoV-2 variants have emerged that harbor mutations in the S protein,which confer neutralization resistance and allow viral spread in immunologically nonnaive populations.The most prominent example is the highly mutated Omicron variant,which infects convalescent or vaccinated individuals with unprecedented efficiency[1,2]. | Prerna Arora Amy Kempf Inga Nehlmeier Luise Graichen Sebastian Schulz Anne Cossmann Alexandra Dopfer-Jablonka Martin S.Winkler Hans-Martin Jäck Georg M.N.Behrens Stefan Pöhlmann Markus Hoffmann | 2022 | Cellular & Molecular Immunology2022，19，9： | 0 |
| 4 | The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency显示文摘The COVID-19 pandemic,caused by SARS-CoV-2,continues to rage in many countries,straining health systems and economies.Vaccines protect against severe disease and death and are considered central to ending the pandemic.COVID-19 vaccines(and SARS-CoV-2 infection)elicit antibodies that are directed against the viral spike(S)protein and neutralize the virus.However,the emergence of SARS-CoV-2 variants with S protein mutations that confer resistance to neutralization might compromise vaccine efficacy[1]. | Prerna Arora Cheila Rocha Amy Kempf Inga Nehlmeier Luise Graichen Martin S.Winkler Martin Lier Sebastian Schulz Hans-Martin Jäck Anne Cossmann Metodi V.Stankov Georg M.N.Behrens Stefan Pöhlmann Markus Hoffmann | 2021 | Cellular & Molecular Immunology2021，18，12： | 0 |
| 5 | No evidence for increased cell entry or antibody evasion by Delta sublineage AY.4.2显示文摘Since the beginning of the COVID-19 pandemic,multiple SARS-CoV-2 variants have emerged.While some variants spread only locally,others,referred to as variants of concern,disseminated globally and became drivers of the pandemic.All SARS-CoV-2 variants harbor mutations relative to the virus circulating early in the pandemic,and mutations in the viral spike(S)protein are considered of particular relevance since the S protein mediates host cell entry and constitutes the key target of the neutralizing antibody response.As a consequence,mutations in the S protein may increase SARS-CoV-2 infectivity and enable its evasion of neutralizing antibodies.Furthermore,mutations in the S protein can modulate viral transmissibility and pathogenicity. | Prerna Arora Amy Kempf Inga Nehlmeier Luise Graichen Martin S.Winkler Martin Lier Sebastian Schulz Hans-Martin Jäck Stefan Pöhlmann Markus Hoffmann | 2022 | Cellular & Molecular Immunology2022，19，3： | 0 |
| 6 | Host cell entry and neutralisation sensitivity of the SARS-CoV-2 XBB.1.16 lineage显示文摘Despite previous circulation of the highly transmissible and antibody evasive BA.2.75, BQ.1, XBB.1 and XBB.1.5 lineages, the share of infections caused by the SARS-CoV-2 lineage XBB.1.16 has gradually increased in India in early 2023, resulting in XBB.1.16 being the dominating SARS-CoV-2 lineage in India today. Since a similar trend may also take place in other countries and information on the biological properties of the XBB.1.16 lineage is scarce, we conducted a rapid assessment of the SARS-CoV-2 XBB.1.16 lineage with respect to its ability to enter cells and evade neutralisation by antibodies. | Inga Nehlmeier Amy Kempf Prerna Arora Anne Cossmann Alexandra Dopfer-Jablonka Metodi V.Stankov Sebastian R.Schulz Hans-Martin Jäck Georg M.N.Behrens Stefan Pöhlmann Markus Hoffmann | 2023 | Cellular & Molecular Immunology2023，20，8： | 0 |
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