|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evalua tion of Tube Formability and Material Characteris- tics:Hydraulic Bulge Testing of Tubes显示文摘 | Sokolowski T Geke K Ahmetoglu M | 2000 | Journal of Materials Processing Technology2000，98，1： | 1 |
| 2 | Increased risk of thromboembolism in esophageal cancer patients treated with neoadjuvant chemoradiotherapy显示文摘 | Dirk J. Bosch Quirine A. Van Dalfsen Véronique E.M. Mul Geke A.P. Hospers John Th.M. Plukker | 2013 | The American Journal of Surgery2013，，： | 1 |
| 3 | The clinical spectrum of Blake’s pouch cyst: report of six illustrative cases显示文摘 | Erwin M. J. Cornips Geke M. Overvliet Jacobiene W. Weber Alida A. Postma Christianne M. Hoeberigs Marcella M. L. L. Baldewijns Johannes S. H. Vles | 2010 | Child’s Nervous System2010，，8： | 1 |
| 4 | The effect of ceftriaxone on the anaerobic bacterial flora and the bacterial enzymatic activity in the intestinal tract显示文摘 | G. W. Welling Ph. D. Geke J. Meijer-Severs M. S. Gé Helmus Edith Santen R. H. J. Tonk Hilly G. Vries- Hospers M. D. Ph. D. D. Waaij M. D. Ph. D | 1991 | Infection1991，，5： | 1 |
| 5 | Preoperative chemoradiotherapy in locally advanced gastric cancer, a phase I/II feasibility and efficacy study显示文摘 | Anouk K. Trip Boelo J. Poppema Mark I. van Berge Henegouwen Ester Siemerink Jannet C. Beukema Marcel Verheij John T.M. Plukker Dick J. Richel Maarten C.C.M. Hulshof Johanna W. van Sandick Annemieke Cats Edwin P.M. Jansen Geke A.P. Hospers | 2014 | Radiotherapy and Oncology2014，，： | 1 |
| 6 | A dahlia flower extract has antidiabetic properties by improving insulin function in the brain显示文摘Butein,a rare chalcone found in the toxic plant Toxicodendron vernicifluum,has been shown to regulate glucose homeostasis via inhibition of the nuclear factor kappa-B kinase subunit beta(IKKβ)/nuclear factor kappa B(NF-κB)pathway in the brain.Here,we investigated whether the nonpoisonous plant Dahlia pinnata could be a source of butein as a potential treatment for type 2 diabetes(T2D).In mice fed a high-fat diet(HFD)to induce glucose intolerance,an oral D.pinnata petal extract improved glucose tolerance at doses of 3.3 mg/kg body weight and 10 mg/kg body weight.Surprisingly,this effect was not mediated by butein alone but by butein combined with the closely related flavonoids,sulfuretin and/or isoliquiritigenin.Mechanistically,the extract improved systemic insulin tolerance.Inhibition of phosphatidylinositol 3-kinase to block insulin signaling in the brain abrogated the glucoregulatory effect of the orally administered extract.The extract reinstated central insulin signaling and normalized astrogliosis in the hypothalamus of HFD-fed mice.Using NF-κB reporter zebrafish to determine IKKβ/NF-κB activity,a potent anti-inflammatory action of the extract was found.A randomized controlled crossover clinical trial on participants with predia-betes or T2D confirmed the safety and efficacy of the extract in humans.In conclusion,we identified an extract from the flower petals of D.pinnata as a novel treatment option for T2D,potentially targeting the central regulation of glucose homeostasis as a root cause of the disease. | Dominik Pretz Philip M.Heyward Jeremy Krebs Joel Gruchot Charles Barter Pat Silcock Nerida Downes Mohammed Zubair Rizwan Alisa Boucsein Julia Bender Elaine J.Burgess Geke Aline Boer Pramuk Keerthisinghe Nigel B.Perry Alexander Tups | 2023 | Life Metabolism2023，2，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员