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| 1 | Predicting asymptomatic coronary artery stenosis by aortic arch plaque in acute ischemic cerebrovascular disease:beyond the cervicocephalic atherosclerosis?显示文摘Background:Asymptomatic coronary artery stenosis(ACAS)≥50%is common in patients with acute ischemic cerebrovascular disease(AICVD),which portends a poor cardiovascular and cerebrovascular prognosis.Identifying ACAS>50%early may optimize the clinical management and improve the outcomes of these high-risk AICVD patients.This study aimed to investigate whether aortic arch plaque(AAP),an early atherosclerotic manifestation of brain blood-supplying arteries,could be a predictor for ACAS>50%in AICVD.Methods:In this cross-sectional study,atherosclerosis of the coronary and brain blood-supplying arteries was simultaneously evaluated using one-step computed tomography angiography(CTA)in AICVD patients without coronary artery disease history.The patients were divided into ACAS≥50%and non-ACAS≥50%groups according to whether CTA showed stenosis≥50%in at least one coronary arterial segment.The AAP characteristics of CTA were depicted from aspects of thickness,extent,and complexity.Results:Among 118 analyzed patients with AICVD,29/118(24.6%)patients had ACAS≥50%,while AAPs were observed in 86/118(72.9%)patients.Increased AAP thickness per millimeter(adjusted odds ratio[OR]:1.56,95%confidence interval[CI]:1.18-2.05),severe-extent AAP(adjusted OR:13.66,95%CI:2.33-80.15),and presence of complex AAP(adjusted OR:7.27,95%CI:2.30-23.03)were associated with ACAS≥50%among patients with AICVD,independently of clinical demographics and cervicocephalic atherosclerotic stenosis.The combination of AAP thickness,extent,and complexity predicted ACAS≥50%with an area under the receiver-operating characteristic curve of 0.78(95%CI:0.70-0.85,P<0.001).All three AAP characteristics provided additional predictive power beyond cervical and intracranial atherosclerotic stenosis for ACAS≥50%in AICVD(all P<0.05).Conclusions:Thicker,severe-extent,and complex AAP were significant markers of the concomitant ACAS≥50%in AICVD,possibly superior to the indicative value of cervical and intracranial atherosclerotic stenosis.As an integral part of atherosclerosis of brain blood-supplying arteries,AAP should not be overlooked in predicting ACAS≥50%for patients with AICVD. | Xin Ma Qi Kong Chen Wang Gary Rajah Yu-Chuan Ding Yu-Ren Zhang Xiang-Ying Du | 2019 | Chinese Medical Journal2019，，8： | 13 |
| 2 | Global secretome analysis identifies novel mediators of bone metastasis显示文摘骨头是稳固的肿瘤的远转移的一个最普通的地点。分泌蛋白质被知道影响在变形癌症房间和骨头基质之间的病理学的相互作用。为了包括地介绍,分泌了与骨头转移联系的蛋白质,我们使用了量、非量的集体 spectrometry 全球性分析改变从多重种类和癌症的变形能力打的骨头的九根细胞线的 secretomes。由比较父母房间和他们的骨头的 secretomes 变形衍生物,我们识别了特别地在这些房间线与骨头转移被联系的分泌蛋白质。我们然后合并了大临床的转移数据集的生物信息的分析获得强烈与临床、试验性的骨头转移被联系的几个功能的班的候选人小说骨头转移蛋白质的一张表。选择蛋白质的功能的确认显示在 vivo,骨头转移能被高表示支持(1 ) 唾液的 cystatins CST1, CST2,和 CST4;(2 ) plasminogen 使活跃之物小块地和 PLAU;或(3 ) 骨胶原功能蛋白质 PLOD2 和 COL6A1。总的来说,我们的学习揭开了骨头转移并且因此的几个新分泌调停人证明 secretome 分析是为新奇 biomarkers 和候选人的鉴定的一个强大的方法治疗学的目标。 | Maria Andres Blanco Gary LeRoy Zia Khan Ma a Ale kovi Barry M Zee Benjamin A Garcia Yibin Kang | 2012 | Cell Research2012，22，9： | 12 |
| 3 | 寨卡病毒引起小鼠睾丸损伤并导致雄性不育显示文摘虽然寨卡病毒与其他黄病毒属成员,如登革热病毒、乙型脑炎病毒和两尼罗病毒都是通过蚊媒传播,但是前人的研究发现寨卡病毒在精液中存在数月之久,暗示其性接触传播的可能性。本研究表明寨卡病毒影响雄性生殖系统,提示了其对男性健康的潜在危害。 | Wenqiang Ma Shihua Li Shuoqian Ma Lina Jia Fuchun Zhang Yong Zhang Jingyuan Zhang Gary Wong Shanshan Zhang Xuancheng Lu Mei Liu Jinghua Yan Wei Li Chuan Qin Daishu Han Chengfeng Qin Na Wang 李向东 高福 | 2017 | 科学新闻2017，19，4： | 5 |
| 4 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 5 | Duration of poliovirus excretion and its implications for acuteflaccid paralysis surveillance:areview of the literature 显示文摘 | Alexander JP Gary HE Pallansch MA | 1997 | J Infect Dis1997，175，1： | 1 |
| 6 | Alcohol and Mortaiity显示文摘 | Arthur L Armstrong MA Gary D | 1992 | AnnIntern Med1992，117，8： | 1 |
| 7 | Rift Valley Fever Virus and Yellow Fever Virus in Urine: A Potential Source of Infection显示文摘Dear Editor,In recent years,the incidence of human infections caused by emerging or re-emerging pathogens has rapidly increased.Diseases that were once regional now have the ability to spread globally in a short amount of time and pose a wider threat to public health(Weaver et al.2018).Yellow fever virus(YFV,family Flaviviridae,genus Flavivirus)is a mosquito-borne flavivirus that causes yellow fever in humans and has been endemic in Africa and Latin America for many years(Domingo et al.2018). | Meng Li Beibei Wang Liqiang Li Gary Wong Yingxia Liu Jinmin Ma Jiandong Li Hongzhou Lu Mifang Liang Ang Li Xiuqing Zhang Yuhai Bi Hui Zeng | 2019 | Virologica Sinica2019，34，3： | 1 |
| 8 | Duration of poliovirus excretion and its implications for acute flaccid paralysis surveil- lance: a review of the literature 显示文摘 | Alexander JP Gary HE Pallansch MA | 1997 | J Infect Dis1997，175，1： | 1 |
| 9 | The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling 显示文摘 | Chi H Ma Gary J Brenner Takao Omura | 2011 | J Neurosci2011，31，18： | 1 |
| 10 | 3D Stochastic Modelling of Heterogeneous Porous Media – Applications to Reservoir Rocks显示文摘 | Kejian Wu Marinus I. J. Dijke Gary D. Couples Zeyun Jiang Jingsheng Ma Kenneth S. Sorbie John Crawford Iain Young Xiaoxian Zhang | 2006 | Transport in Porous Media2006，，3： | 1 |
| 11 | Technology development and energy productivity in China 显示文摘 | KAREN FISHERVANDEN GARY H JEFFERSON MA JINGKUI | 2006 | Energy Economics2006，28，56： | 1 |
| 12 | Technology Development and Energy Productivity in China 显示文摘 | Fisher-Vanden K Gary H J Ma J K and Xu JY | 2006 | Energy Economics2006，，28： | 1 |
| 13 | Mild hypothermia reduces apoptosis of mouse neurons in Vitro early in the cascade显示文摘 | Xu L Yenari MA Gary KS | 2002 | J Cereb Blood Flow Metab2002，22，1： | 1 |
| 14 | Duration of poliovirus excretion and its implications for acute flaccid paralysis surveillance:a review of the literature显示文摘 | Alexander JP Gary HE Pallansch MA | 1997 | J Infect Dis1997，175，1： | 1 |
| 15 | Alcohol and mortality显示文摘 | Klatsky AL Armstrong MA Gary D | 1992 | Ann Intern Med1992，117，8： | 1 |
| 16 | Use of sulphonylurea and cancer in type 2 diabetes—The Hong Kong Diabetes Registry显示文摘 | Xilin Yang Wing Yee So Ronald C.W. Ma Linda W.Y. Yu Gary T.C. Ko Alice P.S. Kong Vanessa W.S. Ng Andrea O.Y. Luk Risa Ozaki Peter C.Y. Tong Chun-Chung Chow Juliana C.N. Chan | 2010 | Diabetes Research and Clinical Practice2010，，3： | 1 |
| 17 | Biological Imaging With a Neutron Microscope显示文摘 | CREMER JT PIESTRUP MA GARY CK | 2004 | Applied Physics Letters2004，85，3： | 1 |
| 18 | Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses显示文摘 | Sam X. Cheng Yaíma L. Lightfoot Tao Yang Mojgan Zadeh Lieqi Tang Bikash Sahay Gary P. Wang Jennifer L. Owen Mansour Mohamadzadeh | 2014 | FEBS Letters2014，，： | 1 |
| 19 | Causes of failure after initial vitreoretinal surgery for severe proliferative vitreoretinopathy显示文摘 | Hilel L Thomas MA Gary WA | 1991 | Am J Ophthalmol1991，111，1： | 1 |
| 20 | Technology Development and Energy Productivity in China 显示文摘 | Karen Fisher-Vanden Gary H J Ma Jingkui | 2006 | Energy Economics2006，，28： | 1 |
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