|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 3 | Murine lung eosinophil activation and chemokine production in allergic airway inflammation显示文摘Eosinophils play important roles in asthma and lung infections.Murine models are widely used for assessing the functional significance and mechanistic basis for eosinophil involvements in these diseases.However,little is known about tissue eosinophils in homeostasis.In addition,little data on eosinophil chemokine production during allergic airway inflammation are available.In this study,the properties and functions of homeostatic and activated eosinophils were compared.Eosinophils from normal tissues expressed costimulation and adhesion molecules B7-1,B7-2 and ICAM-1 for Ag presentation but little major histocompatibility complex(MHC)class II,and were found to be poor stimulators of T-cell proliferation.However,these eosinophils expressed high levels of chemokine mRNA including C10,macrophage inflammatory protein(MIP)-1a,MIP-1c,MIP-2,eotaxin and monocyte chemoattractant protein-5(MCP-5),and produced chemokine proteins.Eosinophil intracellular chemokines decreased rapidly with concomitant surface marker downregulation upon in vitro culturing consistent with piecemeal degranulation.Lung eosinophils from mice with induced allergic airway inflammation exhibited increased chemokines mRNA expression and chemokines protein production and upregulated MHC class II and CD11c expression.They were also found to be the predominant producers of the CCR1 ligands CCL6/C10 and CCL9/MIP-1c in inflamed lungs.Eosinophil production of C10 and MIP-1c correlated with the marked influx of CD11bhigh lung dendritic cells during allergic airway inflammation and the high expression of CCR1 on these dendritic cells(DCs).The study provided baseline information on tissue eosinophils,documented the upregulation of activation markers and chemokine production in activated eosinophils,and indicated that eosinophils were a key chemokine-producing cell type in allergic lung inflammation. | C Edward Rose Jr Joanne A Lannigan Paul Kim James J Lee Shu Man Fu Sun-sang J Sung | 2010 | Cellular & Molecular Immunology2010，7，5： | 6 |
| 4 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 5 | Unusual Photo Tunneling in the Presence of a Layer with a Negative Refractive Index显示文摘 | ZHANG Z M FU C J | 2002 | Appl Phys Lett2002，80，6： | 1 |
| 6 | Synthesis of functionalized cyclopentenes through catalytic asymmetric cycloadditions of allenes with enones显示文摘 | Wilson J E Fu G C | 2006 | Angew Chem Int Ed2006，45，： | 1 |
| 7 | An Intracellular Protein that Binds Amyloid-beta Peptide and Mediates Neurotoxicity in Alzheimer's Disease显示文摘 | YAN S D FU J SOTO C | 1997 | Nature1997，389，6652： | 1 |
| 8 | A fuzzy neural network for rule acquiring on fuzzy control system显示文摘 | Shann J J Fu H C | 1995 | Fuzzy Sets and Systems1995，71，： | 1 |
| 9 | Monolithic column with zwltterlonlc stationary phase for capillary electrochromatography显示文摘 | FU H J XIE C H DONG J | 2004 | Anal Chem2004，76，： | 1 |
| 10 | Comparison of the expression of the seven ribosomal RNA operons in Escherichia coli显示文摘 | Condon C Philips J Fu Z Y | 1992 | EMBO J1992，11，： | 1 |
| 11 | Fivefold twinned boron carbide nanowires 显示文摘 | Fu X Jiang J Liu C | 2009 | Nanotechnology2009，20，36： | 1 |
| 12 | The effect of acclima- tion to hypoxia and sustained exercise on subsequent hy- poxia tolerance and swimming performance in goldfish (Carassius auratus)显示文摘 | Fu S J Brauner C J Cao Z D | 2011 | The Journal of Experimental Bi- ology2011，214，12： | 1 |
| 13 | One-pot preparation of poly mer-enzyme metallic nanoparticle composite films for high- performance biosensing of glucose and galactose 显示文摘 | Fu Y C Li P H Xie Q J | 2009 | Adv Funct Mater2009，19，11： | 1 |
| 14 | Turn-on ratiometric fluorescent sensor for Pb2 + detection显示文摘 | HOU C XIONG Y J FU N | 2011 | Tetrahedron Lett2011，52，21： | 1 |
| 15 | Suturing versus immobilization of a muscle laceration:a morphological and functional study显示文摘 | Menetrey J Kasemkijwattana C Fu FH | 1999 | Am J Sports Med1999，27，2： | 1 |
| 16 | A Method for real-time compensation of moving ferromagnet′s magnetic moment显示文摘 | Zhou J J Lin C S Fu K | 2013 | Journal of Magnetism and Magnetic Materials2013，325，： | 1 |
| 17 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 18 | Air quality during the 2008 Beijing Olympic Games显示文摘 | STREETS D G FU J S JANG C J | 2007 | Atmospheric Environment2007，41，3： | 1 |
| 19 | Clopidogrel plus aspirin versus aspi- rin alone for reducing embolisation in patients with acute symptom- atic cerebral or carotid artery stenosis ( CLAIR study) a random- ised,opeu-label,blinded-endpoint trial显示文摘 | Wong KS Chen C Fu J | 2010 | Lancet Neurel2010，9，5： | 1 |
| 20 | Top-k typicality queries and efficient query answering methods on large databases显示文摘 | Hua M Pei J Fu A W C | 2009 | The International Journal on Very Large Data Bases(VLDB)2009，32，18： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员