|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 他汀、高密度脂蛋白胆固醇与冠状动脉粥样硬化消退显示文摘背景:他汀类药物可以降低低密度脂蛋白胆固醇(low—density lipoprotein cholesterol,LDL—C)水平并减缓冠状动脉粥样硬化的进展。然而,对于他汀类药物所致高密度脂蛋白胆固醇(high—density lipoprotein cholesterol,HDL—C)变化与疾病进展的关系,目前仍无相关数据描述。目的:了解LDL—C和HDL—C水平变化与动脉粥样硬化的相互关系。设计、地点及患者:对4项前瞻性随机试验(1999~2005年在美国、北美、欧洲和澳大利亚进行)的原始数据进行事后分析。其中1455例经血管造影证实的冠心病患者在接受他汀治疗(18个月或24个月)时进行了系列血管内超声扫描。所有超声分析均在相同的核心实验室中进行。主要观测指标:脂蛋白水平变化与冠状动脉粥样斑块体积的相互关系。结果:他汀治疗期间,LDL—C平均(SD)水平从124.0(38.3)mg,/dL(3.2[0.99]mmol/L)降至87.5(28.8)mg,/dL(2.3[0.75]mmol/L)(下降23.5%;P〈0.001),HDL—C水平从42.5(11.0)mg/dL(1.1[0.28]mmol/L)升至45.1(11.4)mg/dL(1.2[0.29]mmol/L)(上升7.5%;P〈0.001)。LDL—C与HDL—C比值从平均(SD)3.0(1.1)降至2.1(0.9)(下降26.7%;P〈0.001)。这些变化同时伴随平均(SD)百分粥样斑块体积的增加(从39.7%[9.8%]增至40.1%[9.7%])(增加0.5%[3.9%];P=0.001)以及平均(SD)总粥样斑块体积的减小(2.4[23.6]mm^3;P〈0.001)。在单变量分析中,LDL—C、总胆固醇、非HDL胆固醇、载脂蛋白B以及载脂蛋白B与载脂蛋白A-1比值平均水平和治疗引起的变化与动脉粥样硬化进展速率显著相关,而治疗所致HDL—C变化则与动脉粥样斑块体积负相关。在多变量分析中,平均LDL—C水平(β系数,0.11[95%可信区间,0.07~0.15])以及HDL—C升高(β系数,-0.26[95%可信区间,-0.41--0.10])依然为动脉粥样硬化消退的独立预测因子。动脉硬化显著消退(动脉粥样斑块体积减少≥5%)见于治疗期间LDL—C水平低于均值(87.5mg/dL)和HDL—C升高百分比大于均值(7.5%;P〈0.001)的患者。临床事件的发生未见显著差异。结论:在LDL—C显著降低以及HDL上升〉7.5%时,他汀治疗与冠状动脉粥样硬化消退相关。这些结果提示他汀治疗的获益源自致动脉粥样硬化脂蛋白的降低以及HDL.C的升高。尽管血脂水平的这些变化与动脉粥样硬化消退相关,但是后者是否可以转化为临床事件的显著减少,并改善临床预后仍有待进一步研究确定。 | Stephen J. Nicholls, MBBS, PhD E. Murat Tuzcu, MD IIke Sipahi, MD Adam W. Grasso, MD Paul Schoenhagen, MD Tingfei Hu, MS Kathy Wolski, MPH Tim Crowe, BS Milind Y. Desai, MD Stanley L. Hazen, MD, PhD Samir R. Kapadia, MD Steven E. Nissen, MD 李呈亿(译) | 2007 | 美国医学会杂志(中文版)2007，26，3： | 48 |
| 2 | 全球生态系统服务与自然资本的价值估算显示文摘编者按:地球上的生态系统是一种复杂的生命支持系统,生态系统对人类的贡献,在生态学研究中经常用“社会效益和经济效益”来表述,是可以用经济价值来估算的。然而,由于其复杂性和不确定性,对这两个效益如何进行估价,一直是困扰生态学家和经济学家的重要问题。Cos... | Robert Costanza Ralph d'Arge Rudolf de Groot Stephen Farber Monica Grasso Bruce Hannon Karin Limburg Shahid Naeem Robert V.O'neill Jose Paruelo Robert G.Raskin Paul Sutton Marjan van den Belt 陶大立(译) | 1999 | 生态学杂志1999，18，2： | 38 |
| 3 | Micro RNAs as lung cancer biomarkers显示文摘Lung cancer is the leading cause of cancer mortality worldwide. Its high mortality is due to the poor prognosis of the disease caused by a late disease presentation, tumor heterogeneities within histological subtypes, and the relatively limited understanding of tumor biology. Importantly, lung cancer histological subgroups respond differently to some chemotherapeutic substances and side effects of some therapies appear to vary between subgroups. Biomarkers able to stratify for the subtype of lung cancer, prognosticate the course of disease, or predict the response to treatment are in high demand. In the last decade, microR NAs(miR NAs), measured in resected tumor samples or in fine needle aspirate samples have emerged as biomarkers for tumor diagnosis, prognosis and prediction of response to treatment, due to the ease of their detection and in their extreme specificity. Moreover, miR NAs present in sputum, in plasma, in serum or in whole blood have increasingly been explored in the last five years as less invasive biomarkers for the early detection of cancers. In this review we cover the increasing amounts of datathat have accumulated in the last ten years on the use of miR NAs as lung cancer biomarkers. | Valerio Del Vescovo Margherita Grasso Mattia Barbareschi Michela A Denti | 2014 | World Journal of Clinical Oncology2014，5，4： | 11 |
| 4 | Anatomy and physiology of cisternostomy显示文摘 | lype Cherian Giovanni Grasso Antonio Bernardo Sunil Munakomi | 2016 | Chinese Journal of Traumatology2016，19，1： | 9 |
| 5 | Theoretical prediction,synthesis,and crystal structure determination of new MAX phase compound V2SnC显示文摘Guided by the theoretical prediction,a new MAX phase V2SnC was synthesized experimentally for the first time by reaction of V,Sn,and C mixtures at 1000°C.The chemical composition and crystal structure of this new compound were identified by the cross-check combination of first-principles calculations,X-ray diffraction(XRD),energy dispersive X-ray spectroscopy(EDS),and high resolution scanning transmission electron microscopy(HR-STEM).The stacking sequence of V2C and Sn layers results in a crystal structure of space group P63/mmc.The a-and c-lattice parameters,which were determined by the Rietveld analysis of powder XRD pattern,are 0.2981(0)nm and 1.3470(6)nm,respectively.The atomic positions are V at 4f(1/3,2/3,0.0776(5)),Sn at 2d(2/3,1/3,1/4),and C at 2a(0,0,0).A new set of XRD data of V2SnC was also obtained.Theoretical calculations suggest that this new compound is stable with negative formation energy and formation enthalpy,satisfied Born-Huang criteria of mechanical stability,and positive phonon branches over the Brillouin zone.It also has low shear deformation resistance c44(second-order elastic constant,cij)and shear modulus(G),positive Cauchy pressure,and low Pugh’s ratio(G/B=0.500<0.571),which is regarded as a quasi-ductile MAX phase.The mechanism underpinning the quasi-ductility is associated with the presence of a metallic bond. | Qiang Xu Yanchun Zhou Haiming Zhang Anna Jiang Quanzheng Tao Jun Lu Johanna Rosén Yunhui Niu Salvatore Grasso Chunfeng Hu | 2020 | Journal of Advanced Ceramics2020，9，4： | 8 |
| 6 | Non-interventional management of resistant hypertension显示文摘Hypertension is one of the most popular fields of re-search in modern medicine due to its high prevalence and its major impact on cardiovascular risk and con-sequently on global health. Indeed, about one third of individuals worldwide has hypertension and is under increased long-term risk of myocardial infarction, stroke or cardiovascular death. On the other hand, resistant hypertension, the 'uncontrollable' part of arterial hy-pertension despite appropriate therapy, comprises a much greater menace since long-standing, high levels of blood pressure along with concomitant debilitating entities such as chronic kidney disease and diabetes mellitus create a prominent high cardiovascular risk milieu. However, despite the alarming consequences, resistant hypertension and its effective management still have not received proper scientific attention. As-pects like the exact prevalence and prognosis are yet tobe clarified. In an effort to manage patients with resis-tant hypertension appropriately, clinical doctors are still racking their brains in order to find the best therapeutic algorithm and surmount the substantial difficulties in controlling this clinical entity. This review aims to shed light on the effective management of resistant hyper-tension and provide practical recommendations for cli-nicians dealing with such patients. | Michael Doumas Costas Tsioufis Charles Faselis Antonios Lazaridis Haris Grassos Vasilios Papademetriou | 2014 | World Journal of Cardiology2014，6，10： | 5 |
| 7 | A review of electromagnetic processing of materials(EPM):Heating,sintering,joining and forming显示文摘Electricity is an efficient form of energy,and the growing interest in electricity-assisted manufacturing is motivated by its inherent energy saving and reduced environmental impact.Beyond this,Electromagnetic Processing of Materials(EPM)allows the fabrication of materials with new compositions,metastable phases and nanograined microstructures that cannot be obtained using conventional heating processes using furnaces.This review covers EPM for the manufacture of ceramic and metal bulk components,with a specific focus on the effects of electric fields and electromagnetic radiations on processing in a wide spectrum of frequencies ranging from DC(f=0 Hz)to visible light(f=10^(14)–10^(15)Hz).The manuscript is divided into two parts.The first part provides a comprehensive overview of the interactions between matter and electric field/current,including heating phenomena(resistive Joule,induction,dielectric heating,electric arcs)and athermal effects(electromigration,electroplasticity,electrochemical reactions,ponderomotive force and others).The second part is focused on the technological application of the techniques,covering heat treatments,joining,sintering and forming.Seven distinct physical phenomena are involved in EPM:resistive Joule and induction heating,electrochemical reactions,electroplasticity,electric arcs and electromagnetic heating based on radio and microwave frequencies(mainly used for heating dielectric materials;i.e.,dielectric heating)or on the IR/visible light(IR heating and lasers). | Mattia Biesuz Theo Saunders Daoyao Ke Michael J.Reece Chungfeng Hu Salvatore Grasso | 2021 | Journal of Materials Science & Technology2021，，10： | 4 |
| 8 | The value of the world’s ecosystem services and natural capital显示文摘 | Robert Costanza Ralph d’Arge Rudolf de Groot Stephen Farber Monica Grasso Bruce Hannon Karin Limburg Shahid Naeem Robert V. O’Neill Jose Paruelo Robert G. Raskin Paul Sutton Marjan van den Belt | 1998 | Ecological Economics1998，，1： | 4 |
| 9 | Synthesis,microstructure,and properties of high purity Mo_(2)TiAlC_(2) ceramics fabricated by spark plasma sintering显示文摘The synthesis,microstructure,and properties of high purity dense bulk Mo_(2)TiAlC_(2) ceramics were studied.High purity Mo_(2)TiAlC_(2) powder was synthesized at 1873 K starting from Mo,Ti,Al,and graphite powders with a molar ratio of 2:1:1.25:2.The synthesis mechanism of Mo_(2)TiAlC_(2) was explored by analyzing the compositions of samples sintered at different temperatures.It was found that the Mo_(2)TiAlC_(2) phase was formed from the reaction among Mo3Al2C,Mo2C,TiC,and C.Dense Mo_(2)TiAlC_(2) bulk sample was prepared by spark plasma sintering(SPS)at 1673 K under a pressure of 40 MPa.The relative density of the dense sample was 98.3%.The mean grain size was 3.5μm in length and 1.5μm in width.The typical layered structure could be clearly observed.The electrical conductivity of Mo_(2)TiAlC_(2) ceramic measured at the temperature range of 2-300 K decreased from 0.95×10^(6) to 0.77×10^(6)Ω^(-1)·m^(-1).Thermal conductivity measured at the temperature range of 300-1273 K decreased from 8.0 to 6.4 W·(m·K)^(-1).The thermal expansion coefficient(TEC)of Mo_(2)TiAlC_(2) measured at the temperature of 350-1100 K was calculated as 9.0×10^(-6) K^(-1).Additionally,the layered structure and fine grain size benefited for excellent mechanical properties of low intrinsic Vickers hardness of 5.2 GPa,high flexural strength of 407.9 MPa,high fracture toughness of 6.5 MPa·m^(1/2),and high compressive strength of 1079 MPa.Even at the indentation load of 300 N,the residual flexural strength could hold 84% of the value of undamaged one,indicating remarkable damage tolerance.Furthermore,it was confirmed that Mo_(2)TiAlC_(2) ceramic had a good oxidation resistance below 1200 K in the air. | Yunhui NIU Shuai FU Kuibao ZHANG Bo DAI Haibin ZHANG Salvatore GRASSO Chunfeng HU | 2020 | Journal of Advanced Ceramics2020，9，6： | 4 |
| 10 | 隧道纵向消防通风的对数理论显示文摘文章介绍了一种新的隧道防火通风理论。与目前通用理论不同的是,该模型没有从Froude相似准则出发,而是通过对基本热流体动力学方程组的简化、分析,揭示了火源放热率与隧道通风速度和隧道高度之间的逻辑关系,提出了以火势为特征的隧道火灾通风理论;依据这一理论,隧道通风临界速度为火势的对数函数,进而解释了大型隧道火灾中临界速度与火源放热率无关这一重要实验现象;利用新的火势概念,该理论给出了定量的火灾分类准则,并从数学上描述了各类火灾的物理特征;与现有实验数据比较,新理论无需任何实验修正,在所有火源放热率范围内成功地预测了隧道通风临界速度,从理论上克服了现有模型中临界速度随放热率无限增大的问题。由于新理论的二维性质,隧道侧壁面对防火通风的影响仍需进一步研究。 | 郭晓平 张启晖 徐书林 Simone Eandi Giuseppe Astore Piergiorgio Grasso | 2013 | 现代隧道技术2013，50，2： | 4 |
| 11 | Are metabolic factors still important in the era of direct antiviral agents in patients with chronic hepatitis C?显示文摘The high rate of sustained viral response(SVR)to boceprevir or telaprevir-based triple therapy in hepatitis C(HCV)-related,non-cirrhotic na ve patients or relapsers to previous antiviral treatment leads clinicians to believe that the impact of metabolic host factors on SVR is minimal when triple therapy is used,unlike what is observed with the peginterferon and ribavirin schedules.This concept is strongly expressed by some opinion leaders on the basis of the data derived from subanalyses of registrative trials as well as from a post-hoc analysis of the phaseⅡC208 clinical trial.The perception of unrestrainable therapeutic success with the use of newer,more powerful antivirals is now reinforced by the brilliant results obtained with sofosbuvir,an HCV NS5B polymerase inhibitor,as well as by the data from the phaseⅡandⅢstudies on the various combinations of second-generation NS3/4A inhibitors and NS5A and/or NS5B inhibitors.However,a great deal of concern has emerged from the real world scenario in which patients are often older and have more comorbidities than patients in the'world of trials'.Furthermore,many of them have advanced fibrosis and previous failure with peginterferon and ribavirin treatment.Some data from the recent literature suggest that the host metabolic factors may play a minor but non-negligible role in these difficult-to-treat patients,an issue that will hopefully be investigated in further studies.This editorial aims to provide a detailed analysis of the role that host metabolic factors played in the past and what role they may play in the era of direct antiviral agents. | Alessandro Grasso Federica Malfatti Roberto Testa | 2013 | World Journal of Gastroenterology2013，19，41： | 4 |
| 12 | TBM及其在中国的应用(2)显示文摘3工程和技术实例
3.1在长大和深埋隧道工程方面其它国家的经验
3.1.1工程实例
在国际上,许多地铁、公路和水利方面的隧道正投入使用或正在建设之中,还有的才处于计划阶段. | Reilly John Arrigoni Gianni Xu Shulin Grasso Piergiorgio 钱七虎 李兴碧 | 2002 | 现代隧道技术2002，39，2： | 3 |
| 13 | TBM及其在中国的应用(4)显示文摘3.12中国利用西方国家的TBM经验加速发展本国TBM技术的理由3.12. | Reilly John Arrigoni Gianni Xu Shulin Grasso Piergiorgio 钱七虎 李兴碧 | 2002 | 现代隧道技术2002，39，4： | 3 |
| 14 | Morphologic changes induced by acetylcholine infusion in normal and atheroclerotic coronary arteries显示文摘 | Arbustini E Grasso M | 1993 | Am J Cardiol1993，71，16： | 2 |
| 15 | Neither hereditary periodic fever nor periodic fever, aphthae, pharingitis, adenitis: Undifferentiated periodic fever in a tertiary pediatric center显示文摘AIM To describe the frequency and clinical characteristics of patients with undifferentiated periodic fever(UPF) and to investigate whether a clinical classification of UPF based on the PRINTO-Eurofever score can help predicting the response to treatment and the outcome at follow-up.METHODS Clinical and therapeutic information of patients with recurrent fever who presented at a single pediatric rheumatology center from January 2006 through April 2016 were retrospectively collected. Patients with a clinical suspicion of hereditary periodic fever(HPF) syndrome and patients with clinical picture of periodic fever, aphthae, pharingitis, adenitis(PFAPA) who were refractory to tonsillectomy underwent molecular analysis of five HPF-related genes: MEFV(NM_000243.2), MVK(NM_000431.3), TNFRSF1 A(NM_001065.3), NLRP3(NM_001079821.2), NLRP12(NM_001277126.1). All patients who had a negative genetic result were defined as UPF and further investigated. PRINTO-Eurofever score for clinical diagnosis of HPF was calculated in all cases. RESULTS Of the 221 patients evaluated for periodic fever, twelve subjects with a clinical picture of PFAPA who were refractory to tonsillectomy and 22 subjects with a clinical suspicion of HPF underwent genetic analysis. Twenty-three patients(10.4%) resulted negative and were classified as UPF. The median age at presentation of patients with UPF was 9.5 mo(IQR 4-24). Patients with UPF had a higher frequency of aphthae(52.2% vs 0%, P = 0.0026) and musculoskeletal pain(65.2% vs 18.2%, P = 0.0255) than patients with genetic confirmed HPF. Also, patients with UPF had a higher frequency of aphthous stomatitis(52.2% vs 10.7%, P < 0.0001), musculoskeletal pain(65.2% vs 8,0%, P < 0.0001), and abdominal pain(52.2% vs 4.8%, P < 0.0001) and a lower frequency of pharyngitis(56.6% vs 81.3%, P = 0.0127) compared with typical PFAPA in the same cohort. Twenty-one of 23 patients with UPF(91.3%) received steroids, being effective in 16; 13(56.2%) were given colchicine, which was effective in 6. Symptoms resolution occurred in 2 patients with UPF at last follow-up. Classification according to the PRINTOEurofever score did not correlate with treatment response and prognosis. CONCLUSION UPF is not a rare diagnosis among patients with periodic fever. Clinical presentation place UPF half way on a clinical spectrum between PFAPA and HPF. The PRINTOEurofever score is not useful to predict clinical outcome and treatment response in these patients. | Silvia De Pauli Sara Lega Serena Pastore Domenico Leonardo Grasso Anna Monica Rosaria Bianco Giovanni Maria Severini Alberto Tommasini Andrea Taddio | 2018 | World Journal of Clinical Pediatrics2018，7，1： | 2 |
| 16 | RETROGRADE URETEROPYELOSCOPIC TREATMENT OF 2 CM. OR GREATER UPPER URINARY TRACT AND MINOR STAGHORN CALCULI显示文摘 | MICHAEL GRASSO MICHAEL CONLIN DEMETRIUS BAGLEY | 1998 | The Journal of Urology1998，，2： | 2 |
| 17 | The value of the world’s ecosystem services and natural capital显示文摘 | Robert Costanza Ralph d'Arge Rudolf de Groot Stephen Farber Monica Grasso Bruce Hannon Karin Limburg Shahid Naeem Robert V. O'Neill Jose Paruelo Robert G. Raskin Paul Sutton Marjan van den Belt | 1998 | Ecological Economics1998，，1： | 2 |
| 18 | Prognostic Significance of Myocardial Fibrosis in Hypertrophic Cardiomyopathy显示文摘 | Rory O’Hanlon Agata Grasso Michael Roughton James C. Moon Susan Clark Ricardo Wage Jessica Webb Meghana Kulkarni Dana Dawson Leena Sulaibeekh Badri Chandrasekaran Chiara Bucciarelli-Ducci Ferdinando Pasquale Martin R. Cowie William J. McKenna Mary N. Shep | 2010 | Journal of the American College of Cardiology2010，，11： | 2 |
| 19 | 城市地区机械化隧道工程的风险管理显示文摘由于相关国际组织长期不懈的努力,隧道工程,特别是城市地区隧道工程的风险管理正成为一种惯例。对于机械化隧道工程情况也是如此,即使常常被认为是一种安全、快速的隧道施工方法,但仍然有许多其它因素决定着这种先进的施工技术的成败。为有助于控制所有重要因素,就需要制定和实施风险管理计划(RMP)。文章介绍了风险管理计划的必要元素,并阐述了隧道掘进计划(PAT)方法,以确保城市地区机械化隧道工程获得成功。 | Piergiorgio Grasso Vittorio Guglielmetti Shulin Xu | 2009 | 现代隧道技术2009，46，2： | 2 |
| 20 | Bladder cancer: a major public health issue显示文摘 | Grasso M | 2008 | Eur Urol Suppl2008，7，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员