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| 1 | Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales显示文摘AIM To define good and poor regression using pathology and magnetic resonance imaging(MRI) regression scales after neo-adjuvant chemotherapy for rectal cancer.METHODS A systematic review was performed on all studies up to December 2015, without language restriction, t h a t w e r e i d e n t i f i e d f r o m M E D L I N E, C o c h r a n e Controlled Trials Register(1960-2015), and EMBASE(1991-2015). Searches were performed of article bibliographies and conference abstracts. MeS H and text words used included 'tumour regression', 'mr TRG', 'poor response' and 'colorectal cancers'. Clinical studies using either MRI or histopathological tumour regression grade(TRG) scales to define good and poor responders were included in relation to outcomes [local recurrence(LR), distant recurrence(DR), disease-free survival(DFS), and overall survival(OS)]. There was no age restriction or stage of cancer restriction for patient inclusion. Data were extracted by two authors working independently and using pre-defined outcome measures.RESULTS Quantitative data(prevalence) were extracted and analysed according to meta-analytical techniques using comprehensive meta-analysis. Qualitative data(LR, DR, DFS and OS) were presented as ranges. The overall proportion of poor responders after neo-adjuvant chemoradiotherapy(CRT) was 37.7%(95%CI: 30.1-45.8). There were 19 different reported histopathological scales and one MRI regression scale(mrT RG). Clinical studies used nine and six histopathological scales for poor and good responders, respectively. All studies using MRI to define good and poor response used one scale. The most common histopathological definition for good response was the Mandard grades 1 and 2 or Dworak grades 3 and 4; Mandard 3, 4 and 5 and Dworak 0, 1 and 2 were used for poor response. For histopathological grades, the 5-year outcomes for poor responders were LR 3.4%-4.3%, DR 14.3%-20.3%, DFS 61.7%-68.1% and OS 60.7-69.1. Good pathological response 5-year outcomes were LR 0%-1.8%, DR 0%-11.6%, DFS 78.4%-86.7%, and OS 77.4%-88.2%. A poor response on MRI(mr TRG 4,5) resulted in 5-year LR 4%-29%, DR 9%, DFS 31%-59% and OS 27%-68%. The 5-year outcomes with a good response on MRI(mrT RG 1,2 and 3) were LR 1%-14%, DR 3%, DFS 64%-83% and OS 72%-90%.CONCLUSION For histopathology regression assessment, Mandard 1, 2/Dworak 3, 4 should be used for good response and Mandard 3, 4, 5/Dworak 0, 1, 2 for poor response. MRI indicates good and poor response by mr TRG1-3 and mrT RG4-5, respectively. | Muhammed RS Siddiqui Jemma Bhoday Nicholas J Battersby Manish Chand Nicholas P West Al-Mutaz Abulafi Paris P Tekkis Gina Brown | 2016 | World Journal of Gastroenterology2016，22，37： | 6 |
| 2 | Novel biomarkers for patient stratification in colorectal cancer:A review of definitions,emerging concepts,and data显示文摘Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of staging with high-resolution imaging has allowed more selective treatments,optimising survival outcomes.The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment,while reducing unnecessary morbidity for the patient.The search for biomarkers in CRC has been of significant interest,with questions remaining on their impact and applicability.The study of biomarkers can be broadly divided into metabolic,molecular,micro RNA,epithelial-to-mesenchymal-transition(EMT),and imaging classes.Although numerous molecules have claimed to impact prognosis and treatment,their clinical application has been limited.Furthermore,routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice,as it increases cost and can adversely affect expectations of treatment.In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC.We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of micro RNAs,analyze metabolic profiles,and highlight key findings for biomarker potential in the EMT pathway. | Manish Chand Deborah S Keller Reza Mirnezami Marc Bullock Aneel Bhangu Brendan Moran Paris P Tekkis Gina Brown Alex Mirnezami Mariana Berho | 2018 | World Journal of Gastrointestinal Oncology2018，10，7： | 2 |
| 3 | Catalytic and photocatalytic ozonation of phenol on MnO2 supported catalysts 显示文摘 | JORGE V PATRICIO R GINA P | 2002 | Catalysis Today2002，76，： | 1 |
| 4 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 5 | Hypothyroidism显示文摘 | Gina M David J A Jerrold P S | 2001 | Cancer2001，92，11： | 1 |
| 6 | Induc'don of pro- inflammatory gene expression by Escberichia coli and mycotoxin zearalenone contamination and protection by a Lactobacillus mixture in porcine IPEC-I cells 显示文摘 | Ionelia T Daniela E M Gina C P e~ al | 2015 | Toxicon2015，97，4： | 1 |
| 7 | Potentiometric method for determining the number and relative strength of acid sites in colored catalysts显示文摘 | Ruby C Gina P | 1985 | Applied of Catalysis A:General1985，14，13： | 1 |
| 8 | Influenza A virus PB1-F2:A small protein with a big punch显示文摘 | GINA M CONENELLO L PETER P | 2007 | Cell Host & Microbe2007，2，： | 1 |
| 9 | Radical Innovation: triggering initiation of opportunity recognition and evaluation 显示文摘 | RICE M P KELLY D PETERS L O'Connor and Gina Colarelli | 2001 | R&D Management2001，31，4： | 1 |
| 10 | Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancer显示文摘 | Rollin J Régina S Vourc'h P | 2007 | Lung Cancer2007，56，2： | 1 |
| 11 | Relations between work team characteristics and effictiveness:a replication and extension 显示文摘 | MICHAEL A C ELLEN M P GINA J M | 1996 | Personnel Psychology1996，49，2： | 1 |
| 12 | Catalytic and photocatalytic ozonation of phenol on MnO2 supported catalysts显示文摘 | JORGE V PATRICIO R GINA P | 2002 | Catalysis Today2002，76，： | 1 |
| 13 | A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer显示文摘 | Cynthia X. Ma Matthew J. C. Ellis Gina R. Petroni Zhanfang Guo Shi-rong Cai Christine E. Ryan A. Craig Lockhart Michael J. Naughton Timothy J. Pluard Christiana M. Brenin Joel Picus Allison N. Creekmore Tibu Mwandoro Erin R. Yarde Jerry Reed Mark Ebbert P | 2013 | Breast Cancer Research and Treatment2013，，2： | 1 |
| 14 | Radical Innovation:triggering initiation of op- portunity recognition and evaluation显示文摘 | RICE M P KELLY D PETERS L O' Connor and Gina Colarelli | 2001 | R&D Manage- ment2001，31，4： | 1 |
| 15 | Influence of MMP-2and MMP-9 promoter polymorphisms on gene expression and clini-cal outcome of non-small cell lung cancer显示文摘 | J ROLLIN S RGINA P VOURC'H | 2007 | Lung Cancer(Am-sterdam Netherlands)2007，56，2： | 1 |
| 16 | The il vitro MN assay ill 2011 : origin and tale, biological sig- nificance,protocols,high throughput methodologies and toxicological relevance 显示文摘 | MICttELINE K V GINA P AZEDDINE E e! al | 2011 | Arch Toxicol2011，，： | 1 |
| 17 | Nyaupane,2008 Incents abroad attitude change toword hosts显示文摘 | Gina P | | 0，，03： | 1 |
| 18 | Green fluorescent protein and its derivatives as versatile markers for gene expression in living Drosophila melanogaster, plant and mammalian cells显示文摘 | Jeffrey D P Richard N D Gina M D | 1996 | Gene1996，，173： | 1 |
| 19 | Banking Relationships: Effects on Debt Terms for Small Spanish Firms 显示文摘 | Hernavdez-Canovas Ginas and Martinez-Solano P | 2006 | Journal of Small Business Management2006，44，3： | 1 |
| 20 | Electronic Monitoring Improves Hand Hygieneand Reduces ICU Infection显示文摘 | Gina P Martin SF | 2004 | Infect Control Hosp Epidemiolo-gy2004，25，1： | 1 |
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