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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | nNOS irthibitors attenuate methamphetamine-induced dopaminergic neurotoxicity but not hyperthermia in mice显示文摘 | Itzhak Y Martin JL Ail SF | 2000 | Neuroroport2000，11，13： | 1 |
| 3 | Evidence for the involvement of spinal cord glia in subcutaneous formalin in- duced hyperalgesia in the rat 显示文摘 | Watkins LR Martin D Maier SF | 1997 | Pain1997，71，3： | 1 |
| 4 | Human papillomavirus viral load in predictinghigh-grade CIN in women with cervical smears showing only atypicalsquamous cells or low-grade squamous intraepithelial lesion显示文摘 | Santos AL Derchain SF Martins MR | 2003 | Sao Paulo Med J2003，121，6： | 1 |
| 5 | Efficacious modification of Mitsunobu reaction for inversions of sterically hindered secondary alcohols 显示文摘 | Martin SF Dodge JA | 1991 | Tetrahedron Lett1991，32，26： | 1 |
| 6 | Clinicopathological correlation and prognostic significance of VEGF-A, VEGF-C, VEGFR-2 and VEGFR-3 expression in colorectal cancer 显示文摘 | Martins SF Gareia EA Luz MA | 2013 | Cancer Cenomics Proteomics2013，10，2： | 1 |
| 7 | Techniques for the Study of QoS in IP Networks显示文摘 | NW MACFADYEN GAR MARTIN | 2002 | BT Technology Journal2002，20，3： | 1 |
| 8 | Clinicopathologi- cal correlation and prognostic significance of VEGF-A, VEGF-C, VEGF-2 and VEGF-3 expression in colorectal cancer显示文摘 | Martins SF Garcia EA Luz MA | 2013 | Cancer Genomics Proteomics2013，10，2： | 1 |
| 9 | Mechanisms of chemical-induced innate immunity in allergic contact dermatitis 显示文摘 | Martin SF Esser PR Weber FC | 2011 | Allergy2011，66，： | 1 |
| 10 | Clinicopathological correlation and prognostic significance of VEGF -A, VEGF -C, VEGFR-2 and VEGFR-3 expression in colorectal cancer显示文摘 | Martins SF Garcia EA Luz MA | 2013 | Cancer Genomics Pro?teomics2013，10，2： | 1 |
| 11 | Clinicopatho-logical Correlation and Prognostic Significance ofVEGF-A, VEGF-C, VEGFR-2 and VEGFR-3 Expressionin Colorectal Cancer 显示文摘 | MARTINS SF GARCI EA LUZ MA | 2013 | Cancer Genomics Proteomics2013，10，2： | 1 |
| 12 | Subelltute Prices in Models of Tourism Demand显示文摘 | Martin C A Witt SF | 1988 | Annals of Tourism Research1988，，15： | 1 |
| 13 | Evaluation of creatine analogues as a new class of anticancer agents using freshly explanted human tumor cells 显示文摘 | Chen SF Clark GM | 1994 | J Natl Cancer Inst1994，86，8： | 1 |
| 14 | Clinicopathological cor- relation and prognostic significance of VEGF-A, VEGF-C, VEGFR-2 and VEGFR-3 expression in colorectal cancer 显示文摘 | Martins SF Gareia EA Luz MA | 2013 | Cancer Genomics Proteomics2013，10，2： | 1 |
| 15 | Clinicopathological cor- relation and prognostic significance of VEGF-A, VEGF-C, VEGFR-2 and VEGFR-3 expression in colorectal cancer 显示文摘 | Martins SF Garcia EA Luz MA | 2013 | Cancer Genomies Pro:eomics2013，10，2： | 1 |
| 16 | Methamphetamine-and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity in inducible nitricoxide synthase-deficient mice显示文摘 | Itzhak Y Martin JL Ali SF | 1999 | Synapse1999，34，4： | 1 |
| 17 | Post traumatic ankle arthritis:anupdate on conservative and surgical management显示文摘 | Martin RL Stewart GW Conti SF | | 0，，05： | 1 |
| 18 | A cute renal failure due to subcap sular renal haematoma in a so litary kidney:improvement after decompression显示文摘 | Martin SF Hsu TH Klein EA | 2002 | J Urol2002，168，6： | 1 |
| 19 | Evaluation of creatine analogues as a new class of anticancer agents using freshly explanted human tumor cells 显示文摘 | Martin K J Chen SF Clark GM | 1994 | J Natl Cancer Inst1994，86，： | 1 |
| 20 | Small leucine-rich proteoglycans (SLRPs) in uterine tissues during pregnancy in mice显示文摘 | San Martin S Soto-Suazo M De Oliveira SF | 2003 | Reproduction2003，125，4： | 1 |
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