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| 1 | 21世纪能力:数字时代的基本素养显示文摘一百年前一个人会读写算,就算“脱盲”了,今天的脱盲标准是什么?《21世纪能力》报告通过采用访谈、问卷、文献调研与观念综合等研究方法,提出了数字时代的基本素养、创新思维、有效沟通和高产出等4大类22条指标,为我们勾勒了面向知识型全球化社会的21世纪素养及其教育目标的最新图景。 | 盛群力 褚献华 Gina Burkhardt | 2004 | 开放教育研究2004，10，5： | 34 |
| 2 | Colorectal cancer with liver metastases:Neoadjuvant chemotherapy,surgical resection first or palliation alone?显示文摘Colorectal cancer(CRC) is one of the commonest cancers with 1.2 million new cases diagnosed each year in the world.It remains the fourth most common cause of cancer-related mortality in the world and accounts for > 600000 cancer-related deaths each year.There have been significant advances in treatment of metastatic CRC in last decade or so,due to availability of new active targeted agents and more aggressive approach towards the management of CRC,particularly with liver-only-metastases;however,these drugs work best when combined with conventional chemotherapy agents.Despite these advances,there is a lack of biomarkers to inform us about the accurate management of the patients with metastatic CRC.It is therefore imperative to carefully select the patients with comprehensive multi-disciplinary team input in order to optimise the management of these patients.In this review we will discuss various treatment options available in management of colorectal liver metastases with potential guidance on how and when to choose these options along with consideration on future directions in management of this disease. | Khurum Khan Anita Wale Gina Brown Ian Chau | 2014 | World Journal of Gastroenterology2014，20，35： | 22 |
| 3 | Systematic review of prognostic importance of extramuralvenous invasion in rectal cancer显示文摘AIM: To systematically review the survival outcomes relating to extramural venous invasion in rectal cancer.METHODS: A systematic review was conducted using PRISMA guidelines. An electronic search was carried out using MEDLINE, EMBASE, CINAHL, Cochrane library databases, Google scholar and Pub Med until October 2014. Search terms were used in combination to yield articles on extramural venous invasion in rectal cancer. Outcome measures included prevalence and 5-year survival rates. These were graphically displayed using Forest plots. Statistical analysis of the data was carried out.RESULTS: Fourteen studies reported the prevalence of extramural venous invasion(EMVI) positive patients. Prevalence ranged from 9%-61%. The pooled prevalence of EMVI positivity was 26% [Random effects: Event rate 0.26(0.18, 0.36)]. Most studies showed that EMVI related to worse oncological outcomes. The pooled overall survival was 39.5% [Random effects: Event rate 0.395(0.29, 0.51)].CONCLUSION: Historically, there has been huge variation in the prevalence of EMVI through inconsistent reporting. However the presence of EMVI clearly leads to worse survival outcomes. As detection rates become more consistent, EMVI may be considered as part of risk-stratification in rectal cancer. Standardised histopathological definitions and the use of magnetic resonance imaging to identify EMVI will improve detection rates in the future. | Manish Chand Muhammed RS Siddiqui Ian Swift Gina Brown | 2016 | World Journal of Gastroenterology2016，22，4： | 15 |
| 4 | Circadian Clock-Regulated Phosphate Transporter PHT4;1 Plays an Important Role in Arabidopsis Defense显示文摘Arabidopsis 加速了异种显示出的房间死亡 6-1 (acd6-1 ) 组成的防卫,房间死亡,和极端使显型相形见绌。在为 acd6-1 suppressors 的一幅屏幕,我们识别了被 T-DNA 在 PHOSPHATE TRANSPORTER 4 破坏的异种; 1 (PHT4; 1 ) 基因。suppressor 异种 pht4; 1-1 是主导的,快车截断了 PHT4; 1 个抄本,并且更产生剧毒的 Pseudomonas syringae 紧张然而并非到几无毒害的紧张。有水杨酸酸(SA ) 的处理收缩筋在 Col-0 和 pht4 导致了抵抗的类似的水平; 1-1,建议那 PHT4; SA 小径在上游的 1 幕。基因分析进一步显示那 PHT4; 1 贡献 SID2 依赖、独立的小径。包含 PHT4 的 DNA 碎片的转基因的表示; 1-1 区域或全身的 PHT4;在到 Pseudomonas 感染的野类型的授与的提高的危险性的 1 基因。有趣地, PHT4 的表示; 1 被生理节奏的钟调整。一起,这些数据建议磷酸盐 transporter PHT4; 1 为基础防卫是批评的并且也含有在调整 Arabidopsis 的天生的免疫的生理节奏的钟的一个潜在的角色。 | Guo-Ying Wang Jiang-Li Shi Gina Ng Stephanie L. Battle Chong Zhang Hua Lu | 2011 | Molecular Plant2011，4，3： | 12 |
| 5 | 社会工作实践的新方向:金融社会工作显示文摘金融社会工作作为社会工作专业的一个学科分支,是国际社会工作实践领域的一种新的发展方向。它是通过运用心理社会的介入方法和优势为本的视角,帮助服务对象掌握更多的金融知识,提高理财能力和改善财务状况,从而实现自我意识、自我感和自尊心的提升以及情绪的稳定,最终达成个人与社会的改变。金融社会工作的适用对象与服务人群非常广泛,有力地丰富了社会工作专业的研究与实践。 | 巫正洪 吴世友 Gina A.Chowa Gina A.Chowa | 2013 | 中国劳动关系学院学报2013，27，6： | 10 |
| 6 | Receptor activator of NF-κB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells显示文摘 | Valerie A Odero-Marah Ruoxiang Wang Gina Chu Majd Zayzafoon Jianchun Xu Chunmeng Shi Fray F Marshall Haiyen E Zhau Leland WK Chung | 2008 | Cell Research2008，18，8： | 6 |
| 7 | Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales显示文摘AIM To define good and poor regression using pathology and magnetic resonance imaging(MRI) regression scales after neo-adjuvant chemotherapy for rectal cancer.METHODS A systematic review was performed on all studies up to December 2015, without language restriction, t h a t w e r e i d e n t i f i e d f r o m M E D L I N E, C o c h r a n e Controlled Trials Register(1960-2015), and EMBASE(1991-2015). Searches were performed of article bibliographies and conference abstracts. MeS H and text words used included 'tumour regression', 'mr TRG', 'poor response' and 'colorectal cancers'. Clinical studies using either MRI or histopathological tumour regression grade(TRG) scales to define good and poor responders were included in relation to outcomes [local recurrence(LR), distant recurrence(DR), disease-free survival(DFS), and overall survival(OS)]. There was no age restriction or stage of cancer restriction for patient inclusion. Data were extracted by two authors working independently and using pre-defined outcome measures.RESULTS Quantitative data(prevalence) were extracted and analysed according to meta-analytical techniques using comprehensive meta-analysis. Qualitative data(LR, DR, DFS and OS) were presented as ranges. The overall proportion of poor responders after neo-adjuvant chemoradiotherapy(CRT) was 37.7%(95%CI: 30.1-45.8). There were 19 different reported histopathological scales and one MRI regression scale(mrT RG). Clinical studies used nine and six histopathological scales for poor and good responders, respectively. All studies using MRI to define good and poor response used one scale. The most common histopathological definition for good response was the Mandard grades 1 and 2 or Dworak grades 3 and 4; Mandard 3, 4 and 5 and Dworak 0, 1 and 2 were used for poor response. For histopathological grades, the 5-year outcomes for poor responders were LR 3.4%-4.3%, DR 14.3%-20.3%, DFS 61.7%-68.1% and OS 60.7-69.1. Good pathological response 5-year outcomes were LR 0%-1.8%, DR 0%-11.6%, DFS 78.4%-86.7%, and OS 77.4%-88.2%. A poor response on MRI(mr TRG 4,5) resulted in 5-year LR 4%-29%, DR 9%, DFS 31%-59% and OS 27%-68%. The 5-year outcomes with a good response on MRI(mrT RG 1,2 and 3) were LR 1%-14%, DR 3%, DFS 64%-83% and OS 72%-90%.CONCLUSION For histopathology regression assessment, Mandard 1, 2/Dworak 3, 4 should be used for good response and Mandard 3, 4, 5/Dworak 0, 1, 2 for poor response. MRI indicates good and poor response by mr TRG1-3 and mrT RG4-5, respectively. | Muhammed RS Siddiqui Jemma Bhoday Nicholas J Battersby Manish Chand Nicholas P West Al-Mutaz Abulafi Paris P Tekkis Gina Brown | 2016 | World Journal of Gastroenterology2016，22，37： | 6 |
| 8 | Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics显示文摘This article describes cell signaling network of metastatic prostate cancer(PCa)to bone and visceral organs in the context of tumor microenvironment and for the development of novel therapeutics.The article focuses on our recent progress in the understanding of:1)The plasticity and dynamics of tumorestroma interaction;2)The significance of epigenetic reprogramming in conferring cancer growth,invasion and metastasis;3)New insights on altered junctional communication affecting PCa bone and brain metastases;4)Novel strategies to overcome therapeutic resistance to hormonal antagonists and chemotherapy;5)Geneticbased therapy to co-target tumor and bone stroma;6)PCa-bone-immune cell interaction and TBX2-WNTprotein signaling in bone metastasis;7)The roles of monoamine oxidase and reactive oxygen species in PCa growth and bone metastasis;and 8)Characterization of imprinting cluster of microRNA,in tumorestroma interaction.This article provides new approaches and insights of PCa metastases with emphasis on basic science and potential for clinical translation.This article referenced the details of the various approaches and discoveries described herein in peer-reviewed publications.We dedicate this article in our fond memory of Dr.Donald S.Coffey who taught us the spirit of sharing and the importance of focusing basic science discoveries toward translational medicine. | Gina Chia-Yi Chu Leland W.K.Chung Murali Gururajan Chia-Ling Hsieh Sajni Josson Srinivas Nandana Shian-Ying Sung Ruoxiang Wang Jason Boyang Wu Haiyen E.Zhau | 2019 | Asian Journal of Urology2019，6，1： | 5 |
| 9 | Optimized stateful material implication logic for three- dimensional data manipulation显示文摘存储器和逻辑电路的整体的三维的集成能戏剧性地改进性能和计算系统的精力效率。一些常规、新兴的记忆对垂直集成合适,包括高度可伸缩的金属氧化物抵抗切换设备(memristors ) 。然而,逻辑电路的集成比期望证明了是更多质问。在这研究,我们由改编最近建议的基于 memristor 的 stateful 材料含意逻辑在一个整体的三维的电路表明了记忆和逻辑功能。由修改原来的电路增加它的坚韧性到设备瑕疵,第一次,我们试验性地在整体地综合的 memristors 的 threedimensional 栈以内显示出可靠多周期多门材料含意逻辑操作和一半蝮蛇电路。在三种尺寸的直接数据操作启用极其紧缩、高产量的 logicin- 记忆计算并且显著地,为在 nanoscale 实现一条8位蝮蛇的 Feynman 宏大挑战介绍一个可行答案。 | Gina C. Adam Brian D. Hoskins Mirko Prezioso Dmitri B. Strukov | 2016 | Nano Research2016，9，12： | 5 |
| 10 | Pyruvate kinase M2 regulates homologous recombination- mediated DNA double-strand break repair显示文摘到 genotoxic 治疗的抵抗是治疗失败和肿瘤复发的一个主要原因。激活 DNA 损坏反应(DDR ) 并且允许癌症房间逃离 genotoxic 治疗的致命的效果的内在的机制仍然保持不清楚。这里,我们揭开通过的意外机制 pyruvate kinase M2 (PKM2 ) ,在癌症房间的高度表示的 PK isoform 和癌症的一个主人管理者新陈代谢的 reprogramming,与 DDR 集成直接支持 DNA 双海滨裂缝(DSB ) 修理。响应电离放射和氧化应力,在导致它的原子累积的 T328 的 ATM phosphorylates PKM2。pT328-PKM2 被要求并且对足够支持通过到在 DNA 的 DSB 和切除术的增加 CtIPs 招募的 T126 上的交往 CtBP 蛋白质(CtIP ) 的 phosphorylation 的调停的 DNA DSB 修理结束的相应再结合(HR ) 。ATM-PKM2-CtIP 轴的混乱敏化癌症房间到许多损坏 DNA 代理人和 PARP1 抑制。而且,增加了原子 pT328-PKM2 水平在 glioblastoma 病人与显著地更坏的幸存被联系。联合,这些数据倡导者是的指向 PKM2 策略的使用不仅破坏癌症新陈代谢而且禁止抵抗的重要机制到 genotoxic 治疗的一个工具。 | Steven T. Sizemore Manchao Zhang Ju Hwan Cho Gina M. Sizemore Brian Hurwitz Balveen Kaur Norman L. Lehman Michael C. Ostrowski Pierre A. Robe Weili Miao Yinsheng Wang Arnab Chakravarti Fen Xia | 2018 | Cell Research2018，28，11： | 5 |
| 11 | Biomechanical Comparison of Unipedicular Versus Bipedicular Kyphoplasty显示文摘 | John Steinmann Craig T. Tingey Gina Cruz Qian Dai | 2005 | Spine2005，，2： | 4 |
| 12 | 基于数字解调器和JESD204B的多通道超声系统设计显示文摘针对多通道超声系统设计中接收电路中模拟前端和数字处理电路间的大数据量传输和大量数据连线的复杂性,提出了一个基于数字解调器和JESD204B接口的超声系统接收方案。该方案大幅降低了模拟前端的输出数据率,同时减少了模拟前端和数字电路部分的连线数目。有效地达到简化电路设计及降低数字处理要求,通过使用软件波束合成和更高阶多波束处理可以实现实时4D和高级影像模式。 | 俞毅刚 Gina Kelso Saad Ashraf | 2016 | 电子技术应用2016，42，11： | 3 |
| 13 | Diagnostic Accuracy of MRI for Assessment of T Category, Lymph Node Metastases, and Circumferential Resection Margin Involvement in Patients with Rectal Cancer: A Systematic Review and Meta-analysis显示文摘 | Eisar Al-Sukhni Laurent Milot Mark Fruitman Joseph Beyene J. Victor Selina Schmocker Gina Brown Robin McLeod Erin Kennedy | 2012 | Annals of Surgical Oncology2012，，7： | 3 |
| 14 | 运用COSO建立内部控制三道防线显示文摘内部控制三道防线的重要性体现在能够促使组织达成目标,应善用三道防线,做好内部控制设计和执行,降低风险到组织可接受的水平。风险和控制二者不同,有些风险可以被接受,有些风险则要完全或部分降低到一定水平。本文分为三个部分:(1)建立内部控制三道防线。(2)建立和协调三道防线。 | 王怡心 Douglas J.Anderson Gina Eubanks | 2016 | 中国内部审计2016，，3： | 3 |
| 15 | Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada显示文摘AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990.These data were integrated with prescription drug,medical visit,hospitalization and mortality data.HBV cases were classified as acute or chronic according to provincial guidelines.We compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative group.RESULTS46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic infections.Problematic alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative individuals.In multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug use.The odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic HBV.Persons with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV infection.These odds increased with increasing socioeconomic deprivation.CONCLUSION Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,prevention,care and treatment programs. | Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua | 2018 | World Journal of Gastroenterology2018，24，11： | 3 |
| 16 | Where is the future of China's biogas? Review, forecast,and policy implications显示文摘This paper discusses the history and present status of different categories of biogas production in China,most of which are classified into rural household production,agriculture-based engineering production,and industry-based engineering production.To evaluate the future biogas production of China,five models including the Hubbert model,the Weibull model,the generalized Weng model,the H-C-Z model,and the Grey model are applied to analyze and forecast the biogas production of each province and the entire country.It is proved that those models which originated from oil research can also be applied to other energy sources.The simulation results reveal that China's total biogas production is unlikely to keep on a fast-growing trend in the next few years,mainly due to a recent decrease in rural household production,and this greatly differs from the previous goal set by the official department.In addition,China's biogas production will present a more uneven pattern among regions in the future.This paper will give preliminary explanation for the regional difference of the three biogas sectors and propose some recommendations for instituting corresponding policies and strategies to promote the development of the biogas industry in China. | Lei Gu Yi-Xin Zhang Jian-Zhou Wang Gina Chen Hugh Battye | 2016 | Petroleum Science2016，13，3： | 2 |
| 17 | Effectiveness and safety of oxaliplatin compared to cisplatin for advanced, unresectable gastric cancer: a systematic review and meta-analysis显示文摘 | Francesco Montagnani Gina Turrisi Claudio Marinozzi Camillo Aliberti Giammaria Fiorentini | 2011 | Gastric Cancer2011，，1： | 2 |
| 18 | Evidence Regarding Human Papillomavirus Testing in Secondary Prevention of Cervical Cancer显示文摘 | Marc Arbyn Guglielmo Ronco Ahti Anttila Chris J.L.M. Meijer Mario Poljak Gina Ogilvie George Koliopoulos Pontus Naucler Rengaswamy Sankaranarayanan Julian Peto | 2012 | Vaccine2012，，： | 2 |
| 19 | Carbon dioxide and methane fluxes by a forest soil under laboratory-controlled moisture and temperature conditions显示文摘 | Richard D. Bowden Kathleen M. Newkirk Gina M. Rullo | 1998 | Soil Biology and Biochemistry1998，，12： | 2 |
| 20 | 红树林湿地植物生长促进菌及其应用展望显示文摘着重介绍从红树林根系中提取的植物促生菌的种类,即固氮细菌、溶磷细菌、光合厌氧细菌及其在红树林植被恢复中的应用前景。 | 廖宝文 李玫 康丽华 郑松发 陈玉军 Yoav Bashan Gina Holguin | 2002 | 生态科学2002，21，3： | 2 |
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