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| 1 | Inflammation and colorectal cancer, when microbiota-host mutualism breaks显示文摘Structural changes in the gut microbial community have been shown to accompany the progressive development of colorectal cancer.In this review we discuss recent hypotheses on the mechanisms involved in the bacteria-mediated carcinogenesis,as well as the triggering factors favoring the shift of the gut microbiota from a mutualistic to a pro-carcinogenic configuration.The possible role of inflammation,bacterial toxins and toxic microbiota metabolites in colorectal cancer onset is specifically discussed.On the other hand,the strategic role of inflammation as the keystone factor in driving microbiota to become carcinogenic is suggested.As a common outcome of different environmental and endogenous triggers,such as diet,aging,pathogen infection or genetic predisposition,inflammation can compromise the microbiota-host mutualism,forcing the increase of pathobionts at the expense of health-promoting groups,and allowing the microbiota to acquire an overall pro-inflammatory configuration.Consolidating inflammation in the gut,and favoring the bloom of toxigenic bacterial drivers,these changes in the gut microbial ecosystem have been suggested as pivotal in promoting carcinogenesis.In this context,it will become of primary importance to implement dietary or probiotics-based interventions aimed at preserving the microbiota-host mutualism along aging,counteracting deviations that favor a pro-carcinogenic microbiota asset. | Marco Candela Silvia Turroni Elena Biagi Franck Carbonero Simone Rampelli Carla Fiorentini Patrizia Brigidi | 2014 | World Journal of Gastroenterology2014，20，4： | 13 |
| 2 | In situ strength of coal bed based on the size effect study on the uniaxial compressive strength显示文摘In the early 1990 s, the Foundation for Science and Technology of Rio Grande do Sul State(CIENTEC)developed a pioneering study in Brazil, related to the simultaneous mining of multiple coal seams.One of the activities included detailed studies on the geomechanical characterization of materials present in the Irapua coal seam, under exploitation in the A-Sangao Mine, located near the city of Criciuma-SC,within the South-Catarinense coalfield. The goal of the laboratory tests was to define the behavior of the uniaxial compressive strength of the Irapua coal seam and establish a first approximation for the in situ strength value of this coal seam, since existing knowledge is solely based on practical mining experience over the years. Large samples of the coal seam were collected, using special techniques to maintain the integrity of the material, and a set of 56 uniaxial compression tests in cubic specimens, with side length ranging from 4.5 to 31 cm, were conducted in laboratory. This paper describes the experimental techniques used in the assays, and also presents the uniaxial compression strength results obtained.Moreover, important aspects of this type of study are considered, highlighting the size effect for the carbonaceous bed and the estimation of in situ strength values for the Irapua coal seam. | Gonzatti C. Zorzi L. Agostini I.M. Fiorentini J.A. Viero A.P. Philipp R.P. | 2014 | International Journal of Mining Science and Technology2014，24，6： | 9 |
| 3 | Polyethylene glycol microspheres loaded with irinotecan for arterially directed embolic therapy of metastatic liver cancer显示文摘AIM To study tumor response, and tolerability of arterially directed embolic therapy(ADET) with polyethylene glycol embolics loaded with irinotecan for the treatment of colorectal cancer liver metastases(CRC-LM). Secondary objectives were to monitor quality of life, time to progression and survival of patients.METHODS Patients were included in the study if they were affected by CRC-LM, refractory to systemic chemotherapy, treated with ADET using polyethylene glycol embolics, and had liver involvement < 50%. Tumor response, performance status(PS), tumor marker antigens, and quality of life(QoL) were monitored at 1, 3 and 6 mo after ADET. QoL was assessed with the Palliative Performance Scale(PPS).RESULTS We treated 50 consecutive CRC-LM patients with ADET using polyethylene glycol embolics. Their tumor response one month after ADET was: 28% of complete response(CR), 48% of partial response(PR), 8% stable disease(SD), and 16% of progression. Tumor response 3 mo after ADET was CR 24%, PR 38%, SD 19% and progression disease(PD) 19%. Tumor response 6 mo after ADET was CR 18%, PR 44%, SD 21% and PD 18%. QoL was 90% PPS at each time point. Median time to progression for patients who progressed was 2.5 mo(range 0.8-6). Median follow-up was 14 mo(0.8-25 range). ADETs were performed with no complications. Observed side effects(mild or moderate intensity) were: Pain in 32% of patients, increase of transaminase levels in 20% and fever in 14%, whereas 30% of patients did not complain any adverse event. CONCLUSION The treatment of unresectable CRC-LM with ADET using polyethylene glycol microspheres loaded with irinotecan was effective in tumor response and resulted in mild toxicity, and good QoL. | Giammaria Fiorentini Riccardo Carandina Donatella Sarti Michele Nardella Odysseas Zoras Stefano Guadagni Riccardo Inchingolo Massimiliano Nestola Alessandro Felicioli Daniel Barnes Navarro Fernando Munoz Gomez Camillo Aliberti | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 6 |
| 4 | Multidisciplinary approach of colorectal cancer liver metastases显示文摘Large bowel cancer is a worldwide public health challenge.More than one third of patients present an advanced stage of disease at diagnosis and the liver is the most common site of metastases.Selection criteria for early diagnosis,chemotherapy and surgery have been recently expanded.The definition of resectability remains unclear.The presence of metastases is the most significant prognostic factor.For this reason the surgical resection of hepatic metastases is the leading treatment.The most appropriate resection approach remains to be defined.The two step and simultaneous resection processes of both primary and metastases have comparable survival long-term outcomes.The advent of targeted biological chemotherapeutic agents and the development of loco-regional therapies(chemoembolization,thermal ablation,arterial infusion chemotherapy) contribute to extend favorable results.Standardized evidence-based protocols are missing,hence optimal management of hepatic metastases should be single patient tailored and decided by a multidisciplinary team.This article reviews the outcomes of resection,systemic and loco-regional therapies of liver metastases originating from large bowel cancer. | Giammaria Fiorentini Donatella Sarti Camillo Aliberti Riccardo Carandina Andrea Mambrini Stefano Guadagni | 2017 | World Journal of Clinical Oncology2017，8，3： | 4 |
| 5 | An Elevated Perspective: Dyke-Related Fracture Networks Analysed with Uav Photogrammetry显示文摘An abundance of data from seismic and geodetic monitoring has provided new insight into dyke propagation and emplacement mechanisms.These studies show that faulting and fracturing is part of the | Gregory DERING Steven MICKLETHWAITE Stephen J.BARNES Marco FIORENTINI Alexander CRUDEN Eric TOHVER | 2016 | Acta Geologica Sinica(English Edition)2016，90，S1： | 3 |
| 6 | Effectiveness and safety of oxaliplatin compared to cisplatin for advanced, unresectable gastric cancer: a systematic review and meta-analysis显示文摘 | Francesco Montagnani Gina Turrisi Claudio Marinozzi Camillo Aliberti Giammaria Fiorentini | 2011 | Gastric Cancer2011，，1： | 2 |
| 7 | Isolated limb infusion chemotherapy with or without hemofiltration for recurrent limb melanoma显示文摘AIM: To better define the efficacy and the safety of intra-arterial infusion performed with or without hemofiltration for recurrent limb melanoma. METHODS: Patients with the following characteristics were included in the study: recurrent limb melanoma not indicated for surgical resection, measurable disease in the extremity, > 18 years, performances status(Eastern Cooperative Oncology Group) was 0-1 and life expectancy of at least 6 mo. Twenty nine consecutive patients were enrolled in the study. Patients underwent fluoroscopic placement of angiographic arterial and venous catheters to infuse the drug in the artery [isolated limb infusion(ILI)], and to stop the out flow(venous). Melphalan was rapidly infused into the isolated limb via the arterial catheter after the inflation of venous balloon catheter. Then the circulation of the limb was completely blocked with a pneumatic cuff at the root of the limb. Haemofiltration(HF) was available only in the main center, and was performed with an extracorporeal perfusion system, in order to reduce high systemic toxic peaks of drug.RESULTS: Thirty seven ILI were done in 29 cases(31 ILI-HF and 6 ILI) between 2001 and 2014 at Ancona and Pesaro Hospitals, Italy. Clinical outcomes were monitored 30 d after treatment. Eleven patients(38%) received infusion of melphalan alone, 7(24%) melphalan associated to mitomicin C and 7(24%) melphalan associated to cisplatin, the remaining 4 were treated with cisplatin, melphalan and epirubicin or cisplatin and mitomicin C. The overall response rate was 66%, in particular, 3 patients(10%) were complete responders and 16(56%) were partial responders; whereas 7 patients(24%) had stable disease, and 3(10%) showed progressive disease. Limb toxicity was assessed adopting Wieberdink scale, with evidence of 90% of low grade(I and II) toxicity.CONCLUSION: ILI-HF and ILI are effective and safe treatments for recurrent non-resectable limb melanoma. They present evidence of favorable clinical benefit and is effective in delaying progression. | Sara Cecchini Donatella Sarti Stefano Ricci Ludovico Delle Vergini Manuela Sallei Stefano Serresi Giuseppe Ricotti Luca Mulazzani Fabrizia Lattanzio Giammaria Fiorentini | 2015 | World Journal of Clinical Oncology2015，6，4： | 2 |
| 8 | Combined hemodynamic overloard of the left and right ventricles as a possible cause of interventricular septum preponderance in high blood press-ure显示文摘 | Fiorentini C Gall C Tamborini G | 1988 | Am Heart J1988，116，： | 1 |
| 9 | Gene expres- sion study of two widely used pig intestinal epithelial cell lines: IPEC-J2 and IPI-2I显示文摘 | Mariani V Palermo S Fiorentini S | 2009 | Vet Immunol Im- munopathol2009，131，4： | 1 |
| 10 | Identification, estimation and testing of conditionally heteroskedastic factor models 显示文摘 | Sentana E and Fiorentini G | 2001 | Journal of Econometrics2001，102，2： | 1 |
| 11 | Imatinibmesylate in- duces responses in patients with liver metastases from gastroin- testinal stromal tumor failing intra- arterial hepatic chemotherapy 显示文摘 | Fiorentini G Bernardeschi P Rossi S | 2006 | Cancer Res Ther2006，2，2： | 1 |
| 12 | Growth factors in pituitary tumors显示文摘 | Missale C Fiorentini C Finardi A | 1999 | Pituitary1999，1，34： | 1 |
| 13 | Doxorubicin induces early lipid peroxidation associated with changes in glucose transport in cultured cardiomyocytes显示文摘 | Hrelia S Fiorentini D Maraldi T | 2002 | Biochim Biophys Acta2002，1567，12： | 1 |
| 14 | Nerve growth factor and retinoic acid interactions in the control of small cell lung cancer proliferation显示文摘 | Fiorentini C Facchetfi M Finardi A | 2002 | Eur J Endocrinol2002，147，3： | 1 |
| 15 | Nonlin- ear robust adaptive control of flexible air-breathing hypersonic ve- hicles 显示文摘 | FIORENTINI L SERRANI A BOLENDER M A | 2009 | Journal of Guidance Control and Dynamics2009，32，2： | 1 |
| 16 | Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro 显示文摘 | Fasano A Fiorentini C Donelli G | 1995 | J Clin Invest1995，96，2： | 1 |
| 17 | Circadian rhythm of the autonomic nervous system in insulin resistant subjects with normoglycemia,impaired fasting glycemia,impaired glucose tolerance,type 2 diabetes mellitus显示文摘 | Perciaccante A Fiorentini A Paris A | 2006 | BMC Cardiovasc Disord2006，6，： | 1 |
| 18 | 查看详情显示文摘 | Zoroddu A Bemardini F Ruggerone P Fiorentini V | | 0，，： | 1 |
| 19 | Electrical stimulation as adjuvant treatment for chronic leg ulcers of different aetiology: an RCT显示文摘 | MAGNONI C ROSSI E FIORENTINI C | 2013 | Journal of Wound Care2013，22，10： | 1 |
| 20 | Spontaneous polarization and piezoelectric constants of Ⅲ - Ⅴ nitrides 显示文摘 | BERNARDINI F FIORENTINI V VANDERBILT D | 1997 | Phys Rev B1997，56，10： | 1 |
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