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| 1 | Co-localization hypothesis:A mechanism for the intrapancreatic activation of digestive enzymes during the early phases of acute pancreatitis显示文摘尖锐胰腺炎通常被相信是胰被它通常生产的消化酶在伤害的疾病。当是的不活跃的酶原通常仅仅在入口之上激活进十二指肠,但是在尖锐胰腺炎的早阶段期间,那些酶原变得过早地在胰以内并且,大概激活,大多数胰腺的腺泡房间生产的潜在地有害的消化酶被综合并且藏匿那激活发生在胰腺的腺泡房间以内。为消化酶酶原的细胞内部的激活负责的机制没与必然被阐明,但是根据一个广泛地公认的理论(“合作本地化假设”) ,消化酶酶原被 lysosomal 水疗院激活当酶的二种类型在一样的细胞内部的分隔空间以内变得 co 局部性时,放射激光。这评论集中于在胰腺炎的早阶段期间作为对消化酶激活的解释支持合作本地化假设的有效性的证据。调查结果,在这评论总结了,支持 lysosomal 水疗院的合作本地化与消化酶酶原戏放射激光的结论在允许导致腺泡房间损害和胰腺炎的消化酶的细胞内部的激活的一个关键角色。 | Gijs JD van Acker George Perides Michael L Steer | 2006 | World Journal of Gastroenterology2006，12，13： | 10 |
| 2 | Effect of the reducing power of a beer on dimethyltrisulfide production during aging显示文摘 | Gijs L Collin S | 2002 | Journal of the American Society of Brewing Chemists2002，60，2： | 1 |
| 3 | Distress, sexual dysfunctions, and DSM: dialogue at cross purposes? 显示文摘 | Hendrickx L Gijs L Enzlin P | 2013 | J Sex M ed2013，10，3： | 1 |
| 4 | The enable right vertricalar circulatory suport systom for bcating heast cornary artery bupase Groft surgery 显示文摘 | Gijs G Andre L Dekker Frederik H Vander-veen Keses B Prenger Audrey A Cramer S Jos G Davidshoshan I | 1999 | Ann Thorac Surg1999，68，： | 1 |
| 5 | Sensorial contribution and fomaation pathways of thiols in lbods: a review显示文摘 | VERMEULEN C GIJS L COLLIN S | | Food Reviews In- ternational0，21，1： | 1 |
| 6 | 单个腺病毒颗粒的原子力显微镜液相成像及样品制备方法显示文摘原子力显微镜(Atomic force microscopy,AFM)作为一种纳米级高分辨率的探针扫描显微镜,在病毒形态学研究等领域有广泛的应用。为更好地利用AFM在接近病毒生理环境(液相)中观测单个病毒颗粒,选择合适的基底吸附病毒样品是重要的前提保障。本文介绍了一种病毒样品制备及AFM液相成像方法。首先制备疏水化处理的玻璃盖玻片作为吸附基底,再将观察样品腺病毒重组载体颗粒(Adenovirus type 5F35,Ad5F35)吸附于基底上,建立在液相下单个病毒颗粒的原子力显微镜成像方法。通过该方法获取了单个腺病毒颗粒在液相下的高分辨率纳米级高度图(height image),且病毒颗粒保持了约90nm的正确测量高度。实验结果表明疏水化处理的玻璃基底具有良好的吸附力,有助于病毒颗粒牢固地吸附在基底上,且不会引起较大的形变。本研究为AFM观测病毒等生物样品提供了一种较为合适的吸附基底和在液相中的AFM成像方法,对后期开展病毒形态结构、物理属性及其与宿主细胞受体相互作用的研究打下基础。 | 梁艳 李晨 Mariska G M van Rosmalen Gijs J L Wuite Wouter H Roos | 2015 | 病毒学报2015，31，6： | 1 |
| 7 | Assessment of added glutathione in yeast propagations, wort fermentations, and beer storage显示文摘 | Gijs L Perpetr P Timmermans A | 2004 | Am Soc Brew Chem2004，62，3： | 1 |
| 8 | 查看详情显示文摘 | Van de Broek B Devoogdt N D'Hollander A Gijs H L Jans K Lagae L Muyldermans S Maes G Borghs G | | 0，，6： | 1 |
| 9 | The performance of wind turbine smart rotor control approaches during extreme loads显示文摘 | Matthew A L Gijs A M Van Kuik | 2010 | Journal of Solar Energy Engineering2010，132，： | 1 |
| 10 | Impact of disease location on fecal calprotectin levels in Crohn’s disease显示文摘 | Krisztina B. Gecse Johannan F. Brandse Sandra van Wilpe Mark Lö wenberg Cyriel Ponsioen Gijs van den Brink Geert D’ Haens | 2015 | Scandinavian Journal of Gastroenterology2015，，7： | 1 |
| 11 | Retention of Sulphur Flavours by Food Matrix and Determination of Sensorial Data Dependant of Themedium Composition 显示文摘 | GIJS L PIRAPREZ G PERASTE P | 2000 | Food Chemistry2000，，69： | 1 |
| 12 | Findings From a Randomized Controlled Trial of Fecal Transplantation for Patients With Ulcerative Colitis显示文摘 | Noortje G. Rossen Susana Fuentes Mirjam J. van der Spek Jan G. Tijssen Jorn H.A. Hartman Ann Duflou Mark L?wenberg Gijs R. van den Brink Elisabeth M.H. Mathus-Vliegen Willem M. de Vos Erwin G. Zoetendal Geert R. D’Haens Cyriel Y. Ponsioen | 2015 | Gastroenterology2015，，： | 1 |
| 13 | Azathioprine does not reduce adenoma formation in a mouse model of sporadic intestinal tumorigenesis显示文摘AIM: To investigate if azathioprine could reduce adenoma formation in ApcMin/+, a mouse model of sporadic intestinal tumorigenesis.METHODS:Azathioprine was administered via drinking water(estimated 6-20 mg/kg body weight per day)to ApcMin/+and wildtype mice.Control animals received vehicle only(DMSO)dissolved in drinking water.At 15wk of age all mice were sacrificed and intestines of ApcMin/+were harvested for evaluation of polyp number.Azathioprine induced toxicity was investigated by immunohistochemical analysis on spleens.RESULTS:All azathioprine treated mice showed signs of drug-associated toxicity such as weight loss and development of splenic T-cell lymphomas.Although this suggests that the thiopurine concentration was clearly in the therapeutic range,it did not reduce tumor formation(48±3.1 adenomas vs 59±5.7 adenomas,P=0.148).CONCLUSION:We conclude that in the absence of inflammation,azathioprine does not affect intestinal tumorigenesis. | Mattheus CB Wielenga Jooske F van Lidth de Jeude Sanne L Rosekrans Alon D Levin Monique Schukking Geert RAM D'Haens Jarom Heijmans Marnix Jansen Vanesa Muncan Gijs R van den Brink | 2014 | World Journal of Gastroenterology2014，20，44： | 0 |
| 14 | 宝马展示厅显示文摘我们通常所见到的建筑几乎都是方方正正,棱角分明,Ekris宝马5系展示厅打破了我们所见到的常规建筑,它外周呈弧形,前半玻璃幕墙,后半银白金属表皮,有像水晶一样的菱形切割面。 | Kas Oosterhuis Ilona Lénárd Gijs Joosen RonaldBrandsma Pim Marsman Paulina Gurak RafaelSeemann Arnest Boender Gerard van den Engel Bas deBeer Sanne Plomp David Milam | 2011 | 中国建筑装饰装修2011，，10： | 0 |
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