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| 1 | Effect of dietary interventions on the intestinal microbiota of Mongolian hosts显示文摘The gut microbiota of Mongolian hosts has distinctive characteristics due to their meat- and dairyoriented daily diets and unique genotype.The aim of the present study was to investigate the effect of switching from the typical high protein and fat Mongolian diets to carbohydrate-rich meals composed principally of wheat,rice and naked oats on the host gut microbiota within 3 weeks.Our study took the advantage of the long sequence reads produced by the Pac Bio single molecule real-time sequencing technology to enable the profiling of subjects' gut microbiota communities along the diet intervention to the species precision.We found that the bacterial richness and diversity decreased apparently along the diet intervention.During the diet intervention,the gut microbiota composition displayed no significant difference at phylum level(with major phyla of Firmicutes,Bacteroidetes,Tenericutes and Proteobacteria).The relative abundances of some genera such as Bacteroidetes,Faecalibacterium,Roseburia,Alistipes,Streptococcus,and Oscillospira were significantly altered after the diet switching started.Notably,significant changes were also observed in the proportions of the species Bacteroides dorei,Bacteroides fragilis,Bacteroides thetaiotaomicron,Ruminococcus albus,Ruminococcus faecis,Roseburia faecis and Eubacterium ventriosum.These results have demonstrated that diet and host gut microbiota is closely linked. | Jing Li Haiyan Xu Zhihong Sun Qiangchuan Hou Lai-Yu Kwok Wuri Laga Yanjie Wang Huimin Ma Zhongjie Yu Bilige Menghe Heping Zhang | 2016 | Science Bulletin2016，61，20： | 14 |
| 2 | 选择性胺过程脱除酸气显示文摘胺溶剂的选择选择性吸收硫化氢(H_2S)的理想溶剂是对H_2S吸收能力高而对二氧化碳(CO_2)吸收能力低。常用的胺溶剂中不存在这样一种溶剂。然而如果应用H_2S和CO_2的吸收速度之差别。 | J.A Lagas 庞名立 | 1983 | 石油与天然气化工1983，12，A01： | 3 |
| 3 | Early experience in human hybrid transgastric and transvaginal endoscopic cholecystectomy显示文摘 | Gustavo Salinas Lil Saavedra Hellen Agurto Rosa Quispe Edwin Ramírez José Grande Juan Tamayo Victoria Sánchez Daniel Málaga Jeffrey M. Marks | 2010 | Surgical Endoscopy2010，，5： | 2 |
| 4 | Non ulcerative sexually transmitted diseases as risk factor for HIV-1 transmission in women: results from a cohort study显示文摘 | Laga M Manoko A Kivuvu M | 1993 | AIDS1993，7，： | 2 |
| 5 | Koumiss Consumption Alleviates Symptoms of Patients with Chronic Atrophic Gastritis:A Possible Link to Modulation of Gut Microbiota显示文摘Intestinal dysbiosis is closely related to a variety of medical conditions,especially gastrointestinal diseases.The present study aimed to investigate the effects of koumiss on chronic atrophic gastritis(CAG)in an outpatient clinical trial(n=10;all female subjects aged 41-55;body mass index ranging from 19.5 to 25.8).Each patient consumed three servings of koumiss per day(i.e.250 ml daily before each of 3 meals)for a 60-day period.The improvement of patients'symptoms was monitored by comparing the total scores of symptoms before and after the treatment.Meanwhile,the changes in the patients’fecal microbiota composition and specific blood parameters were determined.After the 60-day koumiss administration,significant symptom improvements were observed,as evidenced by the reduction of the total symptoms score,and changes in blood platelet and cholesterol levels.The changes in patients’fecal microbiota composition were found.The patients’fecal microbiota fell into two distinct enterotypes,Bacteroides dorei/Bacteroides uniformis(BB-enterotype)and Prevotella copri(P-enterotype).Significant less Bacteroides uniformis was found in the BB-enterotype patient group,while significant more butyrate-producing bacteria(e.g.Eubacterium rectale and Faecalibacterium prausnitzii)were found in the P-enterotype patient group,following koumiss administration.After stopping koumiss consumption,the relative abundance of some biomarker taxa returned to the original level,suggesting that the gut microbiota modulatory effect was not permanent and that continuous koumiss administration was required to maintain the therapeutic effect.In conclusion,koumiss consumption could alleviate the symptoms of CAG patients.Our results may help understand the mechanism of koumiss in alleviating CAG disease symptoms,facilitating the development of such products with desired therapeutic functions. | Chang Kun Li Qiang Chuan Hou Duolana Wuri Laga Hong Xin Liu Siqinbateer Bao Ying Sun Aoqi Lai-Yu Kwok He Ping Zhang Bilige Menghe | 2017 | Journal of Nutritional Oncology2017，2，1： | 2 |
| 6 | Neuroimaging of autism 显示文摘 | Verhoeven JS De Cock P Lagae L | 2010 | Neuroradiology2010，52，1： | 1 |
| 7 | Molecular breeding for high oleic and low linolenic fatty acid composition in Brassica napus显示文摘 | Laga B,Seurinck J,Verhoye T | 2004 | Pflanzenschutz-Nachrichten Bayer2004，57，1： | 1 |
| 8 | Effect of levetiracetam in refractory childhood epilepsy syndromes 显示文摘 | Lagae L Buyse G Deconinck A | 2003 | Eur J Paediatr Neurol2003，7，3： | 1 |
| 9 | Prognostic significance of cyclooxygenase-2 expression in 259 cases of non-small cell lung cancer 显示文摘 | Laga AC Zander DS Cagle PT | 2005 | Arch Pathol Lab Med2005，129，9： | 1 |
| 10 | P-glycoprotein(P-gp/Abcb1),Abcc2,and Abcc3 determine the pharmacokinetics of etoposide显示文摘 | Lagas J S Fan L Wagenaar E | 2010 | Clin Cancer Res2010，16，1： | 1 |
| 11 | Plasmon filters and resonators in metal-insulator-metal waveguides显示文摘 | NEUTENS P LAGAE L BORGHS G | 2012 | Optics Express2012，20，4： | 1 |
| 12 | Neuroimaging of autism显示文摘 | Verhoeven JS De Cock P Lagae L | 2010 | Neuroradiology2010，52，11： | 1 |
| 13 | Brain accumula- tion of sunitinib is restricted by P - glycoprotein ( ABCB1 ) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elaeridar and sunitinib coadministration 显示文摘 | TANG S C LAGAS J S LANKHEET N A | 2012 | lnt J Cancer2012，130，1： | 1 |
| 14 | A procedural object distribution function 显示文摘 | LAGAE A DUTR'E P | 2005 | ACM Transactions on Gruphics2005，24，4： | 1 |
| 15 | Modelling submarine groundwater discharge:an example from the western Baltic Sea显示文摘 | KALERIS V LAGAS G MARCZINEK S | 2002 | J of Hydrology2002，265，： | 1 |
| 16 | Prognostic significance of cyclooxygenase 2 expression in 259 cases of non-small cell lung cancer显示文摘 | Laga A C Zander D S Cagle P T | 2005 | Arch Pathol Lab Med2005，129，9： | 1 |
| 17 | Prognostic significance of cyclooxygenase 2 expression in 259 cases of non-small cell lung cancer显示文摘 | Laga AC Zander DS Cagle PT | 2005 | Archives of Pathology & Laboratory Medicine2005，129，9： | 1 |
| 18 | Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women:results from a cohort study显示文摘 | Laga M Manoka A Kivuvu M | 1993 | AIDS1993，7，： | 1 |
| 19 | The epidemiology of gonorrhoea, chlamydial infection and syphilis in four African cities显示文摘 | Buve A Weiss HA Laga M | 2001 | AIDS2001，15，4： | 1 |
| 20 | Estimation of thyroid gland volume by spiral computed tomography显示文摘 | Hermans R Bowillon R Laga K et a1 | 1997 | Eur Radiol1997，7，2： | 1 |
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