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| 1 | Bile acid homeostasis in female mice deficient in Cyp7a1 and Cyp27a1显示文摘Bile acids(BAs) are amphipathic molecules important for metabolism of cholesterol,absorption of lipids and lipid soluble vitamins,bile flow,and regulation of gut microbiome.There are over 30 different BA species known to exist in humans and mice,which are endogenous modulators of at least 6 different membrane or nuclear receptors.This diversity of ligands and receptors play important roles in health and disease;however,the full functions of each individual BA in vivo remain unclear.We generated a mouse model lacking the initiating enzymes,CYP7 A1 and CYP27 A1,in the two main pathways of BA synthesis.Because females are more susceptible to BA related diseases,such as intrahepatic cholestasis of pregnancy,we expanded this model into female mice.The null mice of Cyp7 a1 and Cyp27 a1 were crossbred to create double knockout(DKO) mice.BA concentrations in female DKO mice had reductions in serum(63%),liver(83%),gallbladder(94%),and small intestine(85%),as compared to WT mice.Despite low BA levels,DKO mice had a similar expression pattern to that of WT mice for genes involved in BA regulation,synthesis,conjugation,and transport.Additionally,through treatment with a synthetic FXR agonist,GW4064,female DKO mice responded to FXR activation similarly to WT mice. | Daniel Rizzolo Bo Kong Rulaiha E.Taylora Anita Brinker Michael Goedken Brian Buckley Grace L.Guo | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 4 |
| 2 | A Meta-Analysis of the Renal Safety of Isosmolar Iodixanol Compared With Low-Osmolar Contrast Media显示文摘 | Peter A. McCullough Michel E. Bertrand Jeffrey A. Brinker Fulvio Stacul | 2006 | Journal of the American College of Cardiology2006，，4： | 2 |
| 3 | Atypical extralobar sequestration: CT - pathological correlation 显示文摘 | Brinker DA Horton KM | 1999 | Clin Imaging1999，23，4： | 1 |
| 4 | Adrenal insufficiency meningococcal sepsis: hioavailable eortisol levels and impact of Interleukin 6 levels and intubation with etomidate on adrenal function and mortality显示文摘 | Brinker M Joosten KF Liem O | 2005 | Clin Endocrinol Metab2005，90，9： | 1 |
| 5 | Henoch schonlein purpura:areview article显示文摘 | Roberts PF Waller TA Brinker TM et aI | 2007 | South Med J2007，100，8： | 1 |
| 6 | Comparison of three monoclonal antibod y-based enzyme immunoassays for detection of herpes simplex vi rus in clinical specimens显示文摘 | Brinker JP Herman JE | 1995 | Eur J Clin Mierohiol Infect Dis1995，14，4： | 1 |
| 7 | Current Concepts Review: ExchangeNailing of Ununited Fractures 显示文摘 | Brinker MR O'Connor DP | 2007 | Bone Joint Sttrg Am2007，89，1： | 1 |
| 8 | Telithromycin-associated hepatotoxicity: clinical spectrum and causality assessment of 42 cases显示文摘 | Brinker AD Wassel RT Lyndly J | 2009 | Hepatology2009，49，1： | 1 |
| 9 | Microarray analyses of gene expression during adventitious root development in Pinus contorta显示文摘 | Brinker M van Zyl L Liu W | 2004 | Plant Physiology2004，135，3： | 1 |
| 10 | National estimates of mortality rates for radical pancreaticoduodenectomy in 25 000 patients 显示文摘 | Kotwall CA Maxwell JG Brinker CC | 2002 | Ann Surg Oncol2002，9，9： | 1 |
| 11 | Renal failure associated with the use of celecoxib and rofecoxib 显示文摘 | Kortepeter C Brinker A | 2002 | Drug Safety2002，25，7： | 1 |
| 12 | Review of Sol-Gel thin film formation 显示文摘 | BRINKER C J HURD A J SCHUNK P R | 1992 | Journal of Non-Crystalline Solids1992，，： | 1 |
| 13 | Henoch-Schonlein purpura: a review article 显示文摘 | ROBERTS P F WALLER T A BRINKER T M | 2007 | South Med J2007，100，8： | 1 |
| 14 | Medicinal chemistry and pharmacology, of genus Tripterygium (Celastraeeae) 显示文摘 | Brinker AM Ma J Lipsky PE | 2007 | Phytochemistry2007，68，6： | 1 |
| 15 | Clinical interactions between pacemaker and automatic implantable cardioverter-defibrillators显示文摘 | Brinker J Veltri EP | 1990 | J Am Coll Cardiol1990，16，： | 1 |
| 16 | A meta-analysis of the renal safety of isosmolar iodixanol compared with low-osmolar contrast media显示文摘 | Mecullough P Bertrand ME Brinker JA | 2006 | J Am Coll Cardiol2006，48，： | 1 |
| 17 | Hepatitis B and C virus co-infection and the risk for hepatotoxicity of highly active antiretroviral therapy in HIV-1 infection显示文摘 | den Brinker M Wit FW Wertheim-van Dillen PM et al | 2000 | AIDS2000，14，： | 1 |
| 18 | Fundamentals of sobgel dip coating显示文摘 | Brinker C J Frye G C Hurd A J | 1991 | Thin Solid Films1991，201，： | 1 |
| 19 | Factors determining the size of suspended solids in a flow-through fish farm显示文摘 | BRINKER A R O SCH R | 2005 | Aquacultural engineering2005，33，1： | 1 |
| 20 | Myocardialinfarction, aortic dissection, and thrombolytic therapy显示文摘 | Kamp TJ Goldschmidt-Clermont PJ Brinker JA | 1994 | Am HeartJ1994，128，： | 1 |
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