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| 1 | Uplift of the Longmen Shan range and the Wenchuan earthquake显示文摘 | Zhiqin Xu Shaocheng Ji Haibing Li Liwei Hou Xiaofang Fu Zhihui Cai | 2008 | Episodes2008，31，3： | 106 |
| 2 | Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4显示文摘最近的尖铁 glycoprotein (S) 鉴别中东呼吸症候群 coronavirus (MERS-CoV ) 指向细胞的受体, dipeptidyl peptidase 4 (DPP4 ) 。顺序比较和当模特儿的分析在病毒的尖铁上揭示了一个通常认为的受体绑定领域(RBD ) ,它调停这个相互作用。我们报导 3.0 Å MERS-CoV RBD 的决定水晶结构跳了到人的 DPP4 的细胞外的领域。我们的结果证明 MERS-CoV RBD 由一个核心和受体绑定子域组成。受体绑定子域与 DPP4 β 交往;推进器然而并非它的内在的 hydrolase 领域。MERS-CoV RBD 和相关 SARS-CoV RBD 分享他们的核心子域的结构的类似的高度,但是在受体绑定子域是尤其是分叉的。Mutagenesis 研究在为到 DPP4 和入口的病毒的绑定是批评的进目标房间的受体绑定子域识别了几关键残余。在在 MERS-CoV RBD 和 DPP4 之间的接口的原子细节提供病毒和受体相互作用的结构的理解,它能对 MERS-CoV 感染指导治疗学和疫苗的开发。 | Nianshuang Wang Xuanling Shi Liwei Jiang Senyan Zhang Dongli Wang Pei Tong Dongxing Guo Lili Fu Ye Cui Xi Liu Kelly C Arledge Ying-Hua Chen Linqi Zhang Xinquan Wang | 2013 | Cell Research2013，23，8： | 26 |
| 3 | Mapping the hotspots and coldspots of ecosystem services in conservation priority setting显示文摘空间明确地热点和 coldspots 印射是在将保存放为生态系统服务(ES ) 的优先级的一个重要连接。然而,很少研究都没识别并且测试了他们的 ES 热点和 coldspots 的紧密和效率,它可以削弱生态的保存的有效性。在这学习,基于 RUSLE 模型和 Getis-Ord 官方补给 * 统计,我们确定了年度土壤保存服务(SC ) 的变化并且从 2000 ~ 2013 在中国的 Shaanxi 省识别了统计上重要的热点和 coldspots。结果显示那, 1 ) 有高 SC 的区域也介绍了一个显著地增加的趋势,当有低 SC 的区域仅仅稍微变化了时;2 ) SC 热点和 coldspots 证明热点主要是的明显的空间 differentiationthe 空间地在南部的 Shaanxi 聚集了,当 coldspots 主要在 Guanzhong 盆和沙多风的高原被散布时;并且 3 ) 识别热点有提供 SC 的最高的能力,与提供的 29.6% 全部的区域, 59.7% 总数满足。相反, coldspots 占据了 46.3% 全部的区域,但是仅仅提供了 17.2% 全部的 SC。除了保存单个 ES, Getis-Ord 官方补给 * 统计方法能也帮助为保存多重 ES 和生物多样性识别多功能的优先级区域。 | LI Yingjie ZHANG Liwei YAN Junping WANG Pengtao HU Ningke CHENG Wei FU Bojie | 2017 | Journal of Geographical Sciences2017，27，6： | 19 |
| 4 | Comparison of the toxicity of silver nanoparticles and silver ions on the growth of terrestrial plant model Arabidopsis thaliana显示文摘Silver nanoparticles (AgNPs) are one of the most widely used nanomaterials, but the mechanism of AgNP toxicity in terrestrial plants is still unclear. We compared the toxic effects of AgNPs and Ag+ on Arabidopsis thaliana at the physiological, ultrastructural and molecular levels. AgNPs did not affect seed germination; however, they showed stronger inhibitory effect on root elongation than Ag+ . The results of transmission electron microscopy and metal content analysis showed that AgNPs could be accumulated in leaves. These absorbed AgNPs disrupted the thylakoid membrane structure and decreased chlorophyll content, which can inhibit plant growth. By comparison, a small amount of Ag+ was absorbed by seedlings, and it did not pronouncedly affect chloroplast structure and other metal ion absorption as AgNPs did. Compared with Ag+ , AgNPs could alter the transcription of antioxidant and aquaporin genes, indicating that AgNPs changed the balance between the oxidant and antioxidant systems, and also affected the homeostasis of water and other small molecules within the plant body. All the data from physiological, ultrastructural and molecular levels suggest that AgNPs were more toxic than Ag+ . | Haifeng Qian Xiaofeng Peng Xiao Han Jie Ren Liwei Sun Zhengwei Fu | 2013 | Journal of Environmental Sciences2013，25，9： | 14 |
| 5 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 6 | Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells显示文摘Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal glands.Our previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of ESS.In this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO levels.Moreover,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS mice.Mechanistically,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in MDSCs.In addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by IL-6.Taken together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases. | Ke Rui Yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun Wang Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，2： | 12 |
| 7 | Metal-Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications显示文摘Investigation of metal–organic frameworks(MOFs)for biomedical applications has attracted much attention in recent years.MOFs are regarded as a promising class of nanocarriers for drug delivery owing to well-defined structure,ultrahigh surface area and porosity,tunable pore size,and easy chemical functionalization.In this review,the unique properties of MOFs and their advantages as nanocarriers for drug delivery in biomedical applications were discussed in the first section.Then,state-ofthe-art strategies to functionalize MOFs with therapeutic agents were summarized,including surface adsorption,pore encapsulation,covalent binding,and functional molecules as building blocks.In the third section,the most recent biological applications of MOFs for intracellular delivery of drugs,proteins,and nucleic acids,especially aptamers,were presented.Finally,challenges and prospects were comprehensively discussed to provide context for future development of MOFs as efficient drug delivery systems. | Yujia Sun Liwei Zheng Yu Yang Xu Qian Ting Fu Xiaowei Li Zunyi Yang He Yan Cheng Cui Weihong Tan | 2020 | Nano-Micro Letters2020，12，8： | 10 |
| 8 | Sediment delivery ratio and its uncertainties on flood event scale:Quantification for the Lower Yellow River显示文摘Sediment delivery ratio(SDR)for fluvial rivers was formulated with sediment rating curve.The observed data of SDR on flood event scale of the Lower Yellow River(LYR)were adopted to examine the formulation and to calibrate the model parameters.A regression formula of SDR was then established and its 95%prediction interval was accordingly quantified to represent its overall uncertainties.Three types of factors including diversity of the incoming flow conditions,river self-regulation processes,and human activities were ascribed to the uncertainties.The following were shown:(1)With the incoming sediment coefficient(ISC)being a variable,it was not necessary to adopt the incoming flow discharge as the second variable in the formulation of SDR;and(2)ISC=0.003 and therefore SDR=2 might be a threshold for distinguishing the characteristics of sediment transport within the LYR.These findings would highlight sediment transport characteristics on the scale of flood event and contribute to uncertainty based analysis of water volume required for sediment transport and channel maintenance of the LYR. | FU XuDong 1,JIANG LiWei 1,WU BaoSheng 1,HU ChunHong 2,WANG GuangQian 1 &FEI XiangJun 1 1State Key Laboratory of Hydroscience and Engineering,Tsinghua University,Beijing 100084,China 2China Institute of Hydropower and Water Resources Research,Beijing 100044,China | 2010 | Science China(Technological Sciences)2010，53，3： | 7 |
| 9 | Advances and prospects in biomimetic multilayered scaffolds for articular cartilage regeneration显示文摘Due to the sophisticated hierarchical structure and limited reparability of articular cartilage(AC),the ideal regeneration of AC defects has been a major challenge in the field of regenerative medicine.As defects progress,they often extend from the cartilage layer to the subchondral bone and ultimately lead to osteoarthritis.Tissue engineering techniques bring new hope for AC regeneration.To meet the regenerative requirements of the heterogeneous and layered structure of native AC tissue,a substantial number of multilayered biomimetic scaffolds have been studied.Ideal multilayered scaffolds should generate zone-specific functional tissue similar to native AC tissue.This review focuses on the current status of multilayered scaffolds developed for AC defect repair,including design strategies based on the degree of defect severity and the zone-specific characteristics of AC tissue,the selection and composition of biomaterials,and techniques for design and manufacturing.The challenges and future perspectives of biomimetic multilayered scaffold strategies for AC regeneration are also discussed. | Liwei Fu Zhen Yang Cangjian Gao Hao Li Zhiguo Yuan Fuxin Wang Xiang Sui Shuyun Liu Quanyi Guo | 2020 | Regenerative Biomaterials2020，7，6： | 7 |
| 10 | Yellow light dilemma zone researches: a review显示文摘The yellow light dilemma zone is widely known as an area on the high-speed intersection approach,where vehicles neither safely stop before the stop line nor proceed through the intersection during amber interval. Within such an area,a vehicle might be involved in a right-angle crash or rear-end collision. This issue has been extensively discussed over five decades in traffic engineering field,covering fromtheory to practice. However,fewcomprehensive reviewliteratures on the amber signal dilemma zone problems can be found. The objective of this paper is to summarize the evolution of yellow light dilemma zone researches. Basic definition and boundary of dilemma zone followed by driver behavior and dilemma zone hazard measurement are depicted. At last,the future directions of yellow light dilemma zone research are discussed. | Yaping Zhang Chuanyun Fu Liwei Hu | 2014 | Journal of Traffic and Transportation Engineering(English Edition)2014，1，5： | 5 |
| 11 | Berberine mediates root remodeling in an immature tooth with apical periodontitis by regulating stem cells from apical papilla differentiation显示文摘Once pulp necrosis or apical periodontitis occurs on immature teeth,the weak root and open root apex are challenging to clinicians.Berberine(BBR)is a potential medicine for bone disorders,therefore,we proposed to apply BBR in root canals to enhance root repair in immature teeth.An in vivo model of immature teeth with apical periodontitis was established in rats,and root canals were filled with BBR,calcium hydroxide or sterilized saline for 3 weeks.The shape of the roots was analyzed by micro-computed tomography and histological staining.In vitro,BBR was introduced into stem cells from apical papilla(SCAPs).Osteogenic differentiation of stem cells from apical papilla was investigated by alkaline phosphatase activity,mineralization ability,and gene expression of osteogenic makers.The signaling pathway,which regulated the osteogenesis of SCAPs was evaluated by quantitative real time PCR,Western blot analysis,and immunofluorescence.In rats treated with BBR,more tissue was formed,with longer roots,thicker root walls,and smaller apex diameters.In addition,we found that BBR promoted SCAPs osteogenesis in a time-dependent and concentration-dependent manner.BBR induced the expression ofβ-catenin and enhancedβ-catenin entering into the nucleus,to up-regulate more runt-related nuclear factor 2 downstream.BBR enhanced root repair in immature teeth with apical periodontitis by activating the canonical Wnt/β-catenin pathway in SCAPs. | Yujia Cui Jing Xie Yujie Fu Chuwen Li Liwei Zheng Dingming Huang Changchun Zhou Jianxun Sun Xuedong Zhou | 2020 | International Journal of Oral Science2020，12，2： | 5 |
| 12 | Ultra-fast densification of CNTs reinforced alumina based on combustion reaction and quick pressing显示文摘An ultra-fast densification method based on high heating rate from the combustion reaction for producing carbon nanotubes(CNTs) reinforced alumina ceramics is reported.The heat generated by combustion reaction is adopted to act as a high temperature source to the sample,which results in a heating rate of 1660°C/min of the sample.Then a great mechanical pressure is applied to the sample when the sample gets the expected temperature.The densification process is finished in several minutes.The results indicate that the densification method is beneficial to protect the CNTs from destruction and creates good interfacial combination between the nanotubes and the matrix.With the addition of 1 wt% CNTs,the fracture toughness of the ceramics prepared increases about 50%. | FU ZhengYi HUANG LiWei ZHANG JinYong TODD Richard | 2012 | Science China(Technological Sciences)2012，55，2： | 3 |
| 13 | Characterization of DNA damage response deficiency in pancreatic cancer patients from China显示文摘To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-apy have been confirmed in pancreatic cancer.Recently,it was substantiated that pancreatic cancer patients carry-ing deleterious mutations of the DNA damage response(DDR)genes are more likely to benefit from platinum-based chemotherapy[2]and poly(adenosine diphosphate-ribose)polymerase(PARP)inhibitor[3]. | Xiaofei Zhang Tiebo Mao Bei Zhang Haiyan Xu Jiujie Cui Feng Jiao Dongqin Chen Yu Wang Jiong Hu Qing Xia Shumin Li Ming Yue Jingyu Ma Jiayu Yao Yongchao Wang Xiao Zhang Shiqing Chen Yuezong Bai Yuexiang Wang Xuebin Zhang Qiang Liu Yongwei Sun Deliang Fu Yingbin Liu Lei Xiong Liwei Wang | 2022 | Cancer Communications2022，42，1： | 2 |
| 14 | Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish ( Danio rerio )显示文摘 | Yuanxiang Jin Xiangxiang Zhang Linjun Shu Lifang Chen Liwei Sun Haifeng Qian Weiping Liu Zhengwei Fu | 2009 | Chemosphere2009，，7： | 2 |
| 15 | Comparison of transpiration between different aged black locust(Robinia pseudoacacia)trees on the semi-arid Loess Plateau,China显示文摘Black locust(Robinia pseudoacacia)is widely planted throughout the semi-arid Loess Plateau of China.The spatial distribution of this species at different ages is highly heterogeneous due to restoration and management practices.In this study,we aimed to compare the transpiration levels between different aged black locusts at the tree and stand scales,clarifying the physiological status of this species with different ages.Black locust trees with two representative age classes(12 and 28 years)were selected in the Yangjuangou catchment on the semi-arid Loess Plateau.Sap flux density(F_d)and environmental variables(solar radiation,air temperature,relative humidity and soil water content)were simultaneously monitored throughout the growing season of 2014.Tree transpiration(E_t)was the product of Fd and sapwood area(A_S),and stand transpiration(E_c)was calculated basing on the stand sap flux density(J_s)and stand total sapwood area(A_(ST)).Stomatal conductance(g_s)was measured in a controlled environment and hydraulic conductance was estimated using the relationship between transpiration rate and vapor pressure deficit(VPD).Our results showed that Et and Ec were higher in the 28-year-old stand than in the 12-year-old stand.The gs and hydraulic conductance of 28-year-old trees were also higher than those of 12-year-old trees,and the two parameters were thus the causes of variations in transpiration between different age classes.After rainfall,mean Fd increased by 9% in 28-year-old trees and by 5% in 12-year-old trees.This study thus suggests that stand age should be considered for estimating transpiration at the catchment and region scales in this area.These results provide ecophysiological evidences that the older black locust trees had more active physiological status than the younger ones in this area.These findings also provide basic information for the management of water resources and forests on the semi-arid Loess Plateau. | JIAOLei LU Nan FU Bojie GAO Guangyao WANG Shuai JIN Tiantian ZHANG Liwei LIU Jianbo ZHANG Di | 2016 | Journal of Arid Land2016，8，4： | 2 |
| 16 | Tetrahedral framework nucleic acids promote the biological functions and related mechanism of synovium-derived mesenchymal stem cells and show improved articular cartilage regeneration activity in situ显示文摘Many recent studies have shown that joint-resident mesenchymal stem cells(MSCs)play a vital role in articular cartilage(AC)in situ regeneration.Specifically,synovium-derived MSCs(SMSCs),which have strong chondrogenic differentiation potential,may be the main driver of cartilage repair.However,both the insufficient number of MSCs and the lack of an ideal regenerative microenvironment in the defect area will seriously affect the regeneration of AC.Tetrahedral framework nucleic acids(tFNAs),notable novel nanomaterials,are considered prospective biological regulators in biomedical engineering.Here,we aimed to explore whether tFNAs have positive effects on AC in situ regeneration and to investigate the related mechanism.The results of in vitro experiments showed that the proliferation and migration of SMSCs were significantly enhanced by tFNAs.In addition,tFNAs,which were added to chondrogenic induction medium,were shown to promote the chondrogenic capacity of SMSCs by increasing the phosphorylation of Smad2/3.In animal models,the injection of tFNAs improved the therapeutic outcome of cartilage defects compared with that of the control treatments without tFNAs.In conclusion,this is the first report to demonstrate that tFNAs can promote the chondrogenic differentiation of SMSCs in vitro and enhance AC regeneration in vivo,indicating that tFNAs may become a promising therapeutic for AC regeneration. | Liwei Fu Pinxue Li Junyao Zhu Zhiyao Liao Cangjian Gao Hao Li Zhen Yang Tianyuan Zhao Wei Chen Yu Peng Fuyang Cao Chao Ning Xiang Sui Quanyi Guo Yunfeng Lin Shuyun Liu | 2022 | Bioactive Materials2022，7，3： | 1 |
| 17 | Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish ( Danio rerio )显示文摘 | Yuanxiang Jin Xiangxiang Zhang Linjun Shu Lifang Chen Liwei Sun Haifeng Qian Weiping Liu Zhengwei Fu | 2009 | Chemosphere2009，，7： | 1 |
| 18 | Automatic single-image-based rain streaks removal via image decomposition 显示文摘 | Kang Liwei Lin C W Fu Y H | 2012 | IEEE Transactions on Image Processing2012，21，4： | 1 |
| 19 | Three-dimen- sional photonic metamaterials at optical frequencies 显示文摘 | Liu Na Guo Hongcang Fu Liwei | 2007 | Nat Mater2007，7，1： | 1 |
| 20 | Raman spectra evidence for the covalent-like quasi-bonding between exfoliated MoS_(2) and Au films显示文摘Gold-enhanced mechanical exfoliation method attracts broad interests in recent years,which has been widely used for preparing large-area and high-quality 2D single crystals.Even many calculations predict that there is strong interaction between Au film and the exfoliated 2D crystals,direct experimental evidence is still lacking.Here,we perform Raman spectroscopy measurements for few layer MoS_(2) with and without Au film underneath.The main peaks of MoS_(2) on Au film show no obvious change at higher frequency,however,the breathing and shear modes at low-frequency are suppressed,especially for breathing modes.In contrast,both breathing modes and shear modes can be detected on suspended MoS_(2) and the samples are transferred from Au film to SiO_(2)/Si.These comparison results provide direct evidence for the existence of covalent-like quasi-bonding at the interface of Au film and the exfoliated MoS_(2)crystal.This MoS_(2)/Au interface interaction presents a special pinning-effect for low-frequency rigid vibration.Similar pinning-effect is also discovered in WS2/Au system.Our work reports the suppression of low-frequency Raman modes of MoS_(2),WS_(2) on Au film,which will deliver new inspiration for studying other interactions between layered materials and solid surfaces. | Xinyu HUANG Lei ZHANG Liwei LIU Yang QIN Qiang FU Qiong WU Rong YANG Jun-Peng LV Zhenhua NI Lei LIU Wei JI Yeliang WANG Xingjiang ZHOU Yuan HUANG | 2021 | Science China(Information Sciences)2021，64，4： | 1 |
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