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| 1 | Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure显示文摘SIRT1,a mammalian ortholog of yeast silent information regulator 2(Sir2),is an NAD+-dependent protein deacetylase that plays a critical role in the regulation of vascular function.The current study aims to investigate the functional significance of deacetylase activity of SIRT1 in heart.Here we show that the early postnatal hearts expressed the highest level of SIRT1deacetylase activity compared to adult and aged hearts.We generated transgenic mice with cardiac-specific expression of a dominant-negative form of the human SIRT1(SIRT1H363Y),which represses endogenous SIRT1 activity.The transgenic mice displayed dilated atrial and ventricular chambers,and died early in the postnatal period.Pathological,echocardiographic and molecular phenotype confirmed the presence of dilated cardiomyopathy.Terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling analysis revealed a greater abundance of apoptotic nuclei in the hearts of transgenic mice.Furthermore,we show that cardiomyocyte apoptosis caused by suppression of SIRT1 activity is,at least in part,due to increased p53acetylation and upregulated Bax expression.These results indicate that dominant negative form of SIRT1(SIRT1H363Y)overexpression in mouse hearts causes cardiomyocyte apoptosis and early-onset heart failure,suggesting a critical role of SIRT1 in preserving normal cardiac development during the early postnatal period. | MU WenLi ZHANG QingJun TANG XiaoQiang FU WenYan ZHENG Wei LU YunBiao LI HongLiang WEI YuSheng LI Li SHE ZhiGang CHEN HouZao LIU DePei | 2014 | Science China(Life Sciences)2014，57，9： | 12 |
| 2 | A NAC transcription factor, NOR-like1, is a new positive regulator of tomato fruit ripening显示文摘Ripening of the model fruit tomato(Solanum lycopersicum)is controlled by a transcription factor network including NAC(NAM,ATAF1/2,and CUC2)domain proteins such as No-ripening(NOR),SlNAC1,and SlNAC4,but very little is known about the NAC targets or how they regulate ripening.Here,we conducted a systematic search of fruit-expressed NAC genes and showed that silencing NOR-like1(Solyc07g063420)using virus-induced gene silencing(VIGS)inhibited specific aspects of ripening.Ripening initiation was delayed by 14 days when NOR-like1 function was inactivated by CRISPR/Cas9 and fruits showed obviously reduced ethylene production,retarded softening and chlorophyll loss,and reduced lycopene accumulation.RNA-sequencing profiling and gene promoter analysis suggested that genes involved in ethylene biosynthesis(SlACS2,SlACS4),color formation(SlGgpps2,SlSGR1),and cell wall metabolism(SlPG2a,SlPL,SlCEL2,and SlEXP1)are direct targets of NOR-like1.Electrophoretic mobility shift assays(EMSA),chromatin immunoprecipitation-quantitative PCR(ChIP-qPCR),and dual-luciferase reporter assay(DLR)confirmed that NOR-like1 bound to the promoters of these genes both in vitro and in vivo,and activated their expression.Our findings demonstrate that NOR-like1 is a new positive regulator of tomato fruit ripening,with an important role in the transcriptional regulatory network. | Ying Gao Wei Wei Xiaodan Zhao Xiaoli Tan Zhongqi Fan Yiping Zhang Yuan Jing Lanhuan Meng Benzhong Zhu Hongliang Zhu Jianye Chen Cai-Zhong Jiang Donald Grierson Yunbo Luo Da-Qi Fu | 2018 | Horticulture Research2018，5，1： | 9 |
| 3 | Tomato DCL2b is required for the biosynthesis of 22-nt small RNAs, the resulting secondary siRNAs, and the host defense against ToMV显示文摘The tomato encode four functional DCL families,of which DCL2 is poorly studied.Here,we generated loss-of-function mutants for a tomato DCL2 gene,dcl2b,and we identified its major role in defending against tomato mosaic virus in relation to both natural and manual infections.Genome-wide small RNA expression profiling revealed that DCL2b was required for the processing 22-nt small RNAs,including a few species of miRNAs.Interestingly,these DCL2b-dependent 22-nt miRNAs functioned similarly to the DCL1-produced 22-nt miRNAs in Arabidopsis and could serve as triggers to generate a class of secondary siRNAs.In particular,the majority of secondary siRNAs were derived from plant defense genes when the plants were challenged with viruses.We also examined differentially expressed genes in dcl2b through RNA-seq and observed that numerous genes were associated with mitochondrial metabolism and hormone signaling under virus-free conditions.Notably,when the loss-of-function dcl2b mutant was challenged with tomato mosaic virus,a group of defense response genes was activated,whereas the genes related to lipid metabolism were suppressed.Together,our findings provided new insights into the roles of tomato DCL2b in small RNA biogenesis and in antiviral defense. | Tian Wang Zhiqi Deng Xi Zhang Hongzheng Wang Yu Wang Xiuying Liu Songyu Liu Feng Xu Tao Li Daqi Fu Benzhong Zhu Yunbo Luo Hongliang Zhu | 2018 | Horticulture Research2018，5，1： | 4 |
| 4 | Thermoelectric properties of Ag-doped compound:Mg_(3-x)Ag_(x)Sb_(2)显示文摘Mg_(3)Sb_(2)-based thermoelectric materials have poor electrical conductivity which is the key to limit thermoelectric performance that need to be solved.Herein we tuned the carrier concentration of Mg_(3)Sb_(2)-based materials via Ag doping at the Mg sites(at two distinct crystallographic sites)to enhance the electrical performance.Mg_(3-x)Ag_(x)Sb_(2)(0≤x≤0.05)has been prepared successfully by vacuum suspension smelting plus Spark Plasma Sintering technique.Using the vacuum suspension smelting plus Spark Plasma Sintering method,we proved that Ag doping can precisely tune the electrical transport properties and accordingly enhance the power factor.Moreover,the Ag doping leads to a low lattice thermal conductivity due to phonons scattering,and the maximal thermoelectric figure of merit ZT for Mg_(3-x)Ag_(x)Sb_(2)reaches 0.66 at 773 K. | Yanan Fu Xin Zhang Hongliang Liu Jie Tian Jiuxing Zhang | 2018 | Journal of Materiomics2018，4，1： | 2 |
| 5 | Smart heightened-containment biological laboratory:Technologies,modules,and aims显示文摘With the rapid development of intelligent technology,the smart heightened-containment biological laboratory(sHCBL)has moved from concept to reality.Experimental activities and laboratory construction,operation,and management will undoubtedly lead to disruptive changes.Conventional laboratories are increasingly being replaced by smart laboratories;however,the key technologies involved in this transition remain at an exploratory stage.It is necessary for HCBLs to absorb the advanced ideas of smart laboratories to guarantee the establishment of biosafety and biosecurity in a more automated way.This study examines in detail sHCBL module structures,the functions of each module,laboratory operation processes,and the advanced nature of smart laboratories.It may provide a theoretical foundation for the future transformation and smart construction of sHCBLs. | Jiaming Li Zhongyi Wang Gang Tao Yingying Fu Yifei Jin Hongliang Cheng Jingjing Li Xinrong Shu Jianjian Yang Jiuxiang Yang Bing Lu | 2022 | Journal of Biosafety and Biosecurity2022，4，2： | 1 |
| 6 | Maternal genetic history of ancient Tibetans over the past 4000 years显示文摘The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity.Here,we reconstruct a 4000-year maternal genetic history of Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet.The phylogeny of haplotypes M9a1a,M9a1b,D4g2,G2a’c,and D4i show that ancient Tibetans share the most recent common ancestor with ancient Middle and Upper Yellow River populations around the Early and Middle Holocene.In addition,the connections between Tibetans and Northeastern Asians vary over the past 4000 years,with a stronger matrilineal connection between the two during 4000 BPe3000 BP,and a weakened connection after 3000 BP,that are coincident with climate change,followed by a reinforced connection after the Tubo period(1400 BPe1100 BP).Besides,an over 4000-year matrilineal continuity is observed in some of the maternal lineages.We also find the maternal genetic structure of ancient Tibetans is correlated to the geography and interactions between ancient Tibetans and ancient Nepal and Pakistan populations.Overall,the maternal genetic history of Tibetans can be characterized as a long-term matrilineal continuity with frequent internal and external population interactions that are dynamically shaped by geography,climate changes,as well as historical events. | Ganyu Zhang Can Cui Shargan Wangdue Hongliang Lu Honghai Chen Lin Xi Wei He Haibing Yuan Tinley Tsring Zujun Chen Feng Yang Tashi Tsering Shuai Li Norbu Tashi Tsho Yang Yan Tong Xiaohong Wu Linhui Li Yuanhong He Peng Cao Qingyan Dai Feng Liu Xiaotian Feng Tianyi Wang Ruowei Yang Wanjing Ping Ming Zhang Xing Gao Yichen Liu Wenjun Wang Qiaomei Fu | 2023 | Journal of Genetics and Genomics2023，50，10： | 1 |
| 7 | A pre-processing blind multiuser detection algorithm based on LSCM using antenna array显示文摘A pre-processing blind multiuser detection al go rithms based on the least squares constant modulus (P-LSCMA) using antenna arra y is proposed in this paper. It first uses the signals received from every anten na to correlate with the conjugation of the DoA vector of the expected user, and then applies the pre-processed signals to the LSCMA. We simulate and compare t he proposed algorithm with the conventional LSCMA. Simulation results show that the proposed algorithm is superior to LSCMA. | Fu Hongliang Feng Guangzeng | 2006 | Journal of Systems Engineering and Electronics2006，17，2： | 1 |
| 8 | Temporal-spatial Analysis on Urban and Rural Drinking Water Health Monitoring of Tianjin in 2013显示文摘[Objective] Grasp quality and health status of drinking water,and provide scientific basis for decision making of health administrative department. [Method]According to the Standards for Drinking Water Quality( GB 5749- 2006),monitoring results of Tianjin urban and rural drinking water health in 2013 were evaluated,and software SPSS 20. 0 and GeoD a was used for temporal-spatial analysis on water quality. [Result]There were 2 882 copies of monitoring samples in total,in which both finished water and tap water of urban district were qualified,while qualified rates of tap water and secondary water supply from the county were respectively 86. 36% and 93. 91%,and major exceeding indexes were pH and total number of colonies. Qualified rates of tap water and secondary water supply from the county had difference( χ2= 1 576. 875,P < 0. 01). Quality of tap water( χ2= 5. 425,P > 0. 05) and secondary water supply( χ2= 16. 009,P > 0. 05) was stable at temporal distribution( January-December),but spatial distribution of tap water had certain regional difference( χ2= 1 255. 802,P < 0. 01). [Conclusion] General quality situation of Tianjin urban and rural drinking water was better,but qualified rate of water quality in some counties was lower,which had safety risk and threatened the health of residents in the corresponding county. The related departments should enhance the supervision and management of drinking water supply,improve supply water quality,strengthen water quality monitoring,and guarantee drinking water safety. Geographic information system can better realize visualization of drinking water quality monitoring information. | Fu Gang Zeng Qiang Zhao Liang Feng Baojia Wang Rui Zhang Lei Wang Yang Cui Yushan Zhang Yue Liu Hongliang | 2016 | Meteorological and Environmental Research2016，7，3： | 1 |
| 9 | Exact solutions for functionally graded pressure vessels in a uniform magnetic field 显示文摘 | DAI Hongliang FU Yiming DONG Zhiming | 2006 | International Journal of Solids and Structures2006，43，1819： | 1 |
| 10 | rhTSH-aided low-activity versus high-activity regimens of radioiodine in residual ablation for differentiated thyroid cancer: a meta-analysis显示文摘 | Chao Ma Limin Tang Hongliang Fu Jianing Li Hui Wang | 2013 | Nuclear Medicine Communications2013，，12： | 1 |
| 11 | Efficient large fragment deletion in plants:double pairs of sgRNAs are better than dual sgRNAs显示文摘Dear Editor,Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)is a powerful and versatile gene editing system that has been extensively utilized in various animals and plants,which holds enormous potential and value for scientific research and breeding.However,single-targeted CRISPR can only induce a few base deletions,insertions,or substitution.Ideally,thesemutations result in premature termination of the protein encoded by the target gene,leading to a loss of function[1]. | Guoning Zhu Lingling Zhang Liqun Ma Qing Liu Kejian Wang Jinyan Li Guiqin Qu Benzhong Zhu Daqi Fu Yunbo Luo Hongliang Zhu | 2023 | Horticulture Research2023，10，10： | 1 |
| 12 | MapReduce delay scheduling with deadline constraint显示文摘 | Li Hongliang Wei Xiaohui Fu Qingwu | 2014 | Concurrency and Computation:Practice and Experience2014，26，3： | 1 |
| 13 | Analytical solutions of stresses in functionally graded piezoelectric hollow structures显示文摘 | Dai Hongliang Xiao Xia Fu Yiming | 2010 | Solid State Communications2010，150，1516： | 1 |
| 14 | A fast SA algorithm for the design of DOE for uniform illumination显示文摘 | Liu Hongliang Zhao Yiqiong Li Yongping Fu Shaojun Zhang Wei Zhang Xiaobo Shu Fangjie | 2005 | Chinese J Comput Phys2005，33，3： | 1 |
| 15 | Overview of the LAMOST survey in the first decade显示文摘The Large Sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST),also known as the Guoshoujing Telescope,is a major national scientific facility for astronomical research located in Xinglong,China.Beginning with a pilot survey in 2011,LAMOST has been surveying the night sky for more than 10 years.The LAMOST survey covers various objects in the Universe,from normal stars to peculiar ones. | Hongliang Yan Haining Li Song Wang Weikai Zong Haibo Yuan Maosheng Xiang Yang Huang Jiwei Xie Subo Dong Hailong Yuan Shaolan Bi Yaoquan Chu Xiangqun Cui Licai Deng Jianning Fu Zhanwen Han Jinliang Hou Guoping Li Chao Liu Jifeng Liu Xiaowei Liu Ali Luo Jianrong Shi Xuebing Wu Haotong Zhang Gang Zhao Yongheng Zhao | 2022 | The Innovation2022，3，2： | 0 |
| 16 | A Novel Bio-Based Zirconium Phosphonate as a Flame Retardant and Smoke Suppressant for Epoxy Resin显示文摘Although epoxy resin has been widely used in various fields,it still suffers from some problems including brittleness and flammability.In this study,a new phosphonic acid,N,N-bis(phosphomethyl)glycine(GDMP),was prepared by Mannich reaction with bio-based glycine and then a novel layered zirconium phosphonate(ZrGDMP)was synthesized using GDMP and zirconyl chloride hydrate as reactants.The chemical structure of ZrGDMP was well characterized by 1 H and 31P NMR,SEM,XRD and XPS.The effect of ZrGDMP on the flame retardancy,smoke suppression,strengthening and toughening performances of the epoxy matrix was investigated and evaluated.TGA results indicated that compared with pure EP,ZrGDMP-EP composites showed higher char yield due to the catalytic charring effect of ZrGDMP.The pure EP exhibited high flammability,while ZrGDMP-EP composites possessed excellent thermal stability and remarkable fire resistance.The PHRR,THR,and TSP values of 3wt%ZrGDMP-EP were obviously declined by 39.6%,40.2%,and 24.9%compared to these of pure EP.Moreover,the tensile and impact tests implied that the addition of ZrGDMP can significantly reinforce the toughness as well as the strength of EP in terms of higher impact strength(24.8 kJ/m^(2))and tensile strength(57.7 MPa),which was mainly contributed to the uniform dispersion of ZrGDMP within the EP matrix. | Xianling Fu Hongliang Ding Xin Wang Lei Song Yuan Hu | 2022 | Journal of Renewable Materials2022，10，9： | 0 |
| 17 | NOVEL LSCM BEAM-FORMING ALGORITHM IN SMART ANTENNA MC-CDMA SYSTEM显示文摘A novel Least Squares Constant Modulus (LSCM) beam-forming algorithm in smart antenna Multi-Carrier Code Division Multiple Access (MC-CDMA) system is proposed in this paper. It adaptively beam-forms the multi-carrier antenna array signal using the LSCM Algorithm (LSCMA), and in the meantime, the beam-formed signals on every sub-carrier are combined by using Orthogonal Restore Combination (ORC), Equal Gain Combination (EGC) or Maximum Ratio Combination (MRC). Then the decision of the combined signals and the spread-code of the expected user are used to re-construct the signals on every sub-carrier. At last, the difference between the re-constructed signal and the output signal of the beam-former is used to con-trol the coefficients of the beam-former. The bit error probability of the proposed algorithm is analyzed. We simulated and compared it with the conventional LSCM beam-forming algorithm. Simulation results show that the proposed algorithm is superior to the latter in Bit Error Rate (BER). | Fu Hongliang Feng Guangzeng | 2006 | Journal of Electronics(China)2006，23，4： | 0 |
| 18 | Oral administration of Bacillus coagulans TQ-35 alleviates allergic responses in OVA-sensitive BALB/c mice显示文摘Bacillus coagulans has been extensively studied so far,but there has been a lack of research on its usage in allergy.In this study,we designed to assess the effect of different concentrations of B.coagulans on food allergy in a BALB/c mouse model of ovalbumin(OVA)-induced food allergy and its effect on gut microbes.The assessment of symptoms,specific immunoglobulin E(IgE),T-cell differentiation,and related gene expression levels in sensitized mice by assay indicated that high doses of oral B.coagulans could alleviate allergic symptoms.Treatment with B.coagulans,in the high-dose group,significantly reduced IgE and IgG1 levels and modulated the balance of T helper type 1 cell(Th1)and Th2 and the expression of relevant genes in the spleen.16S rRNA analysis showed that probiotics improved the structure of the microbiota,in particular by boosting the percentage of Clostridia,Bacteroides vulgatus and Enterococcus faecium,and by increasing the abundance of microbial species,thereby modulating the immune system.Therefore,this study can provide insights into the practical application of B.coagulans doses to alleviate OVA allergy. | Yifan Wang Shanjun Chen Chong Wang Yi Zhang Hongliang Zeng Linglin Fu Yanbo Wang | 2024 | Food Science and Human Wellness2024，13，3： | 0 |
| 19 | MECHANICAL AND ACOUSTIC RESPONSE OF AN UNDERWATER STRUCTURE SUBJECTED TO MECHANICAL EXCITATION显示文摘In this paper, an underwater structure is modeled as a cylindrical shell with internal bulkheads, and closed by a truncated conical shell, and it consists of metal substrate and sound absorbing coating, whose FGM core is considered. Suppose the inner cavity and outer space of the structure are filled with air and fluid mediums, the mechanical response of the underwater structure is calculated with Galerkin method while the acoustic response is investigated by means of the Helmholtz integral. Some numerical examples are given and the effect of geometrical size and material parameters on mechanical and acoustic response is discussed. | Xuetao Weng Shijian Zhu Hongliang Dai Yiming Fu Yiqi Mao | 2014 | Acta Mechanica Solida Sinica2014，27，3： | 0 |
| 20 | Accurate quantification of TiO_(2)(B)'s phase purity via Raman spectroscopy显示文摘Bronze phase titanium dioxide(TiO_(2)(B))could be a promising high-power anode for lithium ion battery.However,TiO_(2)(B)is a metastable material,so the as-synthesized samples are inevitably accompanied by the existence of anatase phases.It has been found that the TiO_(2)(B)'s purity is positively correlated with its electrochemical performance.Herein,we have established an accurate quantification of the TiO_(2)(B)/anatase ratio,by figuring out the function between the purity of TiO_(2)(B)phase in the high purity range and its Raman spectra features in combination of the calibration by the synchrotron radiation X-ray diffraction(XRD).Compared with the time-consuming electrochemical method,the rapid,sensitive and non-destructive features of Raman spectroscopy have made it a promising candidate for determining the purity of TiO_(2)(B).Further,the correlations developed in this work should be instructive in synthesizing pure TiO_(2)(B)and furthermore optimizing its electrochemical charge storage properties. | Jiamiao Ran Hui Liu Hongliang Dong Peng Gao Haowei Cheng Jianing Xu Hailun Wang Zixing Wang Qingfeng Fu Jiaxu Yan Jilei Liu | 2023 | Green Energy & Environment2023，8，5： | 0 |
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