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| 1 | Reduction of the incidence and mortality of rectal cancer bypolypectomy:a prospective cohort study in Haining County显示文摘AIM: To reduce the incidence and morlality of rectal cancerand address the hypothesis that colorectal cancer often arisefrom precursor lesion (s), either adenomas or non-alenomatous polyps, by conducting a population-basedmass screening for colorectal cancer in Haining County,Zhejiang, PRCMETHODS: From 1977 to 1980, physicians screened thepopulation of Haining County using 15 cm rigid endoscopy.Of over 240 000 participants, 4076 of them were diagnoselwith Precursor Iesions, eitler alenomas or non-adenomatous polyps, which were then removedl surgically.All individuals with precursor lesionswere followed up andreexamined by endoscopy every two to five years upto 1998.RESULTS: After the initial screening, 953 metactronousadenomas and 417 non-adenomatous polyps ware detected andremoved from the members of this cohort. Further, 27 cases ofcolorectal cancer were detected and treated. Log-rank tuestsshowed that the survival time among those cancer patients whounderwent mass screening increased significantly comparedtothat of other colorectal cancer patients (P < 0.0001). Accordingto the population-based cancer registry in Haining County,age-adjusted incidence and mortality of rectal cancer decreasedby 41% and 29 % from 1977-1981 to 1992-1996, respectively.Observed cumulative 20-year rectal cancer incidence was 31%lower than the expected in the screened group; the mortalitydue to rectal cancer was 18 % lower thah the expected in thescreened group.CONCLUSION: Mass screening for rectal cancer andprecursor lesions with protocoscopy in the generalpopulation and periodical following-up with routineendoscopy for high-risk patients may decrease both theincidence and mortality of rectal cancer. | Shu Zheng Xi-Yong Liu Qi Dong,Cancer Institute,Zhejiang University,88 Jiefang Road,HangZhou 310009,Zhejiang Province,China Ke-feng Ding Lin-Bo Wang Pei-Lin Qiu Su-Zhan Zhang,The 2~(nd)affiliated Hospital,Medical School of Zhejiang University,88 Jiefang Road,HangZhou 310009,Zhejiang Province,China Xin-Feng Ding Yong-Zhou Shen Gao-Fei Shen Oi-Rong Sun Wei-Dong Li,Haining Cancer Institute,Haining 314400,Zhejiang Province,China | 2002 | World Journal of Gastroenterology2002，8，3： | 37 |
| 2 | 'Micro-deletions' of the human Y chromosome and their relationship with male infertility显示文摘The Y chromosome evolves from an autochromosome and accumulates male-related genes including sex-determining region of Y-chromosome (SRY) and several spermatogenesis-related genes. The human Y chromosome (60 Mb long) is largely composed of repeti-tive sequences that give it a heterochromatic appearance, and it consists of pseudoautosomal, euchromatic, and heterochromatic regions. Located on the two extremities of the Y chromosome, pseudoautosomal regions 1 and 2 (PAR1 and PAR2, 2.6 Mb and 320 bp long, re-spectively) are homologs with the termini of the X chromosome. The euchromatic region and some of the repeat-rich heterochromatic parts of the Y chromosome are called 'male-specific Y' (MSY), which occupy more than 95% of the whole Y chromosome. After evolu-tion, the Y chromosome becomes the smallest in size with the least number of genes but with the most number of copies of genes that are mostly spermatogenesis-related. The Y chromosome is characterized by highly repetitive sequences (including direct repeats, inverted repeats, and palindromes) and high polymorphism. Several gene rearrangements on the Y chromosome occur during evolution owing to its specific gene structure. The consequences of such rearrangements are not only loss but also gain of specific genes. One hundred and fifty three haplotypes have been discovered in the human Y chromosome. The structure of the Y chromosome in the GenBank belongs to haplotype R1. There are 220 genes (104 coding genes, 111 pseudogenes, and 5 other uncategorized genes) according to the most recent count. The 104 coding genes encode a total of about 48 proteins/protein families (including putative proteins/protein families). Among them, 16 gene products have been discovered in the azoospermia factor region (AZF) and are related to spermatogenesis. It has been dis-covered that one subset of gene rearrangements on the Y chromosome, 'micro-deletions', is a major cause of male infertility in some populations. However, controversies exist about different Y chromosome haplotypes. Six AZFs of the Y chromosome have been discov-ered including AZFa, AZFb, AZFc, and their combinations AZFbc, AZFabc, and partial AZFc called AZFc/gr/gr. Different deletions in AZF lead to different content spermatogenesis loss from teratozoospermia to infertility in different populations depending on their Y hap-lotypes. This article describes the structure of the human Y chromosome and investigates the causes of micro-deletions and their relation-ship with male infertility from the view of chromosome evolution. After analysis of the relationship between AZFc and male infertility, we concluded that spermatogenesis is controlled by a network of genes, which may locate on the Y chromosome, the autochromosomes, or even on the X chromosome. Further investigation of the molecular mechanisms underlying male fertility/infertility will facilitate our knowledge of functional genomics. | Zheng Li Christopher J Haines Yibing Han | 2008 | Journal of Genetics and Genomics2008，35，4： | 25 |
| 3 | miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A显示文摘增加的证据建议 hsa-miR-126 (miR-126 ) 在房间衬里的非小的房间肺癌症(NSCLC ) 是下面调整的, miR-126 的恢复由指向特定的分子损害肿瘤房间增长,移植,侵略,和幸存。这里,我们第一次报导 miR-126 涉及调整 NSCLC 房间的反应到癌症化疗。在有 miR-126 的房间模仿的 transfected A549 或禁止者以后,我们发现 miR-126 的提高的水平显著地与减少的一半被联系 adriamycin ( ADM )和长春新碱的最大的禁止的集中, ADM 的增加的累积,脉管的 endothelial 生长因素 A ( VEGFA )和 multidrug 的下面规定联系抵抗的蛋白质 1 ( MRP1 ),并且 Akt 的 inactivation 发信号的小径。而且,提高了 miR-126 的表示压制了 A549 异种皮移植的生长并且禁止了 VEGFA 和 MRP1 的表示。miR-126 能高效地通过和 VEGFA 3-untranslated 区域的相互作用的下面调整 VEGFA 表示,而 VEGFA 的恢复能部分由 miR-126 稀释 MRP1 的抑制。然而, LY294002,表明小径的 PI3K/Akt 的一个禁止者,减少这效果,建议 miR-126 的那提高的表情通过发信号的 VEGF/PI3K/Akt/MRP1 的否定规定增加了 NSCLC 房间的敏感到 anticancer 代理人小径。 | Xiaolan Zhu Hao Li Lulu Long Lulu Hui Haining Chen Xuefeng Wang Huiling Shen Wenlin Xu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，6： | 23 |
| 4 | Enhanced removal of ethylbenzene from gas streams in biotrickling filters by Tween-20 and Zn(Ⅱ)显示文摘The effects of Tween-20 and Zn(II)on ethylbenzene removal were evaluated using two biotrickling filters(BTFs),BTF1 and BTF2.Only BTF1 was fed with Tween-20 and Zn(II).Results show that ethylbenzene removal decreased from 94%to 69%for BTF1 and from 74%to 54%for BTF2 with increased organic loading from 64.8 to 189.0 g ethylbenzene/(m3·hr)at EBRT of 40 sec.The effect of EBRT(60–15 sec)at a constant ethylbenzene inlet concentration was more significant than that of EBRT(30–10 sec)at a constant organic loading.Biomass accumulation rate within packing media was reduced significantly. | Lu Wang Chunping Yang Yan Cheng Jian Huang Haining Yang Guangming Zeng Li Lu Shanying He | 2014 | Journal of Environmental Sciences2014，26，12： | 8 |
| 5 | An efficient bifunctional electrocatalyst derived from layer-by-layer self-assembly of a three-dimensional porous Co-N-C@graphene显示文摘Three-dimensional (3D) porous carbon-based materials with tunable composition and microstructure are of great interest for the development of oxygen involved electrocatalytic reactions. Here, we report the synthesis of 3D porous carbon-based electrocatalyst by self-assembling Co-metal organic frameworks (MOF) building blocks on graphene via a layer-by-layer technique. Precise control of the structure and morphology is achieved by varying the MOF layer to tune the electrocatalytic properties. The as-produced electrocatalyst exhibits an excellent catalytic activity for the oxygen reduction reaction in 0.1molL^-1 KOH, showing a high onset potential of 0.963V vs. reversible hydrogen electrode (RHE) and a low tafel slope of 54mVdec^-1, compared to Pt/C (0.934V and 52mVdec^-1, respectively). Additionally, it shows a slightly lower potential vs. RHE (1.72V) than RuO2 (1.75V) at 10mAcm^-2 in an alkaline electrolyte. A rechargeable Zn-air battery based on the as-produced 3D porous catalyst demonstrates a high peak power density of 119mWcm^-2 at a cell voltage of 0.578V while retaining an excellent stability over 250 charge-discharge cycles. | Shichang Cai Rui Wang William M. Yourey Junsheng Li Haining Zhang Haolin Tang | 2019 | Science Bulletin2019，64，14： | 6 |
| 6 | A Plant Immune Receptor Adopts a Two-Step Recognition Mechanism to Enhance Viral Effector Perception显示文摘Plant intracellular nucleotide binding leucine-rich repeat (NLR) immune receptors play critical roles in pathoge n surveillance. Most plant NLRs characterized so far were found to use a single domain/sensor to recognize pathogen effectors. Here we report that the Sw-5b NLR immune receptor uses two distinct domains to detect the viral movement protein NSm encoded by tospovirus. In addition to its leucine-rich repeat (LRR) domain that has been previously reported, the N-terminal Solanaceae domain (SD) of Sw- 5b also interacts with NSm and a conserved 21-amino-acid region of NSm (NSm^21). The specific interaction between Sw-5b SD and NSm is required for releasing the inhibitory effect of coiled-coil domain on the NBARC- LRR region. Furthermore, we found that the binding of NSm affects the nucleotide binding activity of the NB-ARC-LRR in vitro, while Sw-5b NB-ARC-LRR is activated only when NSm and NSm^21 levels are high. Interestingly, Sw-5b SD could significantly enhanee the ability of the NB-ARC-LRR to detect low levels of NSm effector and facilitate its activation and induction of defense response. An Sw-5b SD mutant that is disrupted in NSm recognition failed to enhance the ability of the NB-ARC-LRR to sense low levels of NSm and NSm^21 . Taken together, our results suggest that Sw-5b SD functions as an extra sensor and the NB-ARC-LRR as an activator, and that Sw-5b NLR adopts a two-step recog nition mechanism to enhance viral effector perception. | Jia Li Haining Huang Min Zhu Shen Huang Wenhua Zhang Savithramma P. Dinesh-Kumar Xiaorong Tao | 2019 | Molecular Plant2019，12，2： | 6 |
| 7 | Towed line array sonar platform noise suppression based on spatial matrix filtering technology显示文摘The spatial matrix filter was designed and used for solving the problem to detect a weak target who was influenced by the strong nearby platform noise interference of the towed Une array sonar.The MFP technology and the DOA estimation technology were combined together by using the sound propagation characteristics of both target and interference.The spatial matrix filter with platform noise zero response constraint was designed by the near-field platform noise normal modes copy vectors and the far-field plane wave bearing vectors together.The optimal solution of the optimization problem for designing the spatial matrix filter was deduced directly,and it was simplified by the generalized singular value decomposition.The total response error to the plane wave bearing vectors and the total response to the platform noise copy vectors were given.The phenomena that strong interferences existed in the bearing course and blind areas existed after filtering were analyzed by the correlation between the platform noise copy vectors and the plane wave bearing vectors.It could be found from simulations that it has less blind area and higher detection ability by using the spatial matrix filtering technology. | HAN Dong LI Jian KANG Chunyu HUANG Haining LI Qihu | 2013 | Chinese Journal of Acoustics2013，32，4： | 5 |
| 8 | Dieldrin and endrin removal from water by trioleinembedded adsorbent显示文摘A novel triolein-embedded adsorbent for re-moval of persistent organic pollutants (POPs) from water was developed. In this paper, taking dieldrin and endrin as the target pollutants, different factors (temperature, ion strength, pH, and concentration of humic acid) that affect the adsorption rate were investigated. Adsorption isotherms of these two pollutants fitted to Freundlich model well identi-fied the partition mechanism between the adsorbent and water. However, the equilibrium constant of dieldrin was larger than that of endrin due to larger octanol-water coeffi-cient of dieldrin. Adsorption rate of dieldrin increased with the increase of temperature, the decrease of ion strength, pH and concentration of humic acid, whereas adsorption rate of endrin decreased with the increase of temperature and pH. Humic acid firstly increased, and then decreased the adsorp-tion rate of endrin. Ion strength hardly affected the adsorp-tion rate of endrin. | HUO Jinxian LIU Huijuan QU Jiuhui RU Jia LIU Haining LI Guoting | 2005 | Chinese Science Bulletin2005，50，23： | 5 |
| 9 | Multipath structure of the typical under-ice sound channel in the Arctic:theory and experiment显示文摘Considering the typical acoustic environment of the Arctic, this paper proposes a method based on OASES-Bellhop coupled model to rapidly analyze the multipath structure of the under-ice sound channel. Firstly the proposed model refers to ice plate as stratified elastic media with some roughness. Secondly,it uses the perturbation method and Kirchhoff approximation theory to solve the scattering loss due to the sea ice inhomogeneity. Finally, the model predicts the multipath structure of the under-ice channel through Ray theory. The results of the numerical simulation and experiment indicate that the typical Arctic sound channel presents multipath structures due to the sea ice and seabed in the range of 6 km, respectively.The sea ice reflection paths are stable,with a short multipath spread within 14 ms. The seabed reflection paths have relatively weak strength. The proposed OASES-Bellhop coupled model successfully predicts the amplitude and delay of the multipath structure with small error,which indicates the proposed model is able to analyze and predict the multipath structure of the observed acoustic environment in experiment. | LIU Chonglei HUANG Haining YIN Li LIU Na WEI Chonghua LI Qihu | 2019 | Chinese Journal of Acoustics2019，38，1： | 3 |
| 10 | Effect of Adsorption of ZrO2 in Catalysts on the Efficiency of Hydrolysis of Cellulose to Sugar in Aqueous System under Microwave Radiation显示文摘Summary of main observation and conclusion Five types of ZrO2 are used to simply establish an effective aqueous catalytic system with sulfuric acid for the hydrolysis of cellulose to sugar,respectively.By adjusting surface roughness and particle size of ZrO2 dfferent adsorption is produced.Accordingy,following the thought to inhibit the self-aggregation nature of cellulose,after the introduction of ZrO2 with adsorption in catalysts,the efficiency of the hydrolysis of cellulose to sugar is improved.The results show different ZrO2 can produce different effects during the hydrolysis of the cellulose with rela-tively low crystallinity.Under the optimal conditions,the conversion of cellulose and TRS yield reaches 95.5%and 93.6%,respectively.Through this re-search,it reveals the critical point to organize a feasible and useful way for the hydrolysis of cellulose to sugar with high efficiency in an aqueous system.An important theoretical and technical support is also provided for the conversion and utiliation of cellulose in the future. | Ying Qiao Lixin Feng Zhongqiu Li Zhenyu Zhang Jing Chen Haining Na Jin Zhu Lai Chen | 2020 | Chinese Journal of Chemistry2020，38，4： | 3 |
| 11 | Research on beamforming method for dual-line array with space mismatch between the two line arrays显示文摘当在双线的数组的二个线数组之间的空格是延期和的 mismatched.The 择向性功能,延期减去 beamforming 被推出,延期和和延期减去 beamforming 的港口/右舷辨别也在理想的地位下面两个都被学习时,双线的数组的港口/右舷辨别的性能将严重被降级并且在双线的数组的二个线数组之间的空格在下面被错配的地位。分析结果证明延期减去 beamforming 有港口 / 右舷辨别的更好的性能。最后,海试用结果表明理论结果。 | WANG Huakui LI Qihu HUANG Haining YE Qinghua LI Shuqiu ZHANG Chunhua | 2008 | Chinese Journal of Acoustics2008，27，1： | 2 |
| 12 | Prison Term Prediction on Criminal Case Description with Deep Learning显示文摘The task of prison term prediction is to predict the term of penalty based on textual fact description for a certain type of criminal case.Recent advances in deep learning frameworks inspire us to propose a two-step method to address this problem.To obtain a better understanding and more specific representation of the legal texts,we summarize a judgment model according to relevant law articles and then apply it in the extraction of case feature from judgment documents.By formalizing prison term prediction as a regression problem,we adopt the linear regression model and the neural network model to train the prison term predictor.In experiments,we construct a real-world dataset of theft case judgment documents.Experimental results demonstrate that our method can effectively extract judgment-specific case features from textual fact descriptions.The best performance of the proposed predictor is obtained with a mean absolute error of 3.2087 months,and the accuracy of 72.54%and 90.01%at the error upper bounds of three and six months,respectively. | Shang Li Hongli Zhang Lin Ye Shen Su Xiaoding Guo Haining Yu Binxing Fang | 2020 | Computers, Materials & Continua2020，，3： | 2 |
| 13 | Effect of electroacupuncture at Ximen(PC 4) and Hegu(LI 4) on expression of Akt in rats with myocardial ischemia-reperfusion injury显示文摘OBJECTIVE: To investigate the effect of electroacupuncture(EA) at acupoints on the pericardium meridian on the expression of phosphorylated Akt(p-Akt) protein in rat myocardium after ischemia and reperfusion.METHODS: Seventy Wistar rats were evenly randomized into seven groups: the sham operation group(group A), ischemia-reperfusion model Ⅰgroup(group B), ischemia-reperfusion model Ⅱgroup(group C), EA at Neiguan(PC 6) group(group D), EA at Ximen(PC 4) group(group E), EA at Hegu(LI 4) group(group F), and LY294002 + EA at Neiguan(PC 6) group(group G). All processes were monitored by electrocardiography. In group A, the left anterior descending coronary artery was only threaded without ligation for 100 min. In group B,the left anterior descending coronary artery was ligated for 40 min and reperfused for 60 min. The left anterior descending coronary artery in group C was ligated for 40 min and reperfused for 100 min.Groups D, E, and F received EA for 20 min before undergoing ischemia for 40 min, and then received EA for 20 min before undergoing reperfusion for 60 min. Before modeling, group G was injected with LY294002(0.3 mg/kg) into the tail vein, and then underwent the same intervention as the other EA groups. After reperfusion, myocardial tissue from the left cardiac ventricle was collected to enable Western blot analysis of the p-Akt level, and analysis of electrocardiographic changes.RESULTS: In groups B and C, electrocardiography showed obvious elevation of the ST-segment Ⅱlead(ECG-STⅡ), while the ECG-STⅡvalues were significantly lower in groups D, E, and G(P < 0.01). The p-Akt levels in groups D and E were significantly greater than those in groups B and C(P < 0.01).Compared with all other groups, group G showed a significantly different expression of p-Akt(P < 0.01).CONCLUSION: The expression of p-Akt protein in cardiomyocytes was significantly greater in rats that were injected with LY294002 and received EA at Ximen(PC 4) compared with all other groups.This suggests that EA at Ximen(PC 4) resulted in activation of the phosphoinositide 3-kinase/Akt signaling pathway and phosphorylation of Akt. | Tian Yuefeng Gao Haining Li Leiyong Wang Jun Zhai Chuntao | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 2 |
| 14 | Treadmill Exercise Relieves Chronic Restraint Stress-induced Cognitive Impairments in Mice Via Activating Protein Phosphatase 2A显示文摘Dear Editor,Aerobic exercise is well known to improve cognitive functions including hippocampus-dependent spatial memory[1]and object recognition[2].Regarding the molecular mechanisms,the indispensable role of brain-derived neurotrophic factor(BDNF)in governing exercise-induced neural plasticity has been demonstrated for the improvement of learning and memory[3].Our recent study further demonstrated the activation of mechanistic target of rapamycin pathways downstream of BDNF to drive synaptic protein synthesis upon persistent exercise[4],but leaving the effect of exercise on the post-translational modification of proteins largely unknown. | Wenjing Zhang Haining Ou Borui Zhang Meifeng Zheng Lan Yan Yang Chen Kwok-Fai So Li Zhang | 2021 | Neuroscience Bulletin2021，37，10： | 2 |
| 15 | Transarterial chemoembolization in combination with programmed death-1/programmed cell death-ligand 1 immunotherapy for hepatocellular显示文摘Hepatocellular carcinoma(HCC)is one of the most common malignancies worldwide.With the development of systemic therapies,several studies are currently underway,especially those related to the use of programmed death-1/programmed cell death-ligand 1(PD-1/PD-L1)immunotherapy.Moreover,studies on transarterial che-moembolization(TACE)and PD-1/PD-L1 immunotherapy have demonstrated some interesting outcomes.This article reviewed the current clinical evidence on the combination of TACE and PD-1/PD-L1 immunotherapy.Overall,our review summarized that a favorable survival time could be achieved using this combination in most patients.However,complications such as hyperprogression should be taken seriously,and the underlying mechanisms need to be explored. | Jingxin Yan Manjun Deng Shunyu Kong Ting Li Zhenwu Lei Lushun Zhang Yutong Zhuang Xin He Huanwei Wang Haining Fan Yingxing Guo | 2022 | iLIVER2022，1，4： | 2 |
| 16 | A Preliminary Study on the Datong Fault Belt显示文摘The Datong fault belt is a NE trending fault in the northern Qinghai-Xizang (Tibet) Plateau and controls the boundary of the Xining Basin and Datong Basin. It consists of the Maziying-Miaogou (F_1) fault and the Laoye Mountain-Nanmenxia fault (F_2). There is obvious displacement in vertical direction along the belt. The field investigation results show that this belt has long-term activity. There are several meters long crushed zones and veins along the fault side in the basement rock. On the fault section,the Cambria system thrusts over the red-brick-colored Quaternary Period gravel,and there is a fault gouge of several centimeters thick developed on the fault plane. The fault gouge date (ESR) on the fault plane is 610±61ka. The covering deluvial loess is not dislocated,and the OSL result is 14.6±1.5ka. So it can be concluded that the fault belt was active in the middle Pleistocene,but inactive in the late Pleistocene according to the age data and geomorphologic features. Interior formations of the Datong basin features fold with the major axis orienting northwest. According to the relation of fault and fold deformation,Datong fault is a transversal tear,which is due to uneven compression of the folds in different parts and NNE trending regional compressive stress. It is common among the NE trending faults in the northeast of Qinghai-Xizang (Tibet) Plateau. These NE trending faults aren't large,and most are located in the active plate. They are all nearly vertical to the axis of the folds and compressive basins. | Li Zhimin Tian Qinjian Yao Shenghai Li Wenqiao Chen Youshun Zou Haining Gao Zhanwu | 2008 | Earthquake Research in China2008，22，3： | 2 |
| 17 | Retrospective case review of pediatric patients with uveitis treated with inflix- iraab 显示文摘 | Rajaraman RT Kimura Y Li S Haines K Chu DS | 2006 | Ophthalmology2006，113，2： | 1 |
| 18 | Degradation of azo dye Acid Orange 7 in water by Fe^0/granular activated carbon system in the presence of ultrasound 显示文摘 | Haining Liu Guoting Li Jiuhui Qu | 2007 | Journal of Hazardous Materials2007，144，12： | 1 |
| 19 | A study on object tracking quality under probabilistic coverage in sensor networks显示文摘 | Ren Shansi Li Qun Wang Haining | 2005 | ACM Mobile Computing and Communication Review2005，9，1： | 1 |
| 20 | Survivin, a key component of the Wnt/β?catenin signaling pathway, contributesto traumatic brain injury-induced adult neurogenesis in the mouse dentate gyrus显示文摘 | Lin Zhang Rong Yan Qi Zhang Haining Wang Xiaokui Kang Jia Li Shuyuan Yang Jianning Zhang Zhenlin Liu Xinyu Yang | 2013 | International Journal of Molecular Medicine2013，，4： | 1 |
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