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| 1 | Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo显示文摘Tumor cell proliferation, infiltration, migration, and neovascularization are known causes of treatment resistance in glioblastoma multiforme(GBM). The purpose of this study was to determine the effect of radiation on the growth characteristics of primary human GBM developed in a nude rat. Primary GBM cells grown from explanted GBM tissues were implanted orthotopically in nude rats. Tumor growth was confirmed by magnetic resonance imaging on day 77(baseline) after implantation. The rats underwent irradiation to a dose of 50 Gy delivered subcuratively on day 84 postimplantation(n = 8), or underwent no radiation(n = 8). Brain tissues were obtained on day 112(nonirradiated) or day 133(irradiated). Immunohistochemistry was performed to determine tumor cell proliferation(Ki-67) and to assess the expression of infiltration marker(matrix metalloproteinase-2, MMP-2) and cell migration marker(CD44). Tumor neovascularization was assessed by microvessel density using von-Willebrand factor(vWF) staining. Magnetic resonance imaging showed well-developed, infiltrative tumors in 11 weeks postimplantation. The proportion of Ki-67-positive cells in tumors undergoing radiation was(71 ± 15)% compared with(25 ± 12)% in the nonirradiated group(P = 0.02). The number of MMP-2-positive areas and proportion of CD44-positive cells were also high in tumors receiving radiation, indicating great invasion and infiltration. Microvessel density analysis did not show a significant difference between nonirradiated and irradiated tumors. Taken together, we found that subcurative radiation significantly increased proliferation, invasion, and migration of primary GBM. Our study provides insights into possible mechanisms of treatment resistance following radiation therapy for GBM. | Adarsh Shankar Sanath Kumar Asm Iskander Nadimpalli RS Varma Branislava Janic Ana deCarvalho Tom Mikkelsen Joseph A Frank Meser M Ali Robert A Knight Stephen Brown Ali S Arbab | 2014 | Chinese Journal of Cancer2014，33，3： | 5 |
| 2 | Environmental magnetism: Principles and applications显示文摘 | Liu Qingsong Roberts Andrew P Larrasoa?a Juan C Banerjee Subir K Guyodo Yohan Tauxe Lisa Oldfield Frank | 2012 | EN2012，，4： | 3 |
| 3 | Human enamel thickness and ENAM polymorphism显示文摘The tooth enamel development gene, enamelin(ENAM), showed evidence of positive selection during a genome-wide scan of human and primate DNA for signs of adaptive evolution. The current study examined the hypothesis that a single-nucleotide polymorphism(SNP) C14625T(rs7671281) in the ENAM gene identified in the genome-wide scan is associated with a change in enamel phenotype. African Americans were selected as the target population, as they have been reported to have a target SNP frequency of approximately 50%, whereas non-Africans are predicted to have a 96% SNP frequency. Digital radiographs and DNA samples from 244 teeth in 133 subjects were analysed, and enamel thickness was assessed in relation to SNP status,controlling for age, sex, tooth number and crown length. Crown length was found to increase with molar number, and females were found to have thicker enamel. Teeth with larger crowns also had thicker enamel, and older subjects had thinner enamel.Linear regression and generalized estimating equations were used to investigate the relationship between enamel thickness of the mandibular molars and ENAM SNP status; enamel in subjects with the derived allele was significantly thinner(P = 0.040)when the results were controlled for sex, age, tooth number and crown length. The derived allele demonstrated a recessive effect on the phenotype. The data indicate that thinner dental enamel is associated with the derived ENAM genotype. This is the first direct evidence of a dental gene implicated in human adaptive evolution as having a phenotypic effect on an oral structure. | Diane M Daubert Joanna L Kelley Yuriy G Udod Carolina Habor Chris G Kleist Ilona K Furman Igor N Tikonov Willie J Swanson Frank A Roberts | 2016 | International Journal of Oral Science2016，8，2： | 2 |
| 4 | Progsterone receptors in bilateral ovarian ependymoma presennting in pregnaacy显示文摘 | Carr K A Roberts J A Frank T S | 1992 | Human Pathol1992，23，： | 1 |
| 5 | On the stabil- ity properties of quadruped creeping gaits显示文摘 | MeGhee Robert B Frank Andrew A | 1968 | Math- ematical Biosciences1968，3，： | 1 |
| 6 | A Dimensionless Model for Predicting the Mass - transfer Area of Structured Packing 显示文摘 | Robert E Tsai A Frank Seibert R Bruce Eldridge | 2011 | Aiche Journal2011，57，5： | 1 |
| 7 | Microcalofimetry of the adsorption of lysozyme onto polymeric substrates显示文摘 | LEE Valerie A CRAIG Robert G FILISHO Frank E | 2005 | Journal of Colloid and Interface Science2005，288，： | 1 |
| 8 | Hierarchical Multi pie Endmember Speetral Mixture Analysis (MESMA) of Hy- perspectral Imagery for Urban Environments 显示文摘 | Franke J Roberts D A Halligan K | 2009 | Remote Sensing of Environment2009，113，8： | 1 |
| 9 | Progesterone receptors in bilat-eral ovarian ependymoma presenting in pregnancy 显示文摘 | Carr K A Roberts J A Frank T S | 1992 | HumPathol1992，23，8： | 1 |
| 10 | Systematic Review: Repair of Unruptured Abdominal Aortic Aneurysm 显示文摘 | Frank A Lederle MD Robert L Kane MD | 2007 | Ann Inter Med2007，146，10： | 1 |
| 11 | Influ- ence of' viscosity and surface tension on the effective mass transfer area of structured packing 显示文摘 | ROBERT E T FRANK A S BRUCE R E | 2009 | Energy Procedia2009，，1： | 1 |
| 12 | Hierarchi-cal Multiple Endmembers Spectral Mixture Analysis(MESMA)of Hyperspectral Imagery for Urban En-vironments显示文摘 | Franke J Roberts D A Halligan K | 2009 | Remote Sensing of Environment2009，113，1： | 1 |
| 13 | Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis显示文摘 | Baldwin S L D'Souza C Roberts A D Kelly B P Frank A A Lui M A | 1998 | Infect Immun1998，66，： | 1 |
| 14 | Soy protein concentrate lowers serum high-density lipoprotein cholesterol concentrations compared with casein in ovariectomized rats fed a low-fat cholesterolfree diet 显示文摘 | Thomas A Robert J Frank O | 2007 | Nutr Res2007，27，： | 1 |
| 15 | Hierarchical multiple endmember spectral mixture analysis (MESMA) of hyperspectral imagery for urban environments显示文摘 | Franke J Roberts D A Halligan K | 2009 | Remote Sensing of Environment2009，113，8： | 1 |
| 16 | Malignant glioma:genetics and biology of a grave matter显示文摘 | Elizabeth A Maher Frank B Furnari Robert M Bachoo | 2001 | Genes Dev2001，15，11： | 1 |
| 17 | Clinical and Phar- macologic Review of Skeletal Muscle Relaxants for Musculo- skeletal Conditions显示文摘 | FRANK A B ROBERT LB STACIEBA | 2005 | Ame Jour Therap2005，，12： | 1 |
| 18 | Lack of protection in mice and necrotizing bronchointerstitial pneumonia bron-chiolitis in sninea pigs immunized with vaccines directed against the HSP65 molecular of Mycobacterium tuberculosis显示文摘 | Turner O C Roberts A D Frank A A | 2000 | Infect Immun2000，68，6： | 1 |
| 19 | Francis Insulin-like Growth Factor (IGF)-Ⅰ but Not IGF-Ⅱ Promotes Lean Growth and Feed Efficiency in Broiler Chickens显示文摘 | Frank M Tomas Robert A Pym John P | 1998 | General and Comparative Endocrinology1998，，： | 1 |
| 20 | Lack of protection in mice and necrotizing bronchointerstitial pneumonia with bronchiolitis in guinea pigs immumized with vaccines directed against the hsp60 molecule of Mycobacterium tuberculosis显示文摘 | Turner O C Roberts A D Frank A A | 2000 | Infect Immunol2000，68，6： | 1 |
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