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| 1 | Benefit of combination β-blocker and endoscopic treatment to prevent variceal rebleeding: A meta-analysis显示文摘AIM: To determine whether the association of β-blockers with endoscopic treatment is superior to endoscopic treatment alone for the secondary prophylaxis of oesophageal variceal bleeding. METHODS: Randomised controlled trials comparing sclerotherapy (SCL) with SCL plus β-blockers (BB) or banding ligation (BL) with BL plus BB were identif ied.Main outcomes were overall and 6, 12 and 24 mo rebleeding rates, as well as overall and 6, 12 and 24 mo mortality. Two statistical methods were used: Yusuf-Peto, and Der Simonian and Laird. Inter-trial heterogeneity was systematically taken into account. RESULTS: Seventeen randomised controlled trials were included, 14 with SCL and 3 with BL. Combination β-blocker and endoscopic treatment signif icantly reduced rebleeding rates at 6, 12 and 24 mo and overall [odds ratio (OR): 2.20, 95% conf idence interval (CI): 1.69-2.85, P<0.0001] compared to endoscopic treatment alone. Mortality at 24 mo was signif icantly lower for the combined treatment group (OR: 1.83, 95% CI:1.16-2.90, P= 0.009), as well as overall mortality (OR: 1.43, 95% CI:1.03-1.98, P= 0.03). CONCLUSION: Combination therapy should thus be recommended as the fi rst line treatment for secondary prophylaxis of oesophageal variceal bleeding. | Natalie Funakoshi Frédérique Ségalas-Largey Yohan Duny Frédéric Oberti Jean-Christophe Valats Michael Bismuth Jean-Pierre Daurès Pierre Blanc | 2010 | World Journal of Gastroenterology2010，16，47： | 24 |
| 2 | 高粱(Sorghum bicolor)分子图谱的构建及寄生草(Striga asiatica)萌发诱导物基因的定位显示文摘高粱是世界上第五大主要粮食作物,也是非洲国家的主要粮食来源之一,Striga asiatica是一种寄生于高粱等主要农作物的野生草之一。选用两个对寄生草抗性表现差异的 高粱品系“山桂红”和“SRN39”作亲本,构建了一个重组近交系群体(Recombinant inbred, RI),并随机筛选出94个系用于构建分子连锁图谱和基因定位。在应用的286个多态性标记 中,有251个标记分别标定在10条不同的连锁群上,标记间的平均图距为7.1cm,总图谱覆盖 了高粱基因组的1779cm,是目前国际上几个比较完整的高粱分子连锁图谱之一。群体的共 分离分析表明,与寄生草抗性有关的萌发诱导物基因(Germinination stimulant gene-GermStim) 位于高粱的遗传连锁群J上,相距较近的分子标记为13cm。进一步的精细定位分析,发现有 两个分子标记分别位于基因的两侧,距离为1.6和2.1个cm。 | 徐吉臣 Yohan M. Weerasuriya Jeffery L. Bennetzen | 2001 | Acta Genetica Sinica2001，28，9： | 13 |
| 3 | Endometrial response to conceptus-derived estrogen and interleukin-1β at the time of implantation in pigs显示文摘The establishment of pregnancy is a complex process that requires a well-coordinated interaction between the implanting conceptus and the maternal uterus. In pigs, the conceptus undergoes dramatic morphological and functional changes at the time of implantation and introduces various factors, including estrogens and cytokines,interleukin-1β2(IL1 B2), interferon-γ(IFNG), and IFN-δ(IFND), into the uterine lumen. In response to ovarian steroid hormones and conceptus-derived factors, the uterine endometrium becomes receptive to the implanting conceptus by changing its expression of cell adhesion molecules, secretory activity, and immune response. Conceptus-derived estrogens act as a signal for maternal recognition of pregnancy by changing the direction of prostaglandin(PG) F2αfrom the uterine vasculature to the uterine lumen. Estrogens also induce the expression of many endometrial genes,including genes related to growth factors, the synthesis and transport of PGs, and immunity. IL1 B2, a pro-inflammatory cytokine, is produced by the elongating conceptus. The direct effect of IL1 B2 on endometrial function is not fully understood. IL1 B activates the expression of endometrial genes, including the genes involved in IL1 B signaling and PG synthesis and transport. In addition, estrogen or IL1 B stimulates endometrial expression of IFN signaling molecules,suggesting that estrogen and IL1 B act cooperatively in priming the endometrial function of conceptus-produced IFNG and IFND that, in turn, modulate endometrial immune response during early pregnancy. This review addresses information about maternal-conceptus interactions with respect to endometrial gene expression in response to conceptus-derived factors, focusing on the roles of estrogen and IL1 B during early pregnancy in pigs. | Hakhyun Ka Heewon Seo Yohan Choi Inkyu Yoo Jisoo Han | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 5 |
| 4 | Fabrication of sharp silicon hollow microneedles by deep-reactive ion etching towards minimally invasive diagnostics显示文摘Microneedle technologies have the potential for expanding the capabilities of wearable health monitoring from physiology to biochemistry.This paper presents the fabrication of silicon hollow microneedles by a deep-reactive ion etching(DRIE)process,with the aim of exploring the feasibility of microneedle-based in-vivo monitoring of biomarkers in skin fluid.Such devices shall have the ability to allow the sensing elements to be integrated either within the needle borehole or on the backside of the device,relying on capillary filling of the borehole with dermal interstitial fluid(ISF)for transporting clinically relevant biomarkers to the sensor sites.The modified DRIE process was utilized for the anisotropic etching of circular holes with diameters as small as 30μm to a depth of>300μm by enhancing ion bombardment to efficiently remove the fluorocarbon passivation polymer.Afterward,isotropic wet and/or dry etching was utilized to sharpen the needle due to faster etching at the pillar top,achieving tip radii as small as 5μm.Such sharp microneedles have been demonstrated to be sufficiently robust to penetrate porcine skin without needing any aids such as an impact-insertion applicator,with the needles remaining mechanically intact after repetitive penetrations.The capillary filling of DRIE-etched through-wafer holes with water has also been demonstrated,showing the feasibility of use to transport the analyte to the target sites. | Yan Li Hang Zhang Ruifeng Yang Yohan Laffitte Ulises Schmill Wenhan Hu Moufeed Kaddoura Eric J.M.Blondeel Bo Cui | 2019 | Microsystems & Nanoengineering2019，5，1： | 4 |
| 5 | Elucidating the Uptake and Distribution of Nanoparticles in Solid Tumors via a Multilayered Cell Culture Model显示文摘Multicellular layers(MCLs) have previously been used to determine the pharmacokinetics of a variety of different cancer drugs including paclitaxel, doxorubicin, methotrexate, and 5-fluorouracil across a number of cell lines. It is not known how nanoparticles(NPs) navigate through the tumor microenvironment once they leave the tumor blood vessel.In this study, we used the MCL model to study the uptake and penetration dynamics of NPs. Gold nanoparticles(GNPs)were used as a model system to map the NP distribution within tissue-like structures. Our results show that NP uptake and transport are dependent on the tumor cell type. MDA-MB-231 tissue showed deeper penetration of GNPs as compared to MCF-7 one. Intracellular and extracellular distributions of NPs were mapped using Cyto Viva imaging. The ability of MCLs to mimic tumor tissue characteristics makes them a useful tool in assessing the efficacy of particle distribution in solid tumors. | Darren Yohan Charmainne Cruje Xiaofeng Lu Devika Chithrani | 2015 | Nano-Micro Letters2015，7，2： | 3 |
| 6 | Concurrent infections of dengue viruses serotype 2 and 3 in patient with severe dengue from Jakarta, Indonesia显示文摘Objective: To describe the clinical manifestation of patient with severe dengue, to identify the serotypes and genotypes of dengue viruses(DENV) which concurrently infecting the patient, and to explore the possible relationship of severe dengue with the concurrent infection of DENV. Methods: Dengue diagnosis was performed using NS1 antigen detection and Ig G/Ig M ELISA. Standard clinical and laboratory examinations were performed to obtain the clinical and hematological data. DENV concurrent infections were detected and confirmed using RT-PCR and DENV Envelope gene sequencing. Phylogenetic analyses were performed to determine the genotypes of the viruses. Results: The patient was classified as having severe dengue characterized by severe plasma leakage, hemorrhage, and organ damage involving lung, liver, and kidney. Concurrent infection of DENV serotype 2 and 3 was observed. The infecting DENV-2 virus was grouped into Cosmopolitan genotype while DENV-3 virus was classified into Genotype Ⅰ. Both viruses were closely related to isolates that were endemic in Jakarta. Viremia measurement was conducted and revealed a significantly higher virus titer of DENV-3 compared to DENV-2. Conclusions: The occurrence of multi-serotype DENV infections was presented in a patient with severe clinical manifestation in Indonesia. The hyperendemicity of dengue in Indonesia may contribute to the DENV concurrent infections cases and may underlie the severity of the disease. | Soroy Lardo Yaldiera Utami Benediktus Yohan Seri MMU Tarigan Widayat Djoko Santoso Leonard Nainggolan R Tedjo Sasmono | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，2： | 3 |
| 7 | Environmental magnetism: Principles and applications显示文摘 | Liu Qingsong Roberts Andrew P Larrasoa?a Juan C Banerjee Subir K Guyodo Yohan Tauxe Lisa Oldfield Frank | 2012 | EN2012，，4： | 3 |
| 8 | Size-Dependent Gold Nanoparticle Interaction at Nano–Micro Interface Using Both Monolayer and Multilayer(Tissue-Like) Cell Models显示文摘Gold nanoparticles(GNPs) are emerging as a novel tool to improve existing cancer therapeutics. GNPs are being used as radiation dose enhancers in radiation therapy as well as anticancer drugs carriers in chemotherapy. However,the success of GNP-based therapeutics depends on their ability to penetrate tumor tissue. GNPs of 20 and 50 nm diameters were used to elucidate the effects of size on the GNP interaction with tumor cells at monolayer and multilayer level. At monolayer cell level, smaller NPs had a lower uptake compared to larger NPs at monolayer cell level. However, the order was reversed at tissue-like multilayer level. The smaller NPs penetrated better compared to larger NPs in tissue-like materials.Based on our study using tissue-like materials, we can predict that the smaller NPs are better for future therapeutics due to their greater penetration in tumor tissue once leaving the leaky blood vessels. In this study, tissue-like multilayer cellular structures(MLCs) were grown to model the post-vascular tumor environment. The MLCs exhibited a much more extensive extracellular matrix than monolayer cell cultures. The MLC model can be used to optimize the nano–micro interface at tissue level before moving into animal models. This would accelerate the use of NPs in future cancer therapeutics. | Darren Yohan Charmainne Cruje Xiaofeng Lu Devika B.Chithrani | 2016 | Nano-Micro Letters2016，8，1： | 2 |
| 9 | Clinical Relevance of Coronary Fractional Flow Reserve: Art-of-state显示文摘 | Yohanes Adiputra Shao-Liang Chen | 2015 | Chinese Medical Journal2015，，10： | 2 |
| 10 | Vitamin D Treatment and Mortality in Chronic Kidney Disease: A Systematic Review and Meta-Analysis显示文摘 | Duranton Flore Rodriguez-ortiz Maria E Duny Yohan Rodriguez Mariano Daur?s Jean-pierre Argil?s Angel | 2013 | American Journal of Nephrology2013，，3： | 2 |
| 11 | Applications for T-cell epitope queries and tools in the Immune Epitope Database and Analysis Resource显示文摘 | Yohan K Alessandro S Peters B | 2011 | Journal of Immunological Methods2011，374，30： | 1 |
| 12 | Microstructural evolution and mechanical properties of binary Mg-xBi(x=2,5,and 8 wt%)alloys显示文摘The microstructures and mechanical properties of Mg-x Bi(x=2,5,and 8 wt%)were investigated compared with pure Mg.The ascast Mg-Bi billets consist of dendriticα-Mg grain matrix,divorced eutectic Mg_(3)Bi_(2) phase and secondary precipitated Mg_(3)Bi_(2) phase.After homogenization,secondary precipitated Mg_(3)Bi_(2) particles were all dissolved into the matrix,while most of the divorced eutectic Mg_(3)Bi_(2) intermetallic compounds retained.All the as-extruded samples exhibit fully dynamic recrystallization(DRX)and the average grain size decreases and the amount of nano-scale Mg_(3)Bi_(2) precipitates increases with increasing Bi content.Additionally,Bi alloying has little influence on the texture of the as-extruded pure Mg,with all the samples showing typical basal texture.As the results of grain refinement and precipitation hardening,the strengths of the as-extruded samples increase under both tensile and compressive tests.Besides,the yield asymmetry significantly decreases with Bi content.Moreover,all the as-extruded samples represent similar ductility under compression,while the tensile elongation first increases and then decreases with more Bi added.The as-extruded Mg-5Bi alloy demonstrates good combination of strength and ductility.However,Mg-8Bi alloy displays lower tensile ductility than that of Mg-5Bi alloy due to the presence of abundant undissolved coarse Mg_(3)Bi_(2) particles,which act as cracking sources during tensile test.Furthermore,the strain hardening rate,strain hardening exponent n,and hardening capacity Hc are greatly reduced by Bi addition,mainly owing to the enhanced synergy effects of grain refinement and numerous Mg_(3)Bi_(2) precipitates. | Hui Yu Shaoda Fan Shuaiju Meng Jae Ok Choi Zhongjie Li Yohan Go Young Min Kim Weimin Zhao Bong Sun You Kwang Seon Shin | 2021 | Journal of Magnesium and Alloys2021，9，3： | 1 |
| 13 | Energy-saving strategy for a transport bed flash calcination process applied to magnesite显示文摘A transport bed flash calcination(TBFC)process applied to magnesite is systematically investigated through process simulation to optimize the energy-saving strategy.The high-temperature calciner flue gas is used to preheat the fed magnesite,while the sensible heat with the caustic calcined magnesia(CCM)product is cooled by air sent to the calciner.Pre-decomposition of magnesite during preheating is considered on basis of the kinetics measured using a micro fluidized bed reaction analyzer that allows the minimized effect of external diffusion on reaction.With staged fuel gas supply the TBFC process allows the equivalence ratios around 1.2 for combustion.The preferred arrangement of stages for magnesite preheating and CCM cooling are respectively 4 and 2,leading to the energy consumption of 4100 kJ/kg-CCM and the energy efficiency of 66.8%,which is almost doubly higher than the 33.9%of the conventional reverberatory furnaces(RF).The pre-decomposition occurs mainly in the 1st-stage preheater,and the maximal conversion is about 13%.Varying the stages of preheating appears more influential on the energy saving than varying the cooling stages,while residence time above 1 s in the preheaters has limited effect. | Ping An Zhennan Han Kangjun Wang Jiguang Cheng Zhongkai Zhao Yohanes Andre Situmorang Jenny Rizkiana Abuliti Abudula Guoqing Guan | 2021 | Carbon Resources Conversion2021，4，1： | 1 |
| 14 | Recent Advances in Augmented Reality 显示文摘 | Azuma R T Yohan Baillot | 2001 | IEEE Computer Graphics and Applications2001，21，6： | 1 |
| 15 | Synthesis of V-V sequences with a 2D biomechanical tongue model controlled by the Equilibrium Point Hypothesis显示文摘 | Yohan Payan Pascal Perrier | 1997 | Speech Communication . 1997 (2-3)1997，，2： | 1 |
| 16 | Rigid Registration of Freehand 31) Ultrasound andC'T-Scan Kidney Iniages显示文摘 | Antoine Leroy Pierre Mozer Yohan Fayan | 2004 | Lecture Note in Com-puter Science Volume2004，3216，： | 1 |
| 17 | Smartphone-Based Collaborative and Autonomous Radio Fingerprinting显示文摘 | Yungeun K Yohan C Hojung C | 2012 | IEEE Transactions on System Man and Cybernetics2012，1，42： | 1 |
| 18 | lronuptake and metabolism in the new millennium 显示文摘 | Louise L Dunn Yohan Suryo Rahmanto Des R Richardson | 2006 | Trends in Cell Biology2006，17，2： | 1 |
| 19 | A 13200 year history of century to millennial-scale paleoenvironmental changemagnetically recorded in the Palmer Deep, western Antarctic Peninsula 显示文摘 | Stefanie A B Subir K B Yohan G | 2002 | Earth and Planetary Science Letters2002，194，： | 1 |
| 20 | Dietary phosphatidylcholine alleviates fatty liver induced by orotic acid显示文摘 | Buang Yohanes Wang Yu-Ming Cha Jae-Young | 2005 | Nutrition2005，21，： | 1 |
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