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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | FOLFIRI regimen in metastatic pancreatic adenocarcinoma resistant to gemcitabine and platinum-salts显示文摘AIM: To evaluate the efficacy and safety of the FOLFIRI regimen in patients with metastatic pancreatic adenocarcinoma (PAC) after the failure of gemcitabine and platinum salts. METHODS: All consecutive patients with histologically confirmed, metastatic PAC and World Health Organiza-tion performance status (PS) ≤ 2 received FOLFIRI-1 [irinotecan 180 mg/m2 on day 1 and leucovorin 400 mg/m2 followed by 5-fluorouracil (5-FU) 400 mg/m2 bolus, then 5-FU 2400 mg/m2 as a 46-h infusion, biweekly] or FOLFIRI-3 (irinotecan 100 mg/m2 on day 1 and leucovorin 400 mg/m2, then 5-FU 2400 mg/m2 as a 46-h infusion and irinotecan 100 mg/m2 repeated on day 3, biweekly) after failure of gemcitabine and platinum-based chemotherapies as a systematic policy in two institutions between January 2005 and May 2010. Tumor response, time to progression (TTP), overall survival rate (OS) and grade 3-4 toxicities were retrospectively studied. Subgroup analyses were performed to search for prognostic factors. RESULTS: Sixty-three patients (52.4% male, median age 59 years) were analyzed. Among them, 42.9% were PS 0, 38.1% were PS 1 and 19.0% were PS 2. Fifty one patients (81.0%) had liver metastases. Before the FOLFIRI regimen, patients had received 1 line (n = 19), 2 lines (n = 39) or 3 lines (n = 5) of chemotherapy. Median TTP obtained with the line before FOLFIRI was 3.9 mo (95% CI: 3.4-5.3 mo). A total of 480 cycles was completed (median: 6 cycles, range: 1-51 cycles). The main reason for discontinuing FOLFIRI was tumor progression (90.3%). Tumor control was achieved in 25 patients (39.7%) (partial response: n = 5, stable disease: n = 20) with FOLFIRI. Median TTP was 3.0 mo (95% CI: 2.1-3.9 mo) and median OS was 6.6 mo (95% CI: 5.3-8.1 mo). Dose adaptation was required in 36 patients (57.1%). Fifteen patients (23.8%) had grade 3-4 toxicities, mainly hematological (n = 11) or digestive (n = 4). Febrile neutropenia occurred in 3 patients. There was no toxic death. PS 2 was significantly associated with poor TTP [hazard ratio (HR): 16.036, P < 0.0001] and OS (HR: 4.003, P = 0.004). CONCLUSION: The FOLFIRI regimen had an acceptable toxicity and an interesting efficacy in our study, limited to patients in good condition (PS 0-1). | Cindy Neuzillet Olivia Hentic Benot Rousseau Vinciane Rebours Léla Bengrine-Lefèvre Franck Bonnetain Philippe Lévy Eric Raymond Philippe Ruszniewski Christophe Louvet Pascal Hammel | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 3 | Molecular analysis and chromosomal mapping of amplified genes isolated from a transformedmouse 3T3 cell line显示文摘 | CAHILLY SNYDER L YANG FENG T FRANCKE U | 1987 | Somat Cell Mol Genet1987，13，3： | 1 |
| 4 | All optical switching in dye-doped fiber Fabry-Perot waveguide 显示文摘 | Luckemeger T Francke H | 1998 | Appl Phys Lett1998，53，： | 1 |
| 5 | Chromosomal mapping of genes involved in growth control 显示文摘 | Francke U Yang - Feng T L Brissenden J E | 1986 | Cold Spring Harbor Symposia on Quantitative Biology1986，51，1： | 1 |
| 6 | Mtiller cells in the healthy and diseased retinae 显示文摘 | Bringmann A Pannicke T Grosche J Francke M Wiedemann P Skatchkov SN | 2005 | Prog Retin Eye Res2005，25，4： | 1 |
| 7 | Structural characterisation of hurnic acid-bound PAH residues in soil by 13C-CPMAS-NMR-spectroscopy:evidence of covalent bonds显示文摘 | Kacker T Haupt E Garms C Francke W Steinhart H | 2002 | Chemosphere2002，48，1： | 1 |
| 8 | Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease显示文摘 | Soehn A S Franck T Biskup S | 2010 | Neurogenetics2010，11，2： | 1 |
| 9 | Gaze direction determination in schizophrenia 显示文摘 | Franck N Montoute T Labruyere N | 2002 | Schizophr Res2002，56，2： | 1 |
| 10 | IL-1 beta sensitizes intervertebral disc annulus cells to fluid-induced shear stress显示文摘 | ELFERVIG M K MINCHEW J T FRANCKE E | 2001 | J Cell Biochem2001，82，2： | 1 |
| 11 | Cytokinin modulates catalase activity and coumarin accumulation in in vitro cultures of Tobacco显示文摘 | Petit-Paly G Franck T Brisson L | 1999 | Journal of Plant Physiology1999，155，1： | 1 |
| 12 | Molecular analy- sis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line显示文摘 | Cahilly-Snyder L Yang-Feng T Francke U | 1987 | Somat Cell Mol Genet1987，13，3： | 1 |
| 13 | Molecular ana- lysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line显示文摘 | Cahilly-Snyder L Yang-Feng T Francke U | 1987 | Somat Cell Mol Genet1987，13，3： | 1 |
| 14 | Promising designs of compact heat exchangers for modular HTRs using the Brayton cycle显示文摘 | Franck P Patrice T Christian M | 2008 | Nuclear Engineering and Design2008，238，11： | 1 |
| 15 | RLV candidates for European future launchers preparatory programme显示文摘 | Tomatis C Bouaziz L Franck T | 2009 | Acta Astronautica2009，，65： | 1 |
| 16 | Evaluation of bone mineral density, hormones, biochemical markers of bone metabolism, and osteoprotegerin serum levels in patients with ankylosing spondylitis显示文摘 | Franck H Meurer T Hofbauer LC | 2004 | J Rheumatol2004，31，： | 1 |
| 17 | Uncertainties in the measurement of rock porosity obtained from Laplace inversion of NMR relaxation logs显示文摘 | Saha I Franck J Hopper T | 2009 | Petrophysies2009，50，4： | 1 |
| 18 | Multiplex PCR for enterotoxigenic, attaching and effacing,and Shigatoxin-producing Escherichia coli strains from calves, 显示文摘 | Franck S M Bosworth B T Moon H W | 1998 | J Clin Microbiol1998，36，6： | 1 |
| 19 | Curcumin and resveratroI act by different ways on NADPH oxidase activity and reactive oxygen species produced by equine neutrophils 显示文摘 | Derochette S Franck T Mouithys-Mickalad A | 2013 | Chem Biol Interact2013，206，： | 1 |
| 20 | On the status of the serranid fish genus Epinephelus:evidence for paraphyly based upon 16S DNA sequence显示文摘 | Craig M T Pondella D J Franck J P C | 2001 | Mol Phylogenet Evol2001，19，1： | 1 |
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