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| 1 | Molecular classifications of gastric cancers: Novel insights and possible future applications显示文摘Despite some notable advances in the systemic management of gastric cancer(GC), the prognosis of patients with advanced disease remains overall poor and their chance of cure is anecdotic. In a molecularly selected population, a median overall survival of 13.8 mo has been reached with the use of human epidermal growth factor 2(HER2) inhibitors in combination with chemotherapy, which has soon after become the standard of care for patients with HER2-overexpressing GC. Moreover, oncologists have recognized the clinical utility of conceiving cancers as a collection of different molecularlydriven entities rather than a single disease. Several molecular drivers have been identified as having crucial roles in other tumors and new molecular classifications have been recently proposed for gastric cancer as well. Not only these classifications allow the identification of different tumor subtypes with unique features, but also they serve as springboard for the development of different therapeutic strategies. Hopefully, the application of standard systemic chemotherapy, specifictargeted agents, immunotherapy or even surgery in specific cancer subgroups will help maximizing treatment outcomes and will avoid treating patients with minimal chance to respond, therefore diluting the average benefit. In this review, we aim at elucidating the aspects of GC molecular subtypes, and the possible future applications of such molecular analyses. | Silvio Ken Garattini Debora Basile Monica Cattaneo Valentina Fanotto Elena Ongaro Marta Bonotto Francesca V Negri Rosa Berenato Paola Ermacora Giovanni Gerardo Cardellino Mariella Giovannoni Nicoletta Pella Mario Scartozzi Lorenzo Antonuzzo Nicola Silvestris Gianpiero Fasola Giuseppe Aprile | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 5 |
| 2 | Transarterial chemoembolization using 40 μm drug eluting beads for hepatocellular carcinoma显示文摘AIM To assess the safety and efficacy of transarterial chemoembolization(TACE) of hepatocellular carcinoma(HCC) using a new generation of 40 μm drug eluting beads in patients not eligible for curative treatment.METHODS Drug eluting bead TACE(DEB-TACE) using a new generation of microspheres(embozene tandem,40 μm) preloaded with 100 mg of doxorubicin was performed on 48 early or intermediate HCC patients with compensatedcirrhosis.Response to therapy was assessed with Response Evaluation Criteria in Solid Tumors(RECIST) and modified RECIST(m RECIST) guidelines applied to computed tomography or magnetic resonance imaging.Eleven out of the 48 treated patients treated progressed on to receive liver orthotopic transplantation(OLT).This allowed for histological analysis on the treated explanted nodules.RESULTS DEB-TACE with 40 μm showed a good safety profile without major complications or 30-d mortality.The objective response rate of treated tumors was 72.6% and 26.7% according to m RECIST and RECIST respectively.Histological examination in 11 patients assigned to OLT showed a necrosis degree > 90% in 78.6% of cases.The overall time to progression was 13 mo(11-21).CONCLUSION DEB-TACE with 40 μm particles is an effective treatment for the treatment of HCC in early-intermediate patients(Barcelona Clinic Liver Cancer stage A/B) with a good safety profile and good results in term of objective response rate and necrosis. | Giorgio Greco Tommaso Cascella Antonio Facciorusso Roberto Nani Rodolfo Lanocita Carlo Morosi Marta Vaiani Giuseppina Calareso Francesca G Greco Antonio Ragnanese Marco A Bongini Alfonso V Marchianò Vincenzo Mazzaferro Carlo Spreafico | 2017 | World Journal of Radiology2017，9，5： | 3 |
| 3 | Limited sampling model for the analysis of 5 -fluorouracil pharmacokinetics in adjuvant chemotherapy for colorectal cancer 显示文摘 | ANTONELLO D P ROMANO D FRANCESCA V | 2002 | Clin Pharmacol Ther2002，72，6： | 1 |
| 4 | Pulmonary Pressures and Death in Heart Failure显示文摘 | Francesca Bursi Sheila M. McNallan Margaret M. Redfield Vuyisile T. Nkomo Carolyn S.P. Lam Susan A. Weston Ruoxiang Jiang Véronique L. Roger | 2012 | Journal of the American College of Cardiology2012，，： | 1 |
| 5 | Effects of high pressure homogenization on the activity of lysozyme and lactoferrin against Listeria monocytogenes显示文摘 | I Luciana P Francesca V Melania | 2007 | FOOD CONTROL2007，18，： | 1 |
| 6 | The sequential therapy regi- men for Hclicobacter pylori eradication : a pooled-data analysis 显示文摘 | Zullo A De Francesca V Hassan C | 2007 | Gut2007，56，10： | 1 |
| 7 | First report of a pathogenic mutation on exon 24 of the Notch3 gene in a CADASlL family显示文摘 | Rathella V Silvia B Francesca P | 2011 | J Neural2011，258，9： | 1 |
| 8 | A time-domain raw signal simulator for interferometric SAR 显示文摘 | MORI A FRANCESCA V | 2004 | IEEE Transactions on Geoscience and Remote Sensing2004，42，9： | 1 |
| 9 | Optimized numerical evaluation ofsingular and near-singular potential integrals involving junctionbasis functions显示文摘 | Francesca V Wilton D R | 2011 | IEEE Trans on Antennas and Propaga-tion2011，59，1： | 1 |
| 10 | Hyperuricemia and renal risk显示文摘 | Francesca V Giovanna L Elena R | 2014 | High Blood Press Cardiovasc Prev2014，21，3： | 1 |
| 11 | Study of the reuse of treat- ed wastewater on waste container washing vehicles 显示文摘 | Mentore V Francesca G | 2013 | Waste Management2013，33，2： | 1 |
| 12 | Human papilloma virus DNA testing by PCR - ELISA and hybrid capture Ⅱ from a single cytological specimen: concordance and correlation with cytological results 显示文摘 | SIMONA V MONICA C FRANCESCA B | 2002 | Journal of Clinical Viology2002，32，25： | 1 |
| 13 | Study of adhesion and survival of lactobacilli and bifidobacteria on table olives with the aim of formulating a new probiotic food显示文摘 | PAOLA L FRANCESCA V STELLA L L | 2005 | Applied and Environmental Microbiology2005，71，8： | 1 |
| 14 | Effects of atorvastatin and rosuvastatin on renal function: A meta-analysis 显示文摘 | Gianluigi S Francesca M Massimo V | 2013 | Internation- al Journal of Cardiology2013，167，6： | 1 |
| 15 | Deriving Drainage Networks and Catchment Boundaries: A New Methodology Combining Digital Elevation Data and Environmental Characteristics显示文摘 | Vogt J V Colomboa R Francesca Bertolo | 2003 | Geomorphology2003，，53： | 1 |
| 16 | Infections and solid organ transplant rejection:a cause-and-effect relationship显示文摘 | Francesca C Sandro V | 2002 | Lancet Infect Dis2002，2，： | 1 |
| 17 | Effects of high pressure homogenization on the activity of lysozyme and lactoferrin against Listeria monocyto-genes显示文摘 | I Luciana P Francesca V Melania | | 0，，： | 1 |
| 18 | Fluorophore-assisted carbohydrate electrophoresis for the determination of molecular mass of heparins and low-molecular-weight(LMW)heparins显示文摘 | Dania B Francesca M Nicola V | 2011 | Electrophoresis2011，20，29： | 1 |
| 19 | High frequency of MYH gene mutatiorns in a subset of patients with familial adenomatous polysis显示文摘 | Tiziana V Sara M Francesca C | 2004 | Gastroenterology2004，126，： | 1 |
| 20 | Human recombinant heat shock protein 70 affects the maturation pathways of dendritic cells in vitro and has an in vivo adjuvant activity显示文摘 | Barbara V Annalisa C Francesca E | 2008 | J Leukoc Biol2008，84，1： | 1 |
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