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| 1 | Clinical and histopathological correlations of fecal calprotectin release in colorectal carcinoma显示文摘AIM:To determine calprotectin release before and after colorectal cancer operation and compare it to tumor and histopathological parameters.METHODS:The study was performed on patients with diagnosed colorectal cancer admitted for operation.Calprotectin was measured in a single stool sample before and three months after the operation using an enzymelinked immunosorbent assay(ELISA).Calprotectin levels greater than or equal to 50μg/g were considered positive.The compliance for collecting stool samples was assessed and the value of calprotectin was correlated to tumor and histopathological parameters of intra-and peri-tumoral inflammation.Surgical specimens were fixed in neutral buffered formalin and stained with hematoxylin and eosin.Staging was performed according to the Dukes classification system and the 7th edition tumor node metastasis classification system.Intra-and peri-tumoral inflammation was graded according to the Klintrup criteria.Immunohistochemical quantification was performed for MPO,CD45R0,TIA-1,CD3,CD4,CD8,CD57,and granzyme B.Statistical significance was measured using Wilcoxon signed rank test,Kruskal Wallis test and Spearman’s rank correlation coefficient as appropriate.RESULTS:Between March 2009 and May 2011,80 patients with colorectal cancer(46 men and 34 women,with mean age of 71±11.7 years old)were enrolled in the study.Twenty-six patients had rectal carcinoma,29 had left-side tumors,23 had right-side tumors,and2 had bilateral carcinoma.In total,71.2%of the patients had increased levels of calprotectin before the operation(median 205μg/g,range 50-2405μg/g)and experienced a significant decrease three months after the operation(46μg/g,range 10-384μg/g,P<0001).The compliance for collecting stool samples was 89.5%.Patients with T3 and T4 tumors had significantly higher values than those with T1 and T2 cancers(P=0.022).For all other tumor parameters(N,M,G,L,V,Pn)and location,no significant difference in calprotectin concentration was found.Furthermore,the calprotectin levels and histological grading of both peri-and intra-tumoral inflammation was not correlated.Additional testing with specific markers for lymphocytes and neutrophils also revealed no statistically significant correlation.CONCLUSION:Fecal calprotectin decreases significantly after colorectal cancer operation.Its value depends exclusively on the individual T-stage,but not on other tumor or histopathological parameters. | Frank Serge Lehmann Francesca Trapani Ida Fueglistaler Luigi Maria Terracciano Markus von Flüe Gieri Cathomas Andreas Zettl Pascal Benkert Daniel Oertli Christoph Beglinger | 2014 | World Journal of Gastroenterology2014，20，17： | 6 |
| 2 | Smoking in schizophrenic patients:A critique of the selfmedication hypothesis显示文摘A common remark among laypeople, and notably also among mental health workers, is that individuals with mental illnesses use drugs as self-medication to allay clinical symptoms and the side effects of drug treatments. Roots of the self-medication concept in psychiatry date back at least to the 1980 s. Observations that rates of smokers in schizophrenic patients are multiple times the rates for regular smoking in the general population, as well as those with other disorders, proved particularly tempting for a self-medication explanation. Additional evidence came from experiments with animal models exposed to nicotine and the identification of neurobiological mechanisms suggesting self-medication with smoking is a plausible idea. More recently, results from studies comparing smoking and non-smoking schizophrenic patients have led to the questioning of the self-medication hypothesis. Closer examination of the literature points to the possibility that smoking is less beneficial on schizophrenic symptomology than generally assumed while clearly increasing the risk of cancer and other smoking-related diseases responsible for early mortality. It is a good time to examine the evidence for the self-medication concept as it relates to smoking. Our approach is to focus on data addressing direct or implied predictions of the hypothesis in schizophrenic smokers. | Francesca Manzella Susan E Maloney George T Taylor | 2015 | World Journal of Psychiatry2015，5，1： | 4 |
| 3 | Message in a bottle from the tumor microenvironment:tumor-educated DCs instruct B cells to participate in immunosuppression显示文摘Once tumour cells have overcome the molecular mechanisms that prevent their uncontrolled proliferation,the only enemy they need to deal with is the immune system,which is able to recognize and destroy transformed cells.Paradoxically,one of the evasion mechanisms put in place by the tumour is made by the suppressive arm of the immune system itself. | Francesca Mion Silvia Tonon Viviana Valeri Carlo E Pucillo | 2017 | Cellular & Molecular Immunology2017，14，9： | 4 |
| 4 | Glycyrrhizic acid alters Kaposi sarcoma-associated herpesvirus latency,triggering p53-mediated apoptosis in transformed B lymphocytes显示文摘 | Francesca C Alvin E K Ornella F | 2005 | J Clin Invest2005，115，： | 1 |
| 5 | The prosnostic significance of micrometastases in breast cancer:A SEER population-based analysis显示文摘 | Steven L Chen Francesca M Hoehne Armando E Giuliano | 2007 | Ann Surg Oncol2007，12，14： | 1 |
| 6 | Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the Euro pean Prospective Investigation into Cancer and Nutrition显示文摘 | Crowe Francesca L Allen Naomi E Appleby Paul N | 2008 | The American Journal of Clinical Nutrition2008，88，5： | 1 |
| 7 | Nutrient-based dietarypatterns and the risk of oral and pharyngeal cancer 显示文摘 | Valeria E Francesca B Carlo LV? | 2010 | Oral On-col2010，5，46： | 1 |
| 8 | The flavonoid biosynthetic path way in plants: function and evolution显示文摘 | Francesca Q Joseph N M | 1993 | Bioessays1993，16，： | 1 |
| 9 | ^131I SPECT/CT in the fol- low-up of differentiated thyroid carcinoma:incremental value versus planar imaging 显示文摘 | Angela S Maria E Francesca C | 2009 | J Nuc Med2009，50，2： | 1 |
| 10 | Dynamic modelling of a UK North Sea saline for- mation for CO2 sequestration显示文摘 | Francesca E Watson Simon A Mathias Susie E Daniels | 2014 | Petroleum Geoscience2014，20，： | 1 |
| 11 | The flavonoid biosynthetic pathway in plants:function and evolution显示文摘 | Koes R E Francesca Q Joseph N M | 1994 | Bioessays1994，16，： | 1 |
| 12 | Fluorescent polymerase chain reaction and capillary electrophoresis for IgH rearrangement and minimal residual disease evaluation in multiple myeloma 显示文摘 | Elisabetta N Ilaria G Francesca E | 2002 | Haematologica2002，87，11： | 1 |
| 13 | The clinical and pathogenetic significance of estrogen receptor-β expression in chronic liver diseases and liver carcinoma显示文摘 | Iavarone M Lampertico P Seletti C Francesca Donato M Ronchi G del Ninno E Colombo M | 2003 | Cancer2003，98，3： | 1 |
| 14 | Human recombinant heat shock protein 70 affects the maturation pathways of dendritic cells in vitro and has an in vivo adjuvant activity显示文摘 | Barbara V Annalisa C Francesca E | 2008 | J Leukoc Biol2008，84，1： | 1 |
| 15 | St John's wort:Prozac from the plant kingdom显示文摘 | Francesca B Edzard E | 2001 | Trends Pharmacol Sci2001，22，6： | 1 |
| 16 | Tethering functional ligands onto shell of ultrasound active polymeric microbubbles显示文摘 | FRANCESCA C ELHAMASSI A CHIESSI E | 2006 | Biomacromolecules2006，7，2： | 1 |
| 17 | Impact of acquisi- tion istortions on the quality of steoscopic images 显示文摘 | LUTZ G FRANCESCA D S TOURADJ E | 2009 | IEEE Transactions on Images2009，23，6： | 1 |
| 18 | ^sup 131^I SPECT/CT in the Follow-up of Differentiated Thyroid Carcinoma: Incremental Value Versus Planar Imaging显示文摘 | Spanu Angela Solinas Maria E Chessa Francesca Sanna Daniela Nuvoli Susanna Madeddu Giuseppe | 2009 | The Journal of Nuclear Medicine2009，，： | 1 |
| 19 | Spread-spectrum continuous-phase-modulated signals for satellite navigation显示文摘 | ANDREA E FRANCESCA Z GABRIELEL B | | 0，，04： | 1 |
| 20 | The flavonoid biosynthetic path way in plants:function and evolution 显示文摘 | KOES R E FRANCESCA Q JOSEPH N M | 1994 | Bioessays1994，16，： | 1 |
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