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| 1 | Fat:A matter of disturbance for the immune system显示文摘Obesity is increasingly being recognized as a risk factor for a number of benign and malignant gastrointestinal conditions. However, literature on the underlying pathophysiological mechanisms is sparse and ambiguous. There is compelling evidence that both overnutrition and undernutrition negatively interfere with the immune system. Overnutrition has been found to increase susceptibility to the development of inflammatory diseases, autoimmune diseases and cancer. In the regulation of immune and in? ammatory processes, white adipose tissue plays a critical role, not only as an energy store but also as an important endocrine organ. The obese state is characterised by a low-grade systemic in? ammation, mainly as a result of increased adipocytes as well as fat resident-and recruited-macrophage activity. In the past few years, various products of adipose tissue including adipokines and cytokines have been characterised and a number of pathways linking adipose tissue metabolism with the immune system have been identified. Activation of the innate immune system plays a major role in hepatic steatosis. Non-alcoholic fatty liver disease includes a wide spectrum of diseases, from pure steatosis to non-alcoholic steato-hepatitis in the absence of signif icant alcohol consumption. Although steatosis is considered a non-progressive disease, non-alcoholic steatohepatitis may deteriorate in advanced chronic liver diseases, cirrhosis, and hepatocellular carcinoma. An important parallel between obesityrelated pathology of adipose tissue and liver pertains to the emerging role of macrophages, and growing evidence suggests that Kupffer cells critically contribute to progression of non-alcoholic fatty liver disease. Moreover, a close link between specif ic immune activation and atherosclerosis has been well established, suggesting that fat can directly trigger immune responses. This review discusses the role of fat as 'a matter of disturbance for the immune system' with a focus on hepatic steatosis. | Alessandro Federico Elena D’Aiuto Francesco Borriello Giusi Barra Antonietta Gerarda Gravina Marco Romano Raffaele De Palma | 2010 | World Journal of Gastroenterology2010，16，38： | 12 |
| 2 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 3 | GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma显示文摘 | Jorge A. Marrero Patrick R. Romano Olga Nikolaeva Laura Steel Anand Mehta Claus J. Fimmel Mary Ann Comunale Anthony D’Amelio Anna S. Lok Timothy M. Block | 2005 | Journal of Hepatology2005，，6： | 5 |
| 4 | Hepatitis C virus-related B cell subtypes in non Hodgkin's lymphoma显示文摘AIM:To evaluate if indolent B cell-non Hodgkin's lymphoma(B-NHL) and diffuse large B-cell lymphoma(DLBCL) in hepatitis C virus(HCV) positive patients could have different biological and clinical characteristics requiring different management strategies.METHODS:A group of 24 HCV related B-NHL patients(11 indolent,13 DLBCL) in whom the biological and clinical characteristics were described and confronted.Patients with DLBCL were managed with the standard of care of treatment.Patients with indolent HCV-related B-NHL were managed with antiviral treatment pegylated interferon plus ribavirin and their course observed.The outcomes of the different approaches were compared.RESULTS:Patients with DLBCL had a shorter duration of HCV infection and a higher prevalence of HCV genotype 1 compared to patients with indolent B-NHL in which HCV genotype 2 was the more frequent genotype.Five of the 9 patients with indolent HCV-relatedB-NHL treated with only antiviral therapy,achieved a complete response of their onco-haematological disease(55%).Seven of the 13 DLBCL patients treated with immunochemotheraphy obtained a complete response(54%).CONCLUSION:HCV genotypes and duration of HCV infection differed between B-NHL subtypes.Indolent lymphomas can be managed with antiviral treatment,while DLBCL is not affected by the HCV infection. | Adriano M Pellicelli Massimo Marignani Valerio Zoli Mario Romano Aldo Morrone Lorenzo Nosotti Giuseppe Barbaro Antonio Picardi Umberto Vespasiani Gentilucci Daniele Remotti Cecilia D'Ambrosio Caterina Furlan Fabrizio Mecenate Ettore Mazzoni Ignazio Majolino Roberto Villani Arnaldo Andreoli Giorgio Barbarini | 2011 | World Journal of Hepatology2011，3，11： | 4 |
| 5 | Relationship between Chlamydia pneumoniae infection, inflammatory markers, and coronary heart diseases显示文摘 | ROMANO CARRATELLI C NUZZO I COZZOLINO D | 2006 | Int Immunopharmacol2006，6，： | 1 |
| 6 | Biweekly administration of gemcitabine and vinorelbine as first line therapy in elderly advanced breast cancer 显示文摘 | Dinota A Bilancia D Romano R | 2005 | Breast Cancer Res Treat2005，89，1： | 1 |
| 7 | Qulity, productivity, and learning in framework-based development:An exploratory case study显示文摘 | Morisio M Romano D and Stamelos I | 2002 | IEEE Trans on Software Engineering2002，28，9： | 1 |
| 8 | Celecoxib versus indomethacin in the pre-vention of heterotopic ossification after total hip arthroplasty显示文摘 | Romano CL Duci D Romano D | 2004 | J Arthroplasty2004，19，： | 1 |
| 9 | Steroid hydroxylations with Botryodiplodia malorumand Colletotrichum lini显示文摘 | ROMANO A ROMANO D RAGG E | 2006 | Steroids2006，71，6： | 1 |
| 10 | A new chemoenzymaticsynthesis of d-cloprostenol显示文摘 | Romano A Romano D Molinari F | 2005 | Tetrahedron:Asymmetry2005，16，19： | 1 |
| 11 | Spontaneous resolution of ectopic tubal pregnancy natural history显示文摘 | Shalev E Romano S Peleg D | 1995 | Fertil Steil1995，63，： | 1 |
| 12 | Neovascularization in human germ cell tumors correlates with a marked increase in the expression of the vascular endothelial growth factor but not the placenta-derived growth factor 显示文摘 | Viglietto G Romano A Maglione D | 1996 | Oncogene1996，13，3： | 1 |
| 13 | A Pedagogical Treatment of Bilateral Monopoly 显示文摘 | Roger D Blair David L Kaserman Richard E Romano | 1989 | Southern Economic Journal1989，55，4： | 1 |
| 14 | Association between left atrial myocardial function and exercise capacity in patients with either idiopathic or ischemic dilated cardiomyopathy: a two-di- mensional speckle strain study 显示文摘 | D' Andrea A Caso P Romano S | 2009 | Int J Cardiol2009，132，3： | 1 |
| 15 | Fertility rate evaluation by laparoscopic approach in the experimental animal显示文摘 | Romano D Terzano M G Di Domenico M | 2002 | Clinical and experimental obstetrics & gynecology2002，29，2： | 1 |
| 16 | Alkylphenol ethoxylates in the environment显示文摘 | Naylor C G Mieure J P Adams W J Weeks J A Castaldl F J Ogle L D Romano R R | 1992 | American Oil Chemists Society1992，69，： | 1 |
| 17 | Developments in the produntion and application of dimethyl-carbonate显示文摘 | Delledonne D Rivetti F Romano U | 2001 | Appl Catal A2001，221，12： | 1 |
| 18 | Expression of tetanus toxin fragment C in Escherichia coli:high level expression by removing rare codons显示文摘 | Makoff A J Oxer M D Romanos M A | 1989 | Nucleic Acids Res1989，17，10： | 1 |
| 19 | Candidahumilis-dominant species in sourdoughs for the production of durum wheat bran flour bread 显示文摘 | Gullo M Romano A D Pulvirenti A | 2003 | Intemational journal of food microbiology2003，80，1： | 1 |
| 20 | Pre-surgical planning and MR-tractography utility in brain tumour resection显示文摘 | Romano A D'andrea G Minniti G | 2009 | Eur Radiol2009，19，12： | 1 |
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