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| 1 | Receptor activator of NF-κB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells显示文摘 | Valerie A Odero-Marah Ruoxiang Wang Gina Chu Majd Zayzafoon Jianchun Xu Chunmeng Shi Fray F Marshall Haiyen E Zhau Leland WK Chung | 2008 | Cell Research2008，18，8： | 6 |
| 2 | Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics显示文摘This article describes cell signaling network of metastatic prostate cancer(PCa)to bone and visceral organs in the context of tumor microenvironment and for the development of novel therapeutics.The article focuses on our recent progress in the understanding of:1)The plasticity and dynamics of tumorestroma interaction;2)The significance of epigenetic reprogramming in conferring cancer growth,invasion and metastasis;3)New insights on altered junctional communication affecting PCa bone and brain metastases;4)Novel strategies to overcome therapeutic resistance to hormonal antagonists and chemotherapy;5)Geneticbased therapy to co-target tumor and bone stroma;6)PCa-bone-immune cell interaction and TBX2-WNTprotein signaling in bone metastasis;7)The roles of monoamine oxidase and reactive oxygen species in PCa growth and bone metastasis;and 8)Characterization of imprinting cluster of microRNA,in tumorestroma interaction.This article provides new approaches and insights of PCa metastases with emphasis on basic science and potential for clinical translation.This article referenced the details of the various approaches and discoveries described herein in peer-reviewed publications.We dedicate this article in our fond memory of Dr.Donald S.Coffey who taught us the spirit of sharing and the importance of focusing basic science discoveries toward translational medicine. | Gina Chia-Yi Chu Leland W.K.Chung Murali Gururajan Chia-Ling Hsieh Sajni Josson Srinivas Nandana Shian-Ying Sung Ruoxiang Wang Jason Boyang Wu Haiyen E.Zhau | 2019 | Asian Journal of Urology2019，6，1： | 5 |
| 3 | Cultured circulating tumor cells and their derived xenografts for personalized oncology显示文摘Recent cancer research has demonstrated the existence of circulating tumor cells(CTCs)in cancer patient’s blood.Once identified,CTC biomarkers will be invaluable tools for clinical diagnosis,prognosis and treatment.In this review,we propose ex vivo culture as a rational strategy for large scale amplification of the limited numbers of CTCs from a patient sample,to derive enough CTCs for accurate and reproducible characterization of the biophysical,biochemical,gene expressional and behavioral properties of the harvested cells.Because of tumor cell heterogeneity,it is important to amplify all the CTCs in a blood sample for a comprehensive understanding of their role in cancer metastasis.By analyzing critical steps and technical issues in ex vivo CTC culture,we developed a cost-effective and reproducible protocol directly culturing whole peripheral blood mononuclear cells,relying on an assumed survival advantage in CTCs and CTC-like cells over the normal cells to amplify this specified cluster of cancer cells. | Ruoxiang Wang Gina CYChu Stefan Mrdenovic Alagappan A.Annamalai Andrew E.Hendifar Nicholas N.Nissen James S.Tomlinson Michael Lewis Nallasivam Palanisamy Hsian-Rong Tseng Edwin M.Posadas Michael R.Freeman Stephen J.Pandol Haiyen E.Zhau Leland W.K.Chung | 2016 | Asian Journal of Urology2016，3，4： | 2 |
| 4 | Pulmonary Pressures and Death in Heart Failure显示文摘 | Francesca Bursi Sheila M. McNallan Margaret M. Redfield Vuyisile T. Nkomo Carolyn S.P. Lam Susan A. Weston Ruoxiang Jiang Véronique L. Roger | 2012 | Journal of the American College of Cardiology2012，，： | 1 |
| 5 | 3-Anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection显示文摘 | Wang, Song Luo, Xiaoqin Yan, Ruoxiang Wang, Quanxin Qi, Qiuyue Chi, Xiaojuan Zhang, Lanlan Yu, Ziding Cai, Binxiang Chen, Ji-Long Liu, Hongwei | 2016 | Protein & Cell2016，7，11： | 1 |
| 6 | Three-dimensional co-culture models to study prostate cancer growth, progression, and metastasis to bone显示文摘 | Ruoxiang Wang Jianchun Xu Lisa Juliette Agapito Castilleja John Love Shian-Ying Sung Haiyen E. Zhau Thomas J. Goodwin Leland W.K. Chung | 2005 | Seminars in Cancer Biology2005，，5： | 1 |
| 7 | Securing Patient-Centric Personal Health Records Sharing System in Cloud Computing显示文摘 | CHEN Danwei CHEN Linling FAN Xiaowei HE Liwen PAN Su Hu Ruoxiang | 2014 | China Communications2014，11，A01： | 0 |
| 8 | Boosting Green Development in China’s River Valley Economy显示文摘In line with the requirements of Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era,we need analyze the characteristics of China’s river valley economy,fully consider the development constraints posed by water resources.In addition,advancing the“three water treatments,”which covers water pollution control,water ecological restoration,and water resources protection,is of great theoretical and practical significance in helping to realize the concept of a mountain-river-forest-farmland-lake-grass community of shared life.It also requires effectively coordinating the upper and lower reaches,both riverbanks,the trunk streams and tributaries,and on-shore industrial cities within the area,to foster integration and interaction between major national strategies and create a new pattern for promoting ecological progress. | JIA Ruoxiang ZHANG Yan WANG Jiyuan DOU Hongtao ZHENG Guonan | 2020 | China Economic Transition2020，3，2： | 0 |
| 9 | The shadows hang over immunotherapy-neutrophil extracellular traps in cancer显示文摘The development of immune checkpoint inhibitors(ICIs)was a milestone in the advancement of anticancer treatment.ICIs exert their effects by enhancing the function of T cells via inhibition of immune checkpoints,such as programmed cell death protein-1(PD-1)/programmed cell death-ligand 1(PDL1). | Dan Pu Liyuan Yin Xiaoqian Zhai Ruoxiang Wang Lin Huang Qiang Wu Lingling Zhu Yuwen Zhou Qinghua Zhou Lu Li | 2023 | Science China(Life Sciences)2023，66，5： | 0 |
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