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| 1 | Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients显示文摘AIM:To investigate whether the evaluation of tumor budding can complement K-RAS analysis to improve the individualized prediction of response to anti-epidermal growth factor receptor based therapies in metastatic colorectal cancer (mCRC) patients. METHODS:Forty-three patients with mCRC treated with cetuximab or panitumumab were entered into this study. According to the Response Evaluation Criteria in Solid Tumors criteria, 30 patients had stable or progressive disease (non-responsive), while 13 patients had a partial response. Tumor buds were evaluated from whole tissue sections stained for pan-cytokeratin, evaluated in the densest region using a 40 × objective and 'high-grade' tumor budding was defi ned as 15 buds/high-power f ield.RESULTS: Tumor buds and K-RAS mutation both correctly classif ied 68% of patients. All patients with K-RAS mutation (n=7) or high-grade tumor budding (n=11) were non-responsive, of which 4 patients had both features. All 13 partial responders were K-RAS wild-type with low-grade tumor budding. Combined, the predictive value of K-RAS and tumor budding was 80%. Additionally, high-grade tumor budding was significantly related to worse progression-free survival [HR (95% CI): 2.8 (1.3-6.0, P=0.008)].CONCLUSION: If confirmed in larger cohorts, the addition of tumor budding to K-RAS analysis may represent an effective approach for individualized patient management in the metastatic setting. | Inti Zlobec Francesca Molinari Vittoria Martin Luca Mazzucchelli Piercarlo Saletti Rosangela Trezzi Sara De Dosso Tatjana Vlajnic Milo Frattini Alessandro Lugli | 2010 | World Journal of Gastroenterology2010，16，38： | 4 |
| 2 | Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus显示文摘 | Di Nicolantonio Federica Arena Sabrina Tabernero Josep Grosso Stefano Molinari Francesca Macarulla Teresa Russo Mariangela Cancelliere Carlotta Zecchin Davide Mazzucchelli Luca Sasazuki Takehiko Shirasawa Senji Geuna Massimo Frattini Milo Ba | 2010 | Journal of Clinical Investigation2010，，8： | 1 |
| 3 | Effects of a short-term exercise training on serum factors involved in ventricular remodelling in chronic heart failure patients显示文摘 | Lucia Gatta Andrea Armani Ferdinando Iellamo Claudia Consoli Francesca Molinari Giuseppe Caminiti Maurizio Volterrani Giuseppe M.C. Rosano | 2010 | International Journal of Cardiology2010，，3： | 1 |
| 4 | Aberrant promoter methylation of beta‐1,4 galactosyltransferase 1 as potential cancer‐specific biomarker of colorectal tumors显示文摘 | Maria Luana Poeta Emanuela Massi Paola Parrella Pasquale Pellegrini Mariangela De Robertis Massimiliano Copetti Carla Rabitti Giuseppe Perrone Andrea Onetti Muda Francesca Molinari Elena Zanellato Stefano Crippa Damiano Caputo Marco Caricato Milo Frattini | 2012 | Genes Chromosom Cancer2012，，12： | 1 |
| 5 | Steroid hydroxylations with Botryodiplodia malorum and Colletotrichum lini显示文摘 | Andrea Romano Diego Romano Enzio Ragg Francesca Costantino Roberto Lenna Raffaella Gandolfi Francesco Molinari | 2006 | Steroids2006，，6： | 1 |
| 6 | Postmortem Nasopharyngeal Swabs Performed during the COVID-19 Infection:Analysis of Preliminary Clinical Records by the Genoa Institute of Legal Medicine(North-West Italy)显示文摘COVID-19,the disease caused by the SARS-CoV-2 virus,is highly contagious.The persistence of the virus after infected individuals die remains unclear.This article reports the findings taken from postmortem nasopharyngeal swabs performed to investigate the presence of SARS-CoV-2 in the corpses transferred to the Genoa District Mortuary from the outset of the Italian lockdown(March 9)to the end of the first emergency phase(July 13).One hundred and eighty swabs were carried out:13 corpses resulted positive for the virus,with the diagnosis being reached only after death.Seven were male and 6 female with an average age of 73.5 years old.The most frequent comorbidities recorded were arterial hypertension,diabetes,Alzheimer 5s,and pulmonary disease.In two cases,the swab tested positive at a distance of 125 h and 165 h from actual death.The nasopharyngeal swab results a useful way to screen corpses for COVID-19 and to handle bodies in Legal Medicine Centers where safe autoptic rooms are not available.Swabs are also a means of safeguarding forensic pathologists,identifying the presence of breeding grounds in the community and providing information for the Public Prosecutor's Office in legal cases.They are able to produce reliable results up to at least 7 days following death,provided that the corpse is correctly preserved. | Martina Drommi Rosario Barranco Arianna Bal bo Stefano Errico Francesca Maria Elena Frigiolini Manuela Mangioni Giulia Molinari Alessandra Zappi Patrizia Caligiuri Francesco De Stefano Francesco Ventura | 2022 | Journal of Forensic Science and Medicine2022，8，1： | 0 |
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