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| 1 | Evaluation of non-point source pollution reduction by applying Best Management Practices using a SWAT model and QuickBird high resolution satellite imagery显示文摘This study evaluated the reduction effect of non-point source pollution by applying best management practices (BMPs) to a 1.21 km 2 small agricultural watershed using a SWAT (Soil and Water Assessment Tool) model.Two meter QuickBird land use data were prepared for the watershed.The SWAT was calibrated and validated using daily streamflow and monthly water quality (total phosphorus (TP),total nitrogen (TN),and suspended solids (SS)) records from 1999 to 2000 and from 2001 to 2002.The average Nash and Sutcliffe model efficiency was 0.63 for the streamflow and the coefficients of determination were 0.88,0.72,and 0.68 for SS,TN,and TP,respectively.Four BMP scenarios viz.the application of vegetation filter strip and riparian buffer system,the regulation of Universal Soil Loss Equation P factor,and the fertilizing control amount for crops were applied and analyzed. | MiSeon Lee GeunAe Park MinJi Park JongYoon Park JiWan Lee SeongJoon Kim | 2010 | Journal of Environmental Sciences2010，22，6： | 34 |
| 2 | Overcoming endocrine resistance in metastatic breast cancer: Current evidence and future directions显示文摘About 75% of all breast cancers are estrogen receptor(ER)-positive. They generally have a more favorable clinical behavior, prognosis, and pattern of recurrence, and endocrine therapy forms the backbone of treatment. Anti-estrogens(such as tamoxifen and fulvestrant) and aromatase inhibitors(such as anastrozole, letrozole, and exemestane) can effectively control the disease and induce tumor responses in a large proportion of patients. However, the majority of patients progress during endocrine therapy(acquired resistance) and a proportion of patients may fail to respond to initial therapy(de novo resistance). Endocrine resistance is therefore of clinical concern and there is great interest in strategies that delay or circumvent it. A deeper knowledge of the molecular mechanisms that drive endocrine resistance has recently led to development of new strategies that have the promise to effectivelyovercome it. Many resistance mechanisms have been described, and the crosstalk between ER and growth factor receptor signaling pathways seems to represent one of the most relevant. Compounds that are able to inhibit key elements of these pathways and restore endocrine sensitivity have been studied and more are currently under development. The aim of this review is to summarize the molecular pathophysiology of endocrine resistance in breast cancer and its impact on current clinical management. | Andrea Milani Elena Geuna Gloria Mittica Giorgio Valabrega | 2014 | World Journal of Clinical Oncology2014，5，5： | 18 |
| 3 | Role of neurotrophic factors in enhancing linear axonal growth of ganglionic sensory neurons in vitro显示文摘Neurotrophins play a major role in the regulation of neuronal growth such as neurite sprouting or regeneration in response to nerve injuries. The role of nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor in maintaining the survival of peripheral neurons remains poorly understood. In regenerative medicine, different modalities have been investigated for the delivery of growth factors to the injured neurons, in search of a suitable system for clinical applications. This study was to investigate the influence of nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor on the growth of neurites using two in vitro models of dorsal root ganglia explants and dorsal root ganglia-derived primary cell dissociated cultures. Quantitative data showed that the total neurite length and tortuosity were differently influenced by trophic factors. Nerve growth factor and, indirectly, brain-derived neurotrophic factor stimulate the tortuous growth of sensory fibers and the formation of cell clusters. Neurotrophin-3, however, enhances neurite growth in terms of length and linearity allowing for a more organized and directed axonal elongation towards a peripheral target compared to the other growth factors. These findings could be of considerable importance for any clinical application of neurotrophic factors in peripheral nerve regeneration. Ethical approval was obtained from the Regione Piemonte Animal Ethics Committee ASLTO1(file # 864/2016-PR) on September 14, 2016. | Michele Fornaro Alessia Giovannelli Angelica Foggetti Luisa Muratori Stefano Geuna Giorgia Novajra Isabelle Perroteau | 2020 | Neural Regeneration Research2020，15，9： | 3 |
| 4 | Chitosan tubes enriched with fresh skeletal muscle fibers for delayed repair of peripheral nerve defects显示文摘Nerve regeneration after delayed nerve repair is often unsuccessful. Indeed, the expression of genes associated with regeneration, including neurotrophic and gliotrophic factors, is drastically reduced in the distal stump of chronically transected nerves; moreover, Schwann cells undergo atrophy, losing their ability to sustain regeneration. In the present study, to provide a three-dimensional environment and trophic factors supporting Schwann cell activity and axon re-growth, we combined the use of an effective conduit(a chitosan tube) with a promising intraluminal structure(fresh longitudinal skeletal muscle fibers). This enriched conduit was used to repair a 10-mm rat median nerve gap after 3-month delay and functional and morphometrical analyses were performed 4 months after nerve reconstruction. Our data show that the enriched chitosan conduit is as effective as the hollow chitosan conduit in promoting nerve regeneration,and its efficacy is not statistically different from the autograft, considered the 'gold standard' technique for nerve reconstruction. Since hollow tubes not always lead to good results after long defects(> 20 mm), we believe that the conduit enriched with fresh muscle fibers could be a promising strategy to repair longer gaps, as muscle fibers create a favorable three-dimensional environment and release trophic factors. All procedures were approved by the Bioethical Committee of the University of Torino and by the Italian Ministry of Health(approval number: 864/2016/PR) on September 14, 2016. | AlessANDro Crosio Benedetta Elena Fornasari Giovanna Gambarotta Stefano Geuna Stefania Raimondo Bruno Battiston Pierluigi Tos Giulia Ronchi | 2019 | Neural Regeneration Research2019，14，6： | 2 |
| 5 | Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells显示文摘AIM: To study the therapeutic effect of three tubeguides with electrical conductivity associated to mesenchymal stem cells(MSCs) on neuro-muscular regeneration after neurotmesis.METHODS: Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol(PVA), PVA-carbon nanotubes(CNTs) and MSCs, and PVA-polypyrrole(PPy). The regenerated nerves and tibialis anterior muscles were processed for stereological studies after 20 wk. The functional recovery was assessed serially for gait biomechanical analysis, by extensor postural thrust, sciatic functional index and static sciatic functionalindex(SSI), and by withdrawal reflex latency(WRL). In vitro studies included cytocompatibility, flow cytometry, reverse transcriptase polymerase chain reaction and karyotype analysis of the MSCs. Histopathology of lung, liver, kidneys, and regional lymph nodes ensured the biomaterials biocompatibility. RESULTS: SSI remained negative throughout and independently from treatment. Differences between treted groups in the severity of changes in WRL existed, showing a faster regeneration for PVA-CNTs-MSCs(P < 0.05). At toe-off, less acute ankle joint angles were seen for PVA-CNTs-MSCs group(P = 0.051) suggesting improved ankle muscles function during the push off phase of the gait cycle. In PVA-PPy and PVA-CNTs groups, there was a 25% and 42% increase of average fiber area and a 13% and 21% increase of the 'minimal Feret's diameter' respectively. Stereological analysis disclosed a significantly(P < 0.05) increased myelin thickness(M), ratio myelin thickness/axon diameter(M/d) and ratio axon diameter/fiber diameter(d/D; g-ratio) in PVA-CNT-MSCs group(P < 0.05). CONCLUSION: Results revealed that treatment with MSCs and PVA-CNTs tube-guides induced better nerve fiber regeneration. Functional and kinematics analysis revealed positive synergistic effects brought by MSCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible that might prevent the secondary neurogenic muscular atrophy by improving the reestablishment of the neuro-muscular junction. | Jorge Ribeiro Tiago Pereira Ana Rita Caseiro Paulo Armada-da-Silva Isabel Pires Justina Prada Irina Amorim Sandra Amado Miguel Franca Carolina Goncalves Maria Ascensao Lopes Jose Domingos Santos Dina Morais Silva Stefano Geuna Ana Lúcia Luís Ana Colette Maurício | 2015 | World Journal of Stem Cells2015，7，6： | 2 |
| 6 | Nonpituitary Prolactin Gene Transcription is Independent of Pit-1 and Differentially Controlled in Lymphocytes and in Endometrial Stroma显示文摘 | Galetto A Geuna M | 1994 | J Mol Endocrinol1994，8，3： | 1 |
| 7 | Factors affecting university- industry R&D projects: The importance of searching, screeningand signaling显示文摘 | Fontana R Geuna A Matt M | 2006 | Research Policy2006，35，2： | 1 |
| 8 | Science-technology linkages in an emerging research platform: The case of combinatorial chemistry and biology 显示文摘 | Geuna A Malo S | 2000 | SCIENTOMETRICS2000，47，2： | 1 |
| 9 | Expression of prolactin and prolactin receptors by non-Hodgkin's lymphoma cells显示文摘 | Matera L Geuna M Pastore C | 2000 | Int J Cancer2000，85，1： | 1 |
| 10 | Long-termfunctional and morphological assessment of a stand-ardized rat sciatic nerve crush injury with a non-ser-rated clamp显示文摘 | Luis AL Amado S Geuna S | 2007 | Neurosci Methods2007，163，1： | 1 |
| 11 | Factors affecting university–industry R&D projects: The importance of searching, screening and signalling显示文摘 | Roberto Fontana Aldo Geuna Mireille Matt | 2005 | Research Policy2005，，2： | 1 |
| 12 | A stereological study of long- term regeneration of rat severed siatic nerve repaired by means of muscle-vein-combined grafts显示文摘 | Geuna S Tos P Battiston B | 2000 | Ital Anat Ernbryol2000，103，： | 1 |
| 13 | University Research Evaluation and Funding: An International Comparison显示文摘 | Aldo Geuna Ben R. Martin | 2003 | Minerva2003，，4： | 1 |
| 14 | The changing rationale for European uni- versity research funding: are there negative unintended consequences显示文摘 | ALDO GEUNA | 2001 | Journal of Economic Issues2001，35，3： | 1 |
| 15 | University Research Evaluation and Funding: An International Comparison 显示文摘 | Aldo Geuna & Ben R Martin | 2003 | Minerva2003，，41： | 1 |
| 16 | University patenting and its effects on academic research : The emerging European evidence 显示文摘 | Geuna A Nesta L | 2006 | Research Policy2006，35，6： | 1 |
| 17 | Information and cotmmmication technologies and the production, distribution and use of knowedge显示文摘 | Antonelli C Geuna A Steinmueller W E | 2000 | International Journal of Technology Management2000，，： | 1 |
| 18 | A flow cytometry assay simultaneously detects independent apoptotic parameters显示文摘 | Rasola A Geuna M | 2001 | Cytometry2001，45，： | 1 |
| 19 | Phototherapy and nerve injury:focus on muscle response显示文摘 | Rochkind S Geuna S Shainberg A | 2013 | Int Rev Neurobiol2013，109，： | 1 |
| 20 | Factors affecting university - industry R&D projects: The importance of searching, screening and signaling 显示文摘 | FONTANA R GEUNA A MATI' M | 2006 | Research Policy2006，35，2： | 1 |
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