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| 1 | Subclinical atherosclerosis is linked to small intestinal bacterial overgrowth via vitamin K2-dependent mechanisms显示文摘AIM To assess the rate of matrix Gla-protein carboxylation in patients with small intestinal bacterial overgrowth(SIBO) and to decipher its association with subclinical atherosclerosis.METHODS Patients with suspected SIBO who presented with a low risk for cardiovascular disease and showed no evidence of atherosclerotic plaques were included in the study. A glucose breath test was performed in order to confirm the diagnosis of SIBO and vascular assessment was carried out by ultrasound examination. Plasma levels of the inactive form of MGP(dephosphorylateduncarboxylated matrix Gla-protein) were quantified by ELISA and vitamin K2 intake was estimated using a food frequency questionnaire.RESULTS Thirty-nine patients were included in the study. SIBO was confirmed in 12/39(30.8%) patients who also presented with a higher concentration ofdephosphorylated-uncarboxylated matrix Gla-protein(9.5 μg/L vs 4.2 μg/L; P = 0.004). Arterial stiffness was elevated in the SIBO group(pulse-wave velocity 10.25 m/s vs 7.68 m/s; P = 0.002) and this phenomenon was observed to correlate linearly with the levels of dephosphorylated-uncarboxylated matrix Gla-protein(β = 0.220, R2 = 0.366, P = 0.03). Carotid intima-media thickness and arterial calcifications were not observed to be significantly elevated as compared to controls.CONCLUSION SIBO is associated with reduced matrix Gla-protein activation as well as arterial stiffening. Both these observations are regarded as important indicators of subclinical atherosclerosis. Hence, screening for SIBO, intestinal decontamination and supplementation with vitamin K2 has the potential to be incorporated into clinical practice as additional preventive measures. | Francesca Romana Ponziani Maurizio Pompili Enrico Di Stasio Maria Assunta Zocco Antonio Gasbarrini Roberto Flore | 2017 | World Journal of Gastroenterology2017，23，7： | 9 |
| 2 | Thrombotic risk factors in patients with liver cirrhosis: Correlation with MELD scoring system and portal vein thrombosis development显示文摘 | Maria Assunta Zocco Enrico Di Stasio Raimondo De Cristofaro Marialuisa Novi Maria Elena Ainora Francesca Ponziani Laura Riccardi Stefano Lancellotti Angelo Santoliquido Roberto Flore Maurizio Pompili Gian Lodovico Rapaccini Paolo Tondi Giovanni Battista G | 2009 | Journal of Hepatology2009，，4： | 5 |
| 3 | Clinical effectiveness of palifermin in prevention and treatment of oral mucositis in children with acute lymphoblastic leukaemia: a case–control study显示文摘The aim of this study was to evaluate the efficacy of palifermin, an N-terminal truncated version of endogenous keratinocyte growth factor, in the control of oral mucositis during antiblastic therapy. Twenty patients undergoing allogeneic stem-cell transplantation for acute lymphoblastic leukaemia were treated with palifermin, and compared to a control group with the same number of subjects and similar inclusion criteria. Statistical analysis were performed to compare the outcomes in the treatment vs. control groups. In the treatment group, we found a statistically significant reduction in the duration of parenteral nutrition(P50.002), duration of mucositis(P50.003) and the average grade of mucositis(P50.03). The statistical analysis showed that the drug was able to decrease the severity of mucositis. These data, although preliminary, suggest that palifermin could be a valid therapeutic adjuvant to improve the quality of life of patients suffering from leukaemia. | Dorina Lauritano Massimo Petruzzi Dario Di Stasio Alberta Lucchese | 2014 | International Journal of Oral Science2014，6，1： | 3 |
| 4 | Prediction of meat quality traits in the abattoir using portable near-infrared spectrometers:heritability of predicted traits and genetic correlations with laboratory-measured traits显示文摘Background:The possibility of assessing meat quality traits over the meat chain is strongly limited,especially in the context of selective breeding which requires a large number of phenotypes.The main objective of this study was to investigate the suitability of portable infrared spectrometers for phenotyping beef cattle aiming to genetically improving the quality of their meat.Meat quality traits(pH,color,water holding capacity,tenderness)were appraised on rib eye muscle samples of 1,327 Piemontese young bulls using traditional(i.e.,reference/gold standard)laboratory analyses;the same traits were also predicted from spectra acquired at the abattoir on the intact muscle surface of the same animals 1 d after slaughtering.Genetic parameters were estimated for both laboratory measures of meat quality traits and their spectra-based predictions.Results:The prediction performances of the calibration equations,assessed through external validation,were satisfactory for color traits(R^(2) from 0.52 to 0.80),low for pH and purge losses(R^(2) around 0.30),and very poor for cooking losses and tenderness(R^(2) below 0.20).Except for lightness and purge losses,the heritability estimates of most of the predicted traits were lower than those of the measured traits while the genetic correlations between measured and predicted traits were high(average value 0.81).Conclusions:Results showed that NIRS predictions of color traits,pH,and purge losses could be used as indicator traits for the indirect genetic selection of the reference quality phenotypes.Results for cooking losses were less effective,while the NIR predictions of tenderness were affected by a relatively high uncertainty of estimate.Overall,genetic selection of some meat quality traits,whose direct phenotyping is difficult,can benefit of the application of infrared spectrometers technology. | Simone Savoia Andrea Albera Alberto Brugiapaglia Liliana Di Stasio Alessio Cecchinato Giovanni Bittante | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 3 |
| 5 | Thrombotic risk factors in patients with liver cirrhosis: Correlation with MELD scoring system and portal vein thrombosis development显示文摘 | Maria Assunta Zocco Enrico Di Stasio Raimondo De Cristofaro Marialuisa Novi Maria Elena Ainora Francesca Ponziani Laura Riccardi Stefano Lancellotti Angelo Santoliquido Roberto Flore Maurizio Pompili Gian Lodovico Rapaccini Paolo Tondi Giovanni Battista G | 2009 | Journal of Hepatology2009，，4： | 2 |
| 6 | Correlates of symptoms of depression and anxiety in chronic hemodialysis patients显示文摘 | Bossola M Ciciarelli C Di Stasio E | 2010 | Gen Hosp Psychiatry2010，32，2： | 1 |
| 7 | Thrombotic risk factors in patients with liver cirrhosis:correlation with MELD scoring system and portal vein thrombosis development显示文摘 | Zocco MA Di Stasio E De Cristofaro R | 2009 | J Hepato12009，51，4： | 1 |
| 8 | The effects of calcitriol andnicotinamide on residual pancreatic beta-cell function in patients with recent-onset Type 1 diabetes(IMDIAB XI)显示文摘 | Pitocco D Di Stasio E Manfrini S | | 0，，08： | 1 |
| 9 | Content of α s1-casein and coagulation properties in goat milk显示文摘 | STASIO L D MAZZOCCO P | 1988 | J Dairy Sci1988，71，： | 1 |
| 10 | Trigeminal stimulation elicits a peripheral vestibular imbalance in migraine patients显示文摘 | Marano E Marcelli V Di Stasio E | 2005 | Headache2005，45，4： | 1 |
| 11 | Thrombotic riskfactors in patients with liver cirrhosis:correlation with MELDscoring system and portal vein thrombosis development 显示文摘 | Zocco MA Di Stasio E De Cristofaro R | 2009 | JHepatol2009，51，4： | 1 |
| 12 | Positive end-expiratory pressure dur/ng laparoscopy: cardiac and respiratory effects 显示文摘 | Russo A Di Stasio E Scagliusi A | 2013 | J Clin Anesth2013，25，4： | 1 |
| 13 | Throm- botic risk factors in patients with liver cirrhosis:correla- tion with MELD scoring system and portal vein thrombo- sis development 显示文摘 | Zocco M A Di Stasio De Cristofaro R | 2009 | J Hepatol2009，51，4： | 1 |
| 14 | Early prediction of response to Sorafenib in patients with advanced hepatocellular carcinoma: the role of dynamic contrast enhanced ultrasound显示文摘 | Zocco Maria Assunta Garcovich Matteo Lupascu Andrea Di Stasio Enrico Roccarina Davide Annicchiarico Brigida Elenora Riccardi Laura Ainora Maria Elena Ponziani Francesca Caracciolo Gianluigi Rapaccini Gian Lodovico Landolfi Raffaele Siciliano Massimo Pompi | 2013 | Journal of Hepatology2013，，： | 1 |
| 15 | Botulinum Toxin A and B in sialorrhea: Long-term data and literature overview显示文摘 | Martina Petracca Arianna Guidubaldi Lucia Ricciardi Tàmara Ialongo Alessandra Del Grande Delia Mulas Enrico Di Stasio Anna Rita Bentivoglio | 2015 | Toxicon2015，，： | 1 |
| 16 | Rheological behavior of polysaccharide based pellets for crayfish feeding tested on growth in the crayfish Cherax albidus显示文摘 | Volpe M G Monetta M Stasio M D | 2008 | Aquaculture2008，274，24： | 1 |
| 17 | Positive end-expira- tory pressure during laparoscopy: cardiac and respiratory effects显示文摘 | Russo A Di Stasio E Scaqliusi A | 2013 | J Clin Anesth2013，25，4： | 1 |
| 18 | Polymorphism of the GHR gene in cattle and re-lationships with meat production and quality 显示文摘 | Di Stasio L Destefanis G Brugiapaglia A Albera A and Rolando A | 2005 | Animal Genetics2005，36，2： | 1 |
| 19 | Oxidative stress,nitric oxide,and diabetes显示文摘 | Pitocco D Zaccardi F Di Stasio E | 2010 | Rev Diabet Stud2010，7，1： | 1 |
| 20 | NT-proBNP:a marker of preclinical cardiac damage in arterial hypertension显示文摘 | Di Stasio E Russo A Mettimano M | 2011 | Clin Chim Acta2011，412，1112： | 1 |
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