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| 1 | Platelet-to-lymphocyte ratio in the setting of liver transplantation for hepatocellular cancer: A systematic review and meta-analysis显示文摘AIM To perform a systematic review and meta-analysis on platelet-to-lymphocyte ratio(PLR) as a risk factor for post-transplant hepatocellular cancer(HCC) recurrence. METHODS A systematic literature search was performed using PubM ed. Participants of any age and sex, who underwent liver transplantation for HCC were considered following these criteria:(1) studies comparing pre-transplant low vs high PLR values;(2) studies reporting post-transplant recurrence rates; and(3) if more than one study was reported by the same institute, only the most recent was included. The primary outcome measure was set for HCC recurrence after transplantation. RESULTS A total of 5 articles, published between 2014 and 2017, fulfilled the selection criteria. As for the quality of the reported studies, all the investigated articles presented an overall high quality. A total of 899 cases were investigated: 718 cases(80.0%) were males. Three studies coming from European countries and one from Japan presented HCV as the main cause of cirrhosis. On the opposite, one Chinese study presented a greater incidence of HBV-related cirrhotic cases. In all the studies apart one, the PLR cut-off value of 150 was reported. At meta-analysis, high PLR value was associated with a significant increase in recurrence after transplantation(OR = 3.33; 95%CI: 1.78-6.25; P < 0.001). A moderate heterogeneity was observed among the identified studies according to the Higgins I^2 statistic value.CONCLUSION Pre-transplant high PLR values are connected with an increased risk of post-operative recurrence of hepatocellular cancer. More studies are needed for better clarify the biological mechanisms of this results. | Quirino Lai Fabio Melandro Zoe Larghi Laureiro Francesco Giovanardi Stefano Ginanni Corradini Flaminia Ferri Redan Hassan Massimo Rossi Gianluca Mennini | 2018 | World Journal of Gastroenterology2018，24，15： | 19 |
| 2 | Imaging of the small bowel in Crohn's disease: A review of old and new techniques显示文摘The investigation of small bowel morphology is often mandatory in many patients with Crohn's disease. Traditional radiological techniques (small bowel enteroclysis and small bowel follow-through) have long been the only suitable methods for this purpose. In recent years, several alternative imaging techniques have been proposed. To review the most recent advances in imaging studies of the small bowel, with particular reference to their possible application in Crohn's disease, we conducted a complete review of the most important studies in which traditional and newer imaging methods were performed and compared in patients with Crohn's disease. Several radiological and endoscopic techniques are now available for the study of the small bowel; each of them is characterized by a distinct profile of favourable and unfavourable features. In some cases, they may also be used as complementary rather than alternative techniques. In everyday practice, the choice of the technique to be used stands upon its availability and a careful evaluation of diagnostic accuracy, clinical usefulness, safety and cost. The recent development ofinnovative imaging techniques has opened a new and exciting area in the exploration of the small bowel in Crohn's disease patients. | Simone Saibeni Emanuele Rondonotti Andrea Iozzelli Luisa Spina Gian Eugenio Tontini Flaminia Cavallaro Camilla Ciscato Roberto de Franchis Francesco Sardanelli Maurizio Vecchi | 2007 | World Journal of Gastroenterology2007，13，24： | 6 |
| 3 | Efficacy and tolerability of high and low-volume bowel preparation compared:A real-life single-blinded large-population study显示文摘BACKGROUND Low-volume preparations for colonoscopy have shown similar efficacy compared to high-volume ones in randomized controlled trials(RCT).However,most RCTs do not provide data about clinical outcomes including lesions detection rate.Moreover,real-life comparisons are lacking.AIM To compare efficacy(both in terms of adequate bowel preparation and detection of colorectal lesions)and tolerability of a high-volume(HV:4 L polyethylene glycol,PEG)and a low-volume(LV:2 L PEG plus bisacodyl)bowel preparation in a real-life setting.METHODS Consecutive outpatients referred for colonoscopy were prospectively enrolled between 1 December 2014 and 31 December 2016.Patients could choose either LV or HV preparation,with a day-before schedule for morning colonoscopies and a split-dose for afternoon procedures.Adequate bowel preparation according to Boston Bowel Preparation Scale(BBPS),clinical outcomes including polyp detection rate(PDR),adenoma detection rate(ADR),advanced adenoma detection rate(AADR),sessile/serrated lesion detection rate(SDR)and cancer detection rate and self-reported tolerability of HV and LV were blindly assessed.RESULTS Total 2040 patients were enrolled and 1815(mean age 60.6 years,50.2%men)finally included.LV was chosen by 52%of patients(50.8%of men,54.9%of women).Split-dose schedule was more common with HV(44.7%vs 38.2%,P=0.005).High-definition scopes were used in 33.4%of patients,without difference in the two groups(P=0.605).HV and LV preparations showed similar adequate bowel preparation rates(89.2%vs 86.6%,P=0.098),also considering the two different schedules(HV split-dose 93.8%vs LV split-dose 93.6%,P=1;HV daybefore 85.5%vs LV day-before 82.3%,P=0.182).Mean global BBPS score was higher for HV preparations(7.1±1.7 vs 6.8±1.6,P<0.001).After adjustment for sex,age and indications for colonoscopy,HV preparation resulted higher in PDR[Odds ratio(OR)1.32,95%CI:1.07-1.63,P=0.011]and ADR(OR 1.29,95%CI 1.02–1.63,P=0.038)and comparable to LV in AADR(OR 1.51,95%CI 0.97-2.35,P=0.069),SDR and cancer detection rate.The use of standard-definition colonoscopes was associated to lower PDR(adjusted OR 1.59,95%CI:1.22-2.08,P<0.001),ADR(adjusted OR 1.71,95%CI:1.26–2.30,P<0.001)and AADR(adjusted OR 1.97,95%CI:1.09-3.56,P=0.025)in patients receiving LV preparation.Mean Visual Analogue Scale tolerability scored equally(7,P=0.627)but a≥75%dose intake was more frequent with LV(94.6%vs 92.1%,P=0.003).CONCLUSION In a real-life setting,PEG-based low-volume preparation with bisacodyl showed similar efficacy and tolerability compared to standard HV preparation.However,with higher PDR and ADR,HV should still be considered as the reference standard for clinical trials and the preferred option in screening colonoscopy,especially when colonoscopy is performed with standard resolution imaging. | Vincenzo Occhipinti Paola Soriani Francesco Bagolini Valentina Milani Emanuele Rondonotti Maria Laura Annunziata Flaminia Cavallaro Sara Vavassori Maurizio Vecchi Luca Pastorelli Gian Eugenio Tontini | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，12： | 4 |
| 4 | Beneficial effect of sulphate-bicarbonate-calcium water on gallstone risk and weight control显示文摘AIM:To investigate the effect of drinking sulphate-bicarbonate-calcium thermal water (TW) on risk factors for atherosclerosis and cholesterol gallstone disease.METHODS:Postmenopausal women with functional dy-spepsia and/or constipation underwent a 12 d cycle of thermal (n=20) or tap (n=20) water controlled drinking.Gallbladder fasting volume at ultrasound,blood vitamin E,oxysterols (7-β-hydroxycholesterol and 7-ketocholesterol),bile acid (BA),triglycerides,total/low density lipoprotein and high density lipoprotein cholesterol were measured at baseline and at the end of the study.Food consumption,stool frequency and body weight were recorded daily.RESULTS:Blood lipids,oxysterols and vitamin E were not affected by either thermal or tap water consumption.Fasting gallbladder volume was significantly (P<0.005) smaller at the end of the study than at baseline in the TW (15.7±1.1 mL vs 20.1±1.7 mL) but not in the tap water group (19.0±1.4 mL vs 19.4±1.5 mL).Total serum BA concentration was significantly (P<0.05) higher at the end of the study than at baseline in the TW (5.83±1.24μmol vs 4.25±1.00μmol) but not in the tap water group (3.41±0.46μmol vs 2.91±0.56μmol).The increased BA concentration after TW consumption was mainly accounted for by glycochenodeoxycholic acid.The number of pasta (P<0.001),meat (P<0.001) and vegetable (P<0.005) portions consumed during the study and of bowel movements per day (P<0.05) were significantly higher in the TW than in the tap water group.Body weight did not change at the end of the study as compared to baseline in both groups.CONCLUSION:Sulphate-bicarbonate-calcium water consumption has a positive effect on lithogenic risk and intestinal transit and allows maintenance of a stable body weight despite a high food intake. | Stefano Ginanni Corradini Flaminia Ferri Michela Mordenti Luigi Iuliano Maria Siciliano Maria Antonella Burza Bruno Sordi Barbara Caciotti Maria Pacini Edoardo Poli Adriano De Santis Aldo Roda Carolina Colliva Patrizia Simoni Adolfo Francesco Attili | 2012 | World Journal of Gastroenterology2012，18，9： | 3 |
| 5 | Chronic radiation-induced proctitis: the 4 % formalin application as non-surgical treatment显示文摘 | Daniele Pironi Alessandra Panarese Maurizio Vendettuoli Stefano Pontone Salvatore Candioli Annarita Manigrasso Flaminia Cristofaro Angelo Filippini | 2013 | International Journal of Colorectal Disease2013，，2： | 1 |
| 6 | Determination of endogenous and synthetic glucocorticoids in human urine by gas chromatography-mass spectrometry following microwave-assisted derivatization显示文摘 | Luca Amendola Flaminia Garribba Francesco Botrè | 2003 | Analytica Chimica Acta2003，，489： | 1 |
| 7 | Relax- in prevents cardiac fibroblast-myofibroblast transition via Notch-1- mediated inhibition of TGF-/Smad3 dignaling 显示文摘 | Chiara Sassoli Flaminia Chellini Alessandro Pini | 2013 | PLoS ONE2013，8，63： | 1 |
| 8 | Occurrence of gastric cancer and carcinoids in atrophic gastritis during prospective long-term follow up显示文摘 | Edith Lahner Gianluca Esposito Emanuela Pilozzi Flaminia Purchiaroni Vito D Corleto Emilio Di Giulio Bruno Annibale | 2015 | Scandinavian Journal of Gastroenterology2015，，7： | 1 |
| 9 | Determination of endogenous and synthetic glucocorticoids in human urine by gas chromatography-mass spectrometry following microwave-assisted derivatization显示文摘 | Luca Amendola Flaminia Garribba Francesco Botrè | 2003 | Analytica Chimica Acta2003，，489： | 1 |
| 10 | Serum steroidpro ling by isotopic dilution-liquid chromatography-mass spectrometry: comparison with current imrnunoassays and reference intervals in healthy adults 显示文摘 | Flaminia F Ilaria B Valentina D | 2011 | Steroids2011，76，3： | 1 |
| 11 | Respiratory depression following iatrogenic tramadol overuse in a patient with chronic renal failure显示文摘 | Consalvo M Sandro M Flaminia C | 2004 | J Headache Pain2004，5，： | 1 |
| 12 | Is Internet addiction a psychopathological condition distinct from pathological gambling?显示文摘 | Federico Tonioni Marianna Mazza Gianna Autullo Roberta Cappelluti Valeria Catalano Giuseppe Marano Valerio Fiumana Claudia Moschetti Flaminia Alimonti Massimiliano Luciani Carlo Lai | 2014 | Addictive Behaviors2014，，： | 1 |
| 13 | Effect of denaturants of the structural properties of soybean lipoxygenase-1显示文摘 | Flaminia Malvezzi-Campeggi Nicola Rosato Alessandro Finazzi Agro | 2001 | Biochemical and Biophysical Research Communications2001，28，9： | 1 |
| 14 | Relaxin prevents cardiac fibroblast-myofibroblast transition via Notch-1-mediated Inhibition of TGF-β/smad3signaling显示文摘 | CHIARA S FLAMINIA C ALESSANDRO P | 2013 | Plos One2013，8，63： | 1 |
| 15 | Effects of denaturants on the structural properties of soybean lipoxygenase- 1 显示文摘 | Flaminia M C Nicola R Alessandro F A | 2001 | Biochemcal Biophysical Research Communications2001，289，5： | 1 |
| 16 | Estimation of ref- erence intervals of five endocannabinoids and endo- cannabinoid related compounds in human plasma by two dimensional-LC/MS/MS显示文摘 | Flaminia F Lallo V D D Ilaria B | 2012 | Journal of lipid research2012，53，3： | 1 |
| 17 | Respiratory depression following iatrogenic tramadol overuse in a patient with chronic renal failure显示文摘 | Consalvo M Sandro M Flaminia C | 2004 | J Headache Pain2004，5，2： | 1 |
| 18 | Aniline-based silane as a primer for corrosion inhibition of aluminum显示文摘 | Flaminia D O Trueba M Trasatti S P | 2012 | Progress in OrganicCoatings2012，74，2： | 1 |
| 19 | Safety and efficacy of DEM-TACE performed with drug-eluting microspheres smaller than 300μm in patients with HCC and TIPS显示文摘Aim:Safety and efficacy evidence of drug-eluting-microspheres trans-arterial chemoembolization(DEM-TACE)in patients with hepatocellular carcinoma(HCC)and trans-jugular intrahepatic portosystemic shunt(TIPS)is lacking.The aim of this retrospective study was to report the safety and efficacy of DEM-TACE procedures performed with microspheres smaller than 300μm in patients with HCC and TIPS in a high-volume transplant center.Methods:Embolization was standardized by initiating DEM-TACE with microspheres smaller than 100μm,and if stasis was not achieved,adjunctive embolization with 100-300 or 200μm microspheres was administered.With regards to efficacy,the oncological response was evaluated and categorized according to mRECIST criteria at 1,3-6,9-12,and 15-18 months.Reporting the safety profile,detailed laboratory analysis was performed before,at 36-48 h,and 30-60 days after the procedure.Adverse events(AEs)were recorded;post-embolic syndrome was defined as the onset of fever/nausea/pain after the procedure.Late onset hepatobiliary complications were evaluated by follow-up imaging with computed tomography or magnetic resonance(CT/MR).Results:From December 2007 to November 2020,17 HCC patients(25 HCC nodules)with patent TIPS underwent 20 DEM-TACE.Embolization was performed only with microspheres smaller than 100μm in 3/20 DEM-TACE(15%);adjunctive embolization with 100-300 or 200μm microspheres was required in 17/20 DEMTACE(85%).Reported early AEs were post-embolic syndrome(9/20;45%)all of grade 1-2,late AEs were asymptomatic acute liver bile duct injury(2/20;10%),and in one case we observed hepatic abscess(1/20;5%)resulting in death due to sepsis.With regards to efficacy,the oncological response was evaluated and categorized according to mRECIST criteria.Complete response(CR)at 1,3-6,9-12,and 15-18 months was 52%,50%,50%,and 50%,respectively.Objective response(CR+partial response)at 1,3-6,9-12,and 15-18 months was 95%,71%,70%,and 50%,respectively.Conclusion:DEM-TACE with drug-eluting-microspheres smaller than 300μm can be performed in appropriately selected patients with TIPS. | Pierleone Lucatelli Simone Zilahi De Gyurgyokai Gianluca De Rubeis Renato Argirò Simone Ciaglia Bianca Rocco Flaminia Ferri Simona Parisse Mariana Forlino Alessandro Cannavale FabrizioBasilico Pier Giorgio Nardis Mario Corona Vito Cantisani Carlo Catalano | 2022 | Hepatoma Research2022，8，1： | 0 |
| 20 | 这一年的卫浴理想显示文摘从今年春天开始,一个接一个国际卫浴展让人们对卫浴产品的热情持续升温,卫浴产品几乎像汽车一样成为人们关注与谈论的话题。数不清的新产品、新设计、新技术、新概念一齐涌到人们面前,但究竟哪些才是最好的,哪些才真正代表了2005年乃至2006年的流行趋势?只有那些能够打动人心的设计,才会让人渴望拥有。今年,象征自然的曲线与极简的几何形体成为最受关注的设计要素。曲线与几何分别象征了人们追求自由与简单的生活理想,从两个不同的角度贴近了人们的内心。另外,今年的卫浴产品在功能方面同样有了创新性的突破,科技与设计一同,帮助人们在卫浴的过程中彻底放松,享受生活。现在,就让我们一一细数,那些在这一年里最具代表性的卫浴产品。 | 朱冬熳 唯宝 凯乐玛 汉斯格雅 高仪 卡德维 杜拉维特 FLAMINIA 乐家 | 2005 | 缤纷2005，0，6： | 0 |
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