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| 1 | Possible contribution of artificial neural networks and linear discriminant analysis in recognition of patients with suspected atrophic body gastritis显示文摘AIM: To investigate whether ANNs and LDA could recognize patients with ABG in a database, containing only clinical and biochemical variables, of a pool of patients with and without ABG, by selecting the most predictive variables and by reducing input data to the minimum.METHODS: Data was collected from 350 consecutive outpatients (263 with ABG, 87 with non-atrophic gastritis and/or celiac disease [controls]). Structured questionnaires with 22 items (anagraphic, anamnestic, clinical, and biochemical data) were filled out for each patient. All patients underwent gastroscopy with biopsies. ANNs and LDA were applied to recognize patients with ABG.Experiment 1: random selection on 37 variables, experiment 2: optimization process on 30 variables, experiment 3:input data reduction on 8 variables, experiment 4: use of only clinical input data on 5 variables, and experiment 5:use of only serological variables.RESULTS: In experiment 1, overall accuracies of ANNs and LDA were 96.6% and 94.6%, respectively, for predicting patients with ABG. In experiment 2, ANNs and LDA reached an overall accuracy of 98.8% and 96.8%,respectively. In experiment 3, overall accuracy of ANNs was 98.4%. In experiment 4, overall accuracies of ANNs and LDA were, respectively, 91.3% and 88.6%. In experiment 5, overall accuracies of ANNs and LDA were,respectively, 97.7% and 94.5%.CONCLUSION: This preliminary study suggests that advanced statistical methods, not only ANNs, but also LDA,may contribute to better address bioptic sampling during gastroscopy in a subset of patients in whom ABG may be suspected on the basis of aspecific gastrointestinal symptoms or non-digestive disorders. | Edith Lahner Enzo Grossi Marco Intraligi Massimo Buscema Vito D Corleto Gianfranco Delle Fave Bruno Annibale | 2005 | World Journal of Gastroenterology2005，11，37： | 4 |
| 2 | Enteroscopy in children and adults with inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD)includes Crohn’s disease(CD),ulcerative colitis and unclassified entities.CD commonly involves the terminal ileum and colon but at the time of diagnosis it can be confined to the small bowel(SB)in about 30%of the patients,especially in the young ones.Management of isolated SB-CD can be challenging and objective evaluation of the SB mucosa is essential in differentiating CD from other enteropathies to achieve therapeutic decisions and to plan the follow-up.The introduction of cross-sectional imaging techniques and capsule endoscopy(CE)have significantly expanded the ability to diagnose SB diseases providing a non-invasive test for the visualization of the entire SB mucosa.The main CE limitations are the low specificity,the lack of therapeutic capabilities and the impossibility to take biopsies.Device assisted enteroscopy(DAE)enables histological confirmation when traditional endoscopy,capsule endoscopy and cross-sectional imaging are inconclusive and also allows therapeutic interventions such as balloon stricture dilation,intralesional steroid injection,capsule retrieval and more recently stent insertion.In the current review we will discuss technical aspect,indications and safety profile of DAE in children and adults with IBD. | Giovanni Di Nardo Gianluca Esposito Chiara Ziparo Federica Micheli Luigi Masoni Maria Pia Villa PasqualeParisi Maria Beatrice Manca Flavia Baccini Vito Domenico Corleto | 2020 | World Journal of Gastroenterology2020，26，39： | 2 |
| 3 | Mucosal adhesion and anti-inflammatory effects of Lactobacillus rhamnosus GG in the human colonic mucosa: A proof-of-concept study显示文摘AIM To investigate the adhesion and anti-inflammatory effects of Lactobacil us rhamnosus GG (LGG) in the colonic mucosa of healthy and ulcerative colitis (UC) patients, both in vivo and ex vivo in an organ culture model.METHODS For the ex vivo experiment, a total of 98 patients (68 UC patients and 30 normal subjects) were included. Endoscopic biopsies were collected and incubated with and without LGG or LGG-conditioned media to evaluate the mucosal adhesion and anti-inflammatory effects [reduction of tumor necrosis factor alpha (TNFα) and interleukin (IL)-17 expression] of the bacteria, and extraction of DNA and RNA for quantification by real-time (RT)-PCR occurred after the incubation. A dose-response study was performed by incubating biopsies at 'regular', double and 5 times higher doses of LGG. For the in vivo experiment, a total of 42 patients (20 UC patients and 22 normal controls) were included. Biopsies were taken from the colons of normal subjects who consumed a commercial formulation of LGG for 7 d prior to the colonoscopy,and the adhesion of the bacteria to the colonic mucosa was evaluated by RT-PCR and compared with that of control biopsies from patients who did not consume the formulation. LGG adhesion and TNFα and IL-17 expression were compared between UC patients who consumed a regular or double dose of LGG supplementation prior to colonoscopy.RESULTS In the ex vivo experiment, LGG showed consistent adhesion to the distal and proximal colon in normal subjects and UC patients, with a trend towards higher concentrations in the distal colon, and in UC patients, adhesion was similar in biopsies with active and quiescent inflammation. In addition, bioptic samples from UC patients incubated with LGG conditioned media (CM) showed reduced expression of TNFα and IL-17 compared with the corresponding expression in controls (P < 0.05). Incubation with a double dose of LGG increased mucosal adhesion and the anti-inflammatory effects (P < 0.05). In the in vivo experiment, LGG was detectable only in the colon of patients who consumed the LGG formulation, and bowel cleansing did not affect LGG adhesion. UC patients who consumed the double LGG dose had increased mucosal concentrations of the bacteria and reduced TNFα and IL-17 expression compared with patients who consumed the regular dose (48% and 40% reduction, respectively, P < 0.05).CONCLUSION In an ex vivo organ culture model, LGG showed consistent adhesion and anti-inflammatory effects. Colonization by LGG after consumption for a week was demonstrated in vivo in the human colon. Increasing the administered dose increased the adhesion and effectiveness of the bacteria. For the first time, we demonstrated that LGG effectively adheres to the colonic mucosa and exerts antiinflammatory effects, both ex vivo and in vivo. | Cristiano Pagnini Vito Domenico Corleto Michela Martorelli Claudio Lanini Giancarlo D'Ambra Emilio Di Giulio Gianfranco Delle Fave | 2018 | World Journal of Gastroenterology2018，24，41： | 2 |
| 4 | Alteration of Local Microflora and α-defensins Hyper-production in Colonic Adenoma Mucosa显示文摘 | Cristiano Pagnini Vito D. Corleto Maria Luisa Mangoni Emanuela Pilozzi Maria Simona Torre Rodolfo Marchese Antonella Carnuccio Emilio Di Giulio Gianfranco Delle Fave | 2011 | Journal of Clinical Gastroenterology2011，，7： | 2 |
| 5 | Effect of chronic hypergastrinemia on human enterchromaffin-like cells:insight from patients with sprodiac gastrinomas显示文摘 | Peghini PL Annibale B Azzoni C Milione M Corleto VD Gibril F | 2002 | Gastroenterology2002，123，： | 1 |
| 6 | Long-term octreotide treatment of metastatic carcinoid tumor显示文摘 | Corleto VD Angeletti S Schillaci O | | 0，，04： | 1 |
| 7 | No higher risk for colorectal cancer in atrophic gastritis-related hypergastrinemia显示文摘 | Edith Lahner Andrea Sbrozzi-Vanni Lucy Vannella Vito Domenico Corleto Emilio Di Giulio Gianfranco Delle Fave Bruno Annibale | 2012 | Digestive and Liver Disease2012，，9： | 1 |
| 8 | Dose the widespread use of proton pump inhibitors mask complicate and/or delay the diagnosis of Zollinger-Ellision syndrome? 显示文摘 | Corleto VD Annibale B Gibril F | 2001 | Aliment Phaimacol Ther2001，15，10： | 1 |
| 9 | Nonfunctioning pancreatic endocrine tumors: a multicenter clinical study显示文摘 | Lucio Gullo Marina Migliori Massimo Falconi Paolo Pederzoli Rossella Bettini Riccardo Casadei Gianfranco Delle Fave Vito D Corleto Claudio Ceccarelli Donatella Santini Paola Tomassetti | 2003 | The American Journal of Gastroenterology2003，，11： | 1 |
| 10 | Ablation of atrial fibrillation: does the addition of three-dimensional magnetic resonance imaging of the left atrium to electroanatomic mapping improve the clinical outcome?: A randomized comparison of Carto-Merge vs Carto-XP three-dimensional mapping ablation in patients with paroxysmal and persistent atrial fibrillation显示文摘 | Caponi D Corleto A Scaglione M | 2010 | Europace2010，12，8： | 1 |
| 11 | Expression of somatostatin receptor subtypes on guinea pig gastric and colonic smooth muscle cells显示文摘 | Corleto V D Weber H C Jensen R T | 1999 | American Journal of Physiology1999，277，1： | 1 |
| 12 | Somatostatin receptor subtype 3 mediates the inhibitory action of somatostatin on gastric smooth muscle cells显示文摘 | Gu Z F Corleto V D Mantey S A | 1995 | American Journal of Physiology1995，268，5： | 1 |
| 13 | Somatostatin receptor subtypes mediate contractility on human colonic smooth muscle cells显示文摘 | CORLETO V D SEVERI C ROMANO G | 2006 | Neurogastroenterol Motil2006，18，3： | 1 |
| 14 | Low prevalence of idiopathic peptic ulcer disease: An Italian endoscopic survey显示文摘 | Andrea Sbrozzi-Vanni Angelo Zullo Emilio Di Giulio Cesare Hassan Vito D. Corleto Edith Lahner Bruno Annibale | 2010 | Digestive and Liver Disease2010，，11： | 1 |
| 15 | Human circular colonic smooth muscle cells possess active somatostatin receptors显示文摘 | Corleto VD Romano G Severi C | 1998 | Ital J Gastroenterol Hepatol1998，30，： | 1 |
| 16 | Human circular colonic smooth musle cells possess active somatoscatin receptors显示文摘 | Corleto VD Romano G Severi C | 1998 | Ital J Gastroenterol Hepatol1998，30，： | 1 |
| 17 | Which are the most reliable predictors of recurrence of atrial fibrillation after transcatheter ablation:a meta-analysis显示文摘 | D'Ascenzo F Corleto A Biondi-Zoccai G | 2013 | Int J Cardiol2013，167，5： | 1 |
| 18 | Occurrence of gastric cancer and carcinoids in atrophic gastritis during prospective long-term follow up显示文摘 | Edith Lahner Gianluca Esposito Emanuela Pilozzi Flaminia Purchiaroni Vito D Corleto Emilio Di Giulio Bruno Annibale | 2015 | Scandinavian Journal of Gastroenterology2015，，7： | 1 |
| 19 | The antral mucosa as a new site for endocrine tumors in multiple endocrine neoplasia type 1 and Zollinger-Ellison syndromes显示文摘 | Bordi C Corleto VD Azzoni C | 2001 | J Clin Endocrinol Metab2001，86，5： | 1 |
| 20 | Human circular colonic smooth muscle cells possess active somatostatin receptors显示文摘 | Corleto VD Romano G Severi C | 1998 | Ital J Gastroenterol Hepatol1998，30，： | 1 |
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