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| 1 | Risk for gastric neoplasias in patients with chronic atrophic gastritis:A critical reappraisal显示文摘Chronic atrophic gastritis (CAG) is an inflammatory condition characterized by the loss of gastric glandular structures which are replaced by connective tissue (non-metaplastic atrophy) or by glandular structures inappropriate for location (metaplastic atrophy).Epidemiological data suggest that CAG is associated with two different types of tumors:Intestinal-type gastric cancer (GC) and type Ⅰ gastric carcinoid (TⅠGC).The pathophysiological mechanisms which lead to the development of these gastric tumors are different.It is accepted that a multistep process initiating from Helicobacter pylori-related chronic inflammation of the gastric mucosa progresses to CAG,intestinal metaplasia,dysplasia and,finally,leads to the development of GC.The TⅠGC is a gastrin-dependent tumor and the chronic elevation of gastrin,which is associated with CAG,stimulates the growth of enterochromaffin-like cells with their hyperplasia leading to the development of TⅠGC.Thus,several events occur in the gastric mucosa before the development of intestinal-type GC and/or TⅠGC and these take several years.Knowledge of CAG incidence from superficial gastritis,its prevalence in different clinical settings and possible risk factors associated with the progression of this condition to gastric neoplasias are important issues.This editorial intends to provide a brief review of the main studies regarding incidence and prevalence of CAG and risk factors for the development of gastric neoplasias. | Lucy Vannella Edith Lahner Bruno Annibale | 2012 | World Journal of Gastroenterology2012，18，12： | 73 |
| 2 | Treatment of Helicobacter pylori infection in atrophic gastritis显示文摘Helicobacter pylori(Hp) is a major human pathogen causing chronic, progressive gastric mucosal damage and is linked to gastric atrophy and cancer. Hp-positive individuals constitute the major reservoir for transmission of infection. There is no ideal treatment for Hp. Hp infection is not cured by a single antibiotic, and sometimes, a combined treatment with three or more antibiotics is ineffective. Atrophic gastritis(AG) is a chronic disease whose main features are atrophy and/or intestinal metaplasia of the gastric glands, which arise from long-standing Hp infection. AG is reportedly linked to an increased risk for gastric cancer, particularly when extensive intestinal metaplasia is present. Active or past Hp infection may be detected by conventional methods in about two-thirds of AG patients. By immunoblotting of sera against Hp whole-cell protein lysates, a previous exposure to Hp infection is detected in all AG patients. According to guidelines, AG patients with Hp positivity should receive eradication treatment. The goals of treatment are as follows:(1) Cure of infection, resolution of inflammation and normalization of gastric functions;(2) possible reversal of atrophic and metaplastic changes of the gastric mucosa; and(3) prevention of gastric cancer. An ideal antibiotic regimen for Hp should achieve eradication rates of approximately 90%, and complex multidrug regimens are required to reach this goal. Amongst the factors associated with treatment failure are high bacterial load, high gastric acidity, Hp strain, smoking, low compliance, overweight, and increasing antibiotic resistance. AG, when involving the corporal mucosa, is linked to reduced gastric acid secretion. At a non-acidic intra-gastric p H, the efficacy of the common treatment regimens combining proton pump inhibitors with one or more antibiotics may not be the same as that observed in patients with Hp gastritis in an acid-producing stomach. Although the efficacy of these therapeutic regimens has been thoroughly tested in subjects with Hp infection, there is a paucity of evidence in the subgroupof patients with AG. Bismuth-based therapy may be an attractive treatment in the specific setting of AG, and specific studies on the efficacy of bismuth-based therapies are needed in patients with AG. | Edith Lahner Marilia Carabotti Bruno Annibale | 2018 | World Journal of Gastroenterology2018，24，22： | 57 |
| 3 | Pernicious anemia: New insights from a gastroenterological point of view显示文摘Pernicious anemia (PA) is a macrocytic anemia that is caused by vitamin B12 defi ciency, as a result of intrinsic factor deficiency. PA is associated with atrophic body gastritis (ABG), whose diagnosis is based on histological confirmation of gastric body atrophy. Serological markers that suggest oxyntic mucosa damage are increased fasting gastrin and decreased pepsinogen .Without performing Schilling's test,intrinsic factor deficiency may not be proven, andintrinsic factor and parietal cell antibodies are useful surrogate markers of PA, with 73% sensitivity and 100% specificity. PA is mainly considered a disease of the elderly, but younger patients represent about 15% of patients. PA patients may seek medical advice due to symptoms related to anemia, such as weakness and asthenia. Less commonly, the disease is suspected to be caused by dyspepsia. PA is frequently associated with autoimmune thyroid disease (40%) and other autoimmune disorders, such as diabetes mellitus (10%), as part of the autoimmune polyendocrine syndrome. PA is the end-stage of ABG. Longstanding Helicobacter pylori infection probably plays a role in many patients with PA, in whom the active infectious process has been gradually replaced by an autoimmune disease that terminates in a burned-out infection and the irreversible destruction of the gastricbody mucosa. Human leucocyte antigen-DR genotypes suggest a role for genetic susceptibility in PA. PA patients should be managed by cobalamin replacement treatment and monitoring for onset of iron defi ciency. Moreover, they should be advised about possible gastrointestinal long-term consequences, such as gastric cancer and carcinoids. | Edith Lahner Bruno Annibale | 2009 | World Journal of Gastroenterology2009，15，41： | 13 |
| 4 | Helicobacter pylori infection and drugs malabsorption显示文摘Drug absorption represents an important factor affecting the efficacy of oral drug treatment.Gastric secretion and motility seem to be critical for drug absorption.A causal relationship between impaired absorption of orally administered drugs and Helicobacter pylori(H.pylori)infection has been proposed.Associations have been reported between poor bioavailability of l-thyroxine and l-dopa and H.pylori infection.According to the Maastricht Florence Consensus Report on the management of H.pylori infection,H.pylori treatment improves the bioavailability of both these drugs,whereas the direct clinical benefits to patients still await to be established.Less strong seems the association between H.pylori infection and other drugs malabsorption,such as delavirdine and ketoconazole.The exact mechanisms forming the basis of the relationship between H.pylori infection and impaired drugs absorption and/or bioavailability are not fully elucidated.H.pylori infection may trigger a chronic inflammation of the gastric mucosa,and impaired gastric acid secretion often follows.The reduction of acid secretion closely relates with the wideness and the severity of the damage and may affect drug absorption.This minireview focuses on the evidence of H.pylori infection associated with impaired drug absorption. | Edith Lahner Camilla Virili Maria Giulia Santaguida Bruno Annibale Marco Centanni | 2014 | World Journal of Gastroenterology2014，20，30： | 6 |
| 5 | Lack of specific association between gastric autoimmunity hallmarks and clinical presentations of atrophic body gastritis显示文摘AIM: To investigate the possible relationships between gastric autoimmune phenomena and clinical presentations of this disorder, in consecutive atrophic body gastritis patients.METHODS: A total of 140 atrophic body gastritis patients,diagnosed as consecutive outpatients presenting with macrocytic or iron deficiency anemia, or longstanding dyspepsia underwent gastroscopy with antral and body biopsies, assay of intrinsic factor, parietal cells and Helicobacter pylori(H pylori) antibodies. Gastritis was assessed according to Sydney System.RESULTS: Parietal cell antibodies were equally distributed in all clinical presentations, whereas the positivity of intrinsic factor antibodies (49/140, 35%) was significantly higher in pernicious anemia patients (49.2%) than in iron deficiency (21.1%) and dyspeptic patients (27.8%). No specific pattern of autoantibodies was related to the clinical presentations of atrophic body gastritis. A positive correlation was obtained between the body atrophy score and the intrinsic factor antibody levels (r = 0.2216,P = 0.0085). Associated autoimmune diseases were present in 25/140 (17.9%) patients, but the prevalence of autoimmune diseases was comparable, irrespective of the clinical presentations.CONCLUSION: The so-called hallmarks of gastric autoimmunity, particularly in intrinsic factor antibody cannot be usefully employed in defining an autoimmune pattern in the clinical presentations of ABG. | Bruno Annibale Edith Lahner Riccardo Negrini Flavia Baccini Cesare Bordi Bruno Monarca Gianfranco Delle Fave | 2005 | World Journal of Gastroenterology2005，11，34： | 6 |
| 6 | Artifi cial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis显示文摘AIM: To investigate the role of artifi cial neural networks in predicting the presence of thyroid disease in atrophic body gastritis patients. METHODS: A dataset of 29 input variables of 253 atrophic body gastritis patients was applied to artifi cial neural networks (ANNs) using a data optimisation procedure (standard ANNs,T&T-IS protocol,TWIST protocol). The target variable was the presence of thyroid disease. RESULTS: Standard ANNs obtained a mean accuracy of 64.4% with a sensitivity of 69% and a specifi city of 59.8% in recognizing atrophic body gastritis patients with thyroid disease. The optimization procedures (T&T-IS and TWIST protocol) improved the performance of the recognition task yielding a mean accuracy,sensitivity and specifi city of 74.7% and 75.8%,78.8% and 81.8%,and 70.5% and 69.9%,respectively. The increase of sensitivity of the TWIST protocol was statistically signifi cant compared to T&T-IS. CONCLUSION: This study suggests that artificial neural networks may be taken into consideration as a potential clinical decision-support tool for identifying ABG patients at risk for harbouring an unknown thyroid disease and thus requiring diagnostic work-up of their thyroid status. | Edith Lahner Marco Intraligi Massimo Buscema Marco Centanni Lucy Vannella Enzo Grossi Bruno Annibale | 2008 | World Journal of Gastroenterology2008，14，4： | 6 |
| 7 | Possible contribution of artificial neural networks and linear discriminant analysis in recognition of patients with suspected atrophic body gastritis显示文摘AIM: To investigate whether ANNs and LDA could recognize patients with ABG in a database, containing only clinical and biochemical variables, of a pool of patients with and without ABG, by selecting the most predictive variables and by reducing input data to the minimum.METHODS: Data was collected from 350 consecutive outpatients (263 with ABG, 87 with non-atrophic gastritis and/or celiac disease [controls]). Structured questionnaires with 22 items (anagraphic, anamnestic, clinical, and biochemical data) were filled out for each patient. All patients underwent gastroscopy with biopsies. ANNs and LDA were applied to recognize patients with ABG.Experiment 1: random selection on 37 variables, experiment 2: optimization process on 30 variables, experiment 3:input data reduction on 8 variables, experiment 4: use of only clinical input data on 5 variables, and experiment 5:use of only serological variables.RESULTS: In experiment 1, overall accuracies of ANNs and LDA were 96.6% and 94.6%, respectively, for predicting patients with ABG. In experiment 2, ANNs and LDA reached an overall accuracy of 98.8% and 96.8%,respectively. In experiment 3, overall accuracy of ANNs was 98.4%. In experiment 4, overall accuracies of ANNs and LDA were, respectively, 91.3% and 88.6%. In experiment 5, overall accuracies of ANNs and LDA were,respectively, 97.7% and 94.5%.CONCLUSION: This preliminary study suggests that advanced statistical methods, not only ANNs, but also LDA,may contribute to better address bioptic sampling during gastroscopy in a subset of patients in whom ABG may be suspected on the basis of aspecific gastrointestinal symptoms or non-digestive disorders. | Edith Lahner Enzo Grossi Marco Intraligi Massimo Buscema Vito D Corleto Gianfranco Delle Fave Bruno Annibale | 2005 | World Journal of Gastroenterology2005，11，37： | 4 |
| 8 | Latest developments for dry and wet dedusting systems for converter steel making显示文摘Environmental requirements world wide and in the P.R.of China in particular have increased and authorities are increasing the pressure on steelmakers to comply with always more stringent limits and standards. Modern converter steel making goes along with the innovation and new developments not only for the primary converter process itself but even more for the dedusting technologies.This paper describes the benefits and latest development of advanced off gas cleaning and recovery systems based on dry type cleaning with electrostatic precipitation and wet type gas cleaning based on wet scrubbers.Modern converter dedusting is based on suppressed combustion systems in order to reduce off gas amounts and to be able to use the gas for gas recovery.The dry type primary off gas treatment system based on electrostatic precipitator technology is the most advanced environmental solution available for converter steel making.Dry dedusting has been introduced in China successfully with a significant contribution by Siemens VAI being the market leader for converter dry dedusting systems.Siemens VAI has introduced several design improvements over the last years such as CFD modeling of flow conditions in evaporation cooler,design of chains for dust conveyors,design of ESP inlet,design and thickness of discharge electrodes and operation in energy saving mode.Additionally the DDS process has been successfully implemented in China for the De-P process.The gas recovery system for DDS has been optimized over the years with high quality equipment and integrated automation and control systems.Wet type dedusting for converter gas is a well proven technology for many years and is still widely used due to the simplicity of the process and the lower investment costs.SVAI has continuously improved it’s wet dedusting technologies to provide highly energy efficient systems which can achieve lowest levels of clean gas dust while still maintaining a moderate water and energy consumption with simplified process control and standardized process control packages.Main design and process improvements include expansion joints for connection of scrubber to cooling stack,new type of droplet separator,advanced hood pressure control package,ID fan washing system,ID fan speed control system etc.The focus for wet type gas recovery systems is still on maximum safety and reliability.SVAI has also successfully improved the technological packages for converter gas recovery for wet type dedusting systems.The comparison between the two system shows the advantages of dry dedusting mainly being the lowest clean gas dust content, lower operating costs,easier handling for recycling of residuals and no need for a water treatment plants.Wet type dedusting has it’s main advantages in the simple process and operation of the system,the flexible layout solutions inside the steel shop as well as generally lower investment costs.An overview on the numerous reference installations for dry- and wet type dedusting systems in China as well as world wide is given. | Peter PUSCHITZ Thomas LAHNER | 2010 | Baosteel Technical Research2010，4，S1： | 3 |
| 9 | Type I Gastric Carcinoids: A Prospective Study on Endoscopic Management and Recurrence Rate显示文摘 | Merola Elettra Sbrozzi-vanni Andrea Panzuto Francesco D’ambra Giancarlo Di Giulio Emilio Pilozzi Emanuela Capurso Gabriele Lahner Edith Bordi Cesare Annibale Bruno Delle Fave Gianfranco | 2012 | Neuroendocrinology2012，，3： | 2 |
| 10 | Systematic review: gastric cancer incidence in pernicious anaemia显示文摘 | L. Vannella E. Lahner J. Osborn B. Annibale | 2012 | Aliment Pharmacol Ther2012，，4： | 2 |
| 11 | Deepening trochleoplasty combined with balanced medial patellofemoral ligament reconstruction for an adequate graft tensioning显示文摘AIM To evaluate our modified deepening trochleoplasty com-bined with a balanced medial patellofemoral ligament(MPFL) reconstruction for soft tissue alignement. METHODS Thirty-three knees with with recurrent patellar dislocations and a trochlear dysplasia in 30 patients(m/f = 12/21, mean age 24 ± 9 years) underwent a combination of a modified deepening trochleoplasty and a balanced MPFL reconstruction for a medial soft tissue alignement. After a mean follow-up period of 29 ± 23 mo, patients' return to sports, possible complications as well as the clinical outcomes using the Kujala, International Knee Documentation Committee(IKDC) and Lysholm scoring were evaluated. Moreover, patients' satisfaction with the general outcome, the cosmetic outcome, the pre-and postoperative pain and a potential avoidance behaviour were assessed with additional standardized questionnaires which also included different visual analog scales. RESULTS There were no signs of a persistent instability. The Kujala score improved from a mean of 64 ± 16 points to 94 ± 9 points, the Lysholm score improved from a mean of 63 ± 17 to 95 ± 6 points and the IKDC score from 58 ± 11 to 85 ± 12 points, P < 0.0001, respectively. The assessment of pain using a visual analog scale showed a significant pain reduction from a mean of 4.8 ± 2.0 to 1.3 ± 3.4 points(P < 0.0001). Two of 26 cases(92%) who were engaged in regular physical activity before surgery did not return to full sporting activities. One patient felt that his sport was too risky for his knee and reported an ongoing avoidance behaviour. The other patient preferred to wait for surgery of her contralateral knee. Of the eight patients who were not engaged in sporting activities before surgery, three started regular sporting activities after surgery. In 31 of the 33 cases(94%), the patients were very satisfied with the clinical outcome of the surgery. Regarding the cosmetic results, no patients felt impaired in their self-confidence and in their clothing decisions. CONCLUSION Our technique shows a good clinical outcome in terms of the common scorings as well as in terms of pain, return to sports and patient satisfaction. | Lars V von Engelhardt Pia Weskamp Matthias Lahner Gunter Spahn Joerg Jerosch | 2017 | World Journal of Orthopedics2017，8，12： | 2 |
| 12 | Concomitant altera- tions in intragastric pH and ascorbic acid concentration in patients with heficobacter pylori gastritis and associated iron deficiency anaemia显示文摘 | Annibale B Capurso G Lahner E | 2003 | Gut2003，52，4： | 1 |
| 13 | Incidence of complica- tions in intrahospital transport of critically ill patients experi- ence in an Austrian university hospital 显示文摘 | Lahner D Nikolic A Marhofer P | 2007 | Wien Kiln Wochensehr2007，119，： | 1 |
| 14 | The leaf ionome as a muhivariable system to detect a plant's physiological sta- tus显示文摘 | BAXTER I R VITEK O LAHNER B | 2008 | Proceedings of the National Academy of Sciences2008，105，12： | 1 |
| 15 | Arabidopsis pdr2 reveals a phosphate-sensitive checkpoint in root development 显示文摘 | TICCONI C A DELATORRE C A LAHNER B | 2004 | Plant2004，37，： | 1 |
| 16 | Evaluation of stroke volume variation obtained by arterial pulse contour analysis to predict fluid responsiveness intraoperatively显示文摘 | Lahner D Kabon B Marschalek C | 2009 | Br J Anaesth2009，103，3： | 1 |
| 17 | Helicobacter pylori immunoproteomics in gastric cancer and gastritis of the carcinoma phenotype 显示文摘 | LAHNER E BERNARDINI G SANTUCCI A | 2010 | Expert Rev Proteomics2010，7，2： | 1 |
| 18 | Incidence of complications in intrahospital transport of critically ill patients-experience in an Austrian university hospital显示文摘 | Lahner D Nikolic A Marhofer P | 2007 | Wien Klin Wochenschr2007，119，1314： | 1 |
| 19 | Reassessment of intrinsic factor and parietal cell autoantibodies in atrophic gastritis with respect to cobalamin deficiency显示文摘 | Lahner E Norman GL Severi C | | 0，，： | 1 |
| 20 | No higher risk for colorectal cancer in atrophic gastritis-related hypergastrinemia显示文摘 | Edith Lahner Andrea Sbrozzi-Vanni Lucy Vannella Vito Domenico Corleto Emilio Di Giulio Gianfranco Delle Fave Bruno Annibale | 2012 | Digestive and Liver Disease2012，，9： | 1 |
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