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| 1 | Non-alcoholic fatty liver disease: What has changed in the treatment since the beginning?显示文摘Non-alcoholic fatty liver disease(NAFLD) is an umbrella term to describe the entire spectrum of this common liver disease. In patients with NAFLD, especially those with non-alcoholic steatohepatitis(NASH), most often have one or more components of the metabolic syndrome, but this is not universal. Although most patients with NAFLD share many clinical features, only a subset of patients develops significant liver inflammation and progressive fibrosis. On the other hand, not all patients with NASH exhibit insulin resistance. NASH can be seen in patients who are lean and have no identifiable risk factors. Many clinical studies have tried numerous drugs and alternative medicine, however, investigators have failed to identify a safe and effective therapy for patients with NASH. As summarized, the heterogeneity of pathogenic pathways in individual patients with NASH may warrant the development of an individualized treatment according to the underlying pathogenic pathway. The differentiation of pathogenetic targets may require the development of diagnostic and prognostic biomarkers, and the identification of genetic susceptibilities. At present, evidence-based medicine provides only a few options including life-style modifications targeting weight loss, pioglitazone and vitamin E in non-diabetic patients with biopsy-proven NASH. | Bülent Baran Filiz Akyüz | 2014 | World Journal of Gastroenterology2014，20，39： | 10 |
| 2 | Gastroesophageal reflux in asymptomatic obese subjects:An esophageal impedance-pH study显示文摘AIM:To investigate the relationship between reflux and body mass index(BMI) in the asymptomatic obese population using the impedance-p H technique.METHODS:Gastroesophageal reflux is frequent in the obese population.However,the relationship between acid reflux and BMI in asymptomatic obese people is unclear.Forty-six obese(BMI > 25 kg/m2) people were enrolled in this prospective study.We evaluated the demographic findings and 24-h impedance p H values of the whole group.Gas,acid(p H < 4),weak acid(p H = 4-7) and weak alkaline(p H ≥ 7) reflux parameters were analyzed.RESULTS:The mean age of patients was 49.47±12.24 years,and half of them were men.The mean BMI was 30.64±3.95 kg/m2(25.14-45.58 kg/m2).BMI of 23 was over 30 kg/m2.Seventeen patients had a comorbidity(hypertension,diabetes mellitus,or ischemic heart disease).Endoscopic examination revealed esophagitis in 13 of the 28 subjects(10Grade A,3 Grade B).The subjects were divided into two groups according to BMI(<30 and>30 kg/m2).Demographic and endoscopic findings,and impedance results were similar in these two groups.However,there was a positive correlation between BMI and total and supine p H<4 episodes(P=0.002,r=0.414;P=0.000,r=0.542),p H<4 reflux time(P=0.015,r=0.319;P=0.003,r=0.403),and De Meester score(P=0.012,r=0.333).CONCLUSION:Acid reflux is correlated with BMI in asymptomatic obese individuals. | Filiz Akyüz Ahmet Uyanikoglu Fatih Ermis Serpil Arici ümit Akyüz Divison of Gastroenterology Department of Internal Medicine Faculty of Medicine Yeditepe University Bülent Baran Binnur Pinarbasi Nurdan Gul | 2015 | World Journal of Gastroenterology2015，21，10： | 3 |
| 3 | Atom transfer radical polymerization through N-chlorosulfonamides 显示文摘 | Senkal Filiz B Hizal | 2001 | J Polym Sci Part A: Poly Chem2001，39，： | 2 |
| 4 | Is sildenafil citrate affectendometrial receptivity?an immunohistochemical study显示文摘 | Biyiksiz PC Filiz S Vural B | 2010 | GynecolEndocrinol2010，27，10： | 1 |
| 5 | An Experimental Investigation of Micro Machinability Ofcopper 101 Using Tungsten Carbide Micro end Mills显示文摘 | FILIZ S CONLEY C M WASSERMAN M B | 2007 | International Journal of Machine Tools & Manufacture2007，47，： | 1 |
| 6 | The synthesis of new polymetric sorbent and its application in preconcentration of cadmium and lead in water samples显示文摘 | Filiz S B Ince M Yavuz E | 2007 | Talanta2007，72，3： | 1 |
| 7 | The synthesis of new polymetric sorbent and its application in preeoncentration of cadmium and lead in water samples显示文摘 | Filiz S B Ince M Yavuz E | 2007 | Talanta2007，72，3： | 1 |
| 8 | 1,2-Diaminoethane-containing epoxy resins for separation of aldehydes显示文摘 | Niyazi Bicak A Bahattin Soydan B Filiz Senkal at el | 1999 | Reac Func Polym1999，39，3： | 1 |
| 9 | Maspin overexpression cor-relates with increased expression of vascular endothelia 1growth factors A, C, and D in human ovarian carci-noma显示文摘 | Filiz B Derya G Serk E | 2008 | Pathol Res Pract2008，204，： | 1 |
| 10 | Importance of H2O2/Fe^2+ ratio in Fenton's treatment of a carpet dyeing waste water 显示文摘 | G Ipek A S Gulkaya B D Filiz | 2006 | Journal of Hazardous Materials2006，136，3： | 1 |
| 11 | Comparison of non-invasive ventilation and standard medical therapy in acute hypercapnic respiratory failure:a randomised controlled study at a tertiary health centre in SE Turkey显示文摘 | Ikidag B Filiz A | 2002 | Int J Clin Pract2002，56，2： | 1 |
| 12 | The removal of Pb( Ⅱ ) by Phanerochaete chrysopsporium 显示文摘 | ⅡULKU Y AYLA D FILIZ B D | 2000 | Water Research2000，34，16： | 1 |
| 13 | 1, 2-Diaminoethane-containing epoxy resins for separation of aldehydes显示文摘 | Niyzai bicak A Bahattin Soydan B Filiz Senkal | 1999 | Reac Func Polym1999，39，3： | 1 |
| 14 | Placental expression of insulinlike growth factor-Ⅰ,fibroblast growth,factor-basic,and neural cell adhesion molecule in preeclampsia显示文摘 | Ozkan S Vural B Filiz S | 2008 | Matern Fetal Neonatal Med2008，21，11： | 1 |
| 15 | Novel polymeric resin for solid phase extraction and determination of lead in waters 显示文摘 | NAGIHAN M KARAASLAN B FILIZ S | 2010 | J Clean- Soil Air Water2010，38，11： | 1 |
| 16 | Trihalomethanes and associated potential cancer risks in the water supply in Ankara, Turkey显示文摘 | Burcu T Goksen C Filiz B | 2004 | Environ Res2004，96，： | 1 |
| 17 | Graft copolymer of acrylamide onto cellulose as mercury selective sorbent显示文摘 | Niyazi Bicak David C Sherrington B Filiz Senkal | 1999 | Reactive & Functional Polymers1999，41，： | 1 |
| 18 | Maspin over - expression correlates with increased expression of vascular endothelial growth factors A, C, and D in human ovarian carcinoma 显示文摘 | Filiz B Derya G Serkan E | 2008 | Pathology Research and Practice2008，204，： | 1 |
| 19 | Effect of microwave and infrared drying on the quality of carrot and garlic显示文摘 | Taner B Filiz I Seda E | 2003 | Eur Food Technd2003，218，： | 1 |
| 20 | Placental expression of insulin-like growth factor-I,fibroblast growth factor-basic,and neural cell adhesion molecule in preeclampsia显示文摘 | Ozkan S Vural B Filiz S | 2008 | J Matern Fetal Neonatal Med2008，21，11： | 1 |
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