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| 1 | Triorchidism: a rare genital abnormality显示文摘 | Orcun Celik Salih Budak Ozgur Cakmak Huseyin Tarhan Okan Nabi Yalbuzdag Aziz Peker Yusuf Ozlem Ilbey | 2014 | Asian Journal of Andrology2014，16，6： | 4 |
| 2 | CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvement显示文摘Since it was first recognized in bacteria and archaea as a mechanism for innate viral immunity in the early 2010 s,clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(Cas)has rapidly been developed into a robust,multifunctional genome editing tool with many uses.Following the discovery of the initial CRISPR/Cas-based system,the technology has been advanced to facilitate a multitude of different functions.These include development as a base editor,prime editor,epigenetic editor,and CRISPR interference(CRISPRi)and CRISPR activator(CRISPRa)gene regulators.It can also be used for chromatin and RNA targeting and imaging.Its applications have proved revolutionary across numerous biological fields,especially in biomedical and agricultural improvement.As a diagnostic tool,CRISPR has been developed to aid the detection and screening of both human and plant diseases,and has even been applied during the current coronavirus disease 2019(COVID-19)pandemic.CRISPR/Cas is also being trialed as a new form of gene therapy for treating various human diseases,including cancers,and has aided drug development.In terms of agricultural breeding,precise targeting of biological pathways via CRISPR/Cas has been key to regulating molecular biosynthesis and allowing modification of proteins,starch,oil,and other functional components for crop improvement.Adding to this,CRISPR/Cas has been shown capable of significantly enhancing both plant tolerance to environmental stresses and overall crop yield via the targeting of various agronomically important gene regulators.Looking to the future,increasing the efficiency and precision of CRISPR/Cas delivery systems and limiting off-target activity are two major challenges for wider application of the technology.This review provides an in-depth overview of current CRISPR development,including the advantages and disadvantages of the technology,recent applications,and future considerations. | Chao LI Eleanor BRANT Hikmet BUDAK Baohong ZHANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，4： | 3 |
| 3 | Primary angiitis of the central nervous system: unusual clinical presentation显示文摘 | Ilhan A Budak F | 2000 | International Journal of Angiology2000，9，1： | 2 |
| 4 | Estimation of concentration and temperature profiles for methane-steam reforming reaction in a porous catalyst显示文摘 | Levent M Budak G Karabulut A | 1998 | Fuel Processing Technol1998，55，： | 2 |
| 5 | A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamic control, during colonoscopy under conscious sedation显示文摘 | Kamer Dere Ilker Sucullu Ersel Tan Budak Suleyman Yeyen Ali Ilker Filiz Sezai Ozkan Guner Dagli | 2010 | European Journal of Anaesthesiology2010，，7： | 2 |
| 6 | Molecular characterization of Buffalograss germplasm using sequence-related amplified polymorphism markers 显示文摘 | Budak H Shearman R C Parmaksiz I Gussoin R E Riordan T P Dweikat I | 2004 | Theor Appl Genet2004，108，2： | 1 |
| 7 | Analytical modeling of spindle-tool dynamics on machine tools using Timoshenko beam model and reacceptanee coupling for the prediction of tool point FRF显示文摘 | ERTURK A OZGUVEN H N BUDAK E | 2006 | International Journal of Machine Tools & Manufacture2006，46，： | 1 |
| 8 | Effect analysis of hearing and interface dynamics on tool point FRF for chatter stability in machine tools by using a new ana- lytical model for spindle-tool assemblies显示文摘 | Erturk A Ozguven H N Budak E | 2007 | Interna tional Journal of Machine Tools and Manufacture2007，47，1： | 1 |
| 9 | A comparison of dexmedetomidine versus midazolam for sedation, pain and hemodynamie control, during colonoscopy under conscious sedation显示文摘 | Dere K Sucullu I Budak E T | 2010 | Eur J Anaesthesiol2010，27，7： | 1 |
| 10 | Analysis prediction of stability lobes in milling 显示文摘 | Ahintas Y Budak E | 1995 | Annals CIRP1995，44，1： | 1 |
| 11 | Corruption in Transition Econ-omies:Effects of Government Size, Country 显示文摘 | RajeevK Goel Jelena Budak | 2006 | Journal ofEconomics and Finance2006，30，2： | 1 |
| 12 | Development of Machine Tool Selection System Using AHP显示文摘 | CIMREN E CATAY B BUDAK E | 2007 | The International Jour- nal of Advanced Manufacturing Technology2007，35，34： | 1 |
| 13 | A modeling approach for analysis and improvement of spindle-holder-tool as- sembly dynamics显示文摘 | BUDAK E ERTLIRK A | 2006 | Annals of the CIRP2006，56，1： | 1 |
| 14 | Clinical signifi- cance of detection of multiple acute brain infarcts on diffusion weighted magnetic resonance imaging 显示文摘 | CASO V BUDAK K GEORGIADIS D | 2005 | J Neurol Neurosurg Psychiatry2005，76，4： | 1 |
| 15 | A comparison of dexmedetomidine versus midazolam for sedation,pain and hemodynamic control,during colonoscopy under conscious sedation显示文摘 | Dere K Sucullu I Budak ET | 2010 | Eur J Anaesthesiol2010，27，7： | 1 |
| 16 | Serum monocyte chemoattractant protein-1 and monocyte adhesion molecules in type 1 diabetic patients with nephropathy显示文摘 | KIVICI S ERTURK E BUDAK F | 2006 | Arch Med Res2006，37，8： | 1 |
| 17 | Structural modeling of end mills for form error and stability analysis 显示文摘 | Kivanc E B Budak E | 2004 | International Journal of Machine Tools and Manufacture2004，44，11： | 1 |
| 18 | A comparison of dexmedetomidine versus midazolam for sedation pain and hemodynamic control during colonoscopy under conscious sedation显示文摘 | Dere K Sucullu I Budak ET | 2010 | Eur J Anaesthesiol2010，27，7： | 1 |
| 19 | Analytical prediction of chatter stability in milling - part I : general formulation 显示文摘 | Budak E Altintas Y | 1998 | Journal of Dynamic Systems Measurement and Control1998，120，： | 1 |
| 20 | Antioxidant activity and phenolic content of wine vinegars produced by two different techniques显示文摘 | BUDAK H N GUZEL-SEYDIM Z B | | J Sci Food Agric0，90，12： | 1 |
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