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| 1 | Comparison of the effects of bevacizumab and ranibizumab injection on corneal angiogenesis in an alkali burn induced model显示文摘·AIM:To investigate the effects of bevacizumab and ranibizumab on corneal neovascularization in an alkali burn-induced model of corneal angiogenesis. ·METHODS:Fifteen Wistar-Albino rats were divided randomly into 3 groups after chemical cauterization of the cornea. The first group received a single dose of 0.1mL saline solution as a control group whereas second and third groups received a single dose of 2.5mg bevacizumab or 1mg ranibizumab by subconjunctival injection, respectively. After three weeks, the rat corneas were evaluated by biomicroscopy and corneal photographs were taken. The percentage of neovascularization area, length of the longest new vessel, corneal oedema and corneal opacity scores were assessed. ·RESULTS:The analysis of digital photographs showed that the percentage of neovascularization area to the total corneal area, the length of the longest new vessel, corneal oedema and opacity scores were significantly lower in both study groups compared to the control group (P <0.05). Additionally, the percentage of corneal neovascularization area, the length of the longest new vessel and corneal opacity score were less with bevacizumab than ranibizumab. ·CONCLUSION:Subconjunctival bevacizumab and ranibizumab treatments may be effective methods in reducing corneal neovascularization. Furthermore, bevacizumab is more effective than ranibizumab in the inhibition of corneal neovascularization. | Ayhan Dursun Mustafa Kemal Arici Feyza Dursun Ayse Vural Ozec Mustafa Ilker Toker Haydar Erdogan Aysen Topalkara | 2012 | International Journal of Ophthalmology(English edition)2012，5，4： | 10 |
| 2 | 吸烟,血清抗氧化维生素水平和老年性黄斑变性之间的关系(英文)显示文摘目的:研究老年性黄斑变性(AMD)等级、血清抗氧化维生素水平(维生素A、C和E)和吸烟的关系。方法:对84例患者行黄斑彩色眼底成像,根据AMD损伤率和损伤程度将其分为五组(等级I^V)。应用高效液相色谱法(HPLC)测量血清抗氧化维生素水平。根据吸烟状况分不吸烟者、已戒烟者和吸烟者三组,并统计吸烟者每年的吸烟总量。结果:对照组中,维生素A、E、C水平分别为0.874±0.326mg/L,10.739±4.874mg/L和1.737±0.447mg/L,AMD组中分别为0.880±0.305mg/L,9.487±6.060mg/L和1.870±2.191mg/L,无显著差异(P>0.05)。AMD不同等级分组间维生素A(P=0.881)和E(P=0.293)水平差异无统计学意义,维生素C水平(P=0.044)随AMD程度的加深而增加。根据吸烟状况,AMD组与对照组之间无显著差异。根据每年的吸烟总量,两组之间有显著差异(P=0.02)。AMD越严重,年吸烟总量越高(P=0.007)。结论:研究结果显示AMD与维生素A、E血清水平无关,但和维生素C的血清水平相关,并与吸烟量有关。 | Sezen Akkaya Cakir Ozlem Sahin Haluk Kazokoglu Feyza Tekeli Goncagul Haklar Yelda Ozkurt | 2014 | 国际眼科杂志2014，14，5： | 5 |
| 3 | Total oxidative stress, paraoxonase and arylesterase levels at patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma显示文摘AIM: To investigate the oxidative stress status of the aqueous humor and serum of patients with pseudoexfoliation(PEX) syndrome and pseudoexfoliative glaucoma(PEG) and to measure paraoxonase(PON) and arylesterase(ARE) levels.·METHODS: A total of 78 patients were enrolled in the study, with 26 patients in each separate group. The patients were divided into three groups: the first group entailed PEX syndrome patients, while the second group consisted of patients with PEG and the third group involved patients with no additional systemic diseases,other than the diagnosis of cataract as control. Total oxidative stress(TOS), total antioxidant capacity(TAC),PON, and ARE levels in aqueous humor and serum were measured.·RESULTS: TAC, PON and arylesterase levels in aqueous humor and serum of the PEX syndrome and PEG patients were significantly decreased compared with control group(P <0.05). TOS values were higher in patients with PEX syndrome and PEG than controls(P <0.05). TAC, PON and ARE levels of aqueous humor did not differ significantly between the PEX syndrome and PEG groups·CONCLUSION: These findings are potentially of significance and add to the growing body of evidence for oxidative stress in PEX syndrome and PEG. Decreased antioxidant defense and increased oxidative stress system may play an important role in the pathogenesis of PEX syndrome and PEG. | Feyza Dursun Ayse Vural Ozec Huseyin Aydin Aysen Topalkara Ayhan Dursun Mustafa Ilker Toker Haydar Erdogan Mustafa Kemal Arici | 2015 | International Journal of Ophthalmology(English edition)2015，8，5： | 2 |
| 4 | Discriminating performance of macular ganglion cellinner plexiform layer thicknesses at different stages of glaucoma显示文摘AIM: To determine the discriminating performance of the macular ganglion cell-inner plexiform layer(GCIPL) parameters between all the consecutive stages of glaucoma(from healthy to moderate-to-severe glaucoma), and to compare it with the discriminating performances of the peripapillary retinal nerve fiber layer(RNFL) parameters and optic nerve head(ONH) parameters.METHODS: Totally 147 eyes(40 healthy, 40 glaucoma suspects, 40 early glaucoma, and 27 moderate-to-severe glaucoma) of 133 subjects were included. Optical coherence tomography(OCT) was obtained using Cirrus HD-OCT 5000. The diagnostic performances of GC-IPL, RNFL, and ONH parameters were evaluated by determining the area under the curve(AUC) of the receiver operating characteristics. RESULTS: All GC-IPL parameters discriminated glaucoma suspect patients from subjects with healthy eyes and moderate-to-severe glaucoma from early glaucoma patients(P<0.017, for all). Also, minimum, inferotemporal and inferonasal GC-IPL parameters discriminated early glaucoma patients from glaucoma suspects, whereas no RNFL or ONH parameter could discriminate between the two. The best parameters to discriminate glaucoma suspects from subjects with healthy eyes were superonasal GC-IPL, superior RNFL and average c/d ratio(AUC=0.746, 0.810 and 0.746, respectively). Discriminating performances of all the parameters for early glaucoma vs glaucoma suspect comparison were lower than that of the other consecutive group comparisons, with the bestGC-IPL parameters being minimum and inferotemporal(AUC=0.669 and 0.662, respectively). Moreover, minimum GC-IPL, average RNFL, and rim area(AUC=0.900, 0.858, 0.768, respectively) were the best parameters for discriminating moderate-to-severe glaucoma patients from early glaucoma patients.CONCLUSION: GC-IPL parameters can discriminate glaucoma suspect patients from subjects with healthy eyes, and also all the consecutive stages of glaucoma from each other(from glaucoma suspect to moderate-tosevere glaucoma). Further, the discriminating performance of GC-IPL thicknesses is comparable to that. | Melih Ustaoglu Nilgun Solmaz Feyza Onder | 2019 | International Journal of Ophthalmology(English edition)2019，12，3： | 2 |
| 5 | Hepatocellular carcinoma xenograft supports HCV replication:A mouse model for evaluating antivirals显示文摘AIM: To develop a hepatocellular carcinoma (HCC) xenograft model for studying hepatitis C virus (HCV) replication in a mice, and antiviral treatment.METHODS: We developed a stable S3-green fluorescence protein (GFP) cell line that replicated the GFP-tagged HCV sub-genomic RNA derived from a highly efficient JFH1 virus. S3-GFP replicon cell line was injected subcutaneously into γ-irradiated SCID mice. We showed that the S3-GFP replicon cell line formed human HCC xenografts in SCID mice. Cells were isolated from subcutaneous tumors and then serially passaged multiple times in SCID mice by culturing in growth medium supplemented with G-418. The mouse-adapted S3-GFP replicon cells were implanted subcutaneously and also into the liver of SCID mice via intrasplenic infusion to study the replication of HCV in the HCC xenografts. The tumor model was validated for antiviral testing after intraperitoneal injection of interferon-α (IFN-α). RESULTS: A highly tumorigenic S3-GFP replicon cell line was developed that formed subcutaneous tumors within 2 wk and diffuse liver metastasis within 4 wk in SCID mice. Replication of HCV in the subcutaneous and liver tumors was confirmed by cell colony assay, detection of the viral RNA by ribonuclease protection assay and real-time quantitative reverse transcription polymerase chain reaction. High-level replication of HCV sub-genomic RNA in the tumor could be visualized by GFP expression using fluorescence microscopy. IFN-α cleared HCV RNA replication in the subcutaneous tumors within 2 wk and 4 wk in the liver tumor model. CONCLUSION: A non-infectious mouse model allows us to study replication of HCV in subcutaneous and metastatic liver tumors. Clearance of HCV by IFN-α supports use of this model to test other anti-HCV drugs. | Sidhartha Hazari Henry J Hefler Partha K Chandra Bret Poat Feyza Gunduz Tara Ooms Tong Wu Luis A Balart Srikanta Dash | 2011 | World Journal of Gastroenterology2011，17，3： | 2 |
| 6 | Protective effect of two edible mushrooms against oxidative cell damage and their phenolic composition显示文摘 | Feyza Oke Belma Aslim | 2011 | Food Chemistry2011，，3： | 1 |
| 7 | 2-Mercapto thioxanthone as a chain transfer agent in free-radical polymerization: a versatile route to incorporate thioxanthone moieties into polymer chain-ends显示文摘 | Feyza K Nergis A YusufY | 2007 | Journal of Applied Polymer Science2007，103，： | 1 |
| 8 | Polyostotic monosystemic calvarial and spinal langerhans'cell histiocytosis treated by surgerg and chemotherapy显示文摘 | Feyza KG Seroar BA Erhan E | | 0，，06： | 1 |
| 9 | 2-Mercapto thioxanthone as a chain transfer agent in free-radical polymerization: A versatile route to incorporate thioxanthone moieties into polymer chain-ends 显示文摘 | FEYZA K NERGIS A YUSUF Y | 2007 | J Apply Poly Sci2007，103，： | 1 |
| 10 | Changes in color and total phenolic content of different cultivars ofpersimmon during dehydration显示文摘 | Asiye Akyildiz Feyza Kiroglu Zorlugenc Hakan Benli | 2008 | International Journal of Food Eengineering2008，4，7： | 1 |
| 11 | Energy and cost analysis for greenhouse and open-field grape production显示文摘 | Burhan O Cereal F Feyza C K | 2007 | Energy2007，32，： | 1 |
| 12 | changes in color and total phenolic content of different cuhivars of persimmon during dehydration显示文摘 | Asiye Akyildiz Feyza Kiroglu Zorlugenc Hakan Benli | 2008 | International Journal of Food Eengineering2008，4，7： | 1 |
| 13 | Effect of chronic morphine treatment on the biosynthesis of agmatine in rat brain and other tissues显示文摘 | Aricioglu-Kartal Feyza Regunathan Soundar | 2000 | Life Sci2000，71，17： | 1 |
| 14 | Interferon alpha induced intrahepatic pSTAT1 inversely correlate with serum HCV RNA levels in chronic HCV infection显示文摘 | Feyza Gunduz Chaithanya Mallikarjun Luis A. Balart Srikanta Dash | 2014 | Experimental and Molecular Pathology2014，，1： | 1 |
| 15 | Follow-up height after discontinuation of growth hormone treatment in children with intrauterine growth retardation 显示文摘 | Darendeliler Feyza Bundak Ruveyde Eryilmaz Sema Kabatas | 2002 | J Pediatric Endocrinology & Metabolism2002，5，6： | 1 |
| 16 | Essential oil composition, antimicrobial and antioxidant activities of Satureja cuneifolia Ten.显示文摘 | Feyza Oke Belma Aslim Sahlan Ozturk Senol Altundag | 2008 | Food Chemistry2008，，4： | 1 |
| 17 | Biosorption of chromium(VI), cadmium(II) and copper(II) by Pantoea sp. TEM18显示文摘 | Guven Ozdemir Nur Ceyhan Tansel Ozturk Feyza Akirmak Tamer Cosar | 2004 | Chemical Engineering Journal2004，，3： | 1 |
| 18 | Protective effect of two edible mushrooms against oxidative cell damage and their phenolic composition显示文摘 | Feyza Oke Belma Aslim | 2011 | Food Chemistry2011，，3： | 1 |
| 19 | Associations of sizeat birth and postnatal catch-up growth status with clinical andbiomedical characteristics in prepubertal girls with precociousadrenarche:preliminary results显示文摘 | Ahmet U?ar Michal Yackobovitch-Gavan 0?uz Biilent Erol Ensar Yekeler Nur?in Saka Firdevs Ba?Sukran Poyrazo?lu Ruveyde Bundak Feyza Darendeliler | 2014 | The Journal of clinicalendocrinology and metabolism(2014，99，8： | 1 |
| 20 | Changes in color and total phenolic content of different cultivars of persimmon during dehydration显示文摘 | ASIYE A FEYZA K Z HAKAN B | 2008 | International Journal of Food Engineering2008，4，7： | 1 |
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