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| 1 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 2 | Proteomic characterization by 2-DE in bovine serum and whey from healthy and mastitis affected farm animals显示文摘 | Idoia Alonso-Fauste Marta Andrés María Iturralde Fermín Lampreave Javier Gallart María A. álava | 2011 | Journal of Proteomics2011，，10： | 2 |
| 3 | Molecular typing of isolates of Clostridium perfringens from healthy and diseased pouhry显示文摘 | ENGSTROM B E FERME R C LINDBERG A et a l | 2003 | Vet Microbiol2003，94，3： | 1 |
| 4 | The antioxidant activity of wines determined by theABTS^+ * ^+ method: influence of sample dilution and time 显示文摘 | VILLANO D FERM a NDEZ-PACH a N M S A M | 2004 | Talanta2004，64，： | 1 |
| 5 | ,Methane oxidation in soil profiles of Dutch and Finnish coniferous forests with different soil texture and atmospheric nitrogen deposition显示文摘 | MARTIKAINEN P J FERM A | 1997 | Soil Biol Biochem1997，29，： | 1 |
| 6 | Molecular typing of isolates of Clostridium perfringens from healthy and dis eased poultry 显示文摘 | Engstrom B E Ferme'r C Lindberg A | 2003 | Vet Mierobiol2003，94，： | 1 |
| 7 | Photosystem II efficiency and mechanisms of energy dissipation in iron-deficient, field-grown pear trees (Pyrus communis L.)显示文摘 | Fermín Morales Ramzi Belkhodja Anunciación Abadía Javier Abadía | 2000 | Photosynthesis Research2000，，1： | 1 |
| 8 | Photosystem II efficiency in low chlorophyll, iron-deficient leaves显示文摘 | Javier Abadía Fermín Morales Anunciación Abadía | 1999 | Plant and Soil1999，，2： | 1 |
| 9 | Clinical usefulness of adherence to gastro-esophageal reflux disease guideline by Spanish gastroenterologists显示文摘AIM:To investigate usefulness of adherence to gastroesophageal reflux disease(GERD) guideline established by the Spanish Association of Gastroenterology.METHODS:Prospective,observational and multicentre study of 301 patients with typical symptoms of GERD who should be managed in accordance with guidelines and were attended by gastroenterologists in daily practice.Patients(aged > 18 years) were eligible for inclusion if they had typical symptoms of GERD(heartburn and/or acid regurgitation) as the major complaint in the presence or absence of accompanying atypical symptoms,such as dyspeptic symptoms and/or supraesophageal symptoms.Diagnostic and therapeutic decisions should be made based on specific recommendations of the Spanish clinical practice guideline for GERD which is a widely disseminated and well known instrument among Spanish in digestive disease specialists.RESULTS:Endoscopy was indicated in 123(41%) patients:50 with alarm symptoms,32 with age > 50 years without alarm symptom.Seventy-two patients(58.5%) had esophagitis(grade A,23,grade B,28,grade C,18,grade D,3).In the presence of alarm symptoms,endoscopy was indicated consistently with recommendations in 98% of cases.However,in the absence of alarm symptoms,endoscopy was indicated in 33% of patients > 50 years(not recommended by the guideline).Adherence for proton pump inhibitors(PPIs) therapy was 80%,but doses prescribed were lower(half) in 5% of cases and higher(double) in 15%.Adherence regarding duration of PPI therapy was 69%;duration was shorter than recommended in 1%(4 wk in esophagitis grades C-D) or longer in 30%(8 wk in esophagitis grades A-B or in patients without endoscopy).Treatment response was higher when PPI doses were consistent with guidelines,although differences were not significant(95% vs 85%).CONCLUSION:GERD guideline compliance was quite good although endoscopy was over indicated in patients > 50 years without alarm symptoms;PPIs were prescribed at higher doses and longer duration. | Fermín Mearin Julio Ponce Marta Ponce Agustín Balboa Miguel A González Javier Zapardiel | 2012 | World Journal of Gastroenterology2012，18，35： | 1 |
| 10 | Species identification of smoked and gravad fish products by sodium dodecylsulphate polyacrylamide gel electrophoresis,urea isoelectric focusing and native isoelectric focusing:a collaborative study显示文摘 | I Mackie A Craig M Etienne M Jér(o)me J Fleurence F Jessen A Smelt A Kruijt I Malmheden Yman M Ferm | 2000 | Food Chemistry2000，71，1： | 1 |
| 11 | Control of insect vectors and plant viruses in protected crops by novel pyrethroid‐treated nets显示文摘 | Beatriz Dáder Saioa Legarrea Aránzazu Moreno María Plaza Michele Carmo‐Sousa Fermín Amor Elisa Vi?uela Alberto Fereres | 2015 | Pest. Manag. Sci2015，，： | 1 |
| 12 | Arthroscopic treatment of triangular fibrocartilage complex lesions of the wrist显示文摘 | De Ferm A Steenwerckx A | 1996 | Acta Orthop Belg1996，62，： | 1 |
| 13 | A study on the aqueous dispersion mechanism of CuO powders using Tiron显示文摘 | Guedes M Ferreira J M F Ferm A C | 2009 | Journal of Colloid and Interface Science2009，330，1： | 1 |
| 14 | Comparison of Control Strategies for Shunt Active Power Filters in Three-phase Four-wire Systems显示文摘 | María Isabel Milanés Montero Enrique Romero Cadaval Fermín Barrero González | | 0，，01： | 1 |
| 15 | Cost-efficient techniques for urban- and background measurements of SO2 and NO2 显示文摘 | Ferm M Svanberg P A | 1998 | Atmospheric Environment1998，32，8： | 1 |
| 16 | Multiple sclerosis:Identification and clinical evaluation of novel CSF biomarkers显示文摘 | Ottervald J Franzén B Nilsson K Andersson L I Khademi M Eriksson B Kjellstr(o)m S Marko-Varga G Végvári A Harris R A Laurell T Miliotis T Matusevicius D Salter H Ferm M Olsson T | | 0，，06： | 1 |
| 17 | Association of IL10 promoter polymorphisms with idiopathic achalasia显示文摘 | Concepción Nu?ez María Asunción García-González Jose Luis Santiago María Soledad Benito Fermín Mearín Emilio G. de la Concha Julio Pérez de la Serna Antonio Ruiz de León Elena Urcelay Ana G. Vigo | 2011 | Human Immunology2011，，9： | 1 |
| 18 | Enhanced free cholesterol,SREBP-2 and StAR expression in human NASH显示文摘 | Caballero F Fermández A De Lacy AM | | 0，，： | 1 |
| 19 | Nitric oxide signalling in the regulation of car- diovascular and platelet function 显示文摘 | Gkaliagkousi E Ferm A | 2011 | Front Biosci2011，16，1： | 1 |
| 20 | Low-dose radiation lrcat- mcnt in pulmonary mucosa-associated lymphoid tissue lymphoma: a plausible approach? A single-institution experience in 10 patients 显示文摘 | Girinsky T Paumier A Ferme C | 2012 | hat J Radiat Oncol Biol Phys2012，83，3： | 1 |
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