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| 1 | Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences显示文摘Pre-mRNA splicing is an essential step in the process of gene expression in eukaryotes and consists of the removal ofintrons and the linking of exons to generate mature mRNAs. This is a highly regulated mechanism that allows the alternative usage of exons, the retention ofintronic sequences and the generation of exonic sequences of variable length. Most human genes undergo splicing events, and disruptions of this process have been associated with a variety of diseases, including cancer. Hepatocellular carcinoma (HCC) is a molecularly heterogeneous type of tumor that usually develops in a cirrhotic liver. Alterations in pre-mRNA splicing of some genes have been observed in liver cancer, and although still scarce, the available data suggest that splicing defects may have a role in hepatocarcinogenesis. Here we briefly review the general mechanisms that regulatepre-mRNA splicing, and discuss some examples that illustrate how this process is impaired in liver tumorigenesis, and may contribute to HCC development. We believe that a more thorough examination of pre-mRNA splicing is still needed to accurately draw the molecular portrait of liver cancer. This will surely contribute to a better understanding of the disease and to the development of new effective therapies. | Carmen Berasain Saioa Gońi Josefa Castillo Maria Ujue Latasa Jesús Prieto Matias A Avila | 2010 | World Journal of Gastroenterology2010，16，25： | 2 |
| 2 | Surface modification of sisal fibers: effects on the mechanical and thermal properties of their epoxy composites显示文摘 | Piedad Ganan Saioa Garbizu Rodrigo Llano-Pante | 2005 | Polymer Composites2005，，： | 1 |
| 3 | Evaluation of ad?hesion/ cohesion bond strength of the thick plasma spray coatings by scratch testing on coatings cross-sections 显示文摘 | Aleksandar V Saioa A Gregory F | 2011 | Tribol Int2011，44，11： | 1 |
| 4 | Steroid hormone determination in water using an environmentally friendly membrane based extraction technique显示文摘 | SAIOA Z PAR H LENNART M | 2008 | Journal of Chromatography A2008，1192，： | 1 |
| 5 | Control of insect vectors and plant viruses in protected crops by novel pyrethroid‐treated nets显示文摘 | Beatriz Dáder Saioa Legarrea Aránzazu Moreno María Plaza Michele Carmo‐Sousa Fermín Amor Elisa Vi?uela Alberto Fereres | 2015 | Pest. Manag. Sci2015，，： | 1 |
| 6 | Evaluation of adhesion/cohesion bond strength of the thick plasma spray coatings by scratch testing on coatings cross-sections 显示文摘 | Aleksandar Vencl Saioa Arostegui Gregory Favaro | 2011 | Tribology Interuational2011，44，： | 1 |
| 7 | Evaluation of adhesion/cohesion bond strength of the thick plasma spray coatings by scratch testing on coatings cross-sections 显示文摘 | Aleksandar Vencl Saioa Arostegui Gregory Favaro | 2011 | Tribology International2011，44，： | 1 |
| 8 | Effects of resveratrol on obesity-related inflammation markers in adipose tissue of genetically obese rats显示文摘 | Saioa Gómez-Zorita Alfredo Fernández-Quintela Arrate Lasa Elizabeth Hijona Luis Bujanda María P. Portillo | 2013 | Nutrition2013，，： | 1 |
| 9 | Optimization and application of homogeneous liquid–liquid extraction in preconcentration of copper (II) in a ternary solvent system显示文摘 | Mir Ali Farajzadeh Morteza Bahram Saioa Zorita Behzad Ghorbani Mehr | 2008 | Journal of Hazardous Materials2008，，2： | 1 |
| 10 | Mapping Fe - bearing hydrated sulphate minerals with short wave infrared (SWIR) spectral analysis at San Miguel mine environment, Iberian Pyrite Belt (SW Spain) 显示文摘 | Francisco Velasco Ana Alvaro Saioa Suarez | 2005 | Journal of Geochemical Exploration2005，87，： | 1 |
| 11 | Structural, mechanical and tribological properties of A356 aluminum alloy reinforced with A1203, SiC and SiC+ graphite partieles显示文摘 | Aleksandar Vencl Ilija Bobic Saioa Arostegui | 2010 | J Alloys Compd2010，506，： | 1 |
| 12 | Preparation and characterization of dense nanohydroxyapatite/PLLA composites显示文摘 | Sandrine Gay Saioa Arostegui Jacques Lemaitre | 2009 | Materials Science and Engineering C2009，29，： | 1 |
| 13 | Effect of N-(n-butyl)thiophosphorictriamide on urea metabolism and the assimilation of ammonium by Triticumaestivum L显示文摘 | Ekhie A Saioa C Idoia A | 2011 | Plant Growth Regul2011，63，： | 1 |
| 14 | Surface Modification of Sisal Fibers: Effects on the Mechanical and Thermal Properties of Their Epoxy Composites显示文摘 | Piedad Cranan Saioa Garbizu Rodrigo Llano-Ponte | 2005 | Polymer Composite2005，，： | 1 |
| 15 | Environmental pollution with psychiatric drugs显示文摘Among all contaminants of emerging interest,drugs are the ones that give rise to the greatest concern.Any of the multiple stages of the drug's life cycle(production,consumption and waste management)is a possible entry point to the different environmental matrices.Psychiatric drugs have received special attention because of two reasons.First,their use is increasing.Second,many of them act on phylogenetically highly conserved neuroendocrine systems,so they have the potential to affect many non-target organisms.Currently,wastewater is considered the most important source of drugs to the environment.Furthermore,the currently available wastewater treatment plants are not specifically prepared to remove drugs,so they reach practically all environmental matrices,even tap water.As drugs are designed to produce pharmacological effects at low concentrations,they are capable of producing ecotoxicological effects on microorganisms,flora and fauna,even on human health.It has also been observed that certain antidepressants and antipsychotics can bioaccumulate along the food chain.Drug pollution is a complicated and diffuse problem characterized by scientific uncertainties,a large number of stakeholders with different values and interests,and enormous complexity.Possible solutions consist on acting at source,using medicines more rationally,eco-prescribing or prescribing greener drugs,designing pharmaceuticals that are more readily biodegraded,educating both health professionals and citizens,and improving coordination and collaboration between environmental and healthcare sciences.Besides,end of pipe measures like improving or developing new purification systems(biological,physical,chemical,combination)that eliminate these residues efficiently and at a sustainable cost should be a priority.Here,we describe and discuss the main aspects of drug pollution,highlighting the specific issues of psychiatric drugs. | Julene Argaluza Saioa Domingo-Echaburu Gorka Orive Juan Medrano Rafael Hernandez Unax Lertxundi | 2021 | World Journal of Psychiatry2021，11，10： | 0 |
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